Clonal diversity and host distribution in Bordetella bronchiseptica.

Abstract:

:A total of 303 isolates of Bordetella bronchiseptica recovered from 11 host species were characterized by the electrophoretic mobilities of 15 metabolic enzymes, and 21 distinctive multilocus genotypes (electrophoretic types) were distinguished on the basis of allele profiles at the enzyme loci. The population structure of B. bronchiseptica is clonal, and its genetic diversity is limited in comparison with most other pathogenic bacteria, perhaps reflecting a relatively recent origin of the species. Electrophoretic types mark clones which are, in many cases, nonrandomly associated with host species. Clones differing only slightly in overall chromosomal genetic character may have pronounced differences in virulence potential. There was considerable variation among individual clones and clone families in degree of host specificity and among various species of hosts in the diversity of clones causing disease. The diversity of clones infecting dogs was an order of magnitude greater than that of clones infecting pigs. Most bordetellosis in pigs in the United States and Japan was found to be caused by strains of a single multilocus genotype.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Musser JM,Bemis DA,Ishikawa H,Selander RK

doi

10.1128/jb.169.6.2793-2803.1987

subject

Has Abstract

pub_date

1987-06-01 00:00:00

pages

2793-803

issue

6

eissn

0021-9193

issn

1098-5530

journal_volume

169

pub_type

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