Survival of immunoglobulin G-opsonized Toxoplasma gondii in nonadherent human monocytes.

abstract：:Shigella flexneri 2a is an invasive enteric pathogen that may produce diarrhea when ingested by human beings and subhuman primates. We have previously shown that shigella diarrhea correlates with water and electrolyte transport abnormalities in the jejunum and colon. Dysentery alone is associated only with colonic tra...

journal_title：Infection and immunity

authors： Kinsey MD,Formal SB,Dammin GJ,Giannella RA

更新日期：1976-08-01 00:00:00

abstract：:High-density oligonucleotide microarrays are widely used to study gene expression in cells exposed to a variety of pathogens. This study addressed the global genome-wide transcriptional activation of genes in hosts infected in vivo, which result in radically different clinical outcomes. We present an analysis of the g...

journal_title：Infection and immunity

authors： Schaecher K,Kumar S,Yadava A,Vahey M,Ockenhouse CF

更新日期：2005-09-01 00:00:00

abstract：:We examined the reactivities of Clostridium butyricum neurotoxin to nine monoclonal antibodies against Clostridium botulinum type E neurotoxin which recognize the light chain or the amino-terminal half (H-1 fragment) or the carboxyl-terminal half (H-2 fragment) of the heavy chain of botulinum neurotoxin. Butyricum neu...

journal_title：Infection and immunity

authors： Kozaki S,Onimaru J,Kamata Y,Sakaguchi G

更新日期：1991-01-01 00:00:00

abstract：:Potassium thiocyanate extracts of a virulent Pasteurella multocida 3:A rabbit isolate were prepared and used as a vaccine in rabbits. The extract contained protein, carbohydrate, hyaluronic acid, lipopolysaccharide, DNA, and RNA. The protein and lipopolysaccharide profiles of the extract were similar to those of the P...

journal_title：Infection and immunity

authors： Lu YS,Pakes SP,Massey L,Stefanu C

更新日期：1987-12-01 00:00:00

abstract：:Intestinal segmented filamentous bacteria (SFB) protect from ameba infection, and protection is transferable with bone marrow dendritic cells (BMDCs). SFB cause an increase in serum amyloid A (SAA), suggesting that SAA might mediate SFB's effects on BMDCs. Here we further explored the role of bone marrow in SFB-mediat...

journal_title：Infection and immunity

authors： Burgess SL,Saleh M,Cowardin CA,Buonomo E,Noor Z,Watanabe K,Abhyankar M,Lajoie S,Wills-Karp M,Petri WA Jr

更新日期：2016-09-19 00:00:00

abstract：:The UspA1 and UspA2 proteins of Moraxella catarrhalis are potential vaccine candidates for preventing disease caused by this organism. We have characterized both proteins and evaluated their vaccine potential using both in vitro and in vivo assays. Both proteins were purified from the O35E isolate by Triton X-100 extr...

journal_title：Infection and immunity

authors： McMichael JC,Fiske MJ,Fredenburg RA,Chakravarti DN,VanDerMeid KR,Barniak V,Caplan J,Bortell E,Baker S,Arumugham R,Chen D

更新日期：1998-09-01 00:00:00

abstract：:Treponema hyodysenteriae was shown to attach to mouse peritoneal cells in the absence of serum opsonins in vitro. If serotype-specific antiserum from pigs was added to the media and treponemes of that corresponding serotype were employed in the assay, the amount of attachment increased an average of 3.7 times that of ...

journal_title：Infection and immunity

authors： Nuessen ME,Joens LA

更新日期：1982-12-01 00:00:00

abstract：:YopE is a virulence factor that is secreted into host cells infected by Yersinia species. The YopE C-terminal domain has GTPase-activating protein (GAP) activity. The YopE N-terminal domain contains an epitope that is an immunodominant CD8(+) T cell antigen during primary infection of C57BL/6 mice with Yersinia pseudo...

journal_title：Infection and immunity

authors： Zhang Y,Mena P,Romanov G,Bliska JB

更新日期：2014-07-01 00:00:00

abstract：:The need for agents designed to modify immune response in the treatment of patients with viral infection, immunodeficiency, or cancer prompted the present study on the mechanisms of action of isoprinosine, a compound developed for antiviral use and whose therapeutic activity may involve the immune system. The effect o...

journal_title：Infection and immunity

authors： Hadden JW,Hadden EM,Coffey RG

更新日期：1976-02-01 00:00:00

abstract：:Administration of free muramyl tripeptide phosphatidylethanolamide (MTPPE) or liposome-encapsulated MTPPE (LE-MTPPE) in a twofold-lower dose at 24 h before bacterial inoculation resulted in clearance of intravenously inoculated Klebsiella pneumoniae by tissue macrophages, whereas in control mice, bacteria were not eff...

journal_title：Infection and immunity

authors： Melissen PM,van Vianen W,Bakker-Woudenberg IA

更新日期：1992-11-01 00:00:00

abstract：:Yersinia species pathogenic to humans have been extensively characterized with respect to type III secretion and its essential role in virulence. This study concerns the twin arginine translocation (Tat) pathway utilized by gram-negative bacteria to secrete folded proteins across the bacterial inner membrane into the ...

journal_title：Infection and immunity

authors： Lavander M,Ericsson SK,Bröms JE,Forsberg A

更新日期：2006-03-01 00:00:00

abstract：:The purified recombinant V antigen from Yersinia pestis, expressed in Escherichia coli and adsorbed to aluminum hydroxide, an adjuvant approved for human use, was used to immunize outbred Hsd:ND4 mice subcutaneously. Immunization protected mice from lethal bubonic and pneumonic plague caused by CO92, a wild-type F1+ s...

journal_title：Infection and immunity

authors： Anderson GW Jr,Leary SE,Williamson ED,Titball RW,Welkos SL,Worsham PL,Friedlander AM

更新日期：1996-11-01 00:00:00

abstract：:The mucosal and systemic immune responses after primary and booster immunizations with two attenuated live oral vaccine strains derived from a noninvasive (Vibrio cholerae) and an invasive (Salmonella typhi) enteric pathogen were comparatively evaluated. Vaccination with S. typhi Ty21a elicited antibody-secreting cell...

journal_title：Infection and immunity

authors： Viret JF,Favre D,Wegmüller B,Herzog C,Que JU,Cryz SJ Jr,Lang AB

更新日期：1999-07-01 00:00:00

abstract：:Ureaplasma urealyticum is a common commensal of the female lower urogenital tract, yet it has been shown to be an important cause of chorioamnion infection, respiratory and central nervous system disease, and death in premature infants. It has been suggested that only certain serovars are capable of producing invasive...

journal_title：Infection and immunity

authors： Zheng X,Teng LJ,Watson HL,Glass JI,Blanchard A,Cassell GH

更新日期：1995-03-01 00:00:00

abstract：:Iron is limiting in the human host, and bacterial pathogens respond to this environment by regulating gene expression through the ferric uptake regulator protein (Fur). In vitro studies have demonstrated that Neisseria gonorrhoeae controls the expression of several critical genes through an iron- and Fur-mediated mech...

journal_title：Infection and immunity

authors： Agarwal S,King CA,Klein EK,Soper DE,Rice PA,Wetzler LM,Genco CA

更新日期：2005-07-01 00:00:00

abstract：:The Lyme disease spirochete, Borrelia burgdorferi, exists in a zoonotic cycle involving an arthropod tick and mammalian host. Dissemination of the organism within and between these hosts depends upon the spirochete's ability to traverse through complex tissues. Additionally, the spirochete outruns the host immune cell...

journal_title：Infection and immunity

authors： Sultan SZ,Manne A,Stewart PE,Bestor A,Rosa PA,Charon NW,Motaleb MA

更新日期：2013-06-01 00:00:00

abstract：:A DNA microarray containing fragments of 137 Borrelia burgdorferi B31 putative lipoprotein genes was used to examine Lyme disease spirochetes. DNA from B. burgdorferi sensu stricto B31, 297, and N40; Borrelia garinii IP90; and Borrelia afzelii P/Gau was fluorescently labeled and hybridized to the microarray, demonstra...

journal_title：Infection and immunity

authors： Liang FT,Nelson FK,Fikrig E

更新日期：2002-06-01 00:00:00

abstract：:Several early nonspecific host defense mechanisms were examined in resistant (BALB/c) and susceptible (C3H/He) mice after intraperitoneal inoculation with Rickettsia tsutsugamushi strain Gilliam. Inflammatory exudates were formed in both mouse strains in response to rickettsial inoculation, but the inflammatory respon...

journal_title：Infection and immunity

authors： Nacy CA,Groves MG

更新日期：1981-03-01 00:00:00

abstract：:Apical membrane antigen 1 (AMA1) is expressed on the surfaces of Plasmodium falciparum merozoites and is thought to play an important role in the invasion of erythrocytes by malaria parasites. To select for peptides that mimic conformational B-cell epitopes on AMA1, we screened a phage display library of >10(8) indivi...

journal_title：Infection and immunity

authors： Casey JL,Coley AM,Anders RF,Murphy VJ,Humberstone KS,Thomas AW,Foley M

更新日期：2004-02-01 00:00:00

abstract：:Burkholderia pseudomallei is a CDC tier 1 select agent that causes melioidosis, a severe disease in humans and animals. Persistent infections are common, and there is currently no vaccine available. Lipopolysaccharide (LPS) is a potential vaccine candidate. B. pseudomallei expresses three serologically distinct LPS ty...

journal_title：Infection and immunity

authors： Wikraiphat C,Saiprom N,Tandhavanant S,Heiss C,Azadi P,Wongsuvan G,Tuanyok A,Holden MT,Burtnick MN,Brett PJ,Peacock SJ,Chantratita N

更新日期：2015-05-01 00:00:00

abstract：:Cholera is an acute diarrheal disease that is caused by the gram-negative bacterium Vibrio cholerae. The low efficacy of currently available killed-whole-cell vaccines and the reactinogenicity coupled with potential reversion of live vaccines have thus far precluded widespread vaccination for the control of cholera. R...

journal_title：Infection and immunity

authors： Wu JY,Wade WF,Taylor RK

更新日期：2001-12-01 00:00:00

abstract：:Fimbrial adhesins that mediate attachment to host cells are produced by most virulent Escherichia coli isolates. These virulence factors play an important role in the initial stages of bacterial colonization and also in determination of the host and tissue specificity. Isolates belonging to serotype O78 are known to c...

journal_title：Infection and immunity

authors： Babai R,Stern BE,Hacker J,Ron EZ

更新日期：2000-10-01 00:00:00

abstract：:The chemotactic behavior of Campylobacter jejuni was determined in the presence of different amino acids, carbohydrates, organic acids, and preparations and constituents of mucin and bile. L-Fucose was the only carbohydrate and L-aspartate, L-cysteine, L-glutamate, and L-serine were the only amino acids producing a ch...

journal_title：Infection and immunity

authors： Hugdahl MB,Beery JT,Doyle MP

更新日期：1988-06-01 00:00:00

abstract：:Escherichia coli is a major cause of enteric/diarrheal diseases, urinary tract infections, and sepsis. E. coli K1 is the leading gram-negative organism causing neonatal meningitis, but the microbial basis of E. coli K1 meningitis is incompletely understood. Here we employed comparative genomic hybridization to investi...

journal_title：Infection and immunity

authors： Yao Y,Xie Y,Kim KS

更新日期：2006-04-01 00:00:00

abstract：:Secretion of immunoglobulin A1 (IgA1) proteases is a characteristic of Haemophilus influenzae and several other bacterial pathogens causing infectious diseases, including meningitis. Indirect evidence suggests that the proteases are important virulence factors. In this study, we cloned the iga gene encoding immunoglob...

journal_title：Infection and immunity

authors： Poulsen K,Brandt J,Hjorth JP,Thøgersen HC,Kilian M

更新日期：1989-10-01 00:00:00

abstract：:We found that when group A streptococci are cocultured with human pharyngeal cells, they upregulate and secrete a 25-kDa toxin, determined to be the bacteriophage-encoded streptococcal pyrogenic exotoxin C (SpeC). This prompted us to determine if the bacteriophage themselves are induced during coculture conditions. We...

journal_title：Infection and immunity

authors： Broudy TB,Pancholi V,Fischetti VA

更新日期：2001-03-01 00:00:00

abstract：:Streptococcus pneumoniae is the most common pathogen associated with otitis media. To examine the role of Toll-like receptor 2 (TLR2) in host defense against Streptococcus pneumoniae infection in the middle ear, wild-type (WT; C57BL/6) and TLR2-deficient (TLR2(-/-)) mice were inoculated with Streptococcus pneumoniae (...

journal_title：Infection and immunity

authors： Han F,Yu H,Tian C,Li S,Jacobs MR,Benedict-Alderfer C,Zheng QY

更新日期：2009-07-01 00:00:00

abstract：:This study focuses on the interaction of the three components of the Bacillus cereus Nhe enterotoxin with particular emphasis on the functional roles of NheB and NheC. The results demonstrated that both NheB and NheC were able to bind to Vero cells directly while NheA lacked this ability. It was also shown that Nhe-in...

journal_title：Infection and immunity

authors： Lindbäck T,Hardy SP,Dietrich R,Sødring M,Didier A,Moravek M,Fagerlund A,Bock S,Nielsen C,Casteel M,Granum PE,Märtlbauer E

更新日期：2010-09-01 00:00:00

abstract：:Human lactoferrin is an iron-binding glycoprotein that is particularly prominent in exocrine secretions and leukocytes and is also found in serum, especially during inflammation. It is able to sequester iron from microbes and has immunomodulatory functions, including inhibition of both complement activation and cytoki...

journal_title：Infection and immunity

authors： Håkansson A,Roche H,Mirza S,McDaniel LS,Brooks-Walter A,Briles DE

更新日期：2001-05-01 00:00:00

abstract：:Regulation of the synthesis of Vi polysaccharide, a major virulence determinant in Salmonella enterica serotype Typhi, is under the control of two regulatory systems, ompR-envZ and rscB-rscC, which respond to changes in osmolarity. Some serotype Typhi strains exhibit overexpression of Vi polysaccharide, which masks cl...

journal_title：Infection and immunity

authors： Santander J,Wanda SY,Nickerson CA,Curtiss R 3rd

更新日期：2007-03-01 00:00:00