Eosinophil cationic protein serum levels and allergy in chronic fatigue syndrome.

Abstract:

:Chronic fatigue syndrome (CFS) is a syndrome of uncertain etiopathogenesis characterized by disabling fatigue associated with a variable number of somatic and/or neuropsychologic symptoms. In patients with CFS, several immunologic abnormalities can be detected, including a higher prevalance of allergy. The aim of this study was to determine whether CFS patients, well studied for their allergy profile, show signs of eosinophil activation, as detectable by the measurement in serum of eosinophil cationic protein (ECP) levels. In 35 consecutive CFS outpatients (diagnosis based on the Centers for Disease Control case definition), ECP was measured in serum by a competitive enzyme immunoassay (ECP-FEIA kit, Kabi Pharmacia Diagnostics, Uppsala, Sweden). Fourteen disease-free subjects with no history of CFS or allergy were selected as controls. ECP serum levels were significantly higher in CFS patients than in controls (18.0 +/- 11.3 micrograms/l vs 7.3 +/- 2.1 micrograms/l; P < 0.01). In the CFS population, the prevalence of RAST positivity to one or more allergens was 77%, while no control showed positive RAST. Twelve of the 14 CFS patients with increased ECP serum levels were RAST-positive. However, CFS RAST-positive patients had no significantly higher ECP serum levels than CFS RAST-negative patients (19.3 +/- 12.4 micrograms/l vs 13.6 +/- 3.7 micrograms/l; P = 0.4). This is the first report of increased serum levels of ECP in CFS. On the basis of the available data, it is discussed whether eosinophil activation has a pathogenetic role in CFS or is linked to the frequently associated allergic condition, or, finally, whether a common immunologic background may exist for both atopy and CFS.

journal_name

Allergy

journal_title

Allergy

authors

Conti F,Magrini L,Priori R,Valesini G,Bonini S

subject

Has Abstract

pub_date

1996-02-01 00:00:00

pages

124-7

issue

2

eissn

0105-4538

issn

1398-9995

journal_volume

51

pub_type

杂志文章

相关文献

ALLERGY文献大全
  • Volumetric aerobiological survey of conidial fungi in the North-East Netherlands. II. Comparison of aerobiological data and skin tests with mould extracts in an asthmatic population.

    abstract::A study was undertaken to see whether the principal airborne fungi in the North-East Netherlands were also found to be the most reactive in skin testing. Atmospheric samples were taken weekly with the Andersen sampler, from April 1981, up to and including, June 1983. At the same time skin tests of 833 patients referre...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1985.tb00214.x

    authors: Beaumont F,Kauffman HF,de Monchy JG,Sluiter HJ,de Vries K

    更新日期:1985-04-01 00:00:00

  • The non-specific enhancement of allergy. II. Precipitation of anaphylactic in vitro response capacity and serum IgE and IgG2a antibody synthesis in primed but non-responding rats by injection of alum.

    abstract::PVG rats given injections of 1 microgram ovalbumin (OA) together with 10 mg Silica gel failed to provide serosal mast cells or lung tissue with the capacity to release histamine on in vitro challenge with the antigen. However, if such animals were injected i.p. with 100 mg of alum (without any further antigen addition...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1983.tb01618.x

    authors: Bergstrand H,Andersson I,Nyström I,Pauwels R,Bazin H

    更新日期:1983-05-01 00:00:00

  • Active vaccination against interleukin-5 as long-term treatment for insect-bite hypersensitivity in horses.

    abstract:BACKGROUND:Insect-bite hypersensitivity (IBH) in horses is a chronic allergic dermatitis caused by insect bites. Horses suffer from pruritic skin lesions, caused by type-I/type-IV allergic reactions accompanied by prominent eosinophil infiltration into the skin. Interleukin-5 (IL-5) is the key cytokine for eosinophils ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.13659

    authors: Fettelschoss-Gabriel A,Fettelschoss V,Olomski F,Birkmann K,Thoms F,Bühler M,Kummer M,Zeltins A,Kündig TM,Bachmann MF

    更新日期:2019-03-01 00:00:00

  • Exhaled nitric oxide and exercise-induced bronchoconstriction in young male conscripts: association only in atopics.

    abstract::This study was conducted to evaluate how bronchial responsiveness to direct and indirect stimuli relate to nitric oxide producing airway inflammation, and whether the relationship differs between atopic and nonatopic patients with various degrees of bronchial hyperresponsiveness and airway inflammation in a group of o...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2005.00901.x

    authors: Rouhos A,Ekroos H,Karjalainen J,Sarna S,Sovijärvi AR

    更新日期:2005-12-01 00:00:00

  • Food-induced immediate response of the esophagus-A newly identified syndrome in patients with eosinophilic esophagitis.

    abstract:BACKGROUND:Dysphagia is the main symptom of adult eosinophilic esophagitis (EoE). We describe a novel syndrome, referred to as "food-induced immediate response of the esophagus" (FIRE), observed in EoE patients. METHODS:Food-induced immediate response of the esophagus is an unpleasant/painful sensation, unrelated to d...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14495

    authors: Biedermann L,Holbreich M,Atkins D,Chehade M,Dellon ES,Furuta GT,Hirano I,Gonsalves N,Greuter T,Gupta S,Katzka DA,De Rooij W,Safroneeva E,Schoepfer A,Schreiner P,Simon D,Simon HU,Warners M,Bredenoord AJ,Straumann A

    更新日期:2021-01-01 00:00:00

  • IgE, IgG1, and IgG4 antibody responses to Blomia tropicalis in atopic patients.

    abstract:BACKGROUND:Allergens from house dust mites (HDMs), Dermatophagoides pteronyssinus and Blomia tropicalis are clinically relevant in atopic respiratory diseases in tropical countries. AIMS OF THE STUDY:To evaluate immunoglobulin (Ig)E, IgG1, and IgG4 antibody responses to B. tropicalis in Brazilian atopic patients. MET...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2005.00738.x

    authors: Pereira EA,Silva DA,Cunha-Júnior JP,Almeida KC,Alves R,Sung SJ,Taketomi EA

    更新日期:2005-03-01 00:00:00

  • Histopathological support of antagonism of allergen-induced mast cell mediator release in human skin by a beta-2-agonist.

    abstract::The site of antagonistic action on allergen-induced early skin reactions by the beta 2-agonist terbutaline was studied by light microscopy in 10 atopic subjects. Pretreatment with 1 microgram terbutaline intradermally 5 min prior to challenge with horse dander allergen produced an approximate inhibition of 85 and 55% ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1986.tb00278.x

    authors: Grönneberg R,Lagerholm B

    更新日期:1986-01-01 00:00:00

  • Gastroesophageal reflux and asthma: a review of pathogenesis, diagnosis, and therapy.

    abstract::Gastroesophageal reflux disease (GERD) occurs in up to one-third of the adult US population. Most affected individuals are either unaware of their condition or do not seek medical help, relying on nonprescription acid suppressants and antacids for relief. GERD, a common disorder of infancy, old age, and pregnancy, is ...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.1999.00093.x

    authors: Theodoropoulos DS,Lockey RF,Boyce HW Jr,Bukantz SC

    更新日期:1999-07-01 00:00:00

  • Gender and occupational allergy: Report from the task force of the EAACI Environmental and Occupational Allergy Interest Group.

    abstract::Women's work has traditionally been considered less hazardous to health in comparison with men's work. The increased women's participation in the workforce has led to an increased attention to women's working conditions. Women and men are unequally represented in individual professions or sectors (horizontal segregati...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14317

    authors: Moscato G,Apfelbacher C,Brockow K,Eberle C,Genuneit J,Mortz CG,Quecchia C,Quirce S,Siracusa A,Tarlo SM,van Kampen V,Walusiak-Skorupa J,Raulf M

    更新日期:2020-11-01 00:00:00

  • Surfactant protein levels in bronchoalveolar lavage after segmental allergen challenge in patients with asthma.

    abstract:BACKGROUND:Allergic asthma is associated with airway inflammation and dysfunction of pulmonary surfactant. Because surfactant proteins (SP) account for immunomodulatory functions as well as biophysical functions, we hypothesized that the allergic response in asthma might be accompanied by a dysregulation of SPs. METHO...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2006.01062.x

    authors: Erpenbeck VJ,Schmidt R,Günther A,Krug N,Hohlfeld JM

    更新日期:2006-05-01 00:00:00

  • In allergic asthma experimental exposure to allergens is associated with depletion of blood eosinophils overexpressing LFA-1.

    abstract:BACKGROUND:In atopic individuals, exposure to allergens is followed by recruitment of blood eosinophils in the target tissue. We investigated whether allergen inhalation challenge could result in depletion of blood eosinophils overexpressing adhesion molecules involved in eosinophil migration. METHODS:Blood eosinophil...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2002.23826.x

    authors: Lantero S,Spallarossa D,Silvestri M,Sabatini F,Scarso L,Crimi E,Rossi GA

    更新日期:2002-11-01 00:00:00

  • Efficacy of mequitazine in comparison with placebo assessed by ocular challenge with allergen in allergic conjunctivitis.

    abstract::Pharmacologic intervention in the management of allergic conjunctivitis was evaluated with different topical ocular agents in man. Their effect can be precisely assessed with the conjunctival provocation test (CPT). A potent specific H1-receptor antagonist, 0.05% mequitazine eye-drops, was tested in a double-blind ran...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1997.tb01028.x

    authors: Persi L,Dupin O,Arnaud B,Trinquand C,Michel FB,Bousquet J

    更新日期:1997-04-01 00:00:00

  • Green, Yellow, and Red risk perception in everyday life - a communication tool.

    abstract:BACKGROUND:Adolescents have the highest risk for food allergy-related fatalities. Our main aim was to investigate the level of risk in everyday social situations as perceived by adolescents/young adults with peanut allergy, their families, and their friends. METHODS:The web-based 'Colours Of Risks' (COR) questionnaire...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.13095

    authors: Stensgaard A,DunnGalvin A,Nielsen D,Munch M,Bindslev-Jensen C

    更新日期:2017-07-01 00:00:00

  • The differences of tear function and ocular surface findings in patients with atopic keratoconjunctivitis and vernal keratoconjunctivitis.

    abstract:BACKGROUND:The pathogenesis of the ocular surface disease in atopic keratoconjunctivitis (AKC) and vernal keratoconjunctivitis (VKC) has not been fully understood. We tried to clarify the differences in the ocular surface status in patients with AKC, VKC, and healthy control subjects. METHODS:Twenty-four eyes of 12 AK...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2007.01414.x

    authors: Hu Y,Matsumoto Y,Dogru M,Okada N,Igarashi A,Fukagawa K,Tsubota K,Fujishima H

    更新日期:2007-08-01 00:00:00

  • Bronchial asthma: pathophysiological mechanisms and corticosteroids.

    abstract::The clinical effects in asthma of corticosteroids can be ascribed to their strong anti-inflammatory action. The pathophysiology of asthma is complex. A diversity of mediators and interactions between mediators and between mediators and various cell types enhances and maintains the inflammatory process in the airways r...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.1988.tb00908.x

    authors: Norn S,Clementsen P

    更新日期:1988-08-01 00:00:00

  • Latex allergy in Saudi children with spina bifida.

    abstract:BACKGROUND:Children with spina bifida (SB) are exposed to latex soon after birth during bladder catheterization, rectal disimpaction, and multiple surgical procedures. IgE-mediated latex-allergic reactions have been reported recently in these children. Our study was designed to assess the prevalence of allergic reactio...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.1999.00683.x

    authors: Kattan H,Harfi H,Tipirneni P

    更新日期:1999-01-01 00:00:00

  • Recommendations for standardization of clinical trials with Allergen Specific Immunotherapy for respiratory allergy. A statement of a World Allergy Organization (WAO) taskforce.

    abstract::Specific Immunotherapy for respiratory allergy is used since about one century and there is now solid documentation of its efficacy. Nevertheless, the methods and experimental designs used in clinical trials are quite heterogeneous and there is no unanimously accepted methodological standard. Many studies are planned ...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.2006.01312.x

    authors: Canonica GW,Baena-Cagnani CE,Bousquet J,Bousquet PJ,Lockey RF,Malling HJ,Passalacqua G,Potter P,Valovirta E

    更新日期:2007-03-01 00:00:00

  • Immune mechanisms of allergen-specific sublingual immunotherapy.

    abstract::Sublingual immunotherapy has been shown in some clinical studies to modulate allergen-specific antibody responses [with a decrease in the immunoglobulin E/immunoglobulin G4 (IgE/IgG4) ratio] and to reduce the recruitment and activation of proinflammatory cells in target mucosa. Whereas a central paradigm for successfu...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.2006.01002.x

    authors: Moingeon P,Batard T,Fadel R,Frati F,Sieber J,Van Overtvelt L

    更新日期:2006-02-01 00:00:00

  • Comparison of wheat and rye flour skin prick test solutions for diagnosis of baker's asthma.

    abstract:BACKGROUND:Skin prick tests (SPTs) play an important role in the diagnosis of baker's asthma and in the investigation of sensitization frequencies in field studies. It was the aim of our study to compare different SPT solutions for wheat and rye flour sensitization and to assess the validity of test results. METHODS:S...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1046/j.1398-9995.2003.00349.x

    authors: Sander I,Merget R,Degens PO,Goldscheid N,Brüning T,Raulf-Heimsoth M

    更新日期:2004-01-01 00:00:00

  • Fel d 1 production in the cat skin varies according to anatomical sites.

    abstract:BACKGROUND:Fel d 1 is the major cat allergen, inducing asthma in sensitized individuals. It is produced by the skin and lies on fur. Recently, it was established that the amount of Fel d 1 on fur varies among anatomical sites. However, it is not known whether the allergen production by skin varies in parallel. The obje...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2000.00588.x

    authors: Carayol N,Birnbaum J,Magnan A,Ramadour M,Lanteaume A,Vervloet D,Tessier Y,Pageat P

    更新日期:2000-06-01 00:00:00

  • Farm animal feeders: another group affected by cereal flour asthma.

    abstract::Asthma induced by cereal flour is a long recognized entity. We present studies of three patients affected by asthma related to exposure to cereal flour contained in animal formula feeds. Skin prick test performed with the formula feed components showed positive reactions to cereal flours (wheat, rye and barley) and ne...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1988.tb00909.x

    authors: Valdivieso R,Pola J,Zapata C,Puyana J,Cuesta J,Martin C,Losada E

    更新日期:1988-08-01 00:00:00

  • Hypoxia inducible factor promotes murine allergic airway inflammation and is increased in asthma and rhinitis.

    abstract:BACKGROUND:New therapies are necessary to address inadequate asthma control in many patients. This study sets out to investigate whether hypoxia-inducible factor (HIF) is essential for development of allergic airway inflammation (AAI) and therefore a potential novel target for asthma treatment. METHODS:Mice conditiona...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2011.02594.x

    authors: Huerta-Yepez S,Baay-Guzman GJ,Bebenek IG,Hernandez-Pando R,Vega MI,Chi L,Riedl M,Diaz-Sanchez D,Kleerup E,Tashkin DP,Gonzalez FJ,Bonavida B,Zeidler M,Hankinson O

    更新日期:2011-07-01 00:00:00

  • Cutaneous field stimulation of sensory nerve fibers reduces itch without affecting contact dermatitis.

    abstract:BACKGROUND:A new technique, cutaneous field stimulation (CFS), which activates electrically unmyelinated C-fibers, is used to treat localized itch. Its action is similar to that of capsaicin, the pungent agent in hot peppers, which enhances delayed allergic reactions. The aim of the study was to investigate how experim...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2002.23709.x

    authors: Wallengren J

    更新日期:2002-12-01 00:00:00

  • European Survey on Adverse Systemic Reactions in Allergen Immunotherapy (EASSI): a real-life clinical assessment.

    abstract:BACKGROUND:Outside clinical trials, data on systemic reactions (SRs) due to allergen immunotherapy (AIT) are scarce. METHODS:A prospective, longitudinal, web-based survey of 'real-life' respiratory allergen immunotherapy (AIT) clinical practice was conducted in France, Germany and Spain. SRs were recorded and coded ac...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.13066

    authors: Calderón MA,Vidal C,Rodríguez Del Río P,Just J,Pfaar O,Tabar AI,Sánchez-Machín I,Bubel P,Borja J,Eberle P,Reiber R,Bouvier M,Lepelliez A,Klimek L,Demoly P,EASSI Doctors' Group.

    更新日期:2017-03-01 00:00:00

  • Decreased intercellular adhesion molecule-1 (CD54) and L-selectin (CD62L) expression on peripheral blood natural killer cells in asthmatic children with acute exacerbation.

    abstract:BACKGROUND:The capacity of inflammatory cells to adhere involves an array of adhesion molecules, and is critical to the inflammatory responses seen in childhood asthma. We aimed to determine the changes of intercellular adhesion molecule-1 (ICAM-1) and L-selectin expressed on peripheral blood (PB) T lymphocytes and nat...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2003.t01-1-23697.x

    authors: Lin SJ,Chang LY,Yan DC,Huang YJ,Lin TJ,Lin TY

    更新日期:2003-01-01 00:00:00

  • Elevated levels of peripheral-blood, naturally occurring aliphatic polyamines in bronchial asthmatic patients with active symptoms.

    abstract::The levels of peripheral-blood, naturally occurring aliphatic polyamines, such as putrescine, spermidine, and spermine, from 21 bronchial asthmatic patients (11 atopics and 10 nonatopics) were measured by postcolumn derivatization high-performance liquid chromatography analysis. None of the patients, except the 44-yea...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1992.tb02388.x

    authors: Kurosawa M,Shimizu Y,Tsukagoshi H,Ueki M

    更新日期:1992-12-01 00:00:00

  • Oral immunotherapy of children with rhinoconjunctivitis due to birch pollen allergy. A double blind study.

    abstract::Thirty children with rhinoconjunctivitis due to birch pollinosis were treated in a double blind manner for 10 months with enteric-coated capsules containing either a birch pollen preparation (n = 14) with doses up to 1.4 X 10(6) biologic units per day or placebo (n = 16). Compared with the placebo group the actively t...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1986.tb02028.x

    authors: Möller C,Dreborg S,Lanner A,Björkstén B

    更新日期:1986-05-01 00:00:00

  • Efficacy of the topical nasal steroid budesonide on improving sleep and daytime somnolence in patients with perennial allergic rhinitis.

    abstract:BACKGROUND:Improving quality of life is considered to be a major endpoint and motivation for clinical intervention in patients with perennial allergic rhinitis (PAR). In addition to classical symptoms of congestion, pruritus, and rhinorrhea, patients will often complain of not being able to sleep well at night and of f...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1398-9995.2003.00093.x

    authors: Hughes K,Glass C,Ripchinski M,Gurevich F,Weaver TE,Lehman E,Fisher LH,Craig TJ

    更新日期:2003-05-01 00:00:00

  • Effect of oral and inhaled sodium cromoglycate in exercise-induced asthma.

    abstract::Ten patients with bronchial asthma reacting with bronchoconstriction after exercise were studied to compare the effect of oral sodium cromoglycate against sodium cromoglycate inhalation and placebo. Only sodium cromoglycate inhalations protected against exercise-induced asthma. The effect of sodium cromoglycate seems ...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1980.tb01779.x

    authors: Dahl R,Henriksen JM

    更新日期:1980-06-01 00:00:00

  • Suppression of adrenomedullin contributes to vascular leakage and altered epithelial repair during asthma.

    abstract:BACKGROUND:The anti-inflammatory peptide, adrenomedullin (AM), and its cognate receptor are expressed in lung tissue, but its pathophysiological significance in airway inflammation is unknown. OBJECTIVES:This study investigated whether allergen-induced airway inflammation involves an impaired local AM response. METHO...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2012.02851.x

    authors: Hagner S,Welz H,Kicic A,Alrifai M,Marsh LM,Sutanto EN,Ling KM,Stick SM,Müller B,Weissmann N,Renz H

    更新日期:2012-08-01 00:00:00