Role of viral induced vascular endothelial growth factor (VEGF) production in pleural effusion and malignant mesothelioma.

Abstract:

:Vascular endothelial growth factor (VEGF) plays a key role in formation of pleural effusions and in tumorigenesis and progression of malignant mesothelioma. Mesothelial cells (MC) express the viral receptors Toll-like receptor 3 (TLR3), RIG-I and MDA5. Activation of these receptors by viral RNA exemplified by poly(I:C) RNA leads to a time- and dose-dependent increase of mesothelial VEGF synthesis. To show the specific effect of viral receptors knockdown experiments with siRNA for TLR3, RIG-I and MDA5 were performed. This finding of viral induced mesothelial VEGF synthesis may indicate a novel link between viral infections and formation of pleural effusions and progression of malignant mesothelioma.

journal_name

Cell Biol Int

authors

Wörnle M,Sauter M,Kastenmüller K,Ribeiro A,Roeder M,Mussack T,Ladurner R,Sitter T

doi

10.1016/j.cellbi.2008.10.011

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

180-6

issue

2

eissn

1065-6995

issn

1095-8355

pii

S1065-6995(08)00604-5

journal_volume

33

pub_type

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