The role of peroxisome proliferator-activated receptor-beta/delta in epidermal growth factor-induced HaCaT cell proliferation.

abstract：:p75NTR is a member of the tumor necrosis superfamily of proteins which is variably associated with induction of apoptosis and proliferation. Cyclin D2 is one of the mediators of cellular progression through G1 phase of the cell cycle. The present study demonstrates the inverse relationship between expression of cyclin...

journal_title：Experimental cell research

authors： Fritz MD,Mirnics ZK,Nylander KD,Schor NF

更新日期：2006-10-15 00:00:00

abstract：:Cellular senescence is a state of irreversible cell cycle arrest in which normal cells at the end of their lifespan fail to enter into DNA synthesis upon serum or growth factor stimulation. We examined whether proteins required for G1/S cell cycle progression were irreversibly down-regulated in senescent human fibrobl...

journal_title：Experimental cell research

authors： Afshari CA,Vojta PJ,Annab LA,Futreal PA,Willard TB,Barrett JC

更新日期：1993-12-01 00:00:00

abstract：:Embryonic stem (ES) cells have been tested for potential cell transplantation therapy for CNS disorders. Understanding their differentiation mechanism and identifying factors involved in driving excitatory and inhibitory neuron lineages should enhance the efficacy and efficiency of the cell transplantation therapy. We...

journal_title：Experimental cell research

authors： Theus MH,Wei L,Francis K,Yu SP

更新日期：2006-10-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population and show significant expansion under pathological conditions. microRNA plays important roles in many biological processes, whether microRNAs have a function in the expansion of MDSCs is still not very clear. In this study, miR-34a overexpression c...

journal_title：Experimental cell research

authors： Huang A,Zhang H,Chen S,Xia F,Yang Y,Dong F,Sun D,Xiong S,Zhang J

更新日期：2014-08-15 00:00:00

abstract：:Proliferation of human B- and T-lymphoid cell lines including Raji and Akata cells was found to be arrested at the G1 stage in the cell cycle by dimethyl sulfoxide (DMSO). The G1 arrest by DMSO occurred gradually and was completed within 96 h after addition of 1.5% DMSO concomitantly with a decrease in growth rate. Pr...

journal_title：Experimental cell research

authors： Sawai M,Takase K,Teraoka H,Tsukada K

更新日期：1990-03-01 00:00:00

abstract：:Differentiation and apoptosis are precisely regulated events in early embryogenesis. Retinoic acid-induced differentiation in the embryonal carcinoma (EC) cell line NCR-G3 triggers concurrent induction of apoptosis. Using this system, which serves as a model of early embryogenesis, the expression of various bcl-2-rela...

journal_title：Experimental cell research

authors： Sano M,Umezawa A,Abe H,Akatsuka A,Nonaka S,Shimizu H,Fukuma M,Hata J

更新日期：2001-05-15 00:00:00

abstract：:Sepsis is a major cause of mortality in seriously ill patients characterized by a series of severe systemic inflammatory responses due to an infection. Thus, there is a critically need to search more accurate biomarkers and targets for diagnosis and treatment of sepsis. Our study showed that miR-212-3p was up-regulate...

journal_title：Experimental cell research

authors： Chen W,Ma X,Zhang P,Li Q,Liang X,Liu J

更新日期：2017-01-15 00:00:00

abstract：:Up-regulation of intercellular adhesion molecule-1 (ICAM-1) and its soluble form are involved in the chronic inflammation. For the first time, we demonstrated that resveratrol (RE), a natural polyphenol with antioxidant and anti-inflammatory properties, reduces the increase of expression and release of ICAM-1, due to ...

journal_title：Experimental cell research

authors： Domazetovic V,Bonanomi AG,Stio M,Vincenzini MT,Iantomasi T

更新日期：2019-09-15 00:00:00

abstract：:Gp70 is an esterase originally called crystal protein because of its presence in crystalline structures in aggregation-competent Dictyostelium discoideum cells. Although postulated to break down spore coats, the function of gp70 in vivo was incompletely investigated. Our immunolocalization and biochemical studies of v...

journal_title：Experimental cell research

authors： Yuan A,Chia CP

更新日期：2000-12-15 00:00:00

abstract：:It is known that freshly dissociated thyroid cell clusters form follicles in suspension culture. Thyroid epithelial cell lines, grown for many generations in vitro, fail to show colloid-containing lumina when cultured as monolayers. Several thyroid cell lines, some transformed, have been tested with respect to their a...

journal_title：Experimental cell research

authors： Nitsch L,Tacchetti C,Tramontano D,Ambesi-Impiombato FS

更新日期：1984-05-01 00:00:00

abstract：:A polypeptide growth factor has been isolated from serum-free medium conditioned by mouse PC13 embryonal carcinoma cells, which is strongly mitogenic for Swiss 3T3 fibroblasts. On a CM-2-SW high-performance liquid chromatography cation-exchange column at low pH, this growth factor elutes at a salt concentration very c...

journal_title：Experimental cell research

authors： van Veggel JH,van Oostwaard TM,de Laat SW,van Zoelen EJ

更新日期：1987-04-01 00:00:00

abstract：:Translational control is an essential process in regulation of gene expression, which occurs at the initiation step performed by a number of translation initiation factor complexes. eIF3a (eIF3 p170) is the largest subunit of the eIF3 complex. eIF3a has been suggested to play roles in regulating translation of a subse...

journal_title：Experimental cell research

authors： Dong Z,Liu Z,Cui P,Pincheira R,Yang Y,Liu J,Zhang JT

更新日期：2009-07-01 00:00:00

abstract：:Identification of breast cancer not being a single disease but backed by multiple heterogeneous oncogenic subpopulations is of growing interest in developing personalized therapies to provide optimal outcomes. Through this review, we bring attention to evolution of tumor and microenvironment heterogeneity as a predomi...

journal_title：Experimental cell research

authors： Nandy A,Gangopadhyay S,Mukhopadhyay A

更新日期：2014-01-01 00:00:00

abstract：:In preliminary experiments it was established that the hypertrophic and hyperplastic responses of neonatal cardiac myocytes in culture were associated with enhanced expression of IGF-1 and IGF-1 receptors in these cells. Therefore, to determine the role of IGF-1 receptors on myocyte growth, cells were exposed to antis...

journal_title：Experimental cell research

authors： Kajstura J,Cheng W,Reiss K,Anversa P

更新日期：1994-12-01 00:00:00

abstract：:We have investigated whether restriction endonucleases produce bands on human chromosomes by extracting DNA, using staining methods which are stoichiometric for DNA. Restriction enzymes that produce C-band patterns appear to remove DNA extensively from chromosome arms. In general, however, those restriction enzymes th...

journal_title：Experimental cell research

authors： Mezzanotte R,Ferrucci L,Vanni R,Sumner AT

更新日期：1985-11-01 00:00:00

abstract：:Adriamycin, an anticancer agent acting on topoisomerase II, promotes the arrest of cell division and neurite extension in a "neurite-minus" murine neuroblastoma cell line, N1A-103. This morphological differentiation is accompanied by a blockade in the S phase of the cell cycle, modification of the amount of peripherin...

journal_title：Experimental cell research

authors： Larcher JC,Cordeau-Lossouarn L,Romey G,Gros F,Croizat B,Vayssiere JL

更新日期：1992-11-01 00:00:00

abstract：:Transdifferentiation of vascular smooth muscle cells (VSMC) promotes the development of vascular calcifications such as arteriosclerosis. The aim was to investigate effects of specific extracellular matrix (ECM) components on transdifferentiation of VSMC to identify novel ECM-based therapeutic tools. Human collagens I...

journal_title：Experimental cell research

authors： Freise C,Bobb V,Querfeld U

更新日期：2017-09-15 00:00:00

abstract：:Studies performed over the past five years have demonstrated that there are two major cell-intrinsic pathways for inducing apoptosis, one that begins with ligation of cell surface death receptors and another that involves mitochondrial release of cytochrome c. Several reports have suggested that anticancer drugs kill ...

journal_title：Experimental cell research

authors： Kaufmann SH,Earnshaw WC

更新日期：2000-04-10 00:00:00

abstract：:The aging proteostasis decline manifests in a failure of aging cells and organisms to properly respond to proteotoxic challenges. This proteostasis collapse has long been considered a hallmark of aging in nematodes, and has recently been shown to occur also in human cells upon entry to senescence, opening the way to e...

journal_title：Experimental cell research

authors： Meller A,Shalgi R

更新日期：2021-01-09 00:00:00

abstract：:The puromycin analog N6,N6-dimethyladenine (6-dimethylaminopurine or 6-DMAP) was found to inhibit meiosis reinitiation in starfish oocytes stimulated by the natural hormone 1-methyladenine. Increasing concentrations of this agent delayed and eventually blocked germinal vesicle breakdown. They were found to be effectiv...

journal_title：Experimental cell research

authors： Neant I,Guerrier P

更新日期：1988-05-01 00:00:00

abstract：:The intranuclear localization of SV40 T-antigen (T-Ag) and the cellular protein p53 was studied in SV40 abortively infected baby mouse kidney cells using two complementary methods of ultrastructural immunocytochemistry in combination with preferential staining of nuclear RNP components and electron microscope autoradi...

journal_title：Experimental cell research

authors： Puvion E,Duthu A,Harper F,Ehrhart JC,Viron A,May P

更新日期：1988-07-01 00:00:00

abstract：:Transepithelial resistance (TER) measurement has often been used to study the paracellular transport properties of epithelia grown on permeable filters, especially the barrier function of tight junctions. However, the TER value includes another source, the resistance caused by cell-substrate contact, that may give ris...

journal_title：Experimental cell research

authors： Lo CM,Keese CR,Giaever I

更新日期：1999-08-01 00:00:00

abstract：:The growth of malignant melanoma cells is inhibited by 12-O-tetradecanoylphorbol-13-acetate (TPA) while the growth of normal melanocytes is stimulated. We previously demonstrated that TPA inhibits the growth of Demel melanoma cells and leads to arrest at both at the G1/S and G2/M cell cycle transitions. To investigate...

journal_title：Experimental cell research

authors： Coppock DL,Buffolino P,Kopman C,Nathanson L

更新日期：1995-11-01 00:00:00

abstract：:Glycosaminoglycans (heparins, dermatan sulfate, chondroitin sulfate) with different structures and physicochemical properties were evaluated for their capacity to influence proliferation and differentiation of U-937 cell line. The contrasting and specific effects of glycosaminoglycans (depending on their structures an...

journal_title：Experimental cell research

authors： Volpi N,Petrini M,Conte A,Valentini P,Venturelli T,Bolognani L,Ronca G

更新日期：1994-11-01 00:00:00

abstract：:Gicerin is a novel cell adhesion molecule in the immunoglobulin superfamily and has both homophilic adhesion and heterophilic adhesive activity to neurite outgrowth factor (NOF), an extracellular matrix protein in the laminin family. We investigated the possible involvement of gicerin in oviductal development, regener...

journal_title：Experimental cell research

authors： Tsukamoto Y,Taira E,Kajimura K,Yamate J,Kotani T,Amin H,Kohama K,Sakuma S,Miki N,Sasaki F

更新日期：1999-03-15 00:00:00

abstract：:Bradykinin stimulates [3H]thymidine incorporation and DNA synthesis in resting, serum-deprived NIL8 hamster cells. The ED50 for this stimulation is 4.52 +/- 2.91 nM. Other kinin peptides including lys-bradykinin (kallidin) and met-lys-bradykinin also stimulate [3H]thymidine incorporation in the NIL8 cells, whereas des...

journal_title：Experimental cell research

authors： Straus DS,Pang KJ

更新日期：1984-03-01 00:00:00

abstract：:Prosomes constitute the multicatalytic proteinase (MCP) core of the 26S proteasomes, but were first observed as subcomplexes of untranslated mRNP; this suggests that they play a putative role in the control of protein biosynthesis in addition to their catabolic enzymatic function. In previous investigations it was sho...

journal_title：Experimental cell research

authors： De Conto F,Missorini S,Arcangeletti C,Pinardi F,Montarras D,Pinset C,Vassy J,Géraud G,Chezzi C,Scherrer K

更新日期：1997-05-25 00:00:00

abstract：:The human neuroblastoma cell line SH-SY5Y can differentiate into a functional sympathetic neuronal phenotype when treated with low concentrations of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) in the presence of serum or defined growth factors. When TrkA is introduced into the cells, NGF also induces ...

journal_title：Experimental cell research

authors： Olsson AK,Nånberg E

更新日期：2001-04-15 00:00:00

abstract：:This study was designed to elucidate the mechanisms involved in elevated cell death arising from an altered endogenous oxidant state. Increased levels of cell death were detected in cells lacking Gpx1 following the addition of exogenous H2O2. This increased apoptosis correlated with a down-regulation in the activation...

journal_title：Experimental cell research

authors： Taylor JM,Crack PJ,Gould JA,Ali U,Hertzog PJ,Iannello RC

更新日期：2004-11-01 00:00:00

abstract：:We have evaluated the importance of the Ser/Thr protein phosphorylation and dephosphorylation for chondrogenesis in high-density chicken limb bud mesenchymal cell cultures (HDCs) by using H89, a cell-permeable protein kinase inhibitor, and okadaic acid (OA), a phosphoprotein phosphatase (PP)-specific inhibitor molecul...

journal_title：Experimental cell research

authors： Zákány R,Szucs K,Bakó E,Felszeghy S,Czifra G,Bíró T,Módis L,Gergely P

更新日期：2002-04-15 00:00:00