Once daily fluticasone propionate aqueous nasal spray controls symptoms of most patients with seasonal allergic rhinitis.


:This multicentre, randomized, double-blind, parallel-group study was designed to compare the efficacy and tolerability of fluticasone propionate aqueous nasal spray 200 micrograms once daily (FPANS 200 micrograms od) with FPANS 200 micrograms twice daily (bd) in patients whose seasonal rhinitis symptoms were not completely controlled with FPANS 200 micrograms od. A total of 549 patients initially received FPANS 200 micrograms od during the open-treatment phase of the study. After 2 weeks, 65% of patients had their symptoms well controlled by FPANS 200 micrograms od and continued with this treatment for a further 2 weeks. The remainder received either FPANS 200 micrograms od or FPANS 200 micrograms bd for a further 2 weeks. Efficacy was evaluated by the analysis of symptom-free days. In the uncontrolled group, there was a significant increase in the percentage of symptom-free days in the FPANS 200 micrograms bd group over the FPANS 200 micrograms od group for nasal blockage on waking (P < 0.05) and nasal blockage during the day (P < 0.05). Similar trends were observed for sneezing, rhinorrhoea, nasal itching, and eye symptoms. There was a significant increase in the percentage of days with a symptom score of less than 2 in FPANS 200 micrograms bd group for nasal blockage during the day (P < 0.05). Adverse events were similar in nature and frequency in each treatment group. It is concluded that in the majority of patients symptoms of seasonal rhinitis are well controlled by FPANS 200 micrograms od. In the minority of patients whose symptoms are not adequately controlled by a once daily dose, FPANS 200 micrograms bd provides additional relief, particularly from nasal blockage.






Pedersen B,Dahl R,Richards DH,Jacques LA,Larsen BB,Pichler W,Nykanen KN




Has Abstract


1995-10-01 00:00:00














  • Prick test: evolution towards automated reading.

    abstract::The prick test is one of the most common medical methods for diagnosing allergies, and it has been carried out in a similar and laborious manner over many decades. In an attempt to standardize the reading of the test, many researchers have tried to automate the process of measuring the allergic reactions found by deve...


    pub_type: 杂志文章,评审


    authors: Justo X,Díaz I,Gil JJ,Gastaminza G

    更新日期:2016-08-01 00:00:00

  • Involvement of arachidonate cyclooxygenase products in bronchial hyperresponsiveness induced by subthreshold concentration of aerosolized thromboxane A2 analogue (STA2) in guinea pigs.

    abstract::Effects of a thromboxane synthetase inhibitor (OKY-046) and a cyclooxygenase inhibitor (indomethacin) on bronchial hyperresponsiveness induced by subthreshold concentration of aerosolized thromboxane A2 analogue (STA2) were investigated in anesthetized, artificially ventilated guinea pigs in order to examine the role ...


    pub_type: 杂志文章


    authors: Saito M,Fujimura M,Sakamoto S,Miyake Y,Shintani H,Yasui M,Matsuda T

    更新日期:1992-04-01 00:00:00

  • Risk factors for severe and critically ill COVID-19 patients: A review.

    abstract::The pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused an unprecedented global social and economic impact, and high numbers of deaths. Many risk factors have been identified in the progression of COVID-19 into a severe and critical st...


    pub_type: 杂志文章,评审


    authors: Gao YD,Ding M,Dong X,Zhang JJ,Kursat Azkur A,Azkur D,Gan H,Sun YL,Fu W,Li W,Liang HL,Cao YY,Yan Q,Cao C,Gao HY,Brüggen MC,van de Veen W,Sokolowska M,Akdis M,Akdis CA

    更新日期:2020-11-13 00:00:00

  • Structural changes in calcium-binding allergens: use of circular dichroism to study binding characteristics.

    abstract:BACKGROUND:Several studies showed that calcium-binding proteins have a fixed place in the spectrum of allergenic substances. Often the binding of a calcium ion induces conformational changes and affects immunoglobulin E-binding to the allergen. Hence, the quantitative characterization of the binding to calcium is of im...


    pub_type: 杂志文章


    authors: Hebenstreit D,Ferreira F

    更新日期:2005-09-01 00:00:00

  • HLA DRB1*15-DPB1*05 haplotype: a susceptible gene marker for isocyanate-induced occupational asthma?

    abstract:BACKGROUND:There has been no study for evaluating the associations of human leukocyte antigen (HLA) class I and II alleles with toluene diisocyanate (TDI)-induced asthma in an Asian population. OBJECTIVE:The aim of this study was to investigate a susceptible or protective marker of HLA class I and II alleles in TDI-in...


    pub_type: 杂志文章


    authors: Kim SH,Oh HB,Lee KW,Shin ES,Kim CW,Hong CS,Nahm DH,Park HS

    更新日期:2006-07-01 00:00:00

  • Comparison of nasal immunohistology in patients with seasonal rhinoconjunctivitis treated with topical steroids or specific allergen immunotherapy.

    abstract:BACKGROUND:Specific allergen immunotherapy (SIT) and nasal steroids (NS) are considered effective anti-inflammatory treatments for allergic rhinitis, although their mechanism of action differs. OBJECTIVE:The aim of this study was to examine the effect of treatment with NS and SIT on different populations of inflammato...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rak S,Heinrich C,Scheynius A

    更新日期:2005-05-01 00:00:00

  • Allergic rhinitis: not purely a histamine-related disease.

    abstract::Allergic rhinitis is an inflammatory disorder of the nasal mucosa typified by the symptoms of nasal itch, sneeze, anterior nasal secretions, and nasal blockage. These symptoms arise from the interaction between mediators and neural, vascular, and glandular structures within the nose. Nasal itch, sneezes, and rhinorrho...


    pub_type: 杂志文章,评审


    authors: Howarth PH,Salagean M,Dokic D

    更新日期:2000-01-01 00:00:00

  • Are overweight asthmatics more difficult to control?

    abstract::The relationship between asthma and obesity appears to be quite complex. The aim of this study was to assess the effect of excess weight on asthma control evolution in a cohort of asthmatics. A prospective database was set up, which enrolled adult asthmatics with persistent (mild, moderate or severe) asthma. The contr...


    pub_type: 杂志文章


    authors: Saint-Pierre P,Bourdin A,Chanez P,Daures JP,Godard P

    更新日期:2006-01-01 00:00:00

  • Nucleotide sequence of cDNA encoding the group II allergen of cocksfoot/orchard grass (Dactylis glomerata), Dac g II.

    abstract::Cocksfoot/orchard grass (Dactylis glomerata) anther cDNA clones encoding the group II allergen Dac g II were previously isolated on the basis of immunoreactivity of human, rabbit, and murine antibodies with a 24-kDa protein expressed as a fusion protein with beta-galactosidase. Nucleotide sequencing reveals an open re...


    pub_type: 杂志文章


    authors: Roberts AM,Bevan LJ,Flora PS,Jepson I,Walker MR

    更新日期:1993-11-01 00:00:00

  • Latex allergy in Saudi children with spina bifida.

    abstract:BACKGROUND:Children with spina bifida (SB) are exposed to latex soon after birth during bladder catheterization, rectal disimpaction, and multiple surgical procedures. IgE-mediated latex-allergic reactions have been reported recently in these children. Our study was designed to assess the prevalence of allergic reactio...


    pub_type: 杂志文章


    authors: Kattan H,Harfi HA,Tipirneni P

    更新日期:1999-01-01 00:00:00

  • Measurement of natural rubber latex allergen levels in medical gloves by allergen-specific IgE-ELISA inhibition, RAST inhibition, and skin prick test.

    abstract::Exposure to natural rubber latex (NRL) medical gloves poses risks to patients sensitized to NRL and to users of protective gloves. Previous studies have shown that extractable allergen levels of the gloves vary widely. Since most of the available laboratory methods of NRL allergen measurement lack adequate validation,...


    pub_type: 杂志文章


    authors: Palosuo T,Mäkinen-Kiljunen S,Alenius H,Reunala T,Yip E,Turjanmaa K

    更新日期:1998-01-01 00:00:00

  • Gene expression analysis predicts insect venom anaphylaxis in indolent systemic mastocytosis.

    abstract:BACKGROUND:Anaphylaxis to insect venom (Hymenoptera) is most severe in patients with mastocytosis and may even lead to death. However, not all patients with mastocytosis suffer from anaphylaxis. The aim of the study was to analyze differences in gene expression between patients with indolent systemic mastocytosis (ISM)...


    pub_type: 杂志文章


    authors: Niedoszytko M,Bruinenberg M,van Doormaal JJ,de Monchy JG,Nedoszytko B,Koppelman GH,Nawijn MC,Wijmenga C,Jassem E,Elberink JN

    更新日期:2011-05-01 00:00:00

  • Periodic fever syndromes: a diagnostic challenge for the allergist.

    abstract::The objective was to present a case of periodic fever with aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA), summarize the medical literature on PFAPA, review the differential diagnosis and suggest a diagnostic approach to periodic fevers in children. A PubMed search was conducted for all case reports an...


    pub_type: 杂志文章,评审


    authors: Lierl M

    更新日期:2007-12-01 00:00:00

  • The value of SCORAD and beyond. Towards a standardized evaluation of severity?

    abstract::The clinical scoring systems of atopic dermatitis were analysed and compared. Some biological parameters that can correlate with the clinical score were also reviewed. After the definition of the disease based on validated clinical criteria, the second necessity was the availability of reliable severity scores to allo...


    pub_type: 杂志文章


    authors: Gelmetti C,Colonna C

    更新日期:2004-08-01 00:00:00

  • Multiplexed immunoglobulin E sensitization in relation to exhaled nitric oxide in a population sample of children.

    abstract::This study investigated the relationship between the specific immunoglobulin E (IgE) profile for 40 allergens using a novel microarray technique (BioIC) and fraction of exhaled nitric oxide (FeNO) in a population sample of 1321 children. Significant positive associations were found between FeNO and sensitization to mi...


    pub_type: 杂志文章


    authors: Yao TC,Tsai HJ,Tu YL,Chang SW,Hua MC,Liao SL,Tsai MH,Chiu CY,Lai SH,Yeh KW,Huang JL,PATCH study group.

    更新日期:2014-05-01 00:00:00

  • IgE autoantibodies in atopic dermatitis--occurrence of different antibodies against the CH3 and the CH4 epitopes of IgE.

    abstract::Levels of "free" anti-IgE autoantibodies and IgE/anti-IgE immune complexes were measured in the sera of patients with atopic dermatitis before and after treatment, psoriasis patients, and nonatopic controls. In this measurement, we used two monoclonal antibodies with distinct in vitro functions (LE 27, BSW 17), direct...


    pub_type: 杂志文章


    authors: Czech W,Stadler BM,Schôpf E,Kapp A

    更新日期:1995-03-01 00:00:00

  • A comparative analysis of the cross-reactivity in the polcalcin family including Syr v 3, a new member from lilac pollen.

    abstract:BACKGROUND:Polcalcins are pollen-specific allergens with two EF-hand calcium-binding sites that exhibit strong cross-reactivity. Our objective was to isolate and express the cDNA coding of the EF-hand calcium-binding allergen from lilac pollen and to study cross-reactivity with other polcalcins from related and nonrela...


    pub_type: 杂志文章


    authors: Ledesma A,Barderas R,Westritschnig K,Quiralte J,Pascual CY,Valenta R,Villalba M,Rodríguez R

    更新日期:2006-04-01 00:00:00

  • Histamine N-methyltransferase 939A>G polymorphism affects mRNA stability in patients with acetylsalicylic acid-intolerant chronic urticaria.

    abstract:BACKGROUND:Histamine plays an important role in allergic inflammation. Histamine levels are regulated by histamine N-methyltransferase (HNMT). OBJECTIVE:To investigate the functional variability of HNMT gene in relation to genetic polymorphisms in patients with aspirin intolerant chronic urticaria (AICU). METHODS:Two...


    pub_type: 杂志文章


    authors: Kim SH,Kang YM,Kim SH,Cho BY,Ye YM,Hur GY,Park HS

    更新日期:2009-02-01 00:00:00

  • The basophil activation test in wasp venom allergy: sensitivity, specificity and monitoring specific immunotherapy.

    abstract:BACKGROUND:As in vitro diagnosis of wasp venom sensitization by specific serum IgE has a sensitivity of only 60-80%, additional in vitro tests are desirable. Basophil activation is associated with the expression of CD63 and its measurement has been proposed as a novel in vitro test for immediate-type allergy. Furthermo...


    pub_type: 杂志文章


    authors: Erdmann SM,Sachs B,Kwiecien R,Moll-Slodowy S,Sauer I,Merk HF

    更新日期:2004-10-01 00:00:00

  • Protein phosphatase 5 mediates corticosteroid insensitivity in airway smooth muscle in patients with severe asthma.

    abstract:BACKGROUND:The mechanisms driving glucocorticoid (GC) insensitivity in patients with severe asthma are still unknown. Recent evidence suggests the existence of GC-insensitive pathways in airway smooth muscle (ASM) caused by a defect in GC receptor (GRα) function. We examined whether other mechanisms could potentially e...


    pub_type: 杂志文章


    authors: Chachi L,Abbasian M,Gavrila A,Alzahrani A,Tliba O,Bradding P,Wardlaw AJ,Brightling C,Amrani Y

    更新日期:2017-01-01 00:00:00

  • Ragweed pollen collected along high-traffic roads shows a higher allergenicity than pollen sampled in vegetated areas.

    abstract:BACKGROUND:Pollutants may affect pollen allergenicity and thus the prevalence of allergies. Although a few studies are available in literature, the connection between pollution and the allergenic potential of pollen has yet to be clearly defined. The objective of this study was to evaluate the effect of traffic-related...


    pub_type: 杂志文章


    authors: Ghiani A,Aina R,Asero R,Bellotto E,Citterio S

    更新日期:2012-07-01 00:00:00

  • A 12-week placebo-controlled study of rupatadine 10 mg once daily compared with cetirizine 10 mg once daily, in the treatment of persistent allergic rhinitis.

    abstract:BACKGROUND:With the current increasing incidence of allergies worldwide, new treatments showing efficacy and long term safety are needed for chronic conditions such as persistent allergic rhinitis (PER). New generation H1-antihistamines have demonstrated anti-allergic properties, which could possibly enhance their effe...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Fantin S,Maspero J,Bisbal C,Agache I,Donado E,Borja J,Mola O,Izquierdo I,international Rupatadine study group.

    更新日期:2008-07-01 00:00:00

  • Long-term evaluation of usefulness of skin and incremental challenge tests in patients with history of adverse reaction to local anesthetics.

    abstract::A variety of adverse reactions to local anesthetics has been described, some of which are thought to be allergic. Different protocols of prick and intradermal skin tests as well as subcutaneous challenge tests are used to select a local anesthetic which can safely be used. Their long-term effectiveness has not yet bee...


    pub_type: 杂志文章


    authors: Wasserfallen JB,Frei PC

    更新日期:1995-02-01 00:00:00

  • Role of comorbid conditions in asthma hospitalizations in the south of France.

    abstract:BACKGROUND:Reasons for asthma hospitalizations are dynamic and complex. Comorbid conditions are important contributors to most chronic diseases today. We aim to characterize and describe risk factors associated with hospitalizations due to asthma in the Languedoc-Roussillon region (France) in 2009. METHODS:Programme d...


    pub_type: 杂志文章


    authors: Aubas C,Bourdin A,Aubas P,Gamez AS,Halimi L,Vachier I,Malafaye N,Chanez P,Molinari N

    更新日期:2013-01-01 00:00:00

  • Nonatopic wheezy children have reduced interferon-gamma.

    abstract::Viruses cause asthmatic exacerbations in schoolchildren. We tested the hypothesis that children who wheezed with viral respiratory tract infections secrete higher levels of the type 1 cytokine interferon-gamma (IFN-gamma) in the peripheral circulation than children who had never wheezed. Blood was taken from 13 childr...


    pub_type: 杂志文章


    authors: Leech SC,Price JF,Holmes BJ,Kemeny DM

    更新日期:2000-01-01 00:00:00

  • Chip pile workers and mould exposure. A preliminary clinical and hygienic survey.

    abstract::Chip pile workers are exposed to high concentrations of airborne mould spores. Few sporadic cases of allergic alveolitis have been reported in Finland. Eight non-smoking workers, six on chip piles and two on bark piles, were examined to study the immunological and clinical response to continuous mould spore exposure. ...


    pub_type: 杂志文章


    authors: Jäppinen P,Haahtela T,Liira J

    更新日期:1987-10-01 00:00:00

  • Artemisia annua-sublingual immunotherapy for seasonal allergic rhinitis: A randomized controlled trial.

    abstract:BACKGROUND:Artemisia annua is an important autumnal pollen allergen for seasonal allergic rhinitis (SAR) in northern China. To date, no study has investigated allergen immunotherapy with A annua. We aimed to investigate the efficacy and mechanisms underlying A annua-sublingual immunotherapy (SLIT). METHODS:This was a ...


    pub_type: 杂志文章


    authors: Lou H,Huang Y,Ouyang Y,Zhang Y,Xi L,Chu X,Wang Y,Wang C,Zhang L

    更新日期:2020-08-01 00:00:00

  • Dual cutaneous reactions to anti-human IgE; no change in plasma level of the split product complement C3d or effect of heparin.

    abstract::The possible dependence of the dual cutaneous reaction (DCR) on activation of the complement and coagulation systems was further elucidated. Heterologous whole anti-human IgE was injected intradermally (i.d.) on the volar aspect of the forearms of 17 drug-free healthy volunteers and venous samples for the selected lab...


    pub_type: 杂志文章


    authors: Grönneberg R

    更新日期:1985-11-01 00:00:00

  • Heat treatment modifies the allergenicity of beef and bovine serum albumin.

    abstract::The effect of heat on the allergenicity of beef and bovine serum albumin was investigated among 10 toddlers skin prick test (SPT)-positive to raw and cooked beef. The meat-allergy diagnosis was confirmed during double-blind, placebo-controlled food challenge (DBPCFC) with 180 g of beef cooked for 5 min at 100 degrees ...


    pub_type: 杂志文章


    authors: Fiocchi A,Restani P,Riva E,Mirri GP,Santini I,Bernardo L,Galli CL

    更新日期:1998-08-01 00:00:00

  • Geographical variations in the prevalence of atopic sensitization in six study sites across Canada.

    abstract:BACKGROUND:Geographical variations in atopic sensitization in Canada have not been described previously. This study used the standardized protocol of the European Community Respiratory Health Survey-1 (ECRHS-1) to investigate the distribution and predictors of atopic sensitization in six sites across Canada and to comp...


    pub_type: 杂志文章,多中心研究


    authors: Chan-Yeung M,Anthonisen NR,Becklake MR,Bowie D,Sonia Buist A,Dimich-Ward H,Ernst P,Sears MR,Siersted HC,Sweet L,Van Til L,Manfreda J

    更新日期:2010-11-01 00:00:00