Once daily fluticasone propionate aqueous nasal spray controls symptoms of most patients with seasonal allergic rhinitis.


:This multicentre, randomized, double-blind, parallel-group study was designed to compare the efficacy and tolerability of fluticasone propionate aqueous nasal spray 200 micrograms once daily (FPANS 200 micrograms od) with FPANS 200 micrograms twice daily (bd) in patients whose seasonal rhinitis symptoms were not completely controlled with FPANS 200 micrograms od. A total of 549 patients initially received FPANS 200 micrograms od during the open-treatment phase of the study. After 2 weeks, 65% of patients had their symptoms well controlled by FPANS 200 micrograms od and continued with this treatment for a further 2 weeks. The remainder received either FPANS 200 micrograms od or FPANS 200 micrograms bd for a further 2 weeks. Efficacy was evaluated by the analysis of symptom-free days. In the uncontrolled group, there was a significant increase in the percentage of symptom-free days in the FPANS 200 micrograms bd group over the FPANS 200 micrograms od group for nasal blockage on waking (P < 0.05) and nasal blockage during the day (P < 0.05). Similar trends were observed for sneezing, rhinorrhoea, nasal itching, and eye symptoms. There was a significant increase in the percentage of days with a symptom score of less than 2 in FPANS 200 micrograms bd group for nasal blockage during the day (P < 0.05). Adverse events were similar in nature and frequency in each treatment group. It is concluded that in the majority of patients symptoms of seasonal rhinitis are well controlled by FPANS 200 micrograms od. In the minority of patients whose symptoms are not adequately controlled by a once daily dose, FPANS 200 micrograms bd provides additional relief, particularly from nasal blockage.






Pedersen B,Dahl R,Richards DH,Jacques LA,Larsen BB,Pichler W,Nykanen KN




Has Abstract


1995-10-01 00:00:00














  • The CKLF1-C19 peptide attenuates allergic lung inflammation by inhibiting CCR3- and CCR4-mediated chemotaxis in a mouse model of asthma.

    abstract:BACKGROUND:  Human chemokine-like factor 1 (CKLF1) is a functional ligand for human CCR4, which is highly expressed on Th2 lymphocytes and plays an important role in the pathogenesis of asthma. The expression and function of CKLF1 are associated with asthma. The CKLF1 C-terminal peptides C19 and C27 also interact with ...


    pub_type: 杂志文章


    authors: Tian L,Li W,Wang J,Zhang Y,Zheng Y,Qi H,Guo X,Zhang Y,Ma D,Shen H,Wang Y

    更新日期:2011-02-01 00:00:00

  • The quantity and quality of α-gal-specific antibodies differ in individuals with and without delayed red meat allergy.

    abstract:BACKGROUND:IgG to galactose-α-1,3-galactose (α-gal) are highly abundant natural antibodies (Ab) in humans. α-Gal-specific IgE Ab cause a special form of meat allergy characterized by severe systemic reactions 3-7 h after consumption of red meat. We investigated 20 patients who experienced such reactions and characteriz...


    pub_type: 杂志文章


    authors: Kollmann D,Nagl B,Ebner C,Emminger W,Wöhrl S,Kitzmüller C,Vrtala S,Mangold A,Ankersmit HJ,Bohle B

    更新日期:2017-02-01 00:00:00

  • Allergy to mites: relation to lung function and airway hyperresponsiveness.

    abstract::Exposure to house-dust-mite allergens is an important cause of allergic reactions in sensitized patients. In community-based studies, sensitization to house-dust mites, as ascertained by a positive skin test or by an increased allergen-specific IgE level in serum, is associated with both diminished lung function and e...


    pub_type: 杂志文章,评审


    authors: van der Heide S,Dubois AE,Kauffman HF,de Monchy JG

    更新日期:1998-01-01 00:00:00

  • Elevated levels of peripheral-blood, naturally occurring aliphatic polyamines in bronchial asthmatic patients with active symptoms.

    abstract::The levels of peripheral-blood, naturally occurring aliphatic polyamines, such as putrescine, spermidine, and spermine, from 21 bronchial asthmatic patients (11 atopics and 10 nonatopics) were measured by postcolumn derivatization high-performance liquid chromatography analysis. None of the patients, except the 44-yea...


    pub_type: 杂志文章


    authors: Kurosawa M,Shimizu Y,Tsukagoshi H,Ueki M

    更新日期:1992-12-01 00:00:00

  • Risk of developing Parkinson's disease among patients with asthma: a nationwide longitudinal study.

    abstract:BACKGROUND:A cross-sectional retrospective study suggested a link between allergic diseases and Parkinson's disease. However, the temporal association between asthma and Parkinson's disease remains unknown. METHODS:From the Taiwan National Health Insurance Research Database, 10 455 patients who were diagnosed with ast...


    pub_type: 杂志文章


    authors: Cheng CM,Wu YH,Tsai SJ,Bai YM,Hsu JW,Huang KL,Su TP,Li CT,Tsai CF,Yang AC,Lin WC,Pan TL,Chang WH,Chen TJ,Chen MH

    更新日期:2015-12-01 00:00:00

  • Profilin is a marker of severity in allergic respiratory diseases.

    abstract:BACKGROUND:The capacity of profilin to induce allergic symptoms in patients with respiratory allergy has been questioned. In this sense, the aim of this study was to investigate the correlation between profilin exposure and induction of symptoms in a prospective case-control study. METHODS:The concentration of profili...


    pub_type: 杂志文章


    authors: Ruiz-Hornillos J,López-Matas MA,Berges Jimeno P,Henríquez A,Blanco S,Seoane-Rodríguez M,Mahíllo I,Carnés J

    更新日期:2020-04-01 00:00:00

  • Allergic bronchopulmonary aspergillosis.

    abstract::Allergic bronchopulmonary aspergillosis (ABPA) occurs in nonimmunocompromised patients and belongs to the hypersensitivity disorders induced by Aspergillus. Genetic factors and activation of bronchial epithelial cells in asthma or cystic fibrosis are responsible for the development of a CD(4)+Th2 lymphocyte activation...


    pub_type: 杂志文章,评审


    authors: Tillie-Leblond I,Tonnel AB

    更新日期:2005-08-01 00:00:00

  • A population-based epidemiologic analysis of deaths from anaphylaxis in Florida.

    abstract:BACKGROUND:Previous US population-based epidemiologic studies of anaphylactic deaths have been limited by small populations and/or few deaths. The objective of this study was to determine the 10-year incidence of death from anaphylaxis in Florida and its descriptive epidemiology. METHODS:Patients who died from anaphyl...


    pub_type: 杂志文章


    authors: Simon MR,Mulla ZD

    更新日期:2008-08-01 00:00:00

  • Allergy to date fruits: characterization of antigens and allergens of fruits of the date palm (Phoenix dactylifera L.).

    abstract:BACKGROUND:Date-palm (Phoenix dactylifera L.) fruits are eaten daily by most inhabitants of the Middle East and the neighboring countries. Recent reports have indicated that dates are allergenic. This study aimed to investigate the antigenic and allergenic potential of date fruits. METHODS:Date-fruit extracts from eig...


    pub_type: 杂志文章


    authors: Kwaasi AA,Harfi HA,Parhar RS,Al-Sedairy ST,Collison KS,Panzani RC,Al-Mohanna FA

    更新日期:1999-12-01 00:00:00

  • Comparative efficacy of azelastine nasal spray and terfenadine in seasonal and perennial rhinitis.

    abstract::The efficacy and tolerability of intranasal azelastine (0.14 mg/nostril twice daily) and oral terfenadine (60 mg twice daily) were compared under double-blind conditions in two 6-week, multicenter, parallel-group studies, including 167 patients suffering from seasonal and 52 patients suffering from perennial allergic ...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Gastpar H,Nolte D,Aurich R,Brendt P,Enzmann H,Giesemann G,Kunkel G,Petzold U,Renz W,Schata M

    更新日期:1994-03-01 00:00:00

  • Distribution of serum IgE in children and adolescents aged 7 to 16 years in Copenhagen, in relation to factors of importance.

    abstract::The distribution of total serum-IgE and factors of importance for the level of IgE was studied in a random sample of 508 children and adolescents, aged 7-16 years, from Copenhagen. A detailed history about asthma, rhinitis, dermatitis and urticaria was obtained, and a physical examination, skin prick test with 9 commo...


    pub_type: 杂志文章


    authors: Backer V,Ulrik CS,Wendelboe D,Bach-Mortensen N,Hansen KK,Laursen EM,Dirksen A

    更新日期:1992-10-01 00:00:00

  • Staphylococcus aureus from atopic dermatitis skin accumulates in the lysosomes of keratinocytes with induction of IL-1α secretion via TLR9.

    abstract:BACKGROUND:Staphylococcus aureus (S. aureus) is frequently detected in the skin of patients with atopic dermatitis (AD), and involved in the flare of AD. There are some evidence-specific strains of S. aureus affect the severity of AD. However, the mechanism of predominant colonization and the aggravation of dermatitis ...


    pub_type: 杂志文章


    authors: Moriwaki M,Iwamoto K,Niitsu Y,Matsushima A,Yanase Y,Hisatsune J,Sugai M,Hide M

    更新日期:2019-03-01 00:00:00

  • Real-life study showing uncontrolled rhinosinusitis after sinus surgery in a tertiary referral centre.

    abstract:RATIONALE:The European Position Paper on Sinusitis (EPOS) guidelines provide composite criteria to evaluate chronic rhinosinusitis (CRS) control, taking into consideration the severity of patients' symptoms, aspect of nasal mucosa and medical intake as parameters of CRS control. OBJECTIVES:To study the degree of CRS c...


    pub_type: 杂志文章


    authors: van der Veen J,Seys SF,Timmermans M,Levie P,Jorissen M,Fokkens WJ,Hellings PW

    更新日期:2017-02-01 00:00:00

  • Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - classification, diagnosis and management: review of the EAACI/ENDA(#) and GA2LEN/HANNA*.

    abstract::Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for 21-25% of reported adverse drug events which include immunological and nonimmunological hypersensitivity reactions. This study presents up-to-date information on pathomechanisms, clinical spectrum, diagnostic tools and management of hypersensitivity rea...


    pub_type: 杂志文章,评审


    authors: Kowalski ML,Makowska JS,Blanca M,Bavbek S,Bochenek G,Bousquet J,Bousquet P,Celik G,Demoly P,Gomes ER,Niżankowska-Mogilnicka E,Romano A,Sanchez-Borges M,Sanz M,Torres MJ,De Weck A,Szczeklik A,Brockow K

    更新日期:2011-07-01 00:00:00

  • Eosinophil activities modulate the immune/inflammatory character of allergic respiratory responses in mice.

    abstract:BACKGROUND:The importance and specific role(s) of eosinophils in modulating the immune/inflammatory phenotype of allergic pulmonary disease remain to be defined. Established animal models assessing the role(s) of eosinophils as contributors and/or causative agents of disease have relied on congenitally deficient mice w...


    pub_type: 杂志文章


    authors: Jacobsen EA,Lesuer WE,Willetts L,Zellner KR,Mazzolini K,Antonios N,Beck B,Protheroe C,Ochkur SI,Colbert D,Lacy P,Moqbel R,Appleton J,Lee NA,Lee JJ

    更新日期:2014-03-01 00:00:00

  • Frequency and intensity of responses to mite patch tests are lower in nonatopic subjects with respect to patients with atopic dermatitis.

    abstract:BACKGROUND:So far the issue of patch tests with mite allergens in subjects not affected by atopic dermatitis (AD) has been poorly investigated. The aim of this study was to assess the frequency and intensity of responses to atopy patch tests with Dermatophagoides in non-AD subjects, and to compare them to the ones obse...


    pub_type: 杂志文章


    authors: Seidenari S,Giusti F,Pellacani G,Bertoni L

    更新日期:2003-05-01 00:00:00

  • Comparison of the effect of the beta1-blocking drugs atenolol and metoprolol on bronchial asthma.

    abstract::Twenty patients with severe or medium severe asthma were given atenolol (Atenol ICI-Pharma) and/or metoprolol (Seloken Hässle) for tachycardia, hyperkinetic tremor, arterial hypertension or symptoms of angina pectoris. These cardioselective beta-blocking drugs caused only a very slight decrease in PF values. There was...


    pub_type: 杂志文章


    authors: Carlson C,Järvinen KA

    更新日期:1978-06-01 00:00:00

  • How does dose impact on the severity of food-induced allergic reactions, and can this improve risk assessment for allergenic foods?: Report from an ILSI Europe Food Allergy Task Force Expert Group and Workshop.

    abstract::Quantitative risk assessment (QRA) for food allergens has made considerable progress in recent years, yet acceptability of its outcomes remains stymied because of the limited extent to which it has been possible to incorporate severity as a variable. Reaction severity, particularly following accidental exposure, depen...


    pub_type: 杂志文章,评审


    authors: Dubois AEJ,Turner PJ,Hourihane J,Ballmer-Weber B,Beyer K,Chan CH,Gowland MH,O'Hagan S,Regent L,Remington B,Schnadt S,Stroheker T,Crevel RWR

    更新日期:2018-07-01 00:00:00

  • Cysteinyl-leukotriene release test (CAST) in the diagnosis of immediate drug reactions.

    abstract:BACKGROUND:The diagnosis of allergic reactions to drugs is difficult. Most skin tests are not standardized, and in vitro tests are needed to avoid provocation tests. Cross-linking of IgE on basophils is known to cause the release of both cysteinyl leukotriene (Cys-LT) and histamine. We aimed to evaluate the diagnostic ...


    pub_type: 杂志文章


    authors: Lebel B,Messaad D,Kvedariene V,Rongier M,Bousquet J,Demoly P

    更新日期:2001-07-01 00:00:00

  • The exposome in atopic dermatitis.

    abstract::Atopic dermatitis (AD) is a complex inflammatory disorder with multiple interactions between genetic, immune and external factors. The sum of external factors that an individual is exposed to throughout their lifetime is termed the exposome. The exposome spans multiple domains from population to molecular levels and, ...


    pub_type: 杂志文章,评审


    authors: Stefanovic N,Flohr C,Irvine AD

    更新日期:2020-01-01 00:00:00

  • Double-blind comparison of the protective effect of sodium cromoglycate and ketotifen on exercise-induced asthma in adults.

    abstract::In a double-blind double-placebo study 10 asthmatics exercised on a treadmill after treatment for 1 week with placebo, or ketotifen 1 mg twice daily, or SCG 10 mg four times daily. The post-exercise percentage fall in FEV1 after SCG but not after ketotifen was significantly smaller than after placebo. A 1-week treatme...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tan WC,Lim TK

    更新日期:1987-05-01 00:00:00

  • Polymorphisms at the glutathione S-transferase, GSTP1 locus: a novel mechanism for susceptibility and development of atopic airway inflammation.

    abstract::A common feature of environmental irritants is their ability to cause local inflammation which could alter airway function. The principal targets of such injury are the epithelial cells lining the airway passages and the lower respiratory gas-exchange areas. While host atopy is a recognized risk factor for airway infl...


    pub_type: 杂志文章,评审


    authors: Spiteri MA,Bianco A,Strange RC,Fryer AA

    更新日期:2000-01-01 00:00:00

  • Allergy to betalactam antibiotics in children: a prospective follow-up study in retreated children after negative responses in skin and challenge tests.

    abstract:BACKGROUND:Up to 10% of the patients in whom suspected betalactam hypersensitivity (HS) has been excluded by skin and challenge tests report suspected allergic reactions during subsequent treatments with the same or very similar betalactams. It has been suggested that the reactions may result from a resensitization ind...


    pub_type: 临床试验,杂志文章


    authors: Ponvert C,Weilenmann C,Wassenberg J,Walecki P,Bourgeois ML,de Blic J,Scheinmann P

    更新日期:2007-01-01 00:00:00

  • Is thrombopenia in cord blood indicative of intra-uterine sensitization?

    abstract::The relation between platelet counts (PCT) and IgE was studied in cord blood from 136 European newborns. PCT was significantly lower (P = 0.0014) when cord-IgE was superior to 1.20 IU/ml (n = 29; 245,000/microliter) than when it was inferior to this value (n = 107; 284,080/microliter) which resulted in a significant n...


    pub_type: 杂志文章


    authors: Magnusson CG,de Weck AL

    更新日期:1989-02-01 00:00:00

  • CB2 receptors regulate natural killer cells that limit allergic airway inflammation in a murine model of asthma.

    abstract:BACKGROUND:Allergic asthma is a chronic airway inflammatory disease involving the complementary actions of innate and adaptive immune responses. Endogenously generated cannabinoids acting via CB2 receptors play important roles in both homeostatic and inflammatory processes. However, the contribution of CB2-acting eicos...


    pub_type: 杂志文章


    authors: Ferrini ME,Hong S,Stierle A,Stierle D,Stella N,Roberts K,Jaffar Z

    更新日期:2017-06-01 00:00:00

  • Results of biological standardization with standardized allergen preparations.

    abstract::The aim of biological standardization (BS) is to equilibrate the activity (potency) of allergen extracts from different source materials. This was done by performing skin prick tests (SPT) on patients who were sensitive to one of the following 10 allergens: Birch, alder, hazel, timothy, rye grass, velvet grass, cultiv...


    pub_type: 临床试验,杂志文章


    authors: Dreborg S,Belin L,Eriksson NE,Grimmer O,Kunkel G,Malling HJ,Nilsson G,Sjögren I,Zetterström O

    更新日期:1987-02-01 00:00:00

  • The burden of nonadherence among adults with asthma: a role for shared decision-making.

    abstract::A shared approach to decision-making framework has been suggested for chronic disease management especially where multiple treatment options exist. Shared decision-making (SDM) requires that both physician and patients are actively engaged in the decision-making process, including information exchange; expressing trea...


    pub_type: 杂志文章,评审


    authors: Pollard S,Bansback N,FitzGerld JM,Bryan S

    更新日期:2017-05-01 00:00:00

  • Symptoms after mould exposure including Stachybotrys chartarum, and comparison with darkroom disease.

    abstract:BACKGROUND:Mould-attributed symptoms have included features which overlap with unexplained syndromes such as sick building syndrome. OBJECTIVES:We describe questionnaire and chart review findings in patients following exposure to moulds which include Stachybotrys and compare responses with two control groups. METHODS...


    pub_type: 杂志文章


    authors: Al-Ahmad M,Manno M,Ng V,Ribeiro M,Liss GM,Tarlo SM

    更新日期:2010-02-01 00:00:00

  • Specific interaction of IgE antibodies with a carbohydrate epitope of honey bee venom phospholipase A2.

    abstract::Phospholipase A2 (E.C. is a major allergen of honey bee venom. It exists in a glycosylated and an unglycosylated variant. Both forms and the glycopeptide isolated after exhaustive proteolytic digestion were tested in RAST and RAST inhibition studies. IgE from 11 of 14 bee venom allergy sera exhibited signifi...


    pub_type: 杂志文章


    authors: Weber A,Schröder H,Thalberg K,März L

    更新日期:1987-08-01 00:00:00

  • Contrasting microbiotas between Finnish and Estonian infants: Exposure to Acinetobacter may contribute to the allergy gap.

    abstract:BACKGROUND:Allergic diseases are more common in Finland than in Estonia, which-according to the biodiversity hypothesis-could relate to differences in early microbial exposures. METHODS:We aimed at defining possible microbial perturbations preceding early atopic sensitization. Stool, nasal and skin samples of 6-month-...


    pub_type: 杂志文章


    authors: Ruokolainen L,Parkkola A,Karkman A,Sinkko H,Peet A,Hämäläinen AM,von Hertzen L,Tillmann V,Koski K,Virtanen SM,Niemelä O,Haahtela T,Knip M

    更新日期:2020-09-01 00:00:00