Bacteroides intermedius binds fibrinogen.

Abstract:

:The binding of Bacteroides intermedius VPI 8944 to human fibrinogen has been characterized. The binding is time dependent, at least partially reversible, saturable, and specific. On an average, a maximum of 3,500 fibrinogen molecules bind per bacterial cell, with a dissociation constant of 1.7 X 10(-11) M. These bacteria also exhibit a fibrinogenolytic activity which can be partially inhibited by protease inhibitors. Bacteria release fibrinogenolytic activity into the surrounding medium without loss of binding activity, but more pronounced fibrinogen breakdown occurs when 125I-labeled fibrinogen is associated with the bacteria, suggesting that fibrinogen is degraded at the cell surface. Fibrinogen binding by B. intermedius might represent a mechanism of bacterial tissue adherence.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Lantz MS,Switalski LM,Kornman KS,Höök M

doi

10.1128/JB.163.2.623-628.1985

subject

Has Abstract

pub_date

1985-08-01 00:00:00

pages

623-8

issue

2

eissn

0021-9193

issn

1098-5530

journal_volume

163

pub_type

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