Abstract:
:Metyrapone tartrate, 400 mg/kg i.p. raised the LD50 for acetaminophen from 340 mg/kg i.p. to 540 mg/kg i.p. in fasting male Swiss white mice. The minimum protective dose of metyrapone was 200 mg/kg. Metyrapone was effective in preventing death when given up to 2 h after acetaminophen administration. The LD50 for metyrapone tartrate was 760 mg/kg i.p. Metyrapone decreased or prevented acetaminophen induced hepatic damage measured either by histology or plasma glutamate pyruvate transaminase activity. Metyrapone tartrate, 400 mg/kg i.p., inhibited the severe liver glutathione depletion seen with acetaminophen alone. It is proposed that metyrapone protects mice from acetaminophen induced liver toxicity and death by inhibiting the oxidation of acetaminophen to a toxic intermediate.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Nelson EB,Montes M,Goldstein Mdoi
10.1016/0300-483x(80)90029-3subject
Has Abstractpub_date
1980-01-01 00:00:00pages
73-81issue
1eissn
0300-483Xissn
1879-3185pii
0300-483X(80)90029-3journal_volume
17pub_type
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