Atopy and asthma in rural Poland: a paradigm for the emergence of childhood respiratory allergies in Europe.

abstract：:Specific Immunotherapy for respiratory allergy is used since about one century and there is now solid documentation of its efficacy. Nevertheless, the methods and experimental designs used in clinical trials are quite heterogeneous and there is no unanimously accepted methodological standard. Many studies are planned ...

journal_title：Allergy

authors： Canonica GW,Baena-Cagnani CE,Bousquet J,Bousquet PJ,Lockey RF,Malling HJ,Passalacqua G,Potter P,Valovirta E

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Given the key role of interleukin-5 (IL-5) in eosinophil function, we investigated the regulated expression of the membrane-anchored (TM-IL-5Ralpha) isoform, or a secreted (SOL IL-5Ralpha) isoform, on both protein and transcript level in vitro and in vivo. METHODS:A real-time PCR, FACS and ELISA were establ...

journal_title：Allergy

authors： Gevaert P,Hellman C,Lundblad L,Lundahl J,Holtappels G,van Cauwenberge P,Tavernier J,Bachert C

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Class I chitinase in natural rubber latex (NRL) has been assumed to be an important allergen, especially concerning its cross-reactivity with fruits like avocado and banana. OBJECTIVES:The present study aimed to produce a recombinant latex class I chitinase from Hevea brasiliensis leaves and to study its im...

journal_title：Allergy

authors： Rihs HP,Dumont B,Rozynek P,Lundberg M,Cremer R,Brüning T,Raulf-Heimsoth M

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Eosinophilic airway inflammation is the hallmark of asthma, but it has also been reported in other conditions such as allergic rhinitis. We have tested whether the analysis of cells and chemicals in sputum can distinguish between patients with mild allergic asthma, those with allergic rhinitis, and healthy c...

journal_title：Allergy

authors： Alvarez MJ,Olaguibel JM,García BE,Rodríquez A,Tabar AI,Urbiola E

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:IL-31 is a cytokine expressed by T cells following activation with cytokines or staphylococcal exotoxins. A major function of IL-31 in atopic dermatitis (AD) is the induction of pruritus in the skin via the IL-31 receptor on sensory nerve cells. However, the regulation of the IL-31 receptor and pro-inflammat...

journal_title：Allergy

authors： Kasraie S,Niebuhr M,Werfel T

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Immunoglobulin (Ig) A represents a first-line defence mechanism in the airways, but little is known regarding its implication in upper airway disorders. This study aimed to address the hypothesis that polymeric Ig receptor (pIgR)-mediated secretory IgA immunity could be impaired in chronic upper airway disea...

journal_title：Allergy

authors： Hupin C,Rombaux P,Bowen H,Gould H,Lecocq M,Pilette C

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Allergens from house dust mites (HDMs), Dermatophagoides pteronyssinus and Blomia tropicalis are clinically relevant in atopic respiratory diseases in tropical countries. AIMS OF THE STUDY:To evaluate immunoglobulin (Ig)E, IgG1, and IgG4 antibody responses to B. tropicalis in Brazilian atopic patients. MET...

journal_title：Allergy

authors： Pereira EA,Silva DA,Cunha-Júnior JP,Almeida KC,Alves R,Sung SJ,Taketomi EA

更新日期：2005-03-01 00:00:00

abstract：:Regulatory approaches for allergen immunotherapy (AIT) products and the availability of high-quality AIT products are inherently linked to each other. While allergen products are available in many countries across the globe, their regulation is very heterogeneous. First, we describe the regulatory systems applicable f...

journal_title：Allergy

authors： Bonertz A,Roberts GC,Hoefnagel M,Timon M,Slater JE,Rabin RL,Bridgewater J,Pini C,Pfaar O,Akdis C,Goldstein J,Poulsen LK,van Ree R,Rhyner C,Barber D,Palomares O,Sheikh A,Pawankar R,Hamerlijnk D,Klimek L,Agache I,

更新日期：2018-01-01 00:00:00

abstract：:We present the results of allergen content evaluation in 80 dust samples from 31 homes of atopic patients from two climatic areas (humid and subhumid), collected in two seasons of the year (autumn and winter). Monoclonal antibody-based immunoassays were used to quantify Der p 1, Der f 1, Der 2, Lep d 1, and Fel d 1. T...

journal_title：Allergy

authors： Echechipía S,Ventas P,Audícana M,Urrutia I,Gastaminza G,Polo F,Fernández de Corres L

更新日期：1995-06-01 00:00:00

abstract：:Eighteen children with perennial asthma and allergy to house-dust mite (HDM) underwent a bronchial challenge with HDM. Before and 24 h after the test, a venous blood sample was taken to determine levels of eosinophils, eosinophil cationic protein (ECP), soluble interleukin-2 receptor (IL-2R), and interleukin-6 (IL-6)....

journal_title：Allergy

authors： Van Bever HP,Moens MM,Bridts CH,De Clerck LS,Mertens AV,Bosmans E,Stevens WJ

更新日期：1993-08-01 00:00:00

abstract：:We studied 708 adolescents aged 15-17 years in the 9th grade of school in Imatra. Of the eligible population born in 1962 77% were included. All were skin prick tested with 16 extracts from two manufacturers with 12 common allergens, which included pollens, epithelia, mite, house dust and fish. At least one positive, ...

journal_title：Allergy

authors： Haahtela T,Björkstén F,Heiskala M,Suoniemi I

更新日期：1980-07-01 00:00:00

abstract：BACKGROUND:Allergic asthma is a multifactorial and probably multigenic inflammatory disease of the upper airways, and has been associated with the HLA class II alleles DR4 and DR7. Here we investigated possible associations with other polymorphic susceptibility/resistance genes located within the major histocompatibili...

journal_title：Allergy

authors： Aron Y,Busson M,Polla BS,Dusser D,Lockhart A,Swierczewski E,Favatier F

更新日期：1999-02-01 00:00:00

abstract：:The relation between platelet counts (PCT) and IgE was studied in cord blood from 136 European newborns. PCT was significantly lower (P = 0.0014) when cord-IgE was superior to 1.20 IU/ml (n = 29; 245,000/microliter) than when it was inferior to this value (n = 107; 284,080/microliter) which resulted in a significant n...

journal_title：Allergy

authors： Magnusson CG,de Weck AL

更新日期：1989-02-01 00:00:00

abstract：:During the last years, two new cardiovascular drug classes, namely inhibitors of DPP IV or neprilysin, have been developed. In both cases, there is clinical evidence for their potential to induce angioedema as known already from blockers of the renin-angiotensin-aldosterone system (RAAS). The majority of angioedema in...

journal_title：Allergy

authors： Bas M,Greve J,Strassen U,Khosravani F,Hoffmann TK,Kojda G

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Systemic allergic reactions are a risk for allergen immunotherapy that utilizes intact allergen preparations. We evaluated the safety, efficacy and immune mechanisms of short-course treatment with adjuvant-free Lolium perenne peptides (LPP) following a 6-week dose-escalation protocol. METHODS:In a prospecti...

journal_title：Allergy

authors： Mösges R,Koch AF,Raskopf E,Singh J,Shah-Hosseini K,Astvatsatourov A,Hauswald B,Yarin Y,Corazza F,Haazen L,Pirotton S,Allekotte S,Zadoyan G,Legon T,Durham SR,Shamji MH

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:In cross-sectional clinical studies, rhinitis has been shown to be strongly associated with co-existing chronic cough. However, to date, this association has been poorly delineated from a prospective and epidemiological standpoint. METHODS:We used data from the 'Pisa Prospective Study', a population-based l...

journal_title：Allergy

authors： Guerra S,Sherrill DL,Baldacci S,Carrozzi L,Pistelli F,Di Pede F,Viegi G

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:IL-33 enhances FcεRI-induced mediator release in human basophils without inducing degranulation itself. In contrast, studies in mice suggested that in the presence of high IgE levels, IL-33 triggers degranulation and anaphylaxis of similar severity as specific allergen. Consistent with this view, sera of ato...

journal_title：Allergy

authors： Fux M,Pecaric-Petkovic T,Odermatt A,Hausmann OV,Lorentz A,Bischoff SC,Virchow JC,Dahinden CA

更新日期：2014-02-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for 21-25% of reported adverse drug events which include immunological and nonimmunological hypersensitivity reactions. This study presents up-to-date information on pathomechanisms, clinical spectrum, diagnostic tools and management of hypersensitivity rea...

journal_title：Allergy

authors： Kowalski ML,Makowska JS,Blanca M,Bavbek S,Bochenek G,Bousquet J,Bousquet P,Celik G,Demoly P,Gomes ER,Niżankowska-Mogilnicka E,Romano A,Sanchez-Borges M,Sanz M,Torres MJ,De Weck A,Szczeklik A,Brockow K

更新日期：2011-07-01 00:00:00

abstract：:The cellular immunity to Yersinia enterocolitica serotype 3 and crude human thyroid extract in 64 patients with thyroid diseases and 25 controls was studied by the leucocyte migration test. In the patient group as a whole and in patients with Graves' disease and nontoxic diffuse goitre a significantly reduced leucocyt...

journal_title：Allergy

authors： Bech K,Clemmensen O,Larsen JH,Thyme S,Bendixen G

更新日期：1978-04-01 00:00:00

abstract：BACKGROUND:Local application of allergen extracts in specific immunotherapy is accompanied by increased compliance and significantly reduced side effects. However, efficacy of local immunotherapy in children has yet not been sufficiently demonstrated. This study was performed to determine clinical efficacy of high dose...

journal_title：Allergy

authors： Bufe A,Ziegler-Kirbach E,Stoeckmann E,Heidemann P,Gehlhar K,Holland-Letz T,Braun W

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Specific allergen immunotherapy (SIT) and nasal steroids (NS) are considered effective anti-inflammatory treatments for allergic rhinitis, although their mechanism of action differs. OBJECTIVE:The aim of this study was to examine the effect of treatment with NS and SIT on different populations of inflammato...

journal_title：Allergy

authors： Rak S,Heinrich C,Scheynius A

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:The mechanisms driving glucocorticoid (GC) insensitivity in patients with severe asthma are still unknown. Recent evidence suggests the existence of GC-insensitive pathways in airway smooth muscle (ASM) caused by a defect in GC receptor (GRα) function. We examined whether other mechanisms could potentially e...

journal_title：Allergy

authors： Chachi L,Abbasian M,Gavrila A,Alzahrani A,Tliba O,Bradding P,Wardlaw AJ,Brightling C,Amrani Y

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Although asthma is characterized by variable airways obstruction, most studies of asthma phenotypes are cross-sectional. The stability of phenotypes defined either by biomarkers or by physiological variables was assessed by repeated measures over 1 year in the Pan-European BIOAIR cohort of adult asthmatics. ...

journal_title：Allergy

authors： Kupczyk M,Dahlén B,Sterk PJ,Nizankowska-Mogilnicka E,Papi A,Bel EH,Chanez P,Howarth PH,Holgate ST,Brusselle G,Siafakas NM,Gjomarkaj M,Dahlén SE,BIOAIR investigators.

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:The beta-lactam allergic work-up is mostly standardized. However, the negative predictive value of drug provocation tests is not yet well established. METHOD:A historical-prospective multicentre cohort study was conducted in four centres (one in France, one in Portugal, two in Italy) to assess the negative ...

journal_title：Allergy

authors： Demoly P,Romano A,Botelho C,Bousquet-Rouanet L,Gaeta F,Silva R,Rumi G,Rodrigues Cernadas J,Bousquet PJ

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:The capacity of profilin to induce allergic symptoms in patients with respiratory allergy has been questioned. In this sense, the aim of this study was to investigate the correlation between profilin exposure and induction of symptoms in a prospective case-control study. METHODS:The concentration of profili...

journal_title：Allergy

authors： Ruiz-Hornillos J,López-Matas MA,Berges Jimeno P,Henríquez A,Blanco S,Seoane-Rodríguez M,Mahíllo I,Carnés J

更新日期：2020-04-01 00:00:00

abstract：:Occupational respiratory allergy to green coffee beans in coffee roastery workers is well established. I now report on a 50-year-old female atopic patient sensitized to the coffee plant used for indoor decoration. The symptoms were rhinitis and conjunctivitis on exposure to the plant. Investigation showed a positive s...

journal_title：Allergy

authors： Axelsson IG

更新日期：1994-12-01 00:00:00

abstract：:Inhalation and nasal aspirin challenge has been investigated in asthma patients with co-existing rhinitis. Eight of 39 asthma patients were diagnosed as aspirin-sensitive on the basis of inhalation challenge. Seven aspirin-sensitive asthmatics were subjected to nasal aspirin provocation. During nasal challenge, all se...

journal_title：Allergy

authors： Pawlowicz A,Williams WR,Davies BH

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:Various techniques have been tried in an attempt to reduce allergen levels in homes. This study investigated the effect of dry heat on mite, cat, and dog allergens. METHODS:Samples (50 mg) of Dermatophagoides pteronyssinus and D. farinae cultures, and of house dust rich in the major cat and dog allergens Fe...

journal_title：Allergy

authors： Cain G,Elderfield AJ,Green R,Smillie FI,Chapman MD,Custovic A,Woodcock A

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:As in vitro diagnosis of wasp venom sensitization by specific serum IgE has a sensitivity of only 60-80%, additional in vitro tests are desirable. Basophil activation is associated with the expression of CD63 and its measurement has been proposed as a novel in vitro test for immediate-type allergy. Furthermo...

journal_title：Allergy

authors： Erdmann SM,Sachs B,Kwiecien R,Moll-Slodowy S,Sauer I,Merk HF

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinase (MMP)-9, an enzyme that contributes to inflammatory responses and subsequent tissue remodelling, has recently been suggested to be a good biomarker for monitoring disease activity in patients with chronic urticaria (CU). Here, we assessed whether total MMP-9 and/or active MMP-9 plasm...

journal_title：Allergy

authors： Altrichter S,Boodstein N,Maurer M

更新日期：2009-04-01 00:00:00