Abstract:
:High throughput RNA sequencing techniques have revealed that a large fraction of the genome is transcribed into long non-coding RNAs (lncRNAs). Unlike canonical protein-coding genes, lncRNAs do not contain long open reading frames (ORFs) and tend to be poorly conserved across species. However, many of them contain small ORFs (sORFs) that exhibit translation signatures according to ribosome profiling or proteomics data. These sORFs are a source of putative novel proteins; some of them may confer a selective advantage and be maintained over time, a process known as de novo gene birth. Here we review the mechanisms by which randomly occurring sORFs in lncRNAs can become new functional proteins.
journal_name
Exp Cell Resjournal_title
Experimental cell researchauthors
Ruiz-Orera J,Villanueva-Cañas JL,Albà MMdoi
10.1016/j.yexcr.2020.111940subject
Has Abstractpub_date
2020-06-01 00:00:00pages
111940issue
1eissn
0014-4827issn
1090-2422pii
S0014-4827(20)30145-2journal_volume
391pub_type
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