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Methylated amino acids and lysosomal function in cultured heart cells.

Abstract：

:Methylated amino acids inhibit lysosomal function in cultured rat heart myocytes more effectively than the classically employed lysosomotropic weak bases. Moreover, L-leucine methyl ester (L-Leu-OMe) or L-methionine methyl ester (L-Meth-OMe) do not alter lysosomal pH or inactivate lysosomal cysteine proteinases, but do inhibit protein degradation more efficiently than either chloroquine or NH4Cl. These observations suggest that amino acid methyl esters are more effective probes to investigate lysosomal function in cultured myocytes than chloroquine or NH4Cl.

journal_name

Exp Cell Res

journal_title

Experimental cell research

authors

Decker RS,Fuseler JF

doi

10.1016/0014-4827(84)90690-6

subject

Has Abstract

pub_date

1984-09-01 00:00:00

pages

304-9

issue

1

eissn

0014-4827

issn

1090-2422

pii

0014-4827(84)90690-6

journal_volume

154

pub_type

杂志文章

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