Abstract:
:Eight metH mutants in Salmonella typhimurium with closely linked sites of mutation which could grow only on methionine were isolated from a metE mutant deficient in N(5)-methyltetrahydropteroyltriglutamate-homocysteine transmethylase; their deficiency in cobalamin-dependent N(5)-methyltetrahydrofolate-homocysteine transmethylase was supported by the results of enzyme studies of one of them. Cotransduction of metH and metA (homoserine O-transsuccinylase) mutants was obtained, thus revealing linkage between a second pair of the six known methionine structural genes. One metH mutant clearly differed from the rest in that it reverted at a higher frequency, was temperature sensitive, complemented all other metH mutants, and was located farthest from the metA gene.
journal_name
J Bacterioljournal_title
Journal of bacteriologyauthors
Childs JD,Smith DAdoi
10.1128/JB.100.1.377-382.1969subject
Has Abstractpub_date
1969-10-01 00:00:00pages
377-82issue
1eissn
0021-9193issn
1098-5530journal_volume
100pub_type
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pub_type: 杂志文章
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更新日期:2007-11-01 00:00:00
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更新日期:1962-02-01 00:00:00
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更新日期:1995-01-01 00:00:00
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更新日期:1977-03-01 00:00:00
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更新日期:1994-11-01 00:00:00
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更新日期:1985-08-01 00:00:00