Glucocorticoid-induced attenuation of mucosal exudation of fibrinogen and bradykinins in seasonal allergic rhinitis.

Abstract:

:The mucosal plasma exudate with its proteins, enzymes, derived peptides, and matrix molecules is an important factor in inflammatory airway diseases. This study investigated whether topical glucocorticosteroid treatment influences mucosal exudation of bulk plasma (fibrinogen) and the generation of plasma-derived mediators (bradykinins) in seasonal allergic rhinitis. Twenty-two patients with birch-pollen-induced allergic rhinitis participated in a double-blind, randomized, placebo-controlled study during the birch pollen season in 1989. After a 2-week run-in period, the participants received treatment with budesonide (200 micrograms per nasal cavity and day) or placebo. The patients kept a diary to record their daily nasal symptoms (itching, sneezing, nasal blockage, and secretion). The amount of birch pollen in the air was determined with the aid of a Burkhard pollen trap. A nasal lavage was performed once a week, and the levels of bradykinins and fibrinogen were determined in the lavage fluid samples. The birch pollen season was very mild, resulting in only minor nasal symptoms. In spite of the low pollen exposure, treatment with budesonide reduced the lavage fluid levels of both bradykinins and fibrinogen. The present results show that topical glucocorticosteroid treatment attenuates plasma exudation and the generation of plasma-derived mediators in seasonal allergic rhinitis. This action may not result from simple vascular antipermeability effects of the drug but may rather reflect the anti-inflammatory efficacy of topical glucocorticoids in the airway mucosa.

journal_name

Allergy

journal_title

Allergy

authors

Svensson C,Klementsson H,Andersson M,Pipkorn U,Alkner U,Persson CG

doi

10.1111/j.1398-9995.1994.tb00822.x

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

177-83

issue

3

eissn

0105-4538

issn

1398-9995

journal_volume

49

pub_type

临床试验,杂志文章,随机对照试验

相关文献

ALLERGY文献大全
  • The non-specific enhancement of allergy. II. Precipitation of anaphylactic in vitro response capacity and serum IgE and IgG2a antibody synthesis in primed but non-responding rats by injection of alum.

    abstract::PVG rats given injections of 1 microgram ovalbumin (OA) together with 10 mg Silica gel failed to provide serosal mast cells or lung tissue with the capacity to release histamine on in vitro challenge with the antigen. However, if such animals were injected i.p. with 100 mg of alum (without any further antigen addition...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1983.tb01618.x

    authors: Bergstrand H,Andersson I,Nyström I,Pauwels R,Bazin H

    更新日期:1983-05-01 00:00:00

  • Positivity of patch tests in cutaneous reaction to aminocaproic acid: two case reports.

    abstract::We observed two cases of maculopapular eruption occurring 12-72 h after the administration of aminocaproic acid (ACA). Patch tests performed with ACA were positive. Clinical and allergologic patterns suggest the type IV mechanism of hypersensitivity. We present what we believe are the first two cases described of hype...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1995.tb01217.x

    authors: González Gutiérrez ML,Esteban López MI,Ruíz Ruíz MD

    更新日期:1995-09-01 00:00:00

  • Leukocyte migration inhibition test in children with cow milk allergy.

    abstract::The usefulness of the leukocyte migration inhibition factor (LIF) test to detect cow milk (CM) hypersensitivity was studied in 40 children with suspected allergy to CM. Hypersensitivity was carefully investigated by oral milk challenges, which gave a final confirmation of cow milk hypersensitivity in 12 subjects, and ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1987.tb00392.x

    authors: Vanto T,Smogorzewska EM,Viander M,Kalimo K,Koivikko A

    更新日期:1987-11-01 00:00:00

  • Structure of intact IgE and the mechanism of ligelizumab revealed by electron microscopy.

    abstract:BACKGROUND:IgE is the central antibody isotype in TH2-biased immunity and allergic diseases. The structure of intact IgE and the impact of IgE-targeting molecules on IgE however remain elusive. In order to obtain insights into IgE biology and the clinical impact, we aimed for structure determination of IgE and the comp...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14222

    authors: Jensen RK,Jabs F,Miehe M,Mølgaard B,Pfützner W,Möbs C,Spillner E,Andersen GR

    更新日期:2020-08-01 00:00:00

  • IL-5 expression and release from human CD34 cells in vitro; ex vivo evidence from cases of asthma and Churg-Strauss syndrome.

    abstract:BACKGROUND:Eosinophils develop from hematopoietic CD34(+) progenitor cells in the bone marrow (BM) under the influence of Interleukin-5 (IL-5). The primary source of IL-5 is T-lymphocytes, although other sources may exist. The aims of this study were to determine whether CD34(+) cells from human peripheral blood (PB) a...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2009.02271.x

    authors: Bossios A,Sjöstrand M,Dahlborn AK,Samitas K,Malmhäll C,Gaga M,Lötvall J

    更新日期:2010-07-01 00:00:00

  • Characterization of genetic variation in TLR8 in relation to allergic rhinitis.

    abstract:BACKGROUND:A previous investigation of all 10 TLR genes for associations with allergic rhinitis (AR) detected a number of significant SNPs in the TLR8 locus. The associations indicated that an accumulation of rare variants could explain the signal. This study therefore searches for rare variants in the TLR8 region and ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.12805

    authors: Henmyr V,Lind-Halldén C,Carlberg D,Halldén C,Melén E,Wickman M,Bergström A,Säll T,Cardell LO

    更新日期:2016-03-01 00:00:00

  • Breast milk fatty acid composition has a long-term effect on the risk of asthma, eczema, and sensitization.

    abstract:BACKGROUND:Levels of n-3 polyunsaturated fatty acids (PUFAs) and n-6 PUFAs in breast milk are associated with the development of allergic diseases up to school age. However, it is unknown whether this relationship persists when the child becomes older. We therefore studied the association between levels of n-3 PUFAs an...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.12703

    authors: van Elten TM,van Rossem L,Wijga AH,Brunekreef B,de Jongste JC,Koppelman GH,Smit HA

    更新日期:2015-11-01 00:00:00

  • Environmental and mucosal microbiota and their role in childhood asthma.

    abstract:BACKGROUND:High microbial diversity in the environment has been associated with lower asthma risk, particularly in children exposed to farming. It remains unclear whether this effect operates through an altered microbiome of the mucosal surfaces of the airways. METHODS:DNA from mattress dust and nasal samples of 86 sc...

    journal_title:Allergy

    pub_type: 杂志文章,多中心研究

    doi:10.1111/all.13002

    authors: Birzele LT,Depner M,Ege MJ,Engel M,Kublik S,Bernau C,Loss GJ,Genuneit J,Horak E,Schloter M,Braun-Fahrländer C,Danielewicz H,Heederik D,von Mutius E,Legatzki A

    更新日期:2017-01-01 00:00:00

  • New approach shows no association between maternal milk fatty acid composition and childhood wheeze or asthma.

    abstract:BACKGROUND:Previous observational studies have implied breastmilk fatty acid composition may play a role in the development of atopic eczema or atopic sensitization in breastfed infants and toddlers. However, studies investigating associations with wheeze and asthma in later childhood are scarce and did not account for...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.13161

    authors: Logan CA,Brandt S,Wabitsch M,Brenner H,Wiens F,Stahl B,Marosvölgyi T,Decsi T,Rothenbacher D,Genuneit J

    更新日期:2017-09-01 00:00:00

  • Flowcytometric diagnosis of atracurium-induced anaphylaxis.

    abstract:BACKGROUND:Allergy to atracurium is a rare condition with serious consequences of diagnostic error. However, correct diagnosis is not always straightforward. The aim of this study is to assess the utility of the basophil activation test (BAT) in atracurium sensitization and to investigate its role in identifying cross-...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.12468

    authors: Uyttebroek AP,Sabato V,Leysen J,Bridts CH,De Clerck LS,Ebo DG

    更新日期:2014-10-01 00:00:00

  • Crossed Immunoelectrophoresis analysis of bee venom. Enzymatic identification of antigens.

    abstract::Bee venom obtained by electrical stimulation has been analysed by crossed immunoelectrophoresis against high-titer rabbit antibodies. The antigenic analysis of bee venom revealed that the extract contained 17 antigens, which were detected in the crossed immunoelectrophoresis pattern after staining with Coomassie Brill...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1982.tb01910.x

    authors: Einarsson R,Annerhed A,Karlsson R,Olsson B,Renck B

    更新日期:1982-05-01 00:00:00

  • Effect of an allergy prevention programme on incidence of atopic symptoms in infancy. A prospective study of 159 "high-risk" infants.

    abstract::A total of 105 "high-risk" infants born in 1988 were studied prospectively from birth to 18 months of age. The infants were recommended breastfeeding and/or hypoallergenic formula (Nutramigen or Profylac) combined with avoidance of solid foods during the first 6 months of life. All mothers had unrestricted diet. Avoid...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1992.tb00680.x

    authors: Halken S,Høst A,Hansen LG,Osterballe O

    更新日期:1992-10-01 00:00:00

  • Combined skin prick and patch testing enhances identification of peanut-allergic patients with atopic dermatitis.

    abstract:BACKGROUND:Food atopy patch tests (APTs) are considered a useful tool for the diagnosis of food allergy. Hypersensitivity to peanuts has not been investigated by means of APTs so far. METHODS:APTs and skin prick tests (SPTs) with peanuts were performed in 136 atopic dermatitis (AD) patients. Relevance of positive and ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2003.00153.x

    authors: Seidenari S,Giusti F,Bertoni L,Mantovani L

    更新日期:2003-06-01 00:00:00

  • Results of wearing test with two different latex gloves with and without the use of skin-protection cream.

    abstract::A total of 109 subjects reporting symptoms indicating type I hypersensitivity reactions to natural rubber latex (NRL) gloves was included in this study, and 66 of them had latex-specific IgE antibodies. They underwent provocation tests by wearing two types of NRL gloves with high (n=103) and low (n=75) allergen conten...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1998.tb03920.x

    authors: Baur X,Chen Z,Allmers H,Raulf-Heimsoth M

    更新日期:1998-04-01 00:00:00

  • An Internet-based survey of anaphylactic reactions to foods.

    abstract:BACKGROUND:A favorable outcome of anaphylaxis depends on the rapidity of adequate initial management and epinephrine injection. However, few data on the management of anaphylactic reactions are available. The aim of this study was to investigate the management and awareness of anaphylaxis to foods by mean of an Interne...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2001.056006540.x

    authors: Eigenmann PA,Pastore FD,Zamora SA

    更新日期:2001-06-01 00:00:00

  • Acute autoimmune response in a case of pyromellitic acid dianhydride-induced hemorrhagic alveolitis.

    abstract::A 17-year-old man was occupationally exposed to pyromellitic acid dianhydride dust during the production of epoxy resin in a chemical factory. He was clinically diagnosed as having acute hemorrhagic alveolitis associated with anemia. The serologic analysis revealed a high concentration of IgG antibodies against pyrome...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1994.tb02278.x

    authors: Czuppon AB,Kaplan V,Speich R,Baur X

    更新日期:1994-05-01 00:00:00

  • Prick test: evolution towards automated reading.

    abstract::The prick test is one of the most common medical methods for diagnosing allergies, and it has been carried out in a similar and laborious manner over many decades. In an attempt to standardize the reading of the test, many researchers have tried to automate the process of measuring the allergic reactions found by deve...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/all.12921

    authors: Justo X,Díaz I,Gil JJ,Gastaminza G

    更新日期:2016-08-01 00:00:00

  • Arizona cypress (Cupressus arizonica) pollen allergens. Identification of cross-reactive periodate-resistant and -sensitive epitopes with monoclonal antibodies.

    abstract::Species of the Cupressaceae family are a worldwide cause of respiratory allergies. We used monoclonal antibodies (mAbs) to investigate the presence and the nature of cross-reacting epitopes shared by various components within Cupressus arizonica pollen extract (CaE) or by CaE and pollen extract from C. sempervirens (C...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1998.tb03934.x

    authors: Barletta B,Tinghino R,Corinti S,Afferni C,Iacovacci P,Mari A,Pini C,Di Felice G

    更新日期:1998-06-01 00:00:00

  • Longitudinal evaluation of bone mass in asthmatic children treated with inhaled beclomethasone dipropionate or cromolyn sodium.

    abstract::Inhaled corticosteroids are recommended as first-line therapy in patients with moderate to severe asthma. The use of these agents in the milder form of asthma is controversial because of their potential adverse effects, especially in growing children. We investigated 49 asthmatic children (38 treated with beclomethaso...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1998.tb03957.x

    authors: Martinati LC,Bertoldo F,Gasperi E,Fortunati P,Lo Cascio V,Boner AL

    更新日期:1998-07-01 00:00:00

  • A comparative study of dexchlorpheniramine maleate sustained release tablets and budesonide nasal spray in seasonal allergic rhinitis.

    abstract::It was the aim of the study to compare the efficacy and side effects of oral antihistamine and nasal glucocorticoid therapy in seasonal allergic, rhinitis. In a double blind, double-dummy, group-comparative study, 61 adult grass pollen allergic patients were either treated with dexchlorpheniramine maleate sustained re...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1983.tb02361.x

    authors: Munch EP,Søborg M,Nørreslet TT,Mygind N

    更新日期:1983-10-01 00:00:00

  • Microbial and transcriptional differences elucidate atopic dermatitis heterogeneity across skin sites.

    abstract::It is well established that different sites in healthy human skin are colonized by distinct microbial communities due to different physiological conditions. However, few studies have explored microbial heterogeneity between skin sites in diseased skin, such as atopic dermatitis (AD) lesions. To address this issue, we ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14606

    authors: Ottman N,Barrientos-Somarribas M,Fyhrquist N,Alexander H,Wisgrill L,Olah P,Tsoka S,Greco D,Levi-Schaffer F,Soumelis V,Schröder JM,Kere J,Nestle FO,Barker J,Ranki A,Lauerma A,Homey B,Andersson B,Alenius H

    更新日期:2020-10-01 00:00:00

  • Lymphocyte proliferative responses to the purified Dermatophagoides farinae major allergen in untreated and hyposensitized atopic patients.

    abstract::We investigated the proliferative response of lymphocytes from mite-sensitive patients (RAST D.far greater than 3.5 PRU/ml) in the presence of the major allergen Der.f.I purified from Dermatophagoides farinae. Comparative studies were carried out with peripheral blood mononuclear cells from non-atopic donors (RAST = 0...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1988.tb00409.x

    authors: Cavaillon JM,Fitting C,Guinnepain MT,Rassemont R,David B

    更新日期:1988-02-01 00:00:00

  • Ratio of myeloid and plasmacytoid dendritic cells and TH2 skew in CRS with nasal polyps.

    abstract:BACKGROUND:The role of myeloid and plasmacytoid dendritic cells and its consequences for the T(H)2 skew in chronic rhinosinusitis (CRS) with nasal polyps (CRSNP(+)) should be detailed. METHODS:In 18 CRS patients without nasal polyps (CRSNP(-)), 35 CRSNP(+) patients and 22 patients with nasal structural abnormalities w...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2009.02174.x

    authors: Kirsche H,Niederführ A,Deutschle T,Fuchs C,Riechelmann H

    更新日期:2010-01-01 00:00:00

  • Association of interleukin 18 (IL18) polymorphisms with specific IgE levels to mite allergens among asthmatic patients.

    abstract:BACKGROUND:Allergy is regarded as a multifactorial condition. Its onset and severity are influenced by both genetic and environmental factors. Identification of genetic factors involved in asthma development and related phenotypes is a major task in understanding the genetic background of asthma. The possible involveme...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2005.00619.x

    authors: Shin HD,Kim LH,Park BL,Choi YH,Park HS,Hong SJ,Choi BW,Lee JH,Park CS

    更新日期:2005-07-01 00:00:00

  • Double-blind comparison of the protective effect of sodium cromoglycate and ketotifen on exercise-induced asthma in adults.

    abstract::In a double-blind double-placebo study 10 asthmatics exercised on a treadmill after treatment for 1 week with placebo, or ketotifen 1 mg twice daily, or SCG 10 mg four times daily. The post-exercise percentage fall in FEV1 after SCG but not after ketotifen was significantly smaller than after placebo. A 1-week treatme...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1987.tb02215.x

    authors: Tan WC,Lim TK

    更新日期:1987-05-01 00:00:00

  • Rhinitis symptoms and IgE sensitization as risk factors for development of later allergic rhinitis in adults.

    abstract:BACKGROUND:Rhinitis symptoms and IgE-sensitization often mismatch. Asymptomatic sensitization is an established risk factor for later rhinitis, whereas it is not clear whether rhinitis is a risk factor for later development of IgE-sensitization. OBJECTIVE:To investigate whether nonallergic rhinitis is a risk factor fo...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2006.01140.x

    authors: Bodtger U,Poulsen LK,Linneberg A

    更新日期:2006-06-01 00:00:00

  • Latex allergy in Saudi children with spina bifida.

    abstract:BACKGROUND:Children with spina bifida (SB) are exposed to latex soon after birth during bladder catheterization, rectal disimpaction, and multiple surgical procedures. IgE-mediated latex-allergic reactions have been reported recently in these children. Our study was designed to assess the prevalence of allergic reactio...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:

    authors: Kattan H,Harfi HA,Tipirneni P

    更新日期:1999-01-01 00:00:00

  • Rhinitis is an independent risk factor for developing cough apart from colds among adults.

    abstract:BACKGROUND:In cross-sectional clinical studies, rhinitis has been shown to be strongly associated with co-existing chronic cough. However, to date, this association has been poorly delineated from a prospective and epidemiological standpoint. METHODS:We used data from the 'Pisa Prospective Study', a population-based l...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2005.00717.x

    authors: Guerra S,Sherrill DL,Baldacci S,Carrozzi L,Pistelli F,Di Pede F,Viegi G

    更新日期:2005-03-01 00:00:00

  • The effect of antiallergic intranasal formulations on ciliary beat frequency of human nasal epithelium in vitro.

    abstract::The nasal mucociliary clearance is an important defense mechanism of the upper respiratory tract. It is known to be influenced by many pharmacologic substances. We investigated the effects of three topical intranasal antiallergic formulations containing disodium cromoglycate (DNCG), dimethindene maleate (DMM), and aze...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1998.tb03801.x

    authors: Alberty J,Stoll W

    更新日期:1998-10-01 00:00:00

  • The effect of immediate-hypersensitivity reactions on the level of SLPI, granulocyte elastase, alpha1-antitrypsin, and albumin in nasal secretions, by the method of unilateral antigen challenge.

    abstract:BACKGROUND:The aim of this paper was to investigate the role of SLPI in patients with allergic rhinitis. From this point of view, we also examined leukocyte elastase, alpha1-antitrypsin, and albumin. SLPI is an inhibitor of serine proteases such as leukocyte elastase, cathepsin G, and mast-cell chymase. Since chymase i...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.1999.00938.x

    authors: Westin U,Lundberg E,Wihl JA,Ohlsson K

    更新日期:1999-08-01 00:00:00