Thyroid hormone enhancement of estradiol stimulation of breast carcinoma proliferation.

abstract：:The microtubule cytoskeleton is known to play a role in cell structure and serve as a scaffold for a variety of active molecules in processes as diverse as motility and cell division. The literature on the role of microtubules in signal transduction, however, is marked by inconsistencies. We have investigated a well-s...

journal_title：Experimental cell research

authors： Jackman RW,Rhoads MG,Cornwell E,Kandarian SC

更新日期：2009-11-15 00:00:00

abstract：:Endocytosis is inhibited by overexpression of either dynamin-1 or dynamin-2 mutants because both isoforms form heterotetramers with endogenous dynamin-2 and interfere with its function. By contrast, other phenotypes, which are specifically triggered by overexpression of dynamin-2, but not dynamin-1 are likely to refle...

journal_title：Experimental cell research

authors： Soulet F,Schmid SL,Damke H

更新日期：2006-11-01 00:00:00

abstract：:In addition to previously isolated ratjadone A we describe three new members of this family, ratjadones B, C, and D, from another strain of the myxobacterium Sorangium cellulosum. We have investigated the properties of these ratjadones with respect to their activity on mammalian cell lines. We found IC(50) values in t...

journal_title：Experimental cell research

authors： Köster M,Lykke-Andersen S,Elnakady YA,Gerth K,Washausen P,Höfle G,Sasse F,Kjems J,Hauser H

更新日期：2003-06-10 00:00:00

abstract：:Transcription factor Foxa1 plays a critical role during neural differentiation and is induced immediately after retinoic acid (RA)-initiated differentiation of pluripotent P19 embryonal carcinoma cells, correlated with the downregulated expression of pluripotency-related genes such as Nanog. To study whether Foxa1 par...

journal_title：Experimental cell research

authors： Chen T,He S,Zhang Z,Gao W,Yu L,Tan Y

更新日期：2014-08-15 00:00:00

abstract：:ADP-ribosylation factors (ARFs) are modified by a myristate group that is covalently linked to the second glycine residue at the amino terminus. With the recent evidence that ARF6 localizes to the cell periphery and plays a regulatory role in endocytic traffic, we have investigated the role of myristoylation on the me...

journal_title：Experimental cell research

authors： D'Souza-Schorey C,Stahl PD

更新日期：1995-11-01 00:00:00

abstract：RATIONALE:Vessel formation is a crucial event in tissue repair after injury. Thus, one assumption of innovative therapeutic approaches is the understanding of its molecular mechanisms. Notwithstanding our knowledge of the role of Protein Kinase C epsilon (PKCε) in cardio-protection and vascular restenosis, its role in ...

journal_title：Experimental cell research

authors： Galli D,Carubbi C,Masselli E,Corradi D,Dei Cas A,Nouvenne A,Bucci G,Arcari ML,Mirandola P,Vitale M,Gobbi G

更新日期：2015-01-15 00:00:00

abstract：:We have shown previously that the activity of the long myosin light chain kinase (MLCK) is cell cycle regulated with a decrease in specific activity during mitosis that can be restored following treatment with alkaline phosphatase. To better understand the role and significance of phosphorylation in regulating MLCK fu...

journal_title：Experimental cell research

authors： Dulyaninova NG,Bresnick AR

更新日期：2004-10-01 00:00:00

abstract：:Tendon is a critical unit of musculoskeletal system that connects muscle to bone to control bone movement. More population participate in physical activities, tendon injuries, such as acute tendon rupture and tendinopathy due to overuse, are common causing unbearable pain and disability. However, the process of tendon...

journal_title：Experimental cell research

authors： Lu YF,Chan KM,Li G,Zhang JF

更新日期：2016-02-15 00:00:00

abstract：:Previous studies showed nanosecond pulsed electric field (nsPEF) can ablate solid tumors including hepatocellular carcinoma (HCC) but its effect on cell membrane is not fully understood. We hypothesized nsPEF disrupt the microdomains on outer-cellular membrane with direct mechanical force and as a result the plasma me...

journal_title：Experimental cell research

authors： Yin S,Chen X,Xie H,Zhou L,Guo D,Xu Y,Wu L,Zheng S

更新日期：2016-08-15 00:00:00

abstract：BACKGROUND:The db/db mouse is an animal model of diabetes in which leptin receptor activity is deficient resulting accelerated cardiomyopathy when exposed to angiotensin (AT). Toll-like receptors 4 and 2 (TLR4, TLR2) are pattern recognition receptors, that recognize pathogen-associated molecular patterns and exacerbate...

journal_title：Experimental cell research

authors： Cohen K,Waldman M,Abraham NG,Laniado-Schwartzman M,Gurfield D,Aravot D,Arad M,Hochhauser E

更新日期：2017-01-01 00:00:00

abstract：:Tau pathology in Alzheimer's disease (AD) includes hyperphosphorylation and truncation of tau. Phosphorylation at S422 is found to suppress truncation of tau at D421 that leading to the generation of ΔTau. However, the interrelation between hyperphosphorylation and generation of ΔTau in AD remains elusive. In current ...

journal_title：Experimental cell research

authors： Cao L,Liang Y,Liu Y,Xu Y,Wan W,Zhu C

更新日期：2018-09-01 00:00:00

abstract：:Actions of transforming growth factor-β are largely context dependent. For instance, TGF-β is growth inhibitory to epithelial cells and many tumor cell-lines while it stimulates the growth of mesenchymal cells. TGF-β also activates fibroblast cells to a myofibroblastic phenotype. In order to understand how the respons...

journal_title：Experimental cell research

authors： Chopra S,Kumar N,Rangarajan A,Kondaiah P

更新日期：2015-06-10 00:00:00

abstract：:The expression patterns of the testis-specific and somatic forms of the pyruvate dehydrogenase (PDH) E1 alpha subunit genes were examined in adult mouse testis by in situ hybridization with specific cDNA probes and by immunostaining. A considerable increase in the mRNA level of the testis-specific PDH E1 alpha gene wa...

journal_title：Experimental cell research

authors： Takakubo F,Dahl HH

更新日期：1992-03-01 00:00:00

abstract：:The sensitivity to serine proteinases of cellular proteins involved in cell-matrix adhesion was investigated using C32 melanoma cells. Cells dissociated from monolayers by the metal chelator ethylenediaminetetraacetic acid were incubated with proteolytic enzymes, and then attachment was quantified by standard cell adh...

journal_title：Experimental cell research

authors： Fujii K,Lazarus GS,Schechter NM

更新日期：1993-09-01 00:00:00

abstract：:Carbohydrate-specific monoclonal antibodies were used to demonstrate the expression of a new membrane glycoprotein on F9 murine embryonal carcinoma cells. Sialyl LeX was detected using monoclonal antibody FH6 in a sensitive, cell monolayer radioimmunoassay. The antigen codistributed in gel filtration of a crude homoge...

journal_title：Experimental cell research

authors： Rosenman SJ,Fenderson BA,Hakomori SI

更新日期：1989-02-01 00:00:00

abstract：:Primary cultures of human keratinocytes form a multilayered tissue. By incubating the tissue cultures in Ca2(+)-free medium the differentiated cell layers can be stripped off leaving a basal cell monolayer. We have developed a method for high-frequency transfection of these epidermal basal cells with genes inserted in...

journal_title：Experimental cell research

authors： Jensen TG,Jensen PK,Nørgård JO,Bolund L

更新日期：1990-08-01 00:00:00

abstract：:The biological mechanisms involved in initiating, coordinating, and ultimately terminating cell-cell adhesion in the stratified epithelium are not well understood at present. This study was designed to elucidate the roles of the muscarinic M3, the nicotinic alpha3, and the mixed muscarinic-nicotinic alpha9 acetylcholi...

journal_title：Experimental cell research

authors： Nguyen VT,Chernyavsky AI,Arredondo J,Bercovich D,Orr-Urtreger A,Vetter DE,Wess J,Beaudet AL,Kitajima Y,Grando SA

更新日期：2004-04-01 00:00:00

abstract：:We have compared the in vitro replicative life span and characteristics of immortalization of skin fibroblast cultures derived from ad libitum-fed and caloric-restricted Fischer 344 rats of 6, 24, and 29 months of age. Cells from all 6-, 24-, and 29-month-old animals showed a gradual decline in proliferative potential...

journal_title：Experimental cell research

authors： Pignolo RJ,Masoro EJ,Nichols WW,Bradt CI,Cristofalo VJ

更新日期：1992-07-01 00:00:00

abstract：:Integrin-linked kinase (ILK) is a multifunctional serine/threonine kinase. Accumulating evidences suggest that ILK are involved in cell-matrix interactions, cell proliferation, invasion, migration, angiogenesis and Epithelial-mesenchymal transition (EMT). However, the underlying mechanisms remain largely unknown. EMT ...

journal_title：Experimental cell research

authors： Xing Y,Qi J,Deng S,Wang C,Zhang L,Chen J

更新日期：2013-08-01 00:00:00

abstract：:We examined the relationship of cellular oncogene c-myc and transferrin receptor (TfR) gene expression to cell proliferation and cell cycle progression during myeloid differentiation in the HL-60 myeloid leukemia cell line. In order to determine levels of mRNA for these genes in HL-60 cells induced to differentiate al...

journal_title：Experimental cell research

authors： Barker KA,Newburger PE

更新日期：1990-01-01 00:00:00

abstract：:Rat myotubes in tissue culture form broad areas of close contact with the substrate. These areas often display two distinct, interdigitating sets of membrane domains. One, the "contact domain", is close to the substrate; the other, termed the "AChR domain", is further from the substrate and is rich in acetylcholine re...

journal_title：Experimental cell research

authors： Bloch RJ,Velez M,Krikorian JG,Axelrod D

更新日期：1989-06-01 00:00:00

abstract：:Annexin 2 is a Ca(2+)-dependent phospholipid-binding protein that is involved in secretion. Despite the fact that this protein does not have signals for its secretion, many reports have shown its presence in the extracellular milieu. Here we demonstrate that, upon stimulation of exocytosis in chromaffin cells, a fract...

journal_title：Experimental cell research

authors： Faure AV,Migné C,Devilliers G,Ayala-Sanmartin J

更新日期：2002-05-15 00:00:00

abstract：:Skin extracellular matrix (ECM) molecules regulate a variety of cellular activities, including cell movement, which are central to wound healing and metastasis. Regulated cell movement is modulated by proteases and their associated molecules, including the serine proteases urinary-type plasminogen activator (uPA) and ...

journal_title：Experimental cell research

authors： Jones JM,Cohen RL,Chambers DA

更新日期：2002-11-01 00:00:00

abstract：:The post-traumatic hypertrophic scar (HS) is a fibrotic disease with excessive extracellular matrix (ECM) production by fibroblasts in response to tissue injury. Although dysregulation of miRNAs is known to be involved in a variety of pathophysiologic processes, the role of miRNA in hypertrophic scar formation is uncl...

journal_title：Experimental cell research

authors： Zhou R,Zhang Q,Zhang Y,Fu S,Wang C

更新日期：2015-12-10 00:00:00

abstract：:Osteoporosis due to unloading-induced bone loss is a critical issue in the modern aging society. Although the mechanisms underlying this phenomenon are largely unknown, osteopontin (OPN) is one of the critical mediators required for unloading-induced bone loss [M. Ishijima, S.R. Rittling, T. Yamashita, K. Tsuji, H. Ku...

journal_title：Experimental cell research

authors： Ishijima M,Ezura Y,Tsuji K,Rittling SR,Kurosawa H,Denhardt DT,Emi M,Nifuji A,Noda M

更新日期：2006-10-01 00:00:00

abstract：:Tumor-derived exosomes (TEX) play an important role in the escape of tumor cells from immune surveillance. However, the details of the mechanism are not fully understood. In this study, the apoptosis of CD4+ T cells increased during treatment with B16-derived exosomes in vitro and in vivo, resulting in accelerated gro...

journal_title：Experimental cell research

authors： Zhou J,Yang Y,Wang W,Zhang Y,Chen Z,Hao C,Zhang J

更新日期：2018-10-15 00:00:00

abstract：:The stroma, the middle layer of the cornea, is a connective tissue making up most of the corneal thickness. The stromal extracellular matrix (ECM) consists of highly organised lamellae which are made up of tightly packed fibrils primarily composed of collagens type I and V. This layer is interspersed with keratocytes,...

journal_title：Experimental cell research

authors： Greene CA,Green CR,Dickinson ME,Johnson V,Sherwin T

更新日期：2016-09-10 00:00:00

abstract：:We have established, in continuous cell culture, a spontaneously immortalized chicken embryo fibroblast (CEF) cell line (DF-1) as well as several other immortal CEF cell lines. The immortal DF-1 cells divided more rapidly than primary and other immortal CEF cells. To identify the genes involved in rapidly dividing DF-...

journal_title：Experimental cell research

authors： Kim H,You S,Kim IJ,Farris J,Foster LK,Foster DN

更新日期：2001-05-01 00:00:00

abstract：:We had identified earlier a germ cell-specific lamin of 60 kDa in rat which is related to somatic lamin B. This polypeptide was shown to be the only major component organizing the lamina structure of round spermatids. In the present study, we find that this 60-kDa polypeptide persists in the testicular and epididymal ...

journal_title：Experimental cell research

authors： Sudhakar L,Sivakumar N,Behal A,Rao MR

更新日期：1992-01-01 00:00:00

abstract：:High throughput RNA sequencing techniques have revealed that a large fraction of the genome is transcribed into long non-coding RNAs (lncRNAs). Unlike canonical protein-coding genes, lncRNAs do not contain long open reading frames (ORFs) and tend to be poorly conserved across species. However, many of them contain sma...

journal_title：Experimental cell research

authors： Ruiz-Orera J,Villanueva-Cañas JL,Albà MM

更新日期：2020-06-01 00:00:00