Abstract:
BACKGROUND:IL-33 enhances FcεRI-induced mediator release in human basophils without inducing degranulation itself. In contrast, studies in mice suggested that in the presence of high IgE levels, IL-33 triggers degranulation and anaphylaxis of similar severity as specific allergen. Consistent with this view, sera of atopic patients contain elevated levels of IL-33 after anaphylaxis. In this study, we determined whether IL-33 is potentially anaphylactogenic in humans with high IgE levels by regulating exocytosis independent of FcεRI cross-linking. Furthermore, we investigated whether IL-33 is released upon allergen provocation in vivo. METHODS:In subjects with high serum IgE levels, we measured IL-33-induced histamine/LTC4 in vitro, CD63 translocation ex vivo, and responsiveness of mast cells in vivo by skin prick test (SPT). In asthma patients, release of IL-33 and its correlation with early (tryptase)- and late-phase markers (IL-13 levels, eosinophil numbers) of the allergic response were assessed in bronchoalveolar lavage fluids (BALFs) after allergen challenge. RESULTS:IL-33 itself does not trigger basophil degranulation in vitro and ex vivo, even in subjects with high serum IgE levels, and negative SPTs demonstrate that skin mast cells do not degranulate in response to IL-33. However, in response to allergen challenge, IL-33 is rapidly released into BALFs at levels that do not correlate with other immediate- and late-phase parameters. CONCLUSION:IL-33 is unlikely an independent trigger of anaphylaxis even in subjects with high IgE levels. However, the rapid release of IL-33 upon allergen provocation in vivo supports its role as a mediator of immediate allergic responses.
journal_name
Allergyjournal_title
Allergyauthors
Fux M,Pecaric-Petkovic T,Odermatt A,Hausmann OV,Lorentz A,Bischoff SC,Virchow JC,Dahinden CAdoi
10.1111/all.12309subject
Has Abstractpub_date
2014-02-01 00:00:00pages
216-22issue
2eissn
0105-4538issn
1398-9995journal_volume
69pub_type
杂志文章相关文献
ALLERGY文献大全abstract::This study investigated the relationship between the specific immunoglobulin E (IgE) profile for 40 allergens using a novel microarray technique (BioIC) and fraction of exhaled nitric oxide (FeNO) in a population sample of 1321 children. Significant positive associations were found between FeNO and sensitization to mi...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12378
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:The differential diagnosis of eosinophilic gastroenteritis (EG) includes, among other diseases, parasitic infections such as anisakiasis, which has acquired worldwide importance. METHODS:We reviewed all patients referred to our allergy service who had been diagnosed as having primary EG to determine the pos...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1998.tb03834.x
更新日期:1998-12-01 00:00:00
abstract::This study was undertaken to analyze the differences in exposure and sensitization to five common environmental yeasts. The responses of IgG, IgA, and IgE to Candida albicans, C. utilis, Cryptococcus albidus, Rhodotorula rubra, and Saccharomyces cerevisiae and purified S. cerevisiae enolase were analyzed by immunoblot...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1998.tb04088.x
更新日期:1998-05-01 00:00:00
abstract::Eosinophil cationic protein (ECP) is a cationic protein secreted by eosinophils with toxic properties for the respiratory epithelium. Sputum-ECP levels have been shown to correlate inversely with airflow obstruction in asthma. In the present study we investigated whether ECP concentrations are different between asthma...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1993.tb04712.x
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Two-flow cytometry methods for quantification of degranulated basophil after allergen-specific activation were discussed. The methods are discerned by used membrane receptors--FcepsilonRI or IL-3Ralpha Our goal was to evaluate the diagnostic potential of the methods and to correlate them to allergen-specific...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2006.01087.x
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Clinical tools for predicting poor outcomes in asthma patients are lacking. This study investigated the association of asthma control and subsequent severe asthma-related healthcare events in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. METHODS:The extent of...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2007.01383.x
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Budesonide/formoterol (Symbicort) Maintenance and Reliever Therapy (SMART) is an effective asthma-management approach that treats symptoms with rapid increases in budesonide/formoterol. The cost-effectiveness of SMART vs higher fixed-dose budesonide/formoterol or salmeterol/fluticasone is unknown. METHODS:T...
journal_title:Allergy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1398-9995.2007.01466.x
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Anaphylaxis to insect venom (Hymenoptera) is most severe in patients with mastocytosis and may even lead to death. However, not all patients with mastocytosis suffer from anaphylaxis. The aim of the study was to analyze differences in gene expression between patients with indolent systemic mastocytosis (ISM)...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2010.02521.x
更新日期:2011-05-01 00:00:00
abstract::The background of this study is the finding of several studies that the frequency of respiratory allergies was significantly higher in the former West Germany than the former East Germany. The present study investigated the levels of allergens of house-dust mite (Der p 1 and Der f 1), cat (Fel d 1), and cockroach (Bla...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.1999.00196.x
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:The importance and specific role(s) of eosinophils in modulating the immune/inflammatory phenotype of allergic pulmonary disease remain to be defined. Established animal models assessing the role(s) of eosinophils as contributors and/or causative agents of disease have relied on congenitally deficient mice w...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12321
更新日期:2014-03-01 00:00:00
abstract::We studied 708 adolescents aged 15-17 years in the 9th grade of school in Imatra. Of the eligible population born in 1962 77% were included. All were skin prick tested with 16 extracts from two manufacturers with 12 common allergens, which included pollens, epithelia, mite, house dust and fish. At least one positive, ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1980.tb01789.x
更新日期:1980-07-01 00:00:00
abstract:BACKGROUND:Mannitol-induced bronchoconstriction in subjects with exercise-induced asthma is associated with increased urinary excretion of 9alpha, 11beta-PGF(2), a metabolite of prostaglandin D(2) (PGD(2)) serving as a mast cell marker. It has however been questioned whether or not human mast cells release PGD(2) and l...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2006.01213.x
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:IgE is the central antibody isotype in TH2-biased immunity and allergic diseases. The structure of intact IgE and the impact of IgE-targeting molecules on IgE however remain elusive. In order to obtain insights into IgE biology and the clinical impact, we aimed for structure determination of IgE and the comp...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.14222
更新日期:2020-08-01 00:00:00
abstract::In 77 consecutive patients with grass pollen rhinitis as the only allergic disease, treatment with sodium cromoglycate (SCG) nasal spray, hyposensitization with aluminium hydroxide adsorbed extract of grass pollen as perennial treatment, and a combination of the two was compared. Specific serum-IgE, IgG and IgG4 were ...
journal_title:Allergy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1398-9995.1987.tb02220.x
更新日期:1987-07-01 00:00:00
abstract::Delayed hypersensitivity to rubber chemicals is well known, but there are only a limited number of case reports on an immediate type of hypersensitivity inducing contact urticaria. We have recently seen several patients with rubber glove-induced contact urticaria who have had both positive skin prick tests and positiv...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1987.tb02186.x
更新日期:1987-01-01 00:00:00
abstract::Skin tests and estimation of specific IgE-antibodies by the RAST are evaluated as diagnostic procedures in bee sting hypersensitivity with the followiny extracts. (2) With bee venom results of skin tests and RAST correspond in 82%, with bee wholebody extracts in 68%. (3) Both with skin tests and the RAST with bee veno...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1979.tb01705.x
更新日期:1979-08-01 00:00:00
abstract:BACKGROUND:In addition to the dysregulation of arachidonic acid metabolism in aspirin-intolerant asthma (AIA), aspirin acetylsalicylic acid (ASA) exerts effects on inflammation and immunity; however, many of these effects are unknown. OBJECTIVE:The aim of the study was to evaluate the methylation status of whole genom...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2010.02514.x
更新日期:2011-05-01 00:00:00
abstract::The atopy-predictive value of cord blood (CB) cyclic adenosine monophosphate-phosphodiesterase (cAMP-PDE) in mononuclear leukocytes (MN) was studied prospectively in 57 neonates. Reliable determination of cAMP-PDE was achieved in only 20 CB samples. The levels tended to be higher in infants developing signs of atopy u...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1994.tb00141.x
更新日期:1994-09-01 00:00:00
abstract::Recent advances in experimental immunologic approaches to seasonal allergic rhinitis (SAR) have led to a shift in the concepts of its pathogenesis. The conventional view of SAR as a local response to inhaled allergens has largely given way to a new view of this disorder as a systemic condition with local tissue manife...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1034/j.1398-9995.2001.00102.x
更新日期:2001-01-01 00:00:00
abstract::A safe food supply is a legitimate expectation of consumers, which the food industry must meet. Allergic reactions to food are recognised as a significant public health problem. Protecting allergic consumers against such reactions, while minimising the impact of food allergy on their quality of life, poses a challenge...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2001.00928.x
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Strategies to prevent children from developing allergy have been elaborated on the basis of state-of-the-art reviews of the scientific literature regarding pets and allergies, building dampness and health, and building ventilation and health. A similar multidisciplinary review of infant feeding mode in relat...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1034/j.1398-9995.2003.00264.x
更新日期:2003-09-01 00:00:00
abstract::Several studies have indicated that the incidence and prevalence of allergic diseases are increasing. Such data should not be regarded as mere statistical curiosities, but should be analysed to provide information on the factors contributing to allergy and its changing epidemiology. Extensive evidence has been accumul...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1994.tb04232.x
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Mast cells have recently been shown to control neutrophil recruitment during T-cell mediated cutaneous DTH reaction in vivo through TNF-alpha and MIP-2, the functional murine analogue of human IL-8. Although the nature of signals transmitted from T cells which activate mast cells has not yet been defined, we...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2005.00886.x
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:The function of skin mast cells has been well documented in IgE-mediated allergic reactions, whereas other mast cell functions are poorly defined. This study aimed at identifying novel mast cell proteins by proteome analysis of primary human skin mast cells. METHODS:The proteome of skin mast cells was compa...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12919
更新日期:2017-01-01 00:00:00
abstract::The purpose of this study was to investigate whether uncontrolled asthma was associated with healthcare outcomes among Latin American patients with asthma. We used data from 2168 patients with asthma who participated in the 2011 Latin America Asthma Insights and Management (AIM) survey. Using Global Initiative for Ast...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12237
更新日期:2013-11-01 00:00:00
abstract::The prevalence and specificity of naturally occurring human IgA anti-IgE autoantibodies (a-E Ab) were studied by ELISA with anti-IgA monoclonal antibodies (mAb) and a purified myeloma IgE as solid-phase protein, i.e., IgE-DES(kappa). Such detected IgA a-E Ab were common among adults, and significantly increased geomet...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1994.tb00781.x
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:Omalizumab, a recombinant monoclonal anti-immunoglobulin E (IgE) antibody, shows proven efficacy in the treatment of allergic diseases. A little is known about the immunological pathways affected by the decrease of circulating free IgE during omalizumab treatment. AIM OF THE STUDY:To investigate the immunol...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2006.01180.x
更新日期:2006-09-01 00:00:00
abstract::Atopic eczema (AE) is a challenge for modern medicine, because it is prevalent, severely affects quality of life of patients and their families, and causes high socioeconomic costs. The pathogenesis of AE is complex. While initial studies suggested a Th2 deviation as primary reason for the disease, numerous studies ad...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.12184
更新日期:2013-08-01 00:00:00
abstract::Chip pile workers are exposed to high concentrations of airborne mould spores. Few sporadic cases of allergic alveolitis have been reported in Finland. Eight non-smoking workers, six on chip piles and two on bark piles, were examined to study the immunological and clinical response to continuous mould spore exposure. ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1987.tb00380.x
更新日期:1987-10-01 00:00:00
abstract:BACKGROUND:The aim of this paper was to investigate the role of SLPI in patients with allergic rhinitis. From this point of view, we also examined leukocyte elastase, alpha1-antitrypsin, and albumin. SLPI is an inhibitor of serine proteases such as leukocyte elastase, cathepsin G, and mast-cell chymase. Since chymase i...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.1999.00938.x
更新日期:1999-08-01 00:00:00