Abstract：
:The ontogeny of protein gene product 9.5 (PGP 9.5), serotonin (5-HT), calcitonin gene-related peptide (CGRP), and calcitonin (CT) immunoreactivity was evaluated in small-granule endocrine cells of hamster laryngotracheal epithelium from fetal day 11 to adulthood. Two centrifugal (proximal-to-distal) patterns of differentiation occur. The first pattern begins during fetal life. Endocrine cells, single and clustered in groups (presumptive- or protoneuroepithelial bodies, pNEBs), initially colocalize immunostaining for PGP 9.5, 5-HT, and CGRP in the larynx and proximal 2/3 of the trachea on day 12 and spread to the caudal trachea on day 13. 5-HT disappears fleetingly during the 24 h preceding birth; otherwise immunoreactivity for all three substances persists into adulthood. The clusters of endocrine cells survive beyond birth but are so diluted by expansion of the nonendocrine epithelium as to become inconspicuous. Since innervation was not actually observed, these clusters may persist as pNEBs, without developing connections to afferent or efferent nerve fibers. The second pattern concerns single small-granule cells stainable for CGRP but not for 5-HT. These cells first appear in the larynx and cartilaginous part of the cranial trachea on postnatal day 3, and in the middle and caudal trachea, on day 5. The cells increase in number on day 7. In adults, they predominate among endocrine cells of the cartilaginous region. A subset of these cells begins to co-express CT proximally on postnatal day 10, reaching the caudal end of the trachea by 3 weeks. A few elements of the older 5-HT-positive population may also become immunoreactive for CT in juvenile hamsters.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
McDowell EM,Sorokin SP,Hoyt RF Jrdoi
10.1007/BF00305382subject
Has Abstractpub_date
1994-01-01 00:00:00pages
143-56issue
1eissn
0302-766Xissn
1432-0878journal_volume
275pub_type
杂志文章abstract：:Previous neurohistological studies have been extended to include the structures contained solely or mainly within the junctional esophageal segment which may play an important role in the sphincter mechanism. The main findings were: 1) a progressive cranio-caudal thickening of the muscularis mucosae; 2) a conspicuous ...
journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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更新日期：1978-08-25 00:00:00
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journal_title：Cell and tissue research
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更新日期：1980-01-01 00:00:00
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更新日期：1975-06-09 00:00:00
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更新日期：2000-09-01 00:00:00
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更新日期：1985-01-01 00:00:00
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journal_title：Cell and tissue research
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更新日期：1999-01-01 00:00:00
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更新日期：1992-04-01 00:00:00
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更新日期：1979-01-01 00:00:00
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更新日期：1994-11-01 00:00:00
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更新日期：1995-02-01 00:00:00
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更新日期：1978-10-30 00:00:00
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journal_title：Cell and tissue research
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更新日期：1986-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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