Abstract：
:Granulation tissue fibroblasts (myofibroblasts) develop several ultrastructural and biochemical features of smooth muscle (SM) cells, including the presence of microfilaments bundles and the expression of alpha-SM actin, the actin isoform typical of contractile vascular SM cells. Myofibroblasts have been suggested to play a role in wound contraction and in retractile phenomena observed during fibrotic diseases. When granulation tissue evolves into a scar, myofibroblasts containing alpha-SM actin disappear, probably as a result of apoptosis. In contrast myofibroblasts expressing alpha-Sm actin persist in excessive scarring and in fibrotic conditions. The mechanisms leading to the development of myofibroblastic features remain to be investigated. Studies on the factors regulating the phenotype of myofibroblasts will be necessary for understanding their behavior in vivo, and possibly modifying this behavior during the different clinical settings.
journal_name
Cell Biol Intjournal_title
Cell biology internationalauthors
Desmoulière Adoi
10.1006/cbir.1995.1090subject
Has Abstractpub_date
1995-05-01 00:00:00pages
471-6issue
5eissn
1065-6995issn
1095-8355pii
S1065-6995(85)71090-6journal_volume
19pub_type
杂志文章,评审abstract：:Small heat shock proteins (shsps) are molecular chaperones that are inducible by environmental stress. In this study, immunocytochemical analysis and laser scanning confocal microscopy revealed that the shsp family, hsp30, was localized primarily in the cytoplasm of Xenopus A6 kidney epithelial cells after heat shock ...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1016/j.cellbi.2004.12.006
更新日期：2005-03-01 00:00:00
abstract：:FITC-insulin binding to previously hormone-treated Tetrahymena was studied by flow cytometry and confocal microscopy. Hormones produced by Tetrahymena were chosen for study and the hormone concentrations were administered between 10(-6) and 10(-21)M for 30 min. Endorphin, serotonin and insulin significantly reduced th...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1016/j.cellbi.2006.06.019
更新日期：2006-12-01 00:00:00
abstract：:Osteosarcoma (OS) is the most common type of primary bone tumor that exhibits invasive growth and long-distance organ metastasis. Thus, investigating the specifically targeted therapeutic agents against metastatic osteosarcoma depends on understanding the molecular mechanisms. The long noncoding RNAs (lncRNA) XIST (X-...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1002/cbin.11405
更新日期：2020-10-01 00:00:00
abstract：:We previously reported that mechanical vibration-induced proinflammatory cytokines, interleukin-6 (IL-6) and IL-8, expression in human periodontal ligament (hPDL) cells, however, the underlying mechanism remained unclear. Mechanical stimuli are able to activate cellular responses by inducing the activation of several ...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1002/cbin.11267
更新日期：2020-02-01 00:00:00
abstract：:Vascular endothelial growth factor (VEGF) plays a key role in formation of pleural effusions and in tumorigenesis and progression of malignant mesothelioma. Mesothelial cells (MC) express the viral receptors Toll-like receptor 3 (TLR3), RIG-I and MDA5. Activation of these receptors by viral RNA exemplified by poly(I:C...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1016/j.cellbi.2008.10.011
更新日期：2009-02-01 00:00:00
abstract：:Cervical cancer is considered a common yet preventable cause of death in women. In this report, we studied the role of the NF-kappaB gene family in HeLa human cervical cancer cells, using the Xrel3 c-Rel homologue of Xenopus laevis. The expression of Xrel3/c-Rel slowed cell growth 6-fold, consistent with an upregulate...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1016/j.cellbi.2004.12.014
更新日期：2005-06-01 00:00:00
abstract：:The low density lipoprotein receptor-related protein (alpha(2)MR/LRP) is a cell surface receptor which is present on most cells and tissues. We show that the 85 kDa subunit, containing the transmembrane region and cytoplasmic domain is phosphorylated in vivo. Comparison of the phosphorylation of the low density lipopr...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1006/cbir.2000.0561
更新日期：2000-01-01 00:00:00
abstract：:Primary cilium development along with other components of the centrosome in mammalian cells was analysed ultrastructurally and by immunofluorescent staining with anti-acetylated tubulin antibodies. We categorized two types of primary cilia, nascent cilia that are about 1microm long located inside the cytoplasm, and tr...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1016/j.cellbi.2003.11.013
更新日期：2004-01-01 00:00:00
abstract：:Umbilical cord blood (UCB) is a valuable source for hematopoietic progenitor cell therapy. Moreover, it contains another subset of non-hematopoietic population referred to as mesenchymal progenitor cells (MPCs), which can be ex vivo expanded and differentiated into osteoblasts, chondrocytes and adipocytes. In this stu...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1016/j.cellbi.2005.12.009
更新日期：2006-06-01 00:00:00
abstract：:MicroRNAs (miRNAs) play an increasingly important role in cancer growth by coordinately suppressing genes that control cell migration, proliferation, and invasion. The above results can be achieved through the regulation of gene expression by miRNAs by suppressing translation or the direct sequence-specific degradatio...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1002/cbin.10754
更新日期：2017-12-01 00:00:00
abstract：:A structural link between cell's nucleus and centrosome was proposed years ago. Such a link was suggested to maintain nucleus-centrosome axis, determine polarity of interphase cells and ensure spindle assembly in mitotic cells. The idea of structural link is supported by the facts that centrosomes are usually located ...
journal_title：Cell biology international
pub_type： 杂志文章,评审
doi：10.1002/cbin.10016
更新日期：2013-02-01 00:00:00
abstract：:Cattle plays an important role in providing essential nutrients through meat production. Thus, we focused on epigenetic factors associated with meat yield. To investigate circulating miRNAs that are involved with meat yield and connect biofluids and longissimus dorsi (LD) muscle in Korean cattle, we performed analyses...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1002/cbin.10776
更新日期：2017-07-01 00:00:00
abstract：:The aliphatic polyamines, putrescine, spermine and spermidine belong to a category of molecules implicated in DNA replication. Their synthesis is strongly activated during the G1 period and they have been implicated in the regulation of cell proliferation and differentiation. Terminal transferase is a DNA polymerase p...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1006/cbir.1995.1016
更新日期：1995-10-01 00:00:00
abstract：:Transforming growth factor-β (TGF-β) is a potent inhibitor of the growth of normal mammary epithelial cells, and has a pleiotropic, context-dependent, concentration-dependent action. We found attenuation of TGF-β signalling in mammary adenoma carcinoma cells. Phosphorylation at the linker site of Smad2 occurred in a c...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1002/cbin.10061
更新日期：2013-05-01 00:00:00
abstract：:Life cannot be simply defined in biochemical terms but it is associated with autodynamic behaviour. This fact implies that all aspects of cell biology should be viewed in terms of the resultant temporal features. Theoretical arguments indicate that the dynamic state can be explained only by the existence of periodicit...
journal_title：Cell biology international
pub_type： 杂志文章,评审
doi：10.1006/cbir.2000.0571
更新日期：2000-01-01 00:00:00
abstract：:Arginine vasopressin (AVP)-induced tyrosine phosphorylation was studied in a rat smooth muscle cell line, A-10, by western blotting, using a monoclonal antibody against phosphotyrosine. AVP stimulated the phosphorylation of several cellular proteins of molecular mass 60-130 kDa in a time- and dose-dependent manner. Ph...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1006/cbir.1999.0343
更新日期：1999-01-01 00:00:00
abstract：:This review outlines the basic properties of T-tubules in skeletal muscle cells, and the factors that govern reversible vacuolation in T-tubules under experimental conditions. Comparable membranous transformations, involving the plasma membrane or occurring intracellularly, in non-muscle cells are then considered. Fin...
journal_title：Cell biology international
pub_type： 杂志文章,评审
doi：10.1006/cbir.2002.0945
更新日期：2002-01-01 00:00:00
abstract：:Hepatic heat shock protein Hsp70 synthesis and in vitro phosphorylation were studied in the liver cytosol of intact, adrenalectomized and dexamethasone-administered adrenalectomized rats after 41 degrees C whole body hyperthermic stress. Hsp70 was detected by immunoblotting with N27F3-4 monoclonal antibody recognizing...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1006/cbir.1998.0247
更新日期：1999-01-01 00:00:00
abstract：:The synthesis of proteins from salt-tolerant Brassica oleracea L. var. botrytis L. subvar. cauliflora (Gars.) DC. (cauliflower) cell cultures is modified in relation to controls in several features. There are nine newly induced polypeptides in tolerant cultures (absent in control conditions). Some of them are only pre...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1006/cbir.1993.1146
更新日期：1993-09-01 00:00:00
abstract：:Temperature of culture can be used to modulate cellular metabolism for improving small intestinal cell culture and cryopreservation. An hypothermia pretreatment (2 days at 25 degrees C and 3 hours recovery at 37 degrees C) improved hamster cell survival to freeze-thaw damage (p < 0.01) but decreased the survival of 2 ...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1006/cbir.1994.1029
更新日期：1994-11-01 00:00:00
abstract：:Mitotic spindles of the diatom Pinnularia viritiformis stained with the fluorescent actin-labelling reagent bodipyphallacidin revealed actin among the chromosomes and extending along the spindle to the poles. This is the first report of actin's presence within spindles of this ecologically important group of organisms...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1016/j.cellbi.2004.04.010
更新日期：2004-01-01 00:00:00
abstract：:Although several species of Tetrahymena are often described as histophagous and opportunistic pathogens of fish, little is known about ciliate/fish cell interactions, but one approach for studying these is in vitro with cell lines. In this study, T. thermophila, B1975 (wild type) and NP1 (temperature sensitive mutant ...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1002/cbin.10310
更新日期：2014-10-01 00:00:00
abstract：:We have successfully developed both spontaneous and inductive cardiomyocyte differentiation of iPS cells reprogrammed from human foreskin fibroblasts. The reprogrammed iPS cells morphologically resemble human cardiomyocytes which can beat. RT-PCR and immunostaining show that cardiac markers are expressed that are comp...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1016/j.cellbi.2009.08.008
更新日期：2009-11-01 00:00:00
abstract：:Silicon dioxide induces acute injury and chronic pulmonary fibrosis. International Agency for Research on Cancer (IARC) listed it as a human carcinogen in 1996. However, the molecular mechanisms to induce cancer are not understood yet. The content of poly (ADP-ribose) polymerases (PARP) mRNA and protein in Hela cells ...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1016/j.cellbi.2009.04.010
更新日期：2009-07-01 00:00:00
abstract：:Cell proliferation rates of diagnostic marrow aspirate cells of 21 children with Acute Lymphoblastic Leukaemia and 16 controls were compared using immunocytochemical labelling of PCNA and Ki-67 antigen as assessed by Confocal Laser Scanning Microscopy. The results showed an unexpected, highly significant degree of dis...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1006/cbir.1994.1123
更新日期：1994-09-01 00:00:00
abstract：:Increasing potassium chloride concentration from 0 to 100 mM and magnesium chloride from 0 to 2 mM show a parallel rate increase in polymerizing actin, whereas increasing calcium chloride concentration from 0 to 0.2 mM decreases the rate of polymerizing actin. The presence of alpha-actinin has little influence on the ...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1006/cbir.2002.0898
更新日期：2002-01-01 00:00:00
abstract：:To investigate the role of peroxisome proliferator-activated receptor gamma (PPARgamma) in adipocyte formation within the skeletal muscle of beef cattle, fibroblast-like cells were isolated from the longissimus muscle of cattle and cultured with activators of murine PPARgammaA thiazolidinedione T-174, which is a speci...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1006/cbir.1998.0270
更新日期：1998-01-01 00:00:00
abstract：:Mouse embryonic stem (ES) cells can be differentiated into neural lineage cells, but the differentiation efficiency remains low. This study revealed two important factors that influence the neural differentiation efficiency of mouse ES cells: the first is the quality of embryonic bodies (EBs); good quality of EBs cons...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1016/j.cellbi.2008.04.025
更新日期：2008-09-01 00:00:00
abstract：:Rosbin (Thieno [2, 3-c] piperidine-3-carboxamide-2-[(3-methoxy-naphtha-lene-2-carbonyl)-amino]-6-(benzyl)-, hydrochloride), a synthetic piperidinothieno derivative compound obtained from chemical genetics screenings, significantly suppresses the viability of non-small cell lung cancer A549 cells with an IC50 of 2.05 ±...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1002/cbin.10714
更新日期：2017-02-01 00:00:00
abstract：:microRNAs (miRNAs) have recently been recognized as playing an important role in bone-associated diseases. This study investigated whether the reduced miR-155-5p in steroid-associated osteonecrosis of the femoral head (ONFH) attenuated osteogenic differentiation and cell proliferation by targeting GSK3B. Bone marrow w...
journal_title：Cell biology international
pub_type： 杂志文章
doi：10.1002/cbin.11470
更新日期：2021-01-01 00:00:00
