Treatment of acute bronchoconstriction in children with use of a tube spacer aerosol and a dry powder inhaler.

Abstract:

:In a double blind cross-over study 24 children suffering from acute bronchoconstriction were treated with either placebo, or terbutaline delivered by a pressurized aerosol with a tube spacer (TS), or salbutamol from a dry powder inhaler (Rotahaler = RO). Both active treatments resulted in a significant increase in FEV1 as compared with placebo (P less than 0.001). Furthermore, TS treatment resulted in significantly greater improvement in FEV1 than treatment with the RO (P less than 0.05). Under the conditions of marked airways obstruction problems with correct handling of the RO (loading and breaking the capsule) were prevalent and many children were unable to empty the RO capsule. These difficulties seemed to account for the smaller bronchodilation after RO treatment and were not seen under quiet circumstances. It is recommended that inhalation therapy in children is supervised by an adult during periods of marked airways disease.

journal_name

Allergy

journal_title

Allergy

authors

Pedersen S

doi

10.1111/j.1398-9995.1985.tb00236.x

subject

Has Abstract

pub_date

1985-05-01 00:00:00

pages

300-4

issue

4

eissn

0105-4538

issn

1398-9995

journal_volume

40

pub_type

临床试验,杂志文章,随机对照试验

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