Demonstration of a somatostatin-like activity in retinal cells of the rat.

Abstract:

:A somatostatin-like substance is demonstrated by light microscopic immunohistochemistry (PAP-method) in perikarya and cell processes of the retina of adult and infant rats. These perikarya are identified according to their size, arrangement and distribution. Each of the first two neuronal orders (receptors, bipolar cells, ganglionic cells) of the visual pathway can be associated with retinal cells reacting positively with anti-somatostatin. In the adult rat, perikarya and processes of (i) horizontal cells, (ii) amacrine cells and (iii) large neurons in the ganglionic layer are specifically labeled. The staining of middle-sized and small ganglion cells is probably caused by the close attachment of labeled fibers to non-reacting cells. Postnatally, the immunoreactive elements develop in parallel to the differentiation of the corresponding retinal layers. It is discussed whether the three types of retinal cells containing a somatostatin-like substance provide an inhibitory system to each of the two orders of retinal neurons.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Kirsch B,Leonhardt H

doi

10.1007/BF00235169

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

127-40

issue

1

eissn

0302-766X

issn

1432-0878

journal_volume

204

pub_type

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