Abstract:
:Quantiative immunoelectrophoresis used for the analysis of a dialysed, centrifuged and freeze-dried extract from cow hair and dander revealed 17 antigens. Five of these were identified as serum proteins. Partial identity to antigens of serum and extract from hair and dander of goat, sheep, swine, horse, dog, cat and guinea pig, and to antigens of house dust was demonstrated. Sera from 36 patients with manifest allergy to cow hair and dander selected on the basis of case history, RAST, skin and provocation test, were examined in crossed radioimmunoelectrophoresis (CRIE); sera from five persons with high serum IgE, but without allergy to cow hair and dander, and sera from five normal individuals were controls. 31/36 of the sera contained IgE with specific affinity for two of the antigens of the extract. Further, two major and six minor allergens were identified. The control sera showed no specific IgE binding. A significant positive correlation was found between RAST and CRIE for the first group of patients. The approximate molecular weights of the four major allergens obtained by means of gel chromatography were: 2.4 x 10(4), 2 x 10(4), 2 x 10(5) dalton, respectively. Using Con-A and Con-A Sepharose in crossed immunoaffinoelectrophoresis, eight of the antigens were revealed to contain groups with affinity for Con-A.
journal_name
Allergyjournal_title
Allergyauthors
Prahl P,Weeke B,Løwenstein Hdoi
10.1111/j.1398-9995.1978.tb01544.xsubject
Has Abstractpub_date
1978-10-01 00:00:00pages
241-53issue
5eissn
0105-4538issn
1398-9995journal_volume
33pub_type
杂志文章相关文献
ALLERGY文献大全abstract::It is debatable whether beta 2-receptor agonists produce antiallergic effects in human airways. This question has been addressed in the present study by examination of both mast-cell indices and the physiologic response to allergen challenge in human nasal airways. Twelve asymptomatic patients with seasonal allergic r...
journal_title:Allergy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1398-9995.1995.tb02494.x
更新日期:1995-11-01 00:00:00
abstract::Drug-induced erythema multiforme is reported with many antimicrobial and antipyretic medications. We present one patient who experienced erythema multiforme and urticaria after administration of pyrazinamide for treatment of cutaneous tuberculosis. The side-effects of pyrazinamide include hepatic or dermatologic disor...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1996.tb04620.x
更新日期:1996-05-01 00:00:00
abstract::We performed immunoblotting experiments to determine specific IgE and IgG subclass responses to Candida albicans antigens in allergic bronchopulmonary aspergillosis (ABPA) patients. This is a first report describing C. albicans antigens recognized by serum IgE and IgG subclasses of ABPA patients sensitized to that yea...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1997.tb01018.x
更新日期:1997-04-01 00:00:00
abstract::The yeast Pityrosporum orbiculare (P. orbiculare) is a member of the normal human cutaneous flora, but it is also associated with several clinical manifestations of the skin. We have previously observed IgE-binding components in P. orbiculare extracts, using sera from patients with atopic dermatitis. In the present st...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1994.tb00773.x
更新日期:1994-01-01 00:00:00
abstract::An affinity chromatography method for preparation of patient-related antigens from commercially available allergen extracts has been investigated. IgG1,2,4 from a patient previously hyposensitized with dog hair and dandruff allergen was bound to protein A-sepharose. Secondly, commercial allergen extract was applied to...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1988.tb00927.x
更新日期:1988-11-01 00:00:00
abstract::Airway remodeling is a central feature of asthma. It is exemplified by thickening of the lamina reticularis and structural changes to the epithelium, submucosa, smooth muscle, and vasculature of the airway wall. Airway remodeling may result from persistent airway inflammation. Immunoglobulin E (IgE) is an important me...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.2011.02617.x
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Undernotification is well recognized as a key challenge to the study of anaphylaxis mortality, but it is seldom mentioned that one of its reasons is the difficult coding of the condition under the tenth revision of the international classification of diseases (ICD-10), given that there are no anaphylaxis-spe...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2012.02829.x
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Fel d 1 is the major cat allergen, inducing asthma in sensitized individuals. It is produced by the skin and lies on fur. Recently, it was established that the amount of Fel d 1 on fur varies among anatomical sites. However, it is not known whether the allergen production by skin varies in parallel. The obje...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2000.00588.x
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:Budesonide/formoterol (Symbicort) Maintenance and Reliever Therapy (SMART) is an effective asthma-management approach that treats symptoms with rapid increases in budesonide/formoterol. The cost-effectiveness of SMART vs higher fixed-dose budesonide/formoterol or salmeterol/fluticasone is unknown. METHODS:T...
journal_title:Allergy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1398-9995.2007.01466.x
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:The presence of anti-FcepsilonRI and anti-IgE autoantibodies in a subset of patients with chronic urticaria suggests their aetiopathogenetic role. In clinical practice, the presence of these antibodies is usually considered when the autologous serum skin test (ASST) is positive. AIMS:To evaluate if the posi...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2005.00673.x
更新日期:2005-02-01 00:00:00
abstract::In immunotherapy of grass pollen allergy, an extract of rye (Secale cereale) is often included. The aim of this study was to investigate by skin prick test (SPT) and immunochemical methods whether rye pollen contains specific allergens justifying the use of this extract separately. Twenty grass pollen allergic patient...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1984.tb01964.x
更新日期:1984-08-01 00:00:00
abstract::Allergy to neuromuscular blocking agents (NMBAs) is the most important caue of perioperative anaphylaxis in France. The diagnosis relies on a careful clinical history, the search of serum IgE antibodies, and the realization of skin tests. Although the skin tests are the most important tool and their sensitivity is wid...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2011.02753.x
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:The pollen-food syndrome (PFS) is an association of food allergies to fruits, nuts, and vegetables in patients with pollen allergy. Mal d 1, the major apple allergen, is one of the most commonly associated food allergens for birch pollen-allergic patients suffering from PFS. Although the reactions are due to...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2008.01844.x
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:The role of myeloid and plasmacytoid dendritic cells and its consequences for the T(H)2 skew in chronic rhinosinusitis (CRS) with nasal polyps (CRSNP(+)) should be detailed. METHODS:In 18 CRS patients without nasal polyps (CRSNP(-)), 35 CRSNP(+) patients and 22 patients with nasal structural abnormalities w...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2009.02174.x
更新日期:2010-01-01 00:00:00
abstract::Pharmacologic intervention in the management of allergic conjunctivitis was evaluated with different topical ocular agents in man. Their effect can be precisely assessed with the conjunctival provocation test (CPT). A potent specific H1-receptor antagonist, 0.05% mequitazine eye-drops, was tested in a double-blind ran...
journal_title:Allergy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1398-9995.1997.tb01028.x
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:Efficacy testing of immunotherapy in field studies is often hampered by variation of airborne allergens. Standardized allergen exposure in challenge chamber settings might be an alternative. Therefore, we developed a universal technique to create an atmosphere loaded with allergen particles of adjustable siz...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12947
更新日期:2016-12-01 00:00:00
abstract::The mucosal lining of the upper airways represents the outer surface of the body to the ambient air and its contents and is prepared for it as the first line of defense. Apart from the well-described physical barrier and the mucociliary clearance, a variety of systems, including the airway microbiome, antimicrobial pr...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.12809
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Several studies showed that calcium-binding proteins have a fixed place in the spectrum of allergenic substances. Often the binding of a calcium ion induces conformational changes and affects immunoglobulin E-binding to the allergen. Hence, the quantitative characterization of the binding to calcium is of im...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2005.00907.x
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Analyses of exhaled volatile organic compounds (VOCs) have shown promising results when distinguishing individuals with asthma. Currently, there are no biomarkers for uncontrolled asthma. Therefore, we aimed to assess, in a real-life clinical setting, the ability of the exhaled VOC analysis, using an electro...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.14207
更新日期:2020-07-01 00:00:00
abstract::For screening atopy risk in 6401 (84%) of all infants born during the year 1990 in six obstetric departments of five German cities, cord-blood IgE values were determined with CAP-RAST-FEIA. After cases with elevated IgA values had been excluded, 25% of the values were above the detection limit of 0.35 kU/l, and 8.5% w...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1995.tb02484.x
更新日期:1995-01-01 00:00:00
abstract::During the last years, two new cardiovascular drug classes, namely inhibitors of DPP IV or neprilysin, have been developed. In both cases, there is clinical evidence for their potential to induce angioedema as known already from blockers of the renin-angiotensin-aldosterone system (RAAS). The majority of angioedema in...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.12680
更新日期:2015-10-01 00:00:00
abstract::The skin is the most frequently affected target organ in allergy or intolerance of food and food additives. The most common manifestation is acute urticaria (with or without angioedema), accounting for 40-60% of patients with IgE-mediated food allergy, whereas food additives rather aggravate chronic urticaria (intoler...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.1998.tb04983.x
更新日期:1998-01-01 00:00:00
abstract::B cells are essentially described for their capacity to produce antibodies ensuring anti-infectious immunity or deleterious responses in the case of autoimmunity or allergy. However, abundant data described their ability to restrain inflammation by diverse mechanisms. In allergy, some regulatory B-cell subsets produci...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.12490
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Bakery workers may develop IgE-mediated allergy to liquid and aerosolized hen's egg proteins that are commonly used in the baking and confectionery industries. METHODS:We studied four bakery workers who had work-related allergic respiratory symptoms upon exposure to egg aerosols. The causative role of egg p...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2003.00201.x
更新日期:2003-07-01 00:00:00
abstract::Antigenic extracts prepared from pollen samples collected at weekly intervals during the same season did not exhibit significant variation in protein concentration. Stored pollen samples from different years, however, showed highly significant variations in protein concentration. The protein content of samples from di...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1991.tb00587.x
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND:Synthetic bedding has been associated with increased child wheeze and also higher allergen levels in several studies. We aimed to examine whether the association between synthetic bedding and adverse respiratory outcomes was more evident among skin-prick test (SPT) positive children. METHODS:A cross-section...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2002.1s3234.x
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:Epidemiologic data on asthma and allergies among adults are mainly based on questionnaires: this study validates the questions on asthma, allergic rhinitis, and conjunctivitis of a new Finnish questionnaire. METHODS:To validate questions used in a country-wide study among university students aged 18-25 year...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2001.056005377.x
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:The capacity of profilin to induce allergic symptoms in patients with respiratory allergy has been questioned. In this sense, the aim of this study was to investigate the correlation between profilin exposure and induction of symptoms in a prospective case-control study. METHODS:The concentration of profili...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.14140
更新日期:2020-04-01 00:00:00
abstract::We have evaluated the in vitro leukocyte histamine release tests for the diagnosis of allergy to muscle relaxant drugs in 40 patients (Group A) and a control group of 44 subjects with negative leukocyte histamine release (Group B). Non-IgE dependent histamine release, expressed as a percentage of the total blood hista...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1992.tb00667.x
更新日期:1992-10-01 00:00:00
abstract::The leading priority for the Polish Presidency of the Council of the European Union was to reduce health inequalities across European societies, and, within its framework, prevention and control of respiratory diseases in children. This very important paper contain proposal of international cooperation on the preventi...
journal_title:Allergy
pub_type: 共识发展会议,杂志文章,评审
doi:10.1111/j.1398-9995.2012.02822.x
更新日期:2012-06-01 00:00:00