Cyto- and synaptogenesis in the arcuate nucleus of the rat hypothalamus during fetal and early postnatal life.

Abstract:

:Morphogenesis of the arcuate nucleus of the rat from the 15th fetal day to the 6th postnatal day was investigated light and electron microscopically. The arcuate neurons exhibit a gradual development after the 15th fetal day. All cytoplasmic constituents are present in these nerve cells already during the last days of gestation. Nevertheless, they are not fully differentiated at birth. The first synapse-like structures (presynapses) were observed in 17 day-old, the first synapses in 18 day-old fetuses. During the early postnatal period the number of presynapses decreases, but at the same time there is a gradual increase in the number of the relatively mature synapses. This process starts already during the last days of prenatal life. Although all structural elements of the arcuate nucleus of the adult rat appear to be present at birth, the extent of the neuropil area and the number of ther presynapses indicate that the arcuate nucleus is still in a fairly undeveloped stage during the first postnatal days.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Koritsánszky S

doi

10.1007/BF00236893

subject

Has Abstract

pub_date

1979-08-03 00:00:00

pages

135-46

issue

1

eissn

0302-766X

issn

1432-0878

journal_volume

200

pub_type

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