Genome-wide methylation profile of nasal polyps: relation to aspirin hypersensitivity in asthmatics.

Abstract:

BACKGROUND:In addition to the dysregulation of arachidonic acid metabolism in aspirin-intolerant asthma (AIA), aspirin acetylsalicylic acid (ASA) exerts effects on inflammation and immunity; however, many of these effects are unknown. OBJECTIVE:The aim of the study was to evaluate the methylation status of whole genome in blood and polyp tissues with and without aspirin hypersensitivity. METHODS:Genome-wide DNA methylation levels in nasal polyps and peripheral blood cells were examined by microarray analysis using five subjects with AIA and four subjects with aspirin-tolerant asthma (ATA). RESULTS:In the nasal polyps of the patients with AIA, hypermethylation was detected at 332 loci in 296 genes, while hypomethylation was detected at 158 loci in 141 genes. Gene ontologic and pathway enrichment analyses revealed that genes involved in lymphocyte proliferation, cell proliferation, leukocyte activation, cytokine biosynthesis, cytokine secretion, immune responses, inflammation, and immunoglobulin binding were hypomethylated, while genes involved in ectoderm development, hemostasis, wound healing, calcium ion binding, and oxidoreductase activity were hypermethylated. In the arachidonate pathway, PGDS, ALOX5AP, and LTB4R were hypomethylated, whereas PTGES was hypermethylated. CONCLUSION:The nasal polyps of patients with AIA have characteristic methylation patterns affecting 337 genes. The genes and pathways identified in this study may be associated with the presence of aspirin hypersensitivity in asthmatics and are therefore attractive targets for future research.

journal_name

Allergy

journal_title

Allergy

authors

Cheong HS,Park SM,Kim MO,Park JS,Lee JY,Byun JY,Park BL,Shin HD,Park CS

doi

10.1111/j.1398-9995.2010.02514.x

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

637-44

issue

5

eissn

0105-4538

issn

1398-9995

journal_volume

66

pub_type

杂志文章

相关文献

ALLERGY文献大全
  • Anaphylactic reaction caused by neoallergens in heated pecan nut.

    abstract::An atopic girl experienced an anaphylactic reaction after eating cookies containing pecan nuts. Investigations revealed that she had developed IgE antibodies exclusively specific against allergenic determinants present in aged or heated pecan nuts, but not in fresh pecans. These neoallergenic determinants were located...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1995.tb02513.x

    authors: Malanin K,Lundberg M,Johansson SG

    更新日期:1995-12-01 00:00:00

  • IgE concentrations measured by PRIST in serum of healthy adults and in patients with respiratory allergy. A diagnostic approach.

    abstract::In order to establish reference values for total serum IgE in an adult non-atopic population, 175 individuals, 17-85 years of age, were investigated. The usefulness of a sensitive method (PRIST) for serum IgE determinations in discriminating atopy from non-atopic conditions in allergological routine diagnosis was eluc...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1981.tb01871.x

    authors: Zetterström O,Johansson SG

    更新日期:1981-11-01 00:00:00

  • Lifestyle and parental allergen sensitization are reflected in the intrauterine environment at gene expression level.

    abstract:BACKGROUND:Environmental factors, including the intrauterine environment, can influence the risk of allergy development. In the present study, we investigated whether lifestyle and parental allergen sensitization status are reflected at gene expression level in the intrauterine environment. METHODS:  mRNA expression o...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2010.02328.x

    authors: Joerink M,Oortveld MA,Stenius F,Rindsjö E,Alm J,Scheynius A

    更新日期:2010-10-01 00:00:00

  • Specific interaction of IgE antibodies with a carbohydrate epitope of honey bee venom phospholipase A2.

    abstract::Phospholipase A2 (E.C. 3.1.1.4.) is a major allergen of honey bee venom. It exists in a glycosylated and an unglycosylated variant. Both forms and the glycopeptide isolated after exhaustive proteolytic digestion were tested in RAST and RAST inhibition studies. IgE from 11 of 14 bee venom allergy sera exhibited signifi...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1987.tb00364.x

    authors: Weber A,Schröder H,Thalberg K,März L

    更新日期:1987-08-01 00:00:00

  • Can food allergy be cured? What are the future prospects?

    abstract::Food allergies have become a significant heath burden as prevalence continues to rise, affecting 6%-13% of the global population. In the absence of drugs approved by regulatory agencies, the current standard of care remains avoidance of allergenic foods and management of acute allergic reactions with antihistamines an...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/all.14116

    authors: Sampath V,Sindher SB,Alvarez Pinzon AM,Nadeau KC

    更新日期:2020-06-01 00:00:00

  • Mold-sensitivity in children with moderate-severe asthma is associated with HLA-DR and HLA-DQ.

    abstract:BACKGROUND:Several epidemiologic studies in the United States and Europe have linked Alternaria sensitivity to both persistence and severity of asthma. In this study, we examined T cell responses and HLA class II alleles in children with moderate-severe asthma. METHODS:Ninety-six children with moderate-severe asthma w...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2010.02382.x

    authors: Knutsen AP,Vijay HM,Kumar V,Kariuki B,Santiago LA,Graff R,Wofford JD,Shah MR

    更新日期:2010-11-01 00:00:00

  • Genetic determinants of paediatric food allergy: A systematic review.

    abstract:BACKGROUND:The genetic determinants of food allergy have not been systematically reviewed. We therefore systematically reviewed the literature on the genetic basis of food allergy, identifying areas for further investigation. METHODS:We searched three electronic databases (MEDLINE, EMBASE and PubMed) on 9 January 2018...

    journal_title:Allergy

    pub_type: 杂志文章,meta分析

    doi:10.1111/all.13767

    authors: Suaini NHA,Wang Y,Soriano VX,Martino DJ,Allen KJ,Ellis JA,Koplin JJ

    更新日期:2019-09-01 00:00:00

  • Matrix metalloproteinase-9: a novel biomarker for monitoring disease activity in patients with chronic urticaria patients?

    abstract:BACKGROUND:Matrix metalloproteinase (MMP)-9, an enzyme that contributes to inflammatory responses and subsequent tissue remodelling, has recently been suggested to be a good biomarker for monitoring disease activity in patients with chronic urticaria (CU). Here, we assessed whether total MMP-9 and/or active MMP-9 plasm...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2008.01799.x

    authors: Altrichter S,Boodstein N,Maurer M

    更新日期:2009-04-01 00:00:00

  • Long-term efficacy of preseasonal grass pollen immunotherapy in children.

    abstract:BACKGROUND:In a previous controlled study we demonstrated that preseasonal grass pollen immunotherapy for three years was effective in children. In the current study we examined the same group of patients to see if there is still a benefit six years after discontinuation of treatment. METHODS:Thirteen of 14 patients w...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2002.1o3264.x

    authors: Eng PA,Reinhold M,Gnehm HP

    更新日期:2002-04-01 00:00:00

  • Effect of grass pollen immunotherapy on clinical and local immune response to nasal allergen challenge.

    abstract:RATIONALE:Nasal allergen provocations may be useful in investigating the pathophysiology of allergic rhinitis and effects of treatments. OBJECTIVE:To use grass pollen nasal allergen challenge (NAC) to investigate the effects of allergen immunotherapy in a cross-sectional study. METHODS:We studied nasal and cutaneous ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.12608

    authors: Scadding GW,Eifan AO,Lao-Araya M,Penagos M,Poon SY,Steveling E,Yan R,Switzer A,Phippard D,Togias A,Shamji MH,Durham SR

    更新日期:2015-06-01 00:00:00

  • Comparison of the effect of the beta1-blocking drugs atenolol and metoprolol on bronchial asthma.

    abstract::Twenty patients with severe or medium severe asthma were given atenolol (Atenol ICI-Pharma) and/or metoprolol (Seloken Hässle) for tachycardia, hyperkinetic tremor, arterial hypertension or symptoms of angina pectoris. These cardioselective beta-blocking drugs caused only a very slight decrease in PF values. There was...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1978.tb01525.x

    authors: Carlson C,Järvinen KA

    更新日期:1978-06-01 00:00:00

  • Symptoms and immunologic markers induced by exposure to methyltetrahydrophthalic anhydride.

    abstract::A study was performed in 43 workers exposed to methyltetrahydrophthalic anhydride (MTHPA) used as a hardener in an epoxy resin system. Ten workers sensitized to MTHPA (group SS; presence of serum IgE antibodies against a conjugate of MTHPA and human serum albumin (HSA) detected by RAST) had significantly higher levels...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1994.tb02661.x

    authors: Nielsen J,Welinder H,Bensryd I,Andersson P,Skerfving S

    更新日期:1994-04-01 00:00:00

  • Results of wearing test with two different latex gloves with and without the use of skin-protection cream.

    abstract::A total of 109 subjects reporting symptoms indicating type I hypersensitivity reactions to natural rubber latex (NRL) gloves was included in this study, and 66 of them had latex-specific IgE antibodies. They underwent provocation tests by wearing two types of NRL gloves with high (n=103) and low (n=75) allergen conten...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1998.tb03920.x

    authors: Baur X,Chen Z,Allmers H,Raulf-Heimsoth M

    更新日期:1998-04-01 00:00:00

  • MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation.

    abstract::Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient empowerment. MASK-rh...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/all.12686

    authors: Bousquet J,Schunemann HJ,Fonseca J,Samolinski B,Bachert C,Canonica GW,Casale T,Cruz AA,Demoly P,Hellings P,Valiulis A,Wickman M,Zuberbier T,Bosnic-Anticevitch S,Bedbrook A,Bergmann KC,Caimmi D,Dahl R,Fokkens WJ,Gris

    更新日期:2015-11-01 00:00:00

  • Increased CD69 expression on peripheral blood eosinophils after specific inhalation challenge.

    abstract:BACKGROUND:CD69 is a molecule expressed on human eosinophils after cytokine-activation. Different studies have described the eosinophil activation, evaluated by CD69 expression, at the site of an allergic inflammation. In this study we evaluated the expression of CD69 on peripheral blood eosinophils after a specific in...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2002.23454.x

    authors: Pignatti P,Perfetti L,Galdi E,Pozzi V,Bossi A,Biale C,Moscato G

    更新日期:2002-05-01 00:00:00

  • IgE, IgA, and IgG responses to common yeasts in atopic patients.

    abstract::This study was undertaken to analyze the differences in exposure and sensitization to five common environmental yeasts. The responses of IgG, IgA, and IgE to Candida albicans, C. utilis, Cryptococcus albidus, Rhodotorula rubra, and Saccharomyces cerevisiae and purified S. cerevisiae enolase were analyzed by immunoblot...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1998.tb04088.x

    authors: Savolainen J,Kortekangas-Savolainen O,Nermes M,Viander M,Koivikko A,Kalimo K,Terho EO

    更新日期:1998-05-01 00:00:00

  • EAACI/GA2LEN/EDF guideline: definition, classification and diagnosis of urticaria.

    abstract::This guideline is the result of a consensus reached during a panel discussion at the 2nd International Consensus Meeting on Urticaria, Urticaria 2004, a joint initiative of the European Academy of Allergology and Clinical Immunology Dermatology Section and the European Union (EU)-funded network of excellence, GA2LEN. ...

    journal_title:Allergy

    pub_type: 杂志文章,实务指引,评审

    doi:10.1111/j.1398-9995.2005.00964.x

    authors: Zuberbier T,Bindslev-Jensen C,Canonica W,Grattan CE,Greaves MW,Henz BM,Kapp A,Kozel MM,Maurer M,Merk HF,Schäfer T,Simon D,Vena GA,Wedi B,EAACI\/GA2LEN\/EDF.

    更新日期:2006-03-01 00:00:00

  • Diagnostic workup including CD203c-based basophil activation test in immediate hypersensitivity due to metronidazole and ornidazole and evaluation of cross-reactivity in between.

    abstract:BACKGROUND:Little is known about the diagnostic approaches for immediate hypersensitivity reactions (IHRs) due to 5-nitroimidazole antibiotics. The aim was to evaluate the usefulness of in vivo tests and basophil activation test (BAT) for the diagnosis of IHRs due to metronidazole and ornidazole and to determine possib...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14542

    authors: Beyaz Ş,Akdeniz N,Yılmaz A,Demir S,Öztop N,Çolakoğlu B,Büyüköztürk S,Deniz G,Gelincik A

    更新日期:2020-08-05 00:00:00

  • Nature and function of gastrointestinal antigen-presenting cells.

    abstract::Antigen-presenting cells (APCs) of the human gut are heterogeneous, including both macrophages, a variety of dendritic cells and B cells. They are found both in gut-associated lymphoid tissue and in the mucosal lamina propria, especially beneath the surface epithelium. APCs have diverse phenotypes and therefore probab...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1034/j.1398-9995.2001.00903.x

    authors: Brandtzaeg P

    更新日期:2001-01-01 00:00:00

  • Sleep disturbances in allergic diseases.

    abstract::Sleep is fundamental for physical and mental health as well as daytime performance and represents a crucial aspect in the personal representations of well-being. Sleep disturbances in patients with chronic disorders constitute a factor that contributes to exacerbate symptoms, complicate management, and affect mood and...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.2006.01221.x

    authors: Baiardini I,Braido F,Cauglia S,Canonica GW

    更新日期:2006-11-01 00:00:00

  • How to prescribe antihistamines for chronic idiopathic urticaria: desloratadine daily vs PRN and quality of life.

    abstract:BACKGROUND:Chronic idiopathic urticaria (CIU) impairs quality of life (QoL). Currently, no consensus exists regarding how second-generation H(1)-antihistamines (proven to control CIU symptoms) should be taken long-term: as daily treatment or only when symptoms return (PRN). We sought to determine which regimen improves...

    journal_title:Allergy

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1398-9995.2008.01913.x

    authors: Grob JJ,Auquier P,Dreyfus I,Ortonne JP

    更新日期:2009-04-01 00:00:00

  • Sub-lethal exposure of cockroaches to boric acid pesticide contributes to increased Bla g 2 excretion.

    abstract:BACKGROUND:Several epidemiology studies have found an increase in the major cockroach allergen Bla g 2 with reported pesticide use. AIMS OF THE STUDY:Our aim was to investigate the effect on the excretion of Bla g 1 and Bla g 2 allergens by cockroaches exposed to sub-lethal doses of the pesticides, boric acid and hydr...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2005.00814.x

    authors: Zhang YC,Perzanowski MS,Chew GL

    更新日期:2005-07-01 00:00:00

  • Inhibition of anti-IgE induced skin response in normals by formoterol, a new beta 2-adrenoceptor agonist, and terbutaline. 2. Effect on the late phase reaction.

    abstract::Formoterol, a new beta 2-selective long-acting bronchodilator, was compared with terbutaline in terms of ability to inhibit dual phase skin reactions to anti-human IgE in volunteers. Anti-IgE induced an early wheal and flare reaction (WFR) followed by a progressively increasing induration, the late phase reaction (LCR...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1990.tb00509.x

    authors: Grönneberg R,Zetterström O

    更新日期:1990-07-01 00:00:00

  • Impact of (bio)chemical and physical procedures on food allergen stability.

    abstract::A variety of methods have been used to attempt to decrease the allergenicity of food products, with highly variable success. Limited knowledge of allergen and epitope structures and the factors governing their stability may explain this, and the ensuing need for an empirical approach. A combined effort from a processi...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.2001.00917.x

    authors: Soler-Rivas C,Wichers HJ

    更新日期:2001-01-01 00:00:00

  • The hippo pathway effector Yes-associated protein promotes epithelial proliferation and remodeling in chronic rhinosinusitis with nasal polyps.

    abstract:BACKGROUND:Hippo-Yes-associated protein (YAP) pathway plays an important role in epithelial cell proliferation and development. However, its possible role in chronic rhinosinusitis with nasal polyps (CRSwNP) remains unknown. We aim to investigate it on nasal epithelial proliferation and remodeling in CRSwNP. METHODS:T...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.13647

    authors: Deng H,Sun Y,Wang W,Li M,Yuan T,Kong W,Huang X,Long Z,Chen Z,Wang D,Yang Q

    更新日期:2019-04-01 00:00:00

  • Flowcytometric diagnosis of atracurium-induced anaphylaxis.

    abstract:BACKGROUND:Allergy to atracurium is a rare condition with serious consequences of diagnostic error. However, correct diagnosis is not always straightforward. The aim of this study is to assess the utility of the basophil activation test (BAT) in atracurium sensitization and to investigate its role in identifying cross-...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.12468

    authors: Uyttebroek AP,Sabato V,Leysen J,Bridts CH,De Clerck LS,Ebo DG

    更新日期:2014-10-01 00:00:00

  • Comparison of olfactory function in patients with seasonal and perennial allergic rhinitis.

    abstract::Hyposmia is a common symptom in allergic rhinitis. However, little is known about differences in the olfactory function of patients with seasonal or perennial allergy. A prospective controlled study was performed on 28 patients with allergic rhinitis to grass pollen and on 47 patients with allergic rhinitis to mites. ...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1398-9995.1998.tb03890.x

    authors: Moll B,Klimek L,Eggers G,Mann W

    更新日期:1998-03-01 00:00:00

  • Comparative detection of mite allergens in house dust of homes in Moscow by enzyme-linked immunosorbent assay and acarologic analysis.

    abstract::The present study revealed that 73% of surveyed apartments in Moscow whose residents included children with the atopic form of bronchial asthma and sensitization to Dermatophagoides pteronyssinus allergens were infested with the pyroglyphid mites D. pteronyssinus and D. farinae. The number of mites in the surveyed apa...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1994.tb00780.x

    authors: Zheltikova TM,Ovsyannikova IG,Gervazieva VB,Platts-Mills TA,Chapman MD,Petrova-Nikitina AD,Stepanova GN

    更新日期:1994-12-01 00:00:00

  • TRPV1-mediated itch in seasonal allergic rhinitis.

    abstract:BACKGROUND:Patients with allergic rhinitis may be abnormally sensitive to stimulation of the ion channel transient receptor potential vanilloid-1 (TRPV1). AIM OF THE STUDY:To examine effects of various TRP ion channel activators on sensory symptoms in allergic rhinitis prior to and during seasonal allergen exposure. ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2009.01937.x

    authors: Alenmyr L,Högestätt ED,Zygmunt PM,Greiff L

    更新日期:2009-05-01 00:00:00

  • Occupational asthma caused by exposure to cyanoacrylate.

    abstract:BACKGROUND:Exposure to acrylates may give rise to rhinitis and asthma in both industrial and domestic environments. The mechanisms underlying these respiratory conditions caused by acrylates remain largely unknown. METHODS:We studied two assembly operators exposed to cyanoacrylate glue who developed rhinitis and asthm...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2001.056005446.x

    authors: Quirce S,Baeza ML,Tornero P,Blasco A,Barranco R,Sastre J

    更新日期:2001-05-01 00:00:00