Murine embryonal carcinoma cell-surface sialyl LeX is present on a novel glycoprotein and on high-molecular-weight lactosaminoglycan.

abstract：:Spinal muscular atrophy (SMA), a recessive, neuromuscular disease, is caused by a mutation or deletion in the SMN1 gene. The SMN2 gene is present in the same region of chromosome 5 and is similar in DNA sequence to SMN1 except for a T at position +6 of exon 7 that is likely the predominant functional difference betwee...

journal_title：Experimental cell research

authors： DiMatteo D,Callahan S,Kmiec EB

更新日期：2008-02-15 00:00:00

abstract：:Previously we showed that the potocytosis of 5-methyltetrahydrofolate is dependent on the acidification of plasmalemmal vesicles created each time a caveolae, closes off from the cell surface. We now report that bafilomycin A1, which is a specific inhibitor of the V-type proton ATPase, inhibits 5-methyltetrahydrofolat...

journal_title：Experimental cell research

authors： Mineo C,Anderson RG

更新日期：1996-05-01 00:00:00

abstract：:Autophagy has been shown to be critically associated with the central mechanisms underlying Parkinson's disease (PD), while the mechanisms contributing to the imbalance of autophagy remain unclear. Small nucleolar RNA host gene 1 (SNHG1), a well-studied long noncoding RNA, has been reported to be significantly increas...

journal_title：Experimental cell research

authors： Qian C,Ye Y,Mao H,Yao L,Sun X,Wang B,Zhang H,Xie L,Zhang H,Zhang Y,Zhang S,He X

更新日期：2019-11-01 00:00:00

abstract：:We have previously demonstrated that transient blocking of DNA synthesis with drugs such as 1-beta-D-arabinofuranosylcytosine results in some segments of the chromosomal DNA being replicated more than once in a single cell cycle. One explanation for this phenomenon might be that it is due to a perturbation of the cell...

journal_title：Experimental cell research

authors： Woodcock DM,Crowther PJ,Allan G,Cooper IA

更新日期：1983-08-01 00:00:00

abstract：:Shp-2, a widely expressed cytoplasmic tyrosine phosphatase with two src-homology 2 (SH2) domains, has received much attention in the signal transduction field recently. Significant progress has been made in understanding the structure and function of this phosphatase, together with its Drosophila homologue, Corkscrew,...

journal_title：Experimental cell research

authors： Feng GS

更新日期：1999-11-25 00:00:00

abstract：:Drebrin is an actin-binding protein which is expressed at highly levels in neurons. When introduced into fibroblasts, it has been known to bind to F-actin and to cause remodeling of F-actin. Here, we performed a domain analysis of the actin-binding and actin-remodeling activities of drebrin. Various fragments of drebr...

journal_title：Experimental cell research

authors： Hayashi K,Ishikawa R,Kawai-Hirai R,Takagi T,Taketomi A,Shirao T

更新日期：1999-12-15 00:00:00

abstract：:Members of the cadherin family of cell adhesion molecules participate in calcium-dependent cell-cell adhesions that are necessary for the cell sorting events that regulate early developmental processes. Although individual cadherin molecules have been shown to participate in tissue histogenesis, the regulation of func...

journal_title：Experimental cell research

authors： Ferreira-Cornwell MC,Veneziale RW,Grunwald GB,Menko AS

更新日期：2000-04-10 00:00:00

abstract：:Alpha-Smooth muscle actin is one of the molecular markers for a phenotype of vascular smooth muscle cells, because the actin is a major isoform expressed in vascular smooth muscle cells and its expression is upregulated during differentiation. Here, we first demonstrate that the phenotype-dependent expression of this ...

journal_title：Experimental cell research

authors： Saga H,Kimura K,Hayashi K,Gotow T,Uchiyama Y,Momiyama T,Tadokoro S,Kawashima N,Jimbou A,Sobue K

更新日期：1999-02-25 00:00:00

abstract：:The process of osteoblast differentiation and matrix mineralization requires a rise in alkaline phosphatase enzymatic activity resulting in the generation of free phosphate. The ability of inorganic phosphate to regulate gene transcription and cellular function represents a potentially novel extracellular signaling me...

journal_title：Experimental cell research

authors： Beck GR Jr,Moran E,Knecht N

更新日期：2003-08-15 00:00:00

abstract：:A culture system that facilitates the chondrogenic differentiation of rabbit bone marrow-derived mesenchymal progenitor cells has been developed. Cells obtained in bone marrow aspirates were first isolated by monolayer culture and then transferred into tubes and allowed to form three-dimensional aggregates in a chemic...

journal_title：Experimental cell research

authors： Johnstone B,Hering TM,Caplan AI,Goldberg VM,Yoo JU

更新日期：1998-01-10 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is one of the most common malignant tumors in the urinary system, and its incidence continues to increase. Regulator of calcineurin 1 (RCAN1), one of the genes on chromosome 21, is a crucial mediator of tumor inhibition. RCAN1.4 is best characterized as an endogenous inhibitor o...

journal_title：Experimental cell research

authors： Song Z,Cao Q,Ruan H,Yang H,Wang K,Bao L,Cheng G,Xu T,Xiao H,Wang C,Liu D,Chen K,Zhang X

更新日期：2018-11-15 00:00:00

abstract：:Heat shock proteins (HSPs) have molecular chaperone functions in protein biogenesis as well as cytoprotective functions against deleterious environmental stresses, and they work mainly inside of the cells. HSPs are usually induced in living cells that have been exposed to mild stresses or have recovered from severe st...

journal_title：Experimental cell research

authors： Saito K,Dai Y,Ohtsuka K

更新日期：2005-10-15 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) results from the uncontrolled proliferation and accumulation of B-1 cells, many of which demonstrate self-reactivity. The response of B-1 cells to mitogen after undergoing malignant transformation is still unclear. Using our established malignant B-1 cell lines derived from the NZB m...

journal_title：Experimental cell research

authors： Zhang M,Chong SY,Raveche ES

更新日期：2001-04-01 00:00:00

abstract：:ORP8 is an oxysterol/cholesterol binding protein anchored to the endoplasmic reticulum and the nuclear envelope, and is abundantly expressed in the macrophage. We created and characterized mouse RAW264.7 macrophages with ORP8 stably silenced using shRNA lentiviruses. A microarray transcriptome and gene ontology pathwa...

journal_title：Experimental cell research

authors： Béaslas O,Vihervaara T,Li J,Laurila PP,Yan D,Olkkonen VM

更新日期：2012-09-10 00:00:00

abstract：:Indirect immunofluorescence using anti-human placental bFGF antibodies demonstrates the presence of bFGF-like reactivity in the cytoplasm and in the nucleus of adult bovine aortic endothelial cells and of normal and transformed fetal bovine aortic endothelial AG 7680 and GM 7372 cells. Biologically active immunoreacti...

journal_title：Experimental cell research

authors： Dell'Era P,Presta M,Ragnotti G

更新日期：1991-02-01 00:00:00

abstract：:Centrosomes, the main microtubule-organizing centers (MTOCs) in most animal cells, are important for many cellular activities such as assembly of the mitotic spindle, establishment of cell polarity, and cell movement. In nuclear transfer (NT), MTOCs that are located at the poles of the meiotic spindle are removed from...

journal_title：Experimental cell research

authors： Zhong ZS,Zhang G,Meng XQ,Zhang YL,Chen DY,Schatten H,Sun QY

更新日期：2005-05-15 00:00:00

abstract：:We have used biotinylated rDNA probes to localize by in situ hybridization the extrachromosomal genes for ribosomal RNA in the slime mold Physarum polycephalum. We established conditions that allow for highly specific hybridization at the ultrastructural level and determined that the 60-kb palindromic rDNA molecules a...

journal_title：Experimental cell research

authors： Puvion-Dutilleul F,Pierron G

更新日期：1992-12-01 00:00:00

abstract：:Sepsis is a major cause of mortality in seriously ill patients characterized by a series of severe systemic inflammatory responses due to an infection. Thus, there is a critically need to search more accurate biomarkers and targets for diagnosis and treatment of sepsis. Our study showed that miR-212-3p was up-regulate...

journal_title：Experimental cell research

authors： Chen W,Ma X,Zhang P,Li Q,Liang X,Liu J

更新日期：2017-01-15 00:00:00

abstract：:Recent studies report mitochondrial carrier homolog 2 (MTCH2) as a novel and uncharacterized protein that acts as a receptor-like protein for the truncated BH3-interacting domain death agonist (tBID) protein in the outer membrane of mitochondria. These studies, using mouse embryonic stem cells and fibroblasts as well ...

journal_title：Experimental cell research

authors： Robinson AJ,Kunji ER,Gross A

更新日期：2012-07-01 00:00:00

abstract：:Human amnion epithelial cells attach and flatten slowly (approximately 65 min) onto plastic in the presence of serum but much more rapidly (20-30 min) onto subcellular matrix (SCM) deposited by the same cells. This matrix contains both fibronectin and laminin, but neither molecule on its own can reproduce its adhesive...

journal_title：Experimental cell research

authors： Aplin JD,Campbell S,Foden LJ

更新日期：1984-08-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) plays an important role in breast cancer cell metastasis. Both (megakaryoblastic leukemia)/myocardin-like 1 (MKL-1) and Signal transducer and activator of transcription 3 (STAT3) have been implicated in the control of cellular metabolism, survival and growth. Our previous study ...

journal_title：Experimental cell research

authors： Xiang Y,Liao XH,Yu CX,Yao A,Qin H,Li JP,Hu P,Li H,Guo W,Gu CJ,Zhang TC

更新日期：2017-08-01 00:00:00

abstract：:Autosomal dominantly inherited missense mutations in lamins A and C cause familial partial lipodystrophy of the Dunnigan-type (FPLD), and myopathies including Emery-Dreifuss muscular dystrophy (EDMD). While mutations responsible for FPLD are restricted to the carboxyl-terminal tails, those responsible for EDMD are spr...

journal_title：Experimental cell research

authors： Favreau C,Dubosclard E,Ostlund C,Vigouroux C,Capeau J,Wehnert M,Higuet D,Worman HJ,Courvalin JC,Buendia B

更新日期：2003-01-01 00:00:00

abstract：:Two HL60 clones (C12 and C13) totally insensitive to differentiation induction by dimethylsulfoxide (Me2SO) are described. They have been growing continuously in the presence of the inducer for more than 6 months. The morphological and cytochemical features of the two populations are quite similar to those of the orig...

journal_title：Experimental cell research

authors： Ferrero D,Gallo E,Lanfrancone L,Tarella C

更新日期：1983-08-01 00:00:00

abstract：:Actions of transforming growth factor-β are largely context dependent. For instance, TGF-β is growth inhibitory to epithelial cells and many tumor cell-lines while it stimulates the growth of mesenchymal cells. TGF-β also activates fibroblast cells to a myofibroblastic phenotype. In order to understand how the respons...

journal_title：Experimental cell research

authors： Chopra S,Kumar N,Rangarajan A,Kondaiah P

更新日期：2015-06-10 00:00:00

abstract：:Osteoclasts are postmitotic, multinucleated giant cells generated by the fusion of hematopoietic mononuclear precursors from the monocyte-macrophage lineage. In culture, adherent macrophages from blood-derived monocytes grow, gather, and fuse together to form multinucleated osteoclast-like cells. These events are cont...

journal_title：Experimental cell research

authors： Machuca I,Domenget C,Jurdic P

更新日期：1999-08-01 00:00:00

abstract：:Regulation of TSH receptor (TSHr) mRNA accumulation has been investigated in canine thyrocytes in primary culture by in situ hybridization experiments; the effects of the mitogenic thyrotropin (TSH), epidermal growth factor (EGF), and phorbol ester TPA (12-O-tetradecanoylphorbol-13-acetate) have been compared. Apart f...

journal_title：Experimental cell research

authors： Pohl V,Maenhaut C,Gérard C,Vassart G,Dumont JE

更新日期：1992-04-01 00:00:00

abstract：:Transcription factor Foxa1 plays a critical role during neural differentiation and is induced immediately after retinoic acid (RA)-initiated differentiation of pluripotent P19 embryonal carcinoma cells, correlated with the downregulated expression of pluripotency-related genes such as Nanog. To study whether Foxa1 par...

journal_title：Experimental cell research

authors： Chen T,He S,Zhang Z,Gao W,Yu L,Tan Y

更新日期：2014-08-15 00:00:00

abstract：BACKGROUND:The db/db mouse is an animal model of diabetes in which leptin receptor activity is deficient resulting accelerated cardiomyopathy when exposed to angiotensin (AT). Toll-like receptors 4 and 2 (TLR4, TLR2) are pattern recognition receptors, that recognize pathogen-associated molecular patterns and exacerbate...

journal_title：Experimental cell research

authors： Cohen K,Waldman M,Abraham NG,Laniado-Schwartzman M,Gurfield D,Aravot D,Arad M,Hochhauser E

更新日期：2017-01-01 00:00:00

abstract：:dNTP pools are quite low in immature oocytes of the starfish, expand during the 1-methyladenine-induced maturational process and thereafter reach a maximal level (approx. 35, 20, 15 and 5 fmoles/egg for dTTP, dCTP, dATP and dGTP, respectively) which is maintained in overmatured eggs. Maturing oocytes were inseminated ...

journal_title：Experimental cell research

authors： Nagano H,Okano K,Ikegami S

更新日期：1983-04-15 00:00:00

abstract：:The KIAA0101/p15(PAF)/OEATC-1 protein was initially isolated in a yeast two-hybrid screen for proliferating cell nuclear antigen (PCNA) binding partners, and was shown to bind PCNA competitively with the cell cycle regulator p21(WAF). PCNA is involved in DNA replication and damage repair. Using polyclonal antisera rai...

journal_title：Experimental cell research

authors： Simpson F,Lammerts van Bueren K,Butterfield N,Bennetts JS,Bowles J,Adolphe C,Simms LA,Young J,Walsh MD,Leggett B,Fowles LF,Wicking C

更新日期：2006-01-01 00:00:00