Transcellular transport of angiotensin II through a cultured arterial endothelial monolayer.

abstract：:Human PHA-stimulated mononuclear cells produce a factor which inhibits synovial cell collagen and non-collagen protein synthesis, whereas it enhances hyaluronic acid (HA) production. Indomethacin (10(-4)-10(-6) M), a cyclo-oxygenase inhibitor, suppresses this effect, suggesting that the mechanism is prostaglandin-medi...

journal_title：Experimental cell research

authors： Pujol JP,Penfornis H,Arenzana-Seisdedos F,Bocquet J,Farjanel J,Rattner A,Brisset M,Virelizier JL,Beliard R,Loyau G

更新日期：1985-05-01 00:00:00

abstract：:Gp38k is a 383-amino-acid secreted glycoprotein expressed by cultured vascular smooth muscle cells during the time of transition from a proliferating monolayer culture to a nonproliferating multilayered (differentiated) culture. Expression continues as the cell culture forms multicellular nodules. Because this transit...

journal_title：Experimental cell research

authors： Malinda KM,Ponce L,Kleinman HK,Shackelton LM,Millis AJ

更新日期：1999-07-10 00:00:00

abstract：:The subcellular location of a soluble DNA replication-stimulating factor released from lysolecithin-permeabilized cultured mammalian cells was investigated by cytochalasin B (CB) enucleation. In both Chinese hamster ovary cells and baby hamster kidney (BHK) cells, approx. 70% of the total activity of the replication-s...

journal_title：Experimental cell research

authors： Myers CA,Patel PI,Miller MR

更新日期：1983-01-01 00:00:00

abstract：:We have compared the in vitro replicative life span and characteristics of immortalization of skin fibroblast cultures derived from ad libitum-fed and caloric-restricted Fischer 344 rats of 6, 24, and 29 months of age. Cells from all 6-, 24-, and 29-month-old animals showed a gradual decline in proliferative potential...

journal_title：Experimental cell research

authors： Pignolo RJ,Masoro EJ,Nichols WW,Bradt CI,Cristofalo VJ

更新日期：1992-07-01 00:00:00

abstract：:There are a number of low-abundance small nuclear RNAs (snRNAs) in eukaryotic cells. Many of them have been assigned functions in the biogenesis of cellular RNAs, such as splicing and 3' end processing. Here, we present the sequence of Xenopus U12 snRNA and compare the secondary structures of the low-abundance U11 and...

journal_title：Experimental cell research

authors： Yu YT,Tarn WY,Yario TA,Steitz JA

更新日期：1996-12-15 00:00:00

abstract：:Compact mouse morulae were decompacted in calcium-free medium and allowed to recompact in standard embryo culture medium. When the recompaction medium contained trifluoperazine (TFP)(0.05 mM), an inhibitor of the calcium-dependent protein calmodulin, the embryos failed to recompact. This effect could not be overcome b...

journal_title：Experimental cell research

authors： Bilozur M,Powers RD

更新日期：1982-11-01 00:00:00

abstract：:The stimulatory heterotrimeric Gs protein alpha subunit (Gsα) is a ubiquitous guanine nucleotide-binding protein that regulates the intracellular cAMP signaling pathway and consequently participates in a wide range of biological events. In the reproductive system, despite Gsα being associated with oocyte meiotic arres...

journal_title：Experimental cell research

authors： Xie Y,Wu B,Jin Y,Zhang A,Sun X,Zhang X,Gao X,Dong R,Li H,Gao J

更新日期：2018-09-15 00:00:00

abstract：:The cell cycle of the P388D 1 murine macrophage line was delineated and suspensions of exponentially growing cells were separated by centrifugal elutriation into subpopulations enriched in the various phases of the cycle. Analysis of both growth and labelled mitoses curves disclosed that the doubling and cell-cycle ti...

journal_title：Experimental cell research

authors： Gandour DM,Walker WS

更新日期：1983-02-01 00:00:00

abstract：:Tumor hypoxia correlates to aggressive disease, and while this is explained by a variety of factors, one clue to understand this phenomena was the finding that hypoxia induces a de-differentiated, stem cell-like phenotype in neuroblastoma and breast tumor cells. The hypoxia inducible transcription factors (HIFs) are r...

journal_title：Experimental cell research

authors： Mohlin S,Wigerup C,Jögi A,Påhlman S

更新日期：2017-07-15 00:00:00

abstract：:Sendai virus (SV) glycoproteins were co-reconstituted with the erythrocyte membrane polypeptide designated as band 3 (B3). Fusion of the hybrid vesicles, SV-B3, with L, HeLa and Friend erythroleukemic (FEL) cells led to fusion-mediated implantation of the erythrocyte band 3 into the plasma membranes of the above cells...

journal_title：Experimental cell research

authors： Beigel M,Loyter A

更新日期：1983-10-01 00:00:00

abstract：:Adhesion of hepatocytes to collagenous substrates and their spreading have been shown to involve a specific recognition event, possibly mediated by membrane proteins with affinity for collagen. In the present communication, we describe the isolation of membrane components that are involved in the adhesion of rat hepat...

journal_title：Experimental cell research

authors： Rubin K,Gullberg D,Borg TK,Obrink B

更新日期：1986-05-01 00:00:00

abstract：:The 37 kDa/67 kDa laminin receptor (LRP/LR) is over-expressed in tumor cells and has been implicated in several tumourigenic processes such as metastasis and telomerase activation, however, more importantly the focus of the present study is on the maintenance of cellular viability and the evasion of apoptosis. The aim...

journal_title：Experimental cell research

authors： Rebelo TM,Vania L,Ferreira E,Weiss SFT

更新日期：2018-07-01 00:00:00

abstract：:In a previous paper (Barboro et al., 1993, Biophys. J. 65, 1690-1699) we have shown that cancer development in the resistant hepatocyte model of Solt and Farber is characterized by the progressive unfolding of the higher-order structure of chromatin. A possible functional role of decondensation phenomena in cell trans...

journal_title：Experimental cell research

authors： Barboro P,Alberti I,Sanna P,Parodi S,Balbi C,Allera C,Patrone E

更新日期：1996-06-15 00:00:00

abstract：:Individual tumor cells utilize one of two modes of motility to invade the extracellular matrix, mesenchymal or amoeboid. We have determined that the diterpenoid genkwanine M (GENK) enhances the mesenchymal mode of cell motility that is intrinsic to HT-1080 osteosarcoma cells, stimulates a mesenchymal mode of motility ...

journal_title：Experimental cell research

authors： Zimmerman C,Austin P,Khong A,McLeod S,Bean B,Forestieri R,Andersen RJ,Jan E,Roberge M,Roskelley CD

更新日期：2013-04-01 00:00:00

abstract：:Cytosolic extracts from actively dividing lymphoid cells have been shown to induce DNA synthesis in isolated, quiescent nuclei. An initiating factor in such extracts (activator of DNA replication; ADR) is a > 90-kDa aprotinin-binding protein whose activity is inhibitable not only by aprotinin, but also by several othe...

journal_title：Experimental cell research

authors： Fresa KL,Autieri MV,Coffman FD,Georgoff I,Cohen S

更新日期：1993-04-01 00:00:00

abstract：:Accumulating evidence has suggested that thyroid hormone receptor interacting protein 6 (TRIP6) is a novel tumor-related regulator that is aberrantly expressed in multiple tumors and contributes to tumor progression and metastasis. Yet, little is known about the role of TRIP6 in cervical cancer. In the current study, ...

journal_title：Experimental cell research

authors： Yang F,Li L,Zhang J,Zhang J,Yang L

更新日期：2020-11-01 00:00:00

abstract：:To determine which endocytic compartments are sensitive to sucrose-induced osmotic swelling, CHO and Vero cells were cultured for 1-3 days in media containing 0.03 to 0.05 M sucrose. (Sucrose is internalized but not digested by these cells.) To immunolocalize late endocytic compartments, cells were fixed with formalde...

journal_title：Experimental cell research

authors： DeCourcy K,Storrie B

更新日期：1991-01-01 00:00:00

abstract：:DNA methylation in F9 embryonal carcinoma cells at various stages of retinoic acid-induced differentiation was compared to that in immortalized differentiated derivatives of this cell line. Different repetitive sequences, such as L1 LINE, GAPDH pseudogenes, and major and minor satellite DNA, lost their methylation to ...

journal_title：Experimental cell research

authors： Teubner B,Schulz WA

更新日期：1994-02-01 00:00:00

abstract：:The existence of two different pathways for cell death has been postulated. In addition to the passive and traumatic process leading to necrosis, an active program characterized by organelle integrity and called apoptosis has been described. A positive correlation between the apoptotic cell death process and oxidative...

journal_title：Experimental cell research

authors： Cossarizza A,Franceschi C,Monti D,Salvioli S,Bellesia E,Rivabene R,Biondo L,Rainaldi G,Tinari A,Malorni W

更新日期：1995-09-01 00:00:00

abstract：:Ring finger protein 6 (RNF6), a RING-domain E3 ubiquitin Ligase, functions as a potential tumor promoter in several caners. However, the function and clinical significance of RNF6 in hepatocellular carcinoma (HCC) remains unclear. Here, we found that high RNF6 expression was detected frequently in primary HCC tissues,...

journal_title：Experimental cell research

authors： Cai J,Xiong Q,Jiang X,Zhou S,Liu T

更新日期：2019-01-01 00:00:00

abstract：:Thyroid hormone (T3) and estradiol (Est) modulate biological processes by binding to nuclear receptor proteins that, through interactions with specific response elements in the regulatory regions of genes, modulate gene transcription. Est stimulation of estrogen receptor (ER)-positive breast carcinoma cell growth occu...

journal_title：Experimental cell research

authors： Shao ZM,Sheikh MS,Rishi AK,Dawson MI,Li XS,Wilber JF,Feng P,Fontana JA

更新日期：1995-05-01 00:00:00

abstract：:The objective of this study was to explore the potential use of self-assembled monolayers (SAMs) of alkylamine and arylalkyamine as well-defined, homogeneous, tailored in vitro model surfaces for exploring the effect of hydrodynamic flow on morphology and strength of adhesion of human umbilical vein endothelial cells....

journal_title：Experimental cell research

authors： Kapur R,Rudolph AS

更新日期：1998-10-10 00:00:00

abstract：:We have studied the morphological alterations of the lysosomal compartment in rat hepatocytes following intraperitoneal administration of leupeptin, using electron microscopy and cytochemical techniques. At 30 min after the injection, autophagic vacuoles (autophagosomes and autolysosomes), containing cytoplasmic organ...

journal_title：Experimental cell research

authors： Ishikawa T,Furuno K,Kato K

更新日期：1983-03-01 00:00:00

abstract：:Lithium (Li+) has been used in the treatment of manic-depressive disorders for several decades. More recently, Li+ has been shown to affect the signaling pathway of various neurotransmitters and growth/neurotrophic factors. We examined the effect of Li+ on the survival of cerebellar granule neurons in culture. Treatme...

journal_title：Experimental cell research

authors： D'Mello SR,Anelli R,Calissano P

更新日期：1994-04-01 00:00:00

abstract：:Deregulation of the bone morphogenetic protein (BMP) pathway has been documented in colorectal cancer (CRC). Previously, we investigated possible associations between urokinase-type plasminogen activator (uPA) deficiency and expression of extracellular constituents of BMP signaling in a newly developed mouse model of ...

journal_title：Experimental cell research

authors： Afaloniati H,Karagiannis GS,Hardas A,Poutahidis T,Angelopoulou K

更新日期：2017-12-15 00:00:00

abstract：:Human lacrimal gland biopsies were serially incubated in chelating and enzymatic solutions. Viable single cells were evaluated for outgrowth in growth factor enriched medium using the following culture substrates: Matrigel, Type I collagen gel with or without fibroblasts, and plastic. Each epithelial outgrowth was cha...

journal_title：Experimental cell research

authors： Yoshino K,Tseng SC,Pflugfelder SC

更新日期：1995-09-01 00:00:00

abstract：:The sensitivity to serine proteinases of cellular proteins involved in cell-matrix adhesion was investigated using C32 melanoma cells. Cells dissociated from monolayers by the metal chelator ethylenediaminetetraacetic acid were incubated with proteolytic enzymes, and then attachment was quantified by standard cell adh...

journal_title：Experimental cell research

authors： Fujii K,Lazarus GS,Schechter NM

更新日期：1993-09-01 00:00:00

abstract：:In this study, a somatic cell genetic approach was used to study the regulation of liversolidusbonesoliduskidney alkaline phosphatase (ALPL) gene expression in osteoblasts. ALPL plays an important role in skeletal mineralization and serves as a good index of bone formation. A series of intertypic hybrids constructed b...

journal_title：Experimental cell research

authors： Johnson-Pais TL,Leach RJ

更新日期：1996-07-10 00:00:00

abstract：:Cell migration plays a major role during wound healing and is tightly controlled by a variety of growth factors and extracellular matrix proteins. The experiments reported here have been designed to study whether defined beta 1 integrins are involved in the platelet-derived growth-factor-AB (PDGF-AB)-modulated migrato...

journal_title：Experimental cell research

authors： Kirchberg K,Lange TS,Klein EC,Jungtäubl H,Heinen G,Meyer-Ingold W,Scharffetter-Kochanek K

更新日期：1995-09-01 00:00:00

abstract：:Sensitivity of tumor cells to treatment with anticancer drugs depends on expression and function of antiapoptotic and antioxidant proteins. The goal of our study was to determine the functional role of the novel antioxidant protein Peroxiredoxin V (PrxV), in protection of human lung carcinoma cell lines against apopto...

journal_title：Experimental cell research

authors： Kropotov A,Gogvadze V,Shupliakov O,Tomilin N,Serikov VB,Tomilin NV,Zhivotovsky B

更新日期：2006-09-10 00:00:00