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Lithium induces apoptosis in immature cerebellar granule cells but promotes survival of mature neurons.

Abstract：

:Lithium (Li+) has been used in the treatment of manic-depressive disorders for several decades. More recently, Li+ has been shown to affect the signaling pathway of various neurotransmitters and growth/neurotrophic factors. We examined the effect of Li+ on the survival of cerebellar granule neurons in culture. Treatment of immature granule cells with Li+ resulted in programmed cell death (apoptosis). The death process is accompanied by DNA fragmentation, a hallmark of apoptosis. Following maturation in vitro, granule neurons are dependent on elevated concentrations of extracellular potassium ([K+]o) for survival. Lowering of [K+]o to physiological levels induces apoptosis. Surprisingly, Li+ prevents death of mature neurons caused by low [K+]o. Moreover, the concentration range at which Li+ exerts its protective effect is the same as that at which it induces apoptosis in immature neurons. Thus, a single agent under similar extracellular conditions has opposing effects on survival, depending on the developmental status of the neuron.

journal_name

Exp Cell Res

journal_title

Experimental cell research

authors

D'Mello SR,Anelli R,Calissano P

doi

10.1006/excr.1994.1095

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

332-8

issue

2

eissn

0014-4827

issn

1090-2422

pii

S0014-4827(84)71095-0

journal_volume

211

pub_type

杂志文章

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