Allergen-specific IgE as a biomarker of exposure plus sensitization in inner-city adolescents with asthma.

Abstract:

BACKGROUND:Relationships among allergen-specific IgE levels, allergen exposure and asthma severity are poorly understood since sensitization has previously been evaluated as a dichotomous, rather than continuous characteristic. METHODS:Five hundred and forty-six inner-city adolescents enrolled in the Asthma Control Evaluation study underwent exhaled nitric oxide (FE(NO)) measurement, lung function testing, and completion of a questionnaire. Allergen-specific IgE levels and blood eosinophils were quantified. Dust samples were collected from the participants' bedrooms for quantification of allergen concentrations. Participants were followed for 12 months and clinical outcomes were tracked. RESULTS:Among sensitized participants, allergen-specific IgE levels were correlated with the corresponding settled dust allergen levels for cockroach, dust mite, and mouse (r = 0.38, 0.34, 0.19, respectively; P < 0.0001 for cockroach and dust mite and P = 0.03 for mouse), but not cat (r = -0.02, P = 0.71). Higher cockroach-, mite-, mouse-, and cat-specific IgE levels were associated with higher FE(NO) concentrations, poorer lung function, and higher blood eosinophils. Higher cat, dust mite, and mouse allergen-specific IgE levels were also associated with an increasing risk of exacerbations or hospitalization. CONCLUSIONS:Allergen-specific IgE levels were correlated with allergen exposure among sensitized participants, except for cat. Allergen-specific IgE levels were also associated with more severe asthma across a range of clinical and biologic markers. Adjusting for exposure did not provide additional predictive value, suggesting that higher allergen-specific IgE levels may be indicative of both higher exposure and a greater degree of sensitization, which in turn may result in greater asthma severity.

journal_name

Allergy

journal_title

Allergy

authors

Matsui EC,Sampson HA,Bahnson HT,Gruchalla RS,Pongracic JA,Teach SJ,Gergen PJ,Bloomberg GR,Chmiel JF,Liu AH,Kattan M,Sorkness CA,Steinbach SF,Story RE,Visness CM,Inner-city Asthma Consortium.

doi

10.1111/j.1398-9995.2010.02412.x

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

1414-22

issue

11

eissn

0105-4538

issn

1398-9995

pii

ALL2412

journal_volume

65

pub_type

杂志文章,随机对照试验

相关文献

ALLERGY文献大全
  • The role of house dust mite elimination in the management of childhood asthma: an unresolved issue.

    abstract::Indoor allergens are likely to be direct environmental causes of asthma and mite exposure, and sensitization is the most important environmental risk factor for childhood asthma in temperate zones. Analagous to occupational asthma, allergen avoidance in asthmatic children sensitized and exposed to mite allergens is as...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1034/j.1398-9995.57.s74.5.x

    authors: Boner A,Pescollderungg L,Silverman M

    更新日期:2002-01-01 00:00:00

  • Sleep disturbances in allergic diseases.

    abstract::Sleep is fundamental for physical and mental health as well as daytime performance and represents a crucial aspect in the personal representations of well-being. Sleep disturbances in patients with chronic disorders constitute a factor that contributes to exacerbate symptoms, complicate management, and affect mood and...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.2006.01221.x

    authors: Baiardini I,Braido F,Cauglia S,Canonica GW

    更新日期:2006-11-01 00:00:00

  • Eicosanoid mediator profiles in different phenotypes of nonsteroidal anti-inflammatory drug-induced urticaria.

    abstract:BACKGROUND:The role of arachidonic acid metabolites in NSAID-induced hypersensitivity has been studied in depth for NSAID-exacerbated respiratory disease (NERD) and NSAID-exacerbated cutaneous disease (NECD). However, no information is available for NSAID-induced urticarial/angioedema (NIUA), despite it being the most ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.13725

    authors: Doña I,Jurado-Escobar R,Perkins JR,Ayuso P,Plaza-Serón MC,Pérez-Sánchez N,Campo P,Bogas-Herrera G,Bartra J,Torres MJ,Sanak M,Cornejo-García JA

    更新日期:2019-06-01 00:00:00

  • Genetic and environmental factors in the changing incidence of allergy.

    abstract::Several studies have indicated that the incidence and prevalence of allergic diseases are increasing. Such data should not be regarded as mere statistical curiosities, but should be analysed to provide information on the factors contributing to allergy and its changing epidemiology. Extensive evidence has been accumul...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1994.tb04232.x

    authors: Bonini S,Magrini L,Rotiroti G,Ronchetti MP,Onorati P

    更新日期:1994-01-01 00:00:00

  • Skin tests in patients with hypersensitivity reaction to iodinated contrast media: a meta-analysis.

    abstract:BACKGROUND:Patients with a previous history of hypersensitivity reaction (HSR) to iodinated contrast media (ICM) are at high risk of the development of HSR to ICM. Many studies have tried to evaluate the diagnostic potential of skin tests in this population but have not yet reached a common conclusion. We investigated ...

    journal_title:Allergy

    pub_type: 杂志文章,meta分析

    doi:10.1111/all.12589

    authors: Yoon SH,Lee SY,Kang HR,Kim JY,Hahn S,Park CM,Chang YS,Goo JM,Cho SH

    更新日期:2015-06-01 00:00:00

  • A new tool to evaluate the impact of chronic urticaria on quality of life: chronic urticaria quality of life questionnaire (CU-QoL).

    abstract:BACKGROUND:Health-related quality of Life in patients with chronic urticaria is evaluated by mean of generic instruments or questionnaire designed for skin diseases. No disease-specific tool is now available for the assessment of chronic urticaria impact from patients' viewpoint. OBJECTIVE:The aim of our study is to d...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2005.00833.x

    authors: Baiardini I,Pasquali M,Braido F,Fumagalli F,Guerra L,Compalati E,Braga M,Lombardi C,Fassio O,Canonica GW

    更新日期:2005-08-01 00:00:00

  • Allergen sensitization and exposure to irritants in infancy.

    abstract::We investigated the relationship between residence in the neighbourhood of an aluminium smelter and the prevalence of atopy in schoolchildren (7-13 years of age). Atopy was assessed in 556 of the 620 participants by a skin prick test with eight common aeroallergens. The median exposures to sulphur dioxide and fluoride...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:

    authors: Søyseth V,Kongerud J,Boe J

    更新日期:1996-10-01 00:00:00

  • The epidemiology of anaphylaxis in Europe: a systematic review.

    abstract:BACKGROUND:Anaphylaxis is an acute, potentially fatal, multi-organ system, allergic reaction caused by the release of chemical mediators from mast cells and basophils. Uncertainty exists around epidemiological measures of incidence and prevalence, risk factors, risk of recurrence, and death due to anaphylaxis. This sys...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/all.12272

    authors: Panesar SS,Javad S,de Silva D,Nwaru BI,Hickstein L,Muraro A,Roberts G,Worm M,Bilò MB,Cardona V,Dubois AE,Dunn Galvin A,Eigenmann P,Fernandez-Rivas M,Halken S,Lack G,Niggemann B,Santos AF,Vlieg-Boerstra BJ,Zolkipli Z

    更新日期:2013-11-01 00:00:00

  • Quantification of Blo t 5 in mite and dust extracts by two-site ELISA.

    abstract:BACKGROUND:Blomia tropicalis is an important mite species in the tropical and sub-tropical regions of the world. Blo t 5 is the major allergen with up to 70% sensitization rates in B. tropicalis allergic populations. METHODS:Mice were immunized intramuscularly with naked plasmid DNA encoding Blo t 5 gene with in vivo ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2004.00597.x

    authors: Yi FC,Lee BW,Cheong N,Chua KY

    更新日期:2005-01-01 00:00:00

  • Comparison of antigenic and allergenic components of Holoptelea integrifolia pollen collected from different source materials.

    abstract::Antigenic extracts prepared from pollen samples collected at weekly intervals during the same season did not exhibit significant variation in protein concentration. Stored pollen samples from different years, however, showed highly significant variations in protein concentration. The protein content of samples from di...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1991.tb00587.x

    authors: Malik P,Singh AB,Gangal SV,Babu CR

    更新日期:1991-05-01 00:00:00

  • Effects of ketotifen on symptoms and on bronchial mucosa in patients with atopic asthma.

    abstract::Ketotifen is marketed throughout the world as an antiallergy drug, but whether it affects infiltration of inflammatory cells into airway mucosa is not known. We studied the effects of ketotifen on symptoms, pulmonary function, and airway inflammation in 25 patients with atopic asthma. Patients took ketotifen (1 mg twi...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1997.tb02152.x

    authors: Hoshino M,Nakamura Y,Shin Z,Fukushima Y

    更新日期:1997-08-01 00:00:00

  • Proteome analysis identifies L1CAM/CD171 and DPP4/CD26 as novel markers of human skin mast cells.

    abstract:BACKGROUND:The function of skin mast cells has been well documented in IgE-mediated allergic reactions, whereas other mast cell functions are poorly defined. This study aimed at identifying novel mast cell proteins by proteome analysis of primary human skin mast cells. METHODS:The proteome of skin mast cells was compa...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.12919

    authors: Gschwandtner M,Paulitschke V,Mildner M,Brunner PM,Hacker S,Eisenwort G,Sperr WR,Valent P,Gerner C,Tschachler E

    更新日期:2017-01-01 00:00:00

  • Profilin is a marker of severity in allergic respiratory diseases.

    abstract:BACKGROUND:The capacity of profilin to induce allergic symptoms in patients with respiratory allergy has been questioned. In this sense, the aim of this study was to investigate the correlation between profilin exposure and induction of symptoms in a prospective case-control study. METHODS:The concentration of profili...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14140

    authors: Ruiz-Hornillos J,López-Matas MA,Berges Jimeno P,Henríquez A,Blanco S,Seoane-Rodríguez M,Mahíllo I,Carnés J

    更新日期:2020-04-01 00:00:00

  • Cell type-dependent effects of corticosteroid on periostin production by primary human tissue cells.

    abstract::Overproduction of periostin, an IL-13-inducible matricellular protein, despite corticosteroid treatment is thought to be involved in the chronicity of allergic inflammation seen in corticosteroid-refractory tissue fibrosis. Therefore, we hypothesized that some tissue cells must produce periostin in a corticosteroid-in...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.12240

    authors: Shoda T,Futamura K,Kobayashi F,Saito H,Matsumoto K,Matsuda A

    更新日期:2013-11-01 00:00:00

  • Single-dose inhaled budesonide in subjects with chronic asthma.

    abstract::In 30 stable asthmatics, a comparison was made between the changes in pulmonary function (FEV1, FVC, PEF, MEF75, MEF50 and MEF25) hourly for 9 h after a single dose of inhaled budesonide 1,600 micrograms, and placebo. All subjects used inhaled steroids daily; this medication was, however, withheld 8 days prior to the ...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1991.tb00619.x

    authors: Engel T,Dirksen A,Heinig JH,Nielsen NH,Weeke B,Johansson SA

    更新日期:1991-10-01 00:00:00

  • Indoor allergen levels in settled airborne dust are higher in day-care centers than at home.

    abstract:BACKGROUND:Early-life sensitization to indoor allergens predicts asthma development. The aim of this study was to compare allergen concentrations in day-care centers (DCC) with those in private homes. METHODS:Settled airborne dust was collected 4 times a year from 20 German DCC (620 samples) and from the homes of chil...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.13371

    authors: Sander I,Lotz A,Neumann HD,Czibor C,Flagge A,Zahradnik E,Raulf M

    更新日期:2018-06-01 00:00:00

  • Comparative detection of mite allergens in house dust of homes in Moscow by enzyme-linked immunosorbent assay and acarologic analysis.

    abstract::The present study revealed that 73% of surveyed apartments in Moscow whose residents included children with the atopic form of bronchial asthma and sensitization to Dermatophagoides pteronyssinus allergens were infested with the pyroglyphid mites D. pteronyssinus and D. farinae. The number of mites in the surveyed apa...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1994.tb00780.x

    authors: Zheltikova TM,Ovsyannikova IG,Gervazieva VB,Platts-Mills TA,Chapman MD,Petrova-Nikitina AD,Stepanova GN

    更新日期:1994-12-01 00:00:00

  • Farm animal feeders: another group affected by cereal flour asthma.

    abstract::Asthma induced by cereal flour is a long recognized entity. We present studies of three patients affected by asthma related to exposure to cereal flour contained in animal formula feeds. Skin prick test performed with the formula feed components showed positive reactions to cereal flours (wheat, rye and barley) and ne...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1988.tb00909.x

    authors: Valdivieso R,Pola J,Zapata C,Puyana J,Cuesta J,Martin C,Losada E

    更新日期:1988-08-01 00:00:00

  • Once daily fluticasone propionate aqueous nasal spray controls symptoms of most patients with seasonal allergic rhinitis.

    abstract::This multicentre, randomized, double-blind, parallel-group study was designed to compare the efficacy and tolerability of fluticasone propionate aqueous nasal spray 200 micrograms once daily (FPANS 200 micrograms od) with FPANS 200 micrograms twice daily (bd) in patients whose seasonal rhinitis symptoms were not compl...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1398-9995.1995.tb05051.x

    authors: Pedersen B,Dahl R,Richards DH,Jacques LA,Larsen BB,Pichler W,Nykanen KN

    更新日期:1995-10-01 00:00:00

  • Impact of (bio)chemical and physical procedures on food allergen stability.

    abstract::A variety of methods have been used to attempt to decrease the allergenicity of food products, with highly variable success. Limited knowledge of allergen and epitope structures and the factors governing their stability may explain this, and the ensuing need for an empirical approach. A combined effort from a processi...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.2001.00917.x

    authors: Soler-Rivas C,Wichers HJ

    更新日期:2001-01-01 00:00:00

  • Rationale for specific immunotherapy of grass pollen allergy with extracts of rye pollen. Skin test reactivity and immunochemical relationship between pollen allergens from rye and other common grasses.

    abstract::In immunotherapy of grass pollen allergy, an extract of rye (Secale cereale) is often included. The aim of this study was to investigate by skin prick test (SPT) and immunochemical methods whether rye pollen contains specific allergens justifying the use of this extract separately. Twenty grass pollen allergic patient...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1984.tb01964.x

    authors: Løwenstein H,Wihl JA,Bache Billesbølle K,Bøwadt H

    更新日期:1984-08-01 00:00:00

  • Rupatadine in allergic rhinitis and chronic urticaria.

    abstract::Histamine is the primary mediator involved the pathophysiology of allergic rhinitis and chronic urticaria, and this explains the prominent role that histamine H(1)-receptor antagonists have in the treatment of these disorders. However, histamine is clearly not the only mediator involved in the inflammatory cascade. Th...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.2008.01640.x

    authors: Mullol J,Bousquet J,Bachert C,Canonica WG,Gimenez-Arnau A,Kowalski ML,Martí-Guadaño E,Maurer M,Picado C,Scadding G,Van Cauwenberge P

    更新日期:2008-04-01 00:00:00

  • Identification of B-cell epitopes of Bet v 1 involved in cross-reactivity with food allergens.

    abstract:BACKGROUND:The pollen-food syndrome (PFS) is an association of food allergies to fruits, nuts, and vegetables in patients with pollen allergy. Mal d 1, the major apple allergen, is one of the most commonly associated food allergens for birch pollen-allergic patients suffering from PFS. Although the reactions are due to...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2008.01844.x

    authors: Klinglmayr E,Hauser M,Zimmermann F,Dissertori O,Lackner P,Wopfner N,Ferreira F,Wallner M

    更新日期:2009-04-01 00:00:00

  • Clinical significance of IgG subclass antibodies to wheat flour antigens in bakers.

    abstract::We measured the IgG subclass antibody levels to wheat flour in 42 bakers and 20 controls with an enzyme immunoassay. The levels of total IgG, IgG1 IgG2 and IgG4 antibodies were significantly higher in the bakers than in the unexposed controls. The presence of anti-wheat flour IgG subclass antibodies in the bakers was ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1990.tb00525.x

    authors: Tiikkainen U,Klockars M

    更新日期:1990-10-01 00:00:00

  • Emotional and behavioral problems in adolescents and young adults with food allergy.

    abstract:BACKGROUND:Adolescents with food allergy have poorer psychosocial outcomes compared with their nonallergic counterparts; however, few studies have prospectively examined the mental health of adolescents and young adults in this vulnerable population. Our objectives were to estimate the prevalence of emotional and behav...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.12829

    authors: Ferro MA,Van Lieshout RJ,Ohayon J,Scott JG

    更新日期:2016-04-01 00:00:00

  • Effects of loratadine on anti-IgE-induced inflammation, histamine release, and leukocyte recruitment in skin of atopics.

    abstract::The aim of this study was to assess the ability of the H1-receptor antagonist loratadine to modify anti-IgE-induced cutaneous wheal-and-flare and late-phase reactions (WFR and LPR), as well as histamine release and leukocyte accumulation in skin chambers. For this purpose, 10 atopics with allergic rhinitis were entere...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1995.tb01171.x

    authors: Roquet A,Raud J,Halldén G,van Hage-Hamsten M,Hed J,Hansson LO,Zetterström O,Grönneberg R

    更新日期:1995-05-01 00:00:00

  • Th17 cells: new players in asthma pathogenesis.

    abstract::CD4+ T effector lymphocytes are distinguished in different subsets on the basis of their patterns of cytokine secretion. Th1 cells, thank to IFN-γ production, are responsible for cell-mediated immunity against intracellular pathogens, Th2 cells, through the production of IL-4, provide some degree of protection against...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.2011.02576.x

    authors: Cosmi L,Liotta F,Maggi E,Romagnani S,Annunziato F

    更新日期:2011-08-01 00:00:00

  • Mutational spectrum and phenotypes in Danish families with hereditary angioedema because of C1 inhibitor deficiency.

    abstract:BACKGROUND:Hereditary angioedema (HAE), type I and II, is an autosomal dominant disease with deficiency of functional C1 inhibitor protein causing episodic swellings of skin, mucosa and viscera. HAE is a genetically heterogeneous disease with more than 200 different mutations in the SERPING1 gene. A genotype-phenotype ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2010.02456.x

    authors: Bygum A,Fagerberg CR,Ponard D,Monnier N,Lunardi J,Drouet C

    更新日期:2011-01-01 00:00:00

  • Crossed Immunoelectrophoresis analysis of bee venom. Enzymatic identification of antigens.

    abstract::Bee venom obtained by electrical stimulation has been analysed by crossed immunoelectrophoresis against high-titer rabbit antibodies. The antigenic analysis of bee venom revealed that the extract contained 17 antigens, which were detected in the crossed immunoelectrophoresis pattern after staining with Coomassie Brill...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1982.tb01910.x

    authors: Einarsson R,Annerhed A,Karlsson R,Olsson B,Renck B

    更新日期:1982-05-01 00:00:00

  • Clinical and immunological effects of oral immunotherapy with a standardized birch pollen extract.

    abstract::Oral immunotherapy (IT) was evaluated in a pilot study in two centres in children aged 8-15 years with allergic rhinoconjunctivitis. High doses (up to 20 X 10(6) BU monthly) of a defined freeze-dried birch pollen extract administered in enteric-coated gelatine capsules were given either daily for seven consecutive day...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1986.tb02031.x

    authors: Björkstén B,Möller C,Broberger U,Ahlstedt S,Dreborg S,Johansson SG,Juto P,Lanner A

    更新日期:1986-05-01 00:00:00