Abstract：
:In the developing mammalian nervous system, common progenitors integrate both cell extrinsic and intrinsic regulatory programs to produce distinct neuronal and glial cell types as development proceeds. This spatiotemporal restriction of neural progenitor differentiation is enforced, in part, by the dynamic reorganization of chromatin into repressive domains by Polycomb repressive complexes, effectively limiting the expression of fate-determining genes. Here, we review the distinct roles that Polycomb repressive complexes play during neurogenesis and gliogenesis, while also highlighting recent work describing the molecular mechanisms that govern their dynamic activity in neural development. Further investigation of the way in which Polycomb complexes are regulated in neural development will enable more precise manipulation of neural progenitor differentiation facilitating the efficient generation of specific neuronal and glial cell types for many biological applications.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Corley M,Kroll KLdoi
10.1007/s00441-014-2011-9subject
Has Abstractpub_date
2015-01-01 00:00:00pages
65-85issue
1eissn
0302-766Xissn
1432-0878journal_volume
359pub_type
杂志文章,评审abstract：:Induction of HIF-1α by oxygen limitation promotes increased phosphorylation and catalytic depression of mitochondrial pyruvate dehydrogenase (PDH) and an enhanced glycolytic poise in cells. Cobalt chloride and desferrioxamine are widely used as mimics for hypoxia because they increase the levels of HIF-1α. We evaluate...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-012-1517-2
更新日期：2013-01-01 00:00:00
abstract：:The fine structure of the horny teeth of the lamprey, Entosphenus japonicus, was examined by light- and electron-microscopy. Most of the horny teeth consisted of two horny and two nonhorny layers. The primary horny layer was well keratinized, and the cells were closely packed and intensely interdigitated, being joined...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00215769
更新日期：1983-01-01 00:00:00
abstract：:The surface ultrastructure of Kupffer cells in the rat liver has been studied by scanning electron microscopy (SEM). The results demonstrate that Kupffer cells are both significantly different and clearly distinct from endothelial cells. Kupffer cells have neither pores (and/or "sieve plates") nor fenestrations, all o...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00223015
更新日期：1975-12-10 00:00:00
abstract：:Pimozide, a specific blocker of dopaminergic receptors, was injected for 4 or 9 days in freshwater (FW) eels or eels acclimated to sea water (SW) for 10 or 30 days. The daily dose was 100 or 200 microgram/100 g. Melanophore index values increase in FW and in 1 month-SW injected eels. All the treated fish react by a to...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00209272
更新日期：1978-05-29 00:00:00
abstract：:The wall of the seminiferous tubule in rodents consists of an inner layer of myoid cells covered by an outer layer of endothelial cells. Myoid cells are a type of smooth muscle cell containing α-actin filaments arranged in two independent layers that contract when stimulated by endothelin-1. The irregular surface reli...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-016-2386-x
更新日期：2016-08-01 00:00:00
abstract：:Gap junctions exist in the septa between the segments of the lateral giant axons in the ventral nerve cord of the crayfish Procambarus. A large increase in the resistance (uncoupling) of these gap junctions was brought about by mechanical injury to the axonal segments. Both thin sections and freeze-fracture preparatio...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00217847
更新日期：1984-01-01 00:00:00
abstract：:Ultrastructural post-embedding immuno-gold techniques were applied to the supraoptic nucleus and the neurohypophysis of mice and rats. The primary antibodies were three different monoclonal antineurophysins, used in protein A-gold and immunoglobulin-gold procedures. Conventional plastic embedding as well as hydrophili...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00221868
更新日期：1986-01-01 00:00:00
abstract：:Enterochromaffin (EC) cells regulate gut motility and secretion in response to luminal stimuli, via the release of serotonin (5-HT). Inflammatory bowel disease and other gastrointestinal disorders are associated with increased numbers of EC cells and 5-HT availability. Our aim was to determine whether proliferation of...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-007-0430-6
更新日期：2007-09-01 00:00:00
abstract：:The expression of the gene for vasoactive intestinal polypeptide (VIP) and peptide histidine methionine (PHM) in the human gastrointestinal tract was studied by in situ hybridization and Northern blotting for PHM/VIP mRNA and immunocytochemistry using specific antisera against the bioactive peptides PHM and VIP. In th...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00306108
更新日期：1994-05-01 00:00:00
abstract：:A gelsolin-related protein was isolated from seminal vesicles of the annelid Lumbricus terrestris. Compared with the isoforms of the gelsolin-related protein previously found in the muscle of the annelid body wall, the isolated protein was assigned to the first isoform (EWAM-P1) because of its electrophoretic mobility...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-007-0561-9
更新日期：2008-04-01 00:00:00
abstract：:An increasingly pro-oxidant environment has been widely implicated in causing dysfunction of testicular steroidogenesis, but little progress has been made in understanding the underlying molecular mechanism. Here, we report that gamma-glutamyl transferase 5 (GGT5), a key metabolism component responsible for the cataly...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-016-2458-y
更新日期：2016-11-01 00:00:00
abstract：:Based on its proven anabolic effects on bone in osteoporosis patients, recombinant parathyroid hormone (PTH(1-34)) has been evaluated as a potential therapy for skeletal repair. In animals, the effect of PTH(1-34) has been investigated in various skeletal repair models such as fractures, allografting, spinal arthrodes...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-011-1188-4
更新日期：2012-03-01 00:00:00
abstract：:The brood pouch of the male pipefish (Syngnathus schlegeli) is a ventral organ located on the tail, with the anterior region closely associated with the genital pore. The embryos in the pouch are attached to highly vascularized placenta-like tissue which seals the pouch folds from inside during incubation. The epithel...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410051220
更新日期：1999-01-01 00:00:00
abstract：:Caprine preantral follicles within ovarian fragments were cryopreserved in the absence or presence of 0.5 M sucrose with or without 1 M dimethyl sulfoxide and/or 1 M ethylene glycol (EG). After being thawed, they were washed in minimum essential medium with or without 0.3 M sucrose. Histological analysis of follicle i...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-006-0193-5
更新日期：2006-09-01 00:00:00
abstract：:Germ cells are set aside from somatic cells early in embryogenesis, and are responsible for transmitting genetic information through generations. Vasa is a highly conserved germ cell marker across animal phyla, and widely used to label primordial germ cells. Dabry's sturgeon is a rare and endangered species distribute...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-016-2418-6
更新日期：2016-10-01 00:00:00
abstract：:Ontogenetic development of GRF-containing neurons in the rat hypothalamus was studied employing antisera which were generated against hpGRF (1-44)NH2 and rhGRF(1-43)OH: anti-hpGRF-C and -rhGRF sera recognize the species-specific C-terminal portions of the peptides, and anti-hpGRF-MC and -N sera recognize hpGRF(27-44)N...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00225416
更新日期：1985-01-01 00:00:00
abstract：:The ultrastructure of the seminiferous tubules was studied in rats that had been subjected to whole body irradiation on the 19th day of gestation. The seminiferous tubules from 3 months-old irradiated animals are devoid of germ cells and contain only Sertoli cells. Compared with controls of the same age, the seminifer...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00218294
更新日期：1982-01-01 00:00:00
abstract：:To obtain more information concerning the origin of dendritic reticulum cells, the development of germinal centers in the spleens of rabbits was investigated by conventional light microscopy, enzyme histochemistry, and electron microscopy. Washed sheep erythrocytes were used as antigen. Splenic tissue was examined on ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00237632
更新日期：1980-01-01 00:00:00
abstract：:Vitrification of biological specimens in liquid nitrogen can be achieved under high pressure (2,100 bars). This procedure obviates the use of aldehyde fixation and cryoprotection (glycerol). The present work demonstrates its applicability to the freeze-etching of mammalian brain tissue. Freeze-fracture repicas from ra...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00237626
更新日期：1980-01-01 00:00:00
abstract：:The pattern of innervation on individual iliotibialis muscle fibres from axolotl (Ambystoma mexicanum) has been investigated histologically and electrophysiologically. These polyneural fibres were found to be innervated on average at five end plate sites. The sites were distributed irregularly along each fibre. Averag...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00219663
更新日期：1978-01-09 00:00:00
abstract：:Serine proteases, cysteine proteases, aspartic proteases and matrix metalloproteinases play an essential role in extracellular matrix remodeling and turnover through their proteolytic action on collagens, proteoglycans, fibronectin, elastin and laminin. Proteases can also act on chemokines, receptors and anti-microbia...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-012-1390-z
更新日期：2013-02-01 00:00:00
abstract：:The reduced-folate carrier (Rfc-1), previously also called methotrexate carrier-1 (MTX-1), was recently identified as accounting for approximately 30% of the methotrexate (Mtx) uptake into rat kidney slices. The localization of the carrier and its contribution to secretory or reabsorptive flux of the drug was therefor...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-005-1092-x
更新日期：2005-06-01 00:00:00
abstract：:Complex carbohydrates in secretory granules and at the apical cell surface of mouse gastric mucoid cells were studied during embryogenesis and in the early postnatal period by various cytochemical methods; the periodic acid-thiocarbohydrazide-silver proteinate (PA-TCH-SP) and tannic acid-uranyl acetate (TA-UA) procedu...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00214559
更新日期：1985-01-01 00:00:00
abstract：:Interstitial cells in the pineal gland of the rat were characterized immunocytochemically using the monoclonal antibodies MRC OX-42 and ED1 for macrophages/microglia, and MRC OX-6, which recognizes major histocompatibility complex (MHC) class II antigen. A polyclonal antibody against GFAP was used to identify astrocyt...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00302731
更新日期：1993-05-01 00:00:00
abstract：:The high affinity IgE receptor on mast cells and basophils is composed of 3 subunits, alpha, beta and gamma. A polyclonal antibody was raised in rabbits to a 13 amino acid synthetic peptide corresponding to the amino terminal portion of the gamma subunit. The antiserum was screened using Western blots of solubilized R...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410050575
更新日期：1996-04-01 00:00:00
abstract：:Low-temperature-embedded tissue of the subcommissural organ (SCO) of the rabbit was analyzed for the basal route of secretory product by means of indirect immuno-metal cytochemistry (protein A-gold technique) at the electron-microscopic level. By use of (1) an antiserum against bovine Reissner's fibre (see Sterba et a...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00219221
更新日期：1986-01-01 00:00:00
abstract：:Using specimens of human submandibular glands, we have investigated in vitro the morphological modifications induced by clozapine, a dibenzodiazepine derivative that is used in psychotic patients and that provokes hypersalivation, a side-effect of therapy. The effects of the drug, used alone or in combination with car...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-005-0149-1
更新日期：2006-05-01 00:00:00
abstract：:Ultrastructural and morphometric investigations were performed on the lung of the European salamander, Salamandra salamandra L. Folds of first and second order are covered with a ciliated epithelium containing goblet cells. The respiratory surface of the lung is lined by a single type of cell which, in amphibians, com...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00222429
更新日期：1978-07-27 00:00:00
abstract：:Modulation of the actin cytoskeleton in chondrocytes has been used to prevent or reverse dedifferentiation and to enhance protein synthesis. We have hypothesized that an actin-modifying agent, staurosporine, could be used with fibrochondrocytes to increase the gene expression and synthesis of critical fibrocartilage p...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-008-0705-6
更新日期：2008-12-01 00:00:00
abstract：:Morphogenesis of the arcuate nucleus of the rat from the 15th fetal day to the 6th postnatal day was investigated light and electron microscopically. The arcuate neurons exhibit a gradual development after the 15th fetal day. All cytoplasmic constituents are present in these nerve cells already during the last days of...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00236893
更新日期：1979-08-03 00:00:00
