An electron microscopic, enzyme cytochemical study on the localization of lactate dehydrogenase (LDH) in osteoclasts and peritoneal macrophages of the rat and its implication for the process of bone resorption and the origin of osteoclasts.

Abstract:

:LDH is localized along various intracytoplasmatic membranes of osteoclasts. Macrophages show membrane-bound LDH only after phagocytosis of calcium hydroxylapatite, the main mineral constituent of bone. The localization of LDH in these macrophages is almost the same as in osteoclasts. The significance of this finding, and its possible implication in the process of bone resorption and the origin of osteoclasts are discussed.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Touw JJ,Hemrika-Wagner AM,Vermeiden JP

doi

10.1007/BF00219927

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

111-6

issue

1

eissn

0302-766X

issn

1432-0878

journal_volume

209

pub_type

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