Abstract:
:B cells are essentially described for their capacity to produce antibodies ensuring anti-infectious immunity or deleterious responses in the case of autoimmunity or allergy. However, abundant data described their ability to restrain inflammation by diverse mechanisms. In allergy, some regulatory B-cell subsets producing IL-10 have been recently described as potent suppressive cells able to restrain inflammatory responses both in vitro and in vivo by regulatory T-cell differentiation or directly inhibiting T-cell-mediated inflammation. A specific deficit in regulatory B cells participates to more severe allergic inflammation. Induction of allergen tolerance through specific immunotherapy induces a specific expansion of these cells supporting their role in establishment of allergen tolerance. However, the regulatory functions carried out by B cells are not exclusively IL-10 dependent. Indeed, other regulatory mechanisms mediated by B cells are (i) the production of TGF-β, (ii) the promotion of T-cell apoptosis by Fas-Fas ligand or granzyme-B pathways, and (iii) their capacity to produce inhibitory IgG4 and sialylated IgG able to mediate anti-inflammatory mechanisms. This points to Bregs as interesting targets for the development of new therapies to induce allergen tolerance. In this review, we highlight advances in the study of regulatory mechanisms mediated by B cells and outline what is known about their phenotype as well as their suppressive role in allergy from studies in both mice and humans.
journal_name
Allergyjournal_title
Allergyauthors
Braza F,Chesne J,Castagnet S,Magnan A,Brouard Sdoi
10.1111/all.12490subject
Has Abstractpub_date
2014-11-01 00:00:00pages
1454-63issue
11eissn
0105-4538issn
1398-9995journal_volume
69pub_type
杂志文章,评审相关文献
ALLERGY文献大全abstract::The aim of biological standardization (BS) is to equilibrate the activity (potency) of allergen extracts from different source materials. This was done by performing skin prick tests (SPT) on patients who were sensitive to one of the following 10 allergens: Birch, alder, hazel, timothy, rye grass, velvet grass, cultiv...
journal_title:Allergy
pub_type: 临床试验,杂志文章
doi:10.1111/j.1398-9995.1987.tb02368.x
更新日期:1987-02-01 00:00:00
abstract::This study delineates the prevalence of reactions to condoms among latex-allergic patients seen in allergy consultation services since 1987. Questionnaires were mailed to 374 patients previously found to have clinically significant allergy to latex. Of these, only 238 completed the questionnaire. The respondents we...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1998.tb03827.x
更新日期:1998-11-01 00:00:00
abstract::The usefulness of the leukocyte migration inhibition factor (LIF) test to detect cow milk (CM) hypersensitivity was studied in 40 children with suspected allergy to CM. Hypersensitivity was carefully investigated by oral milk challenges, which gave a final confirmation of cow milk hypersensitivity in 12 subjects, and ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1987.tb00392.x
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND:Jackfruit allergy has been reported just once. It is unknown whether this food allergy is caused by direct sensitization or cross-sensitization to pollen allergens. OBJECTIVE:Establish whether jackfruit allergy is linked to birchpollen allergy. METHODS:Two jackfruit allergic patients and five patients with...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2004.00544.x
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:CD69 is a molecule expressed on human eosinophils after cytokine-activation. Different studies have described the eosinophil activation, evaluated by CD69 expression, at the site of an allergic inflammation. In this study we evaluated the expression of CD69 on peripheral blood eosinophils after a specific in...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2002.23454.x
更新日期:2002-05-01 00:00:00
abstract::In a study of 770 patients with allergic rhinitis, anamnestic data were collected by means of a questionnaire. 484 (63%) of the patients were women and 286 (37%) men. 45.5% of the patients had perennial symptoms, 33.5% had seasonal symptoms only, and 21% had predominantly seasonal but also some perennial symptoms. Mor...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1982.tb02317.x
更新日期:1982-08-01 00:00:00
abstract:BACKGROUND:Modulation of leukocyte recruitment through blocking of chemokine receptors has been proposed as an attractive therapeutic strategy. We have previously demonstrated that n-Nonanoyl-CC chemokine ligand 14 (NNY-CCL14), a modified analog of the naturally occurring chemokine CCL14(9-74) internalizes and desensit...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2008.01787.x
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:Management of atopic dermatitis (AD) requires judging the symptoms of local skin lesions and prescribing a suitable treatment. However, no method has been established in which objective measures can be used to evaluate the severity of local symptoms. We established a method for measuring thymus and activatio...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2010.02361.x
更新日期:2010-09-01 00:00:00
abstract::The red cell-linked antigen-antiglobulin reaction (RCLAAR) with stearoyldextran-coated erythrocytes was used to characterize the immunoglobulin (Ig) classes and IgG subclasses of dextran reactive antibodies (DRA) in 27 dextran reactors (DR) and 96 on reactors (DNR). High titres of dextran reactive IgG were regularly f...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1982.tb02331.x
更新日期:1982-10-01 00:00:00
abstract:BACKGROUND:Nasal congestion is the predominant symptom in perennial allergic rhinitis (PAR), and it seems to be mainly related to the late-phase inflammatory events. The present pilot study aimed to evaluate the therapeutic effect exerted by fexofenadine in patients with PAR due to mite allergy. METHODS:This study was...
journal_title:Allergy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1034/j.1398-9995.2001.00191.x
更新日期:2001-11-01 00:00:00
abstract::In 30 stable asthmatics, a comparison was made between the changes in pulmonary function (FEV1, FVC, PEF, MEF75, MEF50 and MEF25) hourly for 9 h after a single dose of inhaled budesonide 1,600 micrograms, and placebo. All subjects used inhaled steroids daily; this medication was, however, withheld 8 days prior to the ...
journal_title:Allergy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1398-9995.1991.tb00619.x
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND:A new technique, cutaneous field stimulation (CFS), which activates electrically unmyelinated C-fibers, is used to treat localized itch. Its action is similar to that of capsaicin, the pungent agent in hot peppers, which enhances delayed allergic reactions. The aim of the study was to investigate how experim...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2002.23709.x
更新日期:2002-12-01 00:00:00
abstract::Chronic fatigue syndrome (CFS) is a syndrome of uncertain etiopathogenesis characterized by disabling fatigue associated with a variable number of somatic and/or neuropsychologic symptoms. In patients with CFS, several immunologic abnormalities can be detected, including a higher prevalance of allergy. The aim of this...
journal_title:Allergy
pub_type: 杂志文章
doi:
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND:Analyses of exhaled volatile organic compounds (VOCs) have shown promising results when distinguishing individuals with asthma. Currently, there are no biomarkers for uncontrolled asthma. Therefore, we aimed to assess, in a real-life clinical setting, the ability of the exhaled VOC analysis, using an electro...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.14207
更新日期:2020-07-01 00:00:00
abstract::Standardized bronchial allergen provocation with the same individual allergen dose was performed 3-9 times in 20 symptomless adult asthmatic patients at intervals of 1 week or more during 1/2-22 months in order to study variations in bronchial response. The immediate type reaction was recorded by monitoring FEV1, FVC,...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1980.tb01777.x
更新日期:1980-06-01 00:00:00
abstract::Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report, we provide eviden...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12662
更新日期:2015-09-01 00:00:00
abstract::Fourteen adults and 10 children with active atopic dermatitis entered this double blind cross-over study of oral disodium cromoglycate (DSCG) (adults 200 mg qid, children 100 mg qid) compared with placebo. Oral DSCG and placebo were given for 6 weeks in random order. According to the investigators' assessments of ecze...
journal_title:Allergy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1398-9995.1983.tb01601.x
更新日期:1983-04-01 00:00:00
abstract:BACKGROUND:Allergy to atracurium is a rare condition with serious consequences of diagnostic error. However, correct diagnosis is not always straightforward. The aim of this study is to assess the utility of the basophil activation test (BAT) in atracurium sensitization and to investigate its role in identifying cross-...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12468
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:IgE-independent (pseudoallergic) reactions to food and food ingredients are common in a subgroup of adult patients with chronic urticaria, who have daily spontaneous occurrence of wheals. However, for children with chronic urticaria (duration longer than 6 weeks, no physical influence), no data on the import...
journal_title:Allergy
pub_type: 临床试验,杂志文章
doi:10.1111/j.1398-9995.1998.tb03817.x
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND:Epicutaneous sensitization is an important route of immunization for allergens in atopic diseases; however, studies have also shown that application with protein on the intact skin induces antigen-specific tolerance. Langerhans cells (LCs) play an immunosuppressive role in several inflammatory skin diseases ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13813
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Exposure to acrylates may give rise to rhinitis and asthma in both industrial and domestic environments. The mechanisms underlying these respiratory conditions caused by acrylates remain largely unknown. METHODS:We studied two assembly operators exposed to cyanoacrylate glue who developed rhinitis and asthm...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2001.056005446.x
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Characterization of uncontrolled asthma burden in a natural treatment setting can influence treatment recommendations and clinical practice. The objective was to characterize and compare the economic burden of severe or difficult-to-treat asthma in uncontrolled and controlled patients. METHODS:Baseline pati...
journal_title:Allergy
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1398-9995.2006.01254.x
更新日期:2007-02-01 00:00:00
abstract::A total of 105 "high-risk" infants born in 1988 were studied prospectively from birth to 18 months of age. The infants were recommended breastfeeding and/or hypoallergenic formula (Nutramigen or Profylac) combined with avoidance of solid foods during the first 6 months of life. All mothers had unrestricted diet. Avoid...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1992.tb00680.x
更新日期:1992-10-01 00:00:00
abstract::The association between food allergy and celiac disease (CD) is still to be clarified. We screened for CD 319 patients with severe food allergy (IgE > 85 kU/l against food proteins and a history of severe allergic reactions) who underwent specific food oral immunotherapy (OIT), together with 128 children with mild all...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12692
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Mould-attributed symptoms have included features which overlap with unexplained syndromes such as sick building syndrome. OBJECTIVES:We describe questionnaire and chart review findings in patients following exposure to moulds which include Stachybotrys and compare responses with two control groups. METHODS...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2009.02157.x
更新日期:2010-02-01 00:00:00
abstract::Twenty patients with severe or medium severe asthma were given atenolol (Atenol ICI-Pharma) and/or metoprolol (Seloken Hässle) for tachycardia, hyperkinetic tremor, arterial hypertension or symptoms of angina pectoris. These cardioselective beta-blocking drugs caused only a very slight decrease in PF values. There was...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1978.tb01525.x
更新日期:1978-06-01 00:00:00
abstract::Type I allergy against some common microorganisms was investigated in 14 patients with AIDS and 11 human immunodeficiency virus (HIV) antibody-positive homosexual men, and in a control group consisting of 13 heterosexual men without HIV antibodies. Basophil histamine release technique was used as a sensitive method to...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1987.tb02212.x
更新日期:1987-05-01 00:00:00
abstract::Atopic eczema (AE) is a challenge for modern medicine, because it is prevalent, severely affects quality of life of patients and their families, and causes high socioeconomic costs. The pathogenesis of AE is complex. While initial studies suggested a Th2 deviation as primary reason for the disease, numerous studies ad...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.12184
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Relationships among allergen-specific IgE levels, allergen exposure and asthma severity are poorly understood since sensitization has previously been evaluated as a dichotomous, rather than continuous characteristic. METHODS:Five hundred and forty-six inner-city adolescents enrolled in the Asthma Control Ev...
journal_title:Allergy
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1398-9995.2010.02412.x
更新日期:2010-11-01 00:00:00
abstract::Interleukin-33 (IL-33) is a member of the IL-1 cytokine family, which includes IL-1 and IL-18, and is considered to be important for host defense against nematodes by inducing Th2 cytokine production via the IL-33 receptor. IL-33 receptor is a heterodimer of IL-1 receptor-like 1 (IL-1RL1; also called ST2, T1, Der4, an...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.12004
更新日期:2012-10-01 00:00:00