Evolution of new proteins from translated sORFs in long non-coding RNAs.

Abstract:

:High throughput RNA sequencing techniques have revealed that a large fraction of the genome is transcribed into long non-coding RNAs (lncRNAs). Unlike canonical protein-coding genes, lncRNAs do not contain long open reading frames (ORFs) and tend to be poorly conserved across species. However, many of them contain small ORFs (sORFs) that exhibit translation signatures according to ribosome profiling or proteomics data. These sORFs are a source of putative novel proteins; some of them may confer a selective advantage and be maintained over time, a process known as de novo gene birth. Here we review the mechanisms by which randomly occurring sORFs in lncRNAs can become new functional proteins.

journal_name

Exp Cell Res

authors

Ruiz-Orera J,Villanueva-Cañas JL,Albà MM

doi

10.1016/j.yexcr.2020.111940

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

111940

issue

1

eissn

0014-4827

issn

1090-2422

pii

S0014-4827(20)30145-2

journal_volume

391

pub_type

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