Abstract:
:Vascular endothelial growth factor (VEGF) plays a key role in formation of pleural effusions and in tumorigenesis and progression of malignant mesothelioma. Mesothelial cells (MC) express the viral receptors Toll-like receptor 3 (TLR3), RIG-I and MDA5. Activation of these receptors by viral RNA exemplified by poly(I:C) RNA leads to a time- and dose-dependent increase of mesothelial VEGF synthesis. To show the specific effect of viral receptors knockdown experiments with siRNA for TLR3, RIG-I and MDA5 were performed. This finding of viral induced mesothelial VEGF synthesis may indicate a novel link between viral infections and formation of pleural effusions and progression of malignant mesothelioma.
journal_name
Cell Biol Intjournal_title
Cell biology internationalauthors
Wörnle M,Sauter M,Kastenmüller K,Ribeiro A,Roeder M,Mussack T,Ladurner R,Sitter Tdoi
10.1016/j.cellbi.2008.10.011subject
Has Abstractpub_date
2009-02-01 00:00:00pages
180-6issue
2eissn
1065-6995issn
1095-8355pii
S1065-6995(08)00604-5journal_volume
33pub_type
杂志文章abstract::IPF is characterized by fibroblast accumulation, collagen deposition, and ECM remodeling, with myofibroblasts believed to be the effector cell type. Myofibroblasts develop due to EMT of lung alveolar epithelial cells, which can be induced by TGF-β. M2 macrophages, a macrophage subpopulation, secrete large amounts of T...
journal_title:Cell biology international
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pub_type: 杂志文章
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journal_title:Cell biology international
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journal_title:Cell biology international
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