Multiplexed immunoglobulin E sensitization in relation to exhaled nitric oxide in a population sample of children.

Abstract:

:This study investigated the relationship between the specific immunoglobulin E (IgE) profile for 40 allergens using a novel microarray technique (BioIC) and fraction of exhaled nitric oxide (FeNO) in a population sample of 1321 children. Significant positive associations were found between FeNO and sensitization to mites (P < 0.001), animals (P = 0.001), cockroaches (P < 0.001), and foods (P = 0.042), and furthermore, between FeNO and the number of sensitizations (all P < 0.05) or the sum of specific IgE (all P ≤ 0.01) against the aforementioned allergen categories. Specifically, sensitization to the following allergens was significantly related to higher FeNO: Dermatophagoides pteronyssinus, Dermatophagoides farina, Blomia tropicalis, cat, German cockroach, Oriental cockroach, codfish, crab, shrimp, and cheese (all P ≤ 0.01). In conclusion, IgE sensitization to mites, pets, cockroaches, seafood, and cheese, respectively, is significantly associated with elevated FeNO levels in a dose-dependent fashion in children. Our results provide new evidence that sensitization to certain food allergens may contribute to prompt inflammation in the airways.

journal_name

Allergy

journal_title

Allergy

authors

Yao TC,Tsai HJ,Tu YL,Chang SW,Hua MC,Liao SL,Tsai MH,Chiu CY,Lai SH,Yeh KW,Huang JL,PATCH study group.

doi

10.1111/all.12378

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

678-82

issue

5

eissn

0105-4538

issn

1398-9995

journal_volume

69

pub_type

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