Abstract:
:The atopy-predictive value of cord blood (CB) cyclic adenosine monophosphate-phosphodiesterase (cAMP-PDE) in mononuclear leukocytes (MN) was studied prospectively in 57 neonates. Reliable determination of cAMP-PDE was achieved in only 20 CB samples. The levels tended to be higher in infants developing signs of atopy up to 18 months of age. The combination of CB cAMP-PDE and family history (FH) of allergy showed a higher predictive value (P = 0.040) than each of them separately (P = 0.370 and P = 0.102, respectively). The cAMP-PDE levels in CB also correlated to FH of allergy/atopy in accordance with earlier studies (P = 0.027). In conclusion, determination of cAMP-PDE in neonates may have some predictive value, but it is not suitable for general screening.
journal_name
Allergyjournal_title
Allergyauthors
Odelram H,Björkstén B,Chan SC,Hanifin JM,Kjellman NIdoi
10.1111/j.1398-9995.1994.tb00141.xsubject
Has Abstractpub_date
1994-09-01 00:00:00pages
677-9issue
8eissn
0105-4538issn
1398-9995journal_volume
49pub_type
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