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Effect of silicon dioxide on expression of poly (ADP-ribose) polymerase mRNA and protein.

Abstract：

:Silicon dioxide induces acute injury and chronic pulmonary fibrosis. International Agency for Research on Cancer (IARC) listed it as a human carcinogen in 1996. However, the molecular mechanisms to induce cancer are not understood yet. The content of poly (ADP-ribose) polymerases (PARP) mRNA and protein in Hela cells treated with concentrations of silicon dioxide up to 400microg/ml was determined by real-time fluorogenetic quantitative PCR (RQ-PCR) and immunofluorescence assay, respectively. MTT assay was used to determine cell viability. The results showed that viability at 400microg/ml silica was significantly decreased but not at lower concentrations. The protein content of gamma-H2AX in silica-treated group was significantly higher than the controls. The PARP mRNA and protein levels were significantly reduced with a dose response manner from the lowest silicon dioxide level. Our findings suggested that silicon dioxide increased the expression of gamma-H2AX and inhibited the expression of PARP mRNA and protein in Hela cells.

journal_name

Cell Biol Int

journal_title

Cell biology international

authors

Gao A,Song S,Wang D,Peng W,Tian L

doi

10.1016/j.cellbi.2009.04.010

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

749-54

issue

7

eissn

1065-6995

issn

1095-8355

pii

S1065-6995(09)00098-5

journal_volume

33

pub_type

杂志文章

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