Symptoms and immunologic markers induced by exposure to methyltetrahydrophthalic anhydride.

Abstract:

:A study was performed in 43 workers exposed to methyltetrahydrophthalic anhydride (MTHPA) used as a hardener in an epoxy resin system. Ten workers sensitized to MTHPA (group SS; presence of serum IgE antibodies against a conjugate of MTHPA and human serum albumin (HSA) detected by RAST) had significantly higher levels of tryptase in nasal lavage fluid than 19 nonsensitized workers with work-related nasal symptoms (group NS) and 14 nonsensitized workers without nasal symptoms (group NN). This suggests an ongoing mast-cell-mediated reaction in the sensitized group. No statistically significant differences were found in the three groups concerning eosinophil cationic protein (ECP) and TAME-activity in lavage fluid. However, there was a significant increase in serum ECP in the SS group, as compared with a group of unexposed controls. Nasal challenge with MTHPA-HSA, performed in a subsequent study in seven workers from the SS group, six from the NS group, and seven from the NN, caused a larger increase of symptom score and a more pronounced decrease in nasal inspiratory peak flow in the SS group than in the other two groups. No significant rise was recorded for tryptase and ECP in lavage fluid in any of the three groups after challenge. The combined results of the two studies indicate that specific IgE antibodies play a pathogenetic role in at least some of the cases of work-related nasal symptoms associated with MTHPA exposure.

journal_name

Allergy

journal_title

Allergy

authors

Nielsen J,Welinder H,Bensryd I,Andersson P,Skerfving S

doi

10.1111/j.1398-9995.1994.tb02661.x

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

281-6

issue

4

eissn

0105-4538

issn

1398-9995

journal_volume

49

pub_type

杂志文章

相关文献

ALLERGY文献大全
  • A 12-week DBPC dose-finding study with sublingual monomeric allergoid tablets in house dust mite-allergic patients.

    abstract:BACKGROUND:In sublingual immunotherapy, optimal doses are a key factor for therapeutic outcomes. The aim of this study with tablets containing carbamylated monomeric house dust mite allergoids was to determine the most effective and safe dose. METHODS:In this double-blind, placebo-controlled dose-finding study, 131 pa...

    journal_title:Allergy

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/all.12913

    authors: Hüser C,Dieterich P,Singh J,Shah-Hosseini K,Allekotte S,Lehmacher W,Compalati E,Mösges R

    更新日期:2017-01-01 00:00:00

  • Paranasal sinus pathology in allergic and non-allergic respiratory tract diseases.

    abstract::Two hundred and seventy patients with asthma and/or rhinitis (162 or 60% allergic, 108 or 40% non-allergic) were studied for sinus pathology by means of standard X-rays and tomograms. Sinus pathology was defined as abnormal sinus X-rays, either on standard or tomography. Fifty-four percent of the X-rays were classifie...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1986.tb00306.x

    authors: De Cleyn KM,Kersschot EA,De Clerck LS,Ortmanns PM,De Schepper AM,Van Bever HP,Stevens WJ

    更新日期:1986-07-01 00:00:00

  • Allergic respiratory disease: Different allergens, different symptoms.

    abstract:BACKGROUND:Spanish population is rather homogeneous in its genetic and sociocultural characteristics, but allergen sensitization shows wide geographical variations. We aimed at assessing whether sensitization to different allergens in the diverse geographical areas induced different clinical and quality-of-life charact...

    journal_title:Allergy

    pub_type: 杂志文章,多中心研究

    doi:10.1111/all.13141

    authors: Valero A,Quirce S,Dávila I,Delgado J,Domínguez-Ortega J

    更新日期:2017-09-01 00:00:00

  • Double-blind comparison of the protective effect of sodium cromoglycate and ketotifen on exercise-induced asthma in adults.

    abstract::In a double-blind double-placebo study 10 asthmatics exercised on a treadmill after treatment for 1 week with placebo, or ketotifen 1 mg twice daily, or SCG 10 mg four times daily. The post-exercise percentage fall in FEV1 after SCG but not after ketotifen was significantly smaller than after placebo. A 1-week treatme...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1987.tb02215.x

    authors: Tan WC,Lim TK

    更新日期:1987-05-01 00:00:00

  • Mite-allergen levels in Norwegian homes.

    abstract::The scarce data published on mite sensitization and mite-allergen levels in Norway indicate that the mites may not be of the same importance in allergic disease in Norway as in countries such as the UK and the rest of Europe. The problem also involves the low allergen levels and small amounts of dust collected for all...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.1998.tb04999.x

    authors: Gaarder PI

    更新日期:1998-01-01 00:00:00

  • Dependence of immediate hypersensitivity in the adolescent period on factors encountered in infancy.

    abstract::708 unselected adolescents 15-17 years old were studied. They were physically examined, interviewed and skin prick tested with 12 common allergens. Questionnaires were distributed to the adolescents and their parents to investigate past and present symptoms and environmental influences. Emphasis was on the first year ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1981.tb01573.x

    authors: Suoniemi I,Björkstén F,Haahtela T

    更新日期:1981-05-01 00:00:00

  • Airway wall geometry in asthma and nonasthmatic eosinophilic bronchitis.

    abstract:BACKGROUND:Variable airflow obstruction and airway hyperresponsiveness (AHR) are features of asthma, which are absent in nonasthmatic eosinophilic bronchitis (EB). Airway remodelling is characteristic of both conditions suggesting that remodelling and airway dysfunction are disassociated, but whether the airway geometr...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2009.01951.x

    authors: Siddiqui S,Gupta S,Cruse G,Haldar P,Entwisle J,Mcdonald S,Whithers PJ,Hainsworth SV,Coxson HO,Brightling C

    更新日期:2009-06-01 00:00:00

  • A specific mixture of short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides induces a beneficial immunoglobulin profile in infants at high risk for allergy.

    abstract:BACKGROUND:It has been suggested that human breast milk oligosaccharides play a role in the development of the immune system in infants, and may consequently inhibit the onset of allergy. A specific prebiotic mixture of short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides (GOS/FOS) has been shown...

    journal_title:Allergy

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.2008.01765.x

    authors: van Hoffen E,Ruiter B,Faber J,M'Rabet L,Knol EF,Stahl B,Arslanoglu S,Moro G,Boehm G,Garssen J

    更新日期:2009-03-01 00:00:00

  • Prevalence of food sensitization and probable food allergy among adults in India: the EuroPrevall INCO study.

    abstract:BACKGROUND:Data are lacking regarding the prevalence of food sensitization and probable food allergy among general population in India. We report the prevalence of sensitization and probable food allergy to 24 common foods among adults from general population in Karnataka, South India. METHODOLOGY:The study was conduc...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.12868

    authors: Mahesh PA,Wong GW,Ogorodova L,Potts J,Leung TF,Fedorova O,Holla AD,Fernandez-Rivas M,Clare Mills EN,Kummeling I,Versteeg SA,van Ree R,Yazdanbakhsh M,Burney P

    更新日期:2016-07-01 00:00:00

  • Efficacy of mequitazine in comparison with placebo assessed by ocular challenge with allergen in allergic conjunctivitis.

    abstract::Pharmacologic intervention in the management of allergic conjunctivitis was evaluated with different topical ocular agents in man. Their effect can be precisely assessed with the conjunctival provocation test (CPT). A potent specific H1-receptor antagonist, 0.05% mequitazine eye-drops, was tested in a double-blind ran...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1997.tb01028.x

    authors: Persi L,Dupin O,Arnaud B,Trinquand C,Michel FB,Bousquet J

    更新日期:1997-04-01 00:00:00

  • Sputum microbiomic clustering in asthma and chronic obstructive pulmonary disease reveals a Haemophilus-predominant subgroup.

    abstract:BACKGROUND:Airway ecology is altered in asthma and chronic obstructive pulmonary disease (COPD). Anti-microbial interventions might have benefit in subgroups of airway disease. Differences in sputum microbial profiles at acute exacerbation of airways disease are reflected by the γProteobacteria:Firmicutes (γP:F) ratio....

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14058

    authors: Diver S,Richardson M,Haldar K,Ghebre MA,Ramsheh MY,Bafadhel M,Desai D,Cohen ES,Newbold P,Rapley L,Rugman P,Pavord ID,May RD,Barer M,Brightling CE

    更新日期:2020-04-01 00:00:00

  • Helminths can protect themselves against rejection inhibiting hostile respiratory allergy symptoms.

    abstract::The ability of common environmental allergens to stimulate IgE responses and thus to produce allergic diseases has tended to overshadow the fact that helminthic parasites are possibly the most potent inducers of this immunoglobulin that exists in nature. Although it has been well established that during these infectio...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.2006.00983.x

    authors: Mingomataj EC,Xhixha F,Gjata E

    更新日期:2006-04-01 00:00:00

  • Allergen sensitization and exposure to irritants in infancy.

    abstract::We investigated the relationship between residence in the neighbourhood of an aluminium smelter and the prevalence of atopy in schoolchildren (7-13 years of age). Atopy was assessed in 556 of the 620 participants by a skin prick test with eight common aeroallergens. The median exposures to sulphur dioxide and fluoride...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:

    authors: Søyseth V,Kongerud J,Boe J

    更新日期:1996-10-01 00:00:00

  • Design, engineering and in vitro evaluation of MHC class-II targeting allergy vaccines.

    abstract:BACKGROUND:The worldwide increasing incidence of allergic diseases requires the development of new, efficient vaccination strategies, the only curative treatment with a long-lasting effect. Current allergen-specific immunotherapy protocols suffer from limited efficacy and a long treatment time. METHODS:We engineered m...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2006.01292.x

    authors: Crameri R,Flückiger S,Daigle I,Kündig T,Rhyner C

    更新日期:2007-02-01 00:00:00

  • Mast cell activation syndromes: definition and classification.

    abstract::Mast cell activation (MCA) occurs in a number of different clinical conditions, including IgE-dependent allergies, other inflammatory reactions, and mastocytosis. MCA-related symptoms may be mild, moderate, severe, or even life-threatening. The severity of MCA depends on a number of different factors, including geneti...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/all.12126

    authors: Valent P

    更新日期:2013-04-01 00:00:00

  • Long-term reduction in local inflammation by a lipid raft molecule in atopic dermatitis.

    abstract:BACKGROUND:The complex pathogenesis of atopic dermatitis (AD) is guided by cell surface receptor-mediated signal transduction regulated in lipid rafts. Miltefosine is a raft-modulating molecule targeting cell membranes. With this controlled clinical study, the clinical and immunomodulatory efficacy of miltefosine was i...

    journal_title:Allergy

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.2010.02341.x

    authors: Dölle S,Hoser D,Rasche C,Loddenkemper C,Maurer M,Zuberbier T,Worm M

    更新日期:2010-09-01 00:00:00

  • Airway expression of calcitonin gene-related peptide in T-cell peptide-induced late asthmatic reactions in atopics.

    abstract:BACKGROUND:The mechanisms of late asthmatic reactions provoked in atopic asthmatics by allergen-derived T-cell peptide epitopes remain unclear. Previous studies showed no changes in airway eosinophils or mast cell products after peptide challenge. In the present study our aim was to measure calcitonin gene-related pept...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2007.01342.x

    authors: Kay AB,Ali FR,Heaney LG,Benyahia F,Soh CP,Renz H,Lee TH,Larché M

    更新日期:2007-05-01 00:00:00

  • Cost-effectiveness of budesonide/formoterol for maintenance and reliever asthma therapy.

    abstract:BACKGROUND:Budesonide/formoterol (Symbicort) Maintenance and Reliever Therapy (SMART) is an effective asthma-management approach that treats symptoms with rapid increases in budesonide/formoterol. The cost-effectiveness of SMART vs higher fixed-dose budesonide/formoterol or salmeterol/fluticasone is unknown. METHODS:T...

    journal_title:Allergy

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1398-9995.2007.01466.x

    authors: Price D,Wirén A,Kuna P

    更新日期:2007-10-01 00:00:00

  • Molecular cloning, purification, and IgE-binding of a recombinant class I chitinase from Hevea brasiliensis leaves (rHev b 11.0102).

    abstract:BACKGROUND:Class I chitinase in natural rubber latex (NRL) has been assumed to be an important allergen, especially concerning its cross-reactivity with fruits like avocado and banana. OBJECTIVES:The present study aimed to produce a recombinant latex class I chitinase from Hevea brasiliensis leaves and to study its im...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2003.00058.x

    authors: Rihs HP,Dumont B,Rozynek P,Lundberg M,Cremer R,Brüning T,Raulf-Heimsoth M

    更新日期:2003-03-01 00:00:00

  • Gender and occupational allergy: Report from the task force of the EAACI Environmental and Occupational Allergy Interest Group.

    abstract::Women's work has traditionally been considered less hazardous to health in comparison with men's work. The increased women's participation in the workforce has led to an increased attention to women's working conditions. Women and men are unequally represented in individual professions or sectors (horizontal segregati...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14317

    authors: Moscato G,Apfelbacher C,Brockow K,Eberle C,Genuneit J,Mortz CG,Quecchia C,Quirce S,Siracusa A,Tarlo SM,van Kampen V,Walusiak-Skorupa J,Raulf M

    更新日期:2020-11-01 00:00:00

  • Identification of allergen components of the opportunistic yeast Pityrosporum orbiculare by monoclonal antibodies.

    abstract::The yeast Pityrosporum orbiculare (P. orbiculare) is a member of the normal human cutaneous flora, but it is also associated with several clinical manifestations of the skin. We have previously observed IgE-binding components in P. orbiculare extracts, using sera from patients with atopic dermatitis. In the present st...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1994.tb00773.x

    authors: Zargari A,Härfast B,Johansson S,Johansson SG,Scheynius A

    更新日期:1994-01-01 00:00:00

  • A population-based epidemiologic analysis of deaths from anaphylaxis in Florida.

    abstract:BACKGROUND:Previous US population-based epidemiologic studies of anaphylactic deaths have been limited by small populations and/or few deaths. The objective of this study was to determine the 10-year incidence of death from anaphylaxis in Florida and its descriptive epidemiology. METHODS:Patients who died from anaphyl...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2008.01737.x

    authors: Simon MR,Mulla ZD

    更新日期:2008-08-01 00:00:00

  • Treatment of acute bronchoconstriction in children with use of a tube spacer aerosol and a dry powder inhaler.

    abstract::In a double blind cross-over study 24 children suffering from acute bronchoconstriction were treated with either placebo, or terbutaline delivered by a pressurized aerosol with a tube spacer (TS), or salbutamol from a dry powder inhaler (Rotahaler = RO). Both active treatments resulted in a significant increase in FEV...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1985.tb00236.x

    authors: Pedersen S

    更新日期:1985-05-01 00:00:00

  • Effects of in vitro treatment with fluticasone propionate on natural killer and lymphokine-induced killer activity in asthmatic and healthy individuals.

    abstract:BACKGROUND:Topical corticosteroids are beneficial in the treatment of allergic respiratory disorders; they exert effects on a number of cells involved in allergic inflammatory reactions. On the other hand, major histocompatibility complex (MHC)-unrestricted cytotoxicity (i.e., natural killer [NK] cell activity) may pla...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2001.00879.x

    authors: Di Lorenzo G,Esposito Pellitteri M,Drago A,Di Blasi P,Candore G,Balistreri C,Listi F,Caruso C

    更新日期:2001-04-01 00:00:00

  • Mutational spectrum and phenotypes in Danish families with hereditary angioedema because of C1 inhibitor deficiency.

    abstract:BACKGROUND:Hereditary angioedema (HAE), type I and II, is an autosomal dominant disease with deficiency of functional C1 inhibitor protein causing episodic swellings of skin, mucosa and viscera. HAE is a genetically heterogeneous disease with more than 200 different mutations in the SERPING1 gene. A genotype-phenotype ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2010.02456.x

    authors: Bygum A,Fagerberg CR,Ponard D,Monnier N,Lunardi J,Drouet C

    更新日期:2011-01-01 00:00:00

  • Allergy to latex condoms.

    abstract::This study delineates the prevalence of reactions to condoms among latex-allergic patients seen in allergy consultation services since 1987. Questionnaires were mailed to 374 patients previously found to have clinically significant allergy to latex. Of these, only 238 completed the questionnaire. The respondents we...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1998.tb03827.x

    authors: Levy DA,Khouader S,Leynadier F

    更新日期:1998-11-01 00:00:00

  • Increased prevalence of atopy among children exposed to mold in a school building.

    abstract:BACKGROUND:The purpose of this study was to assess the occurrence of immunoglobulin E sensitization to common environmental allergens (atopy) and new allergic diseases among schoolchildren after starting school in a water-damaged school building. The staff and pupils of a Finnish elementary school with visible water da...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2001.056002175.x

    authors: Savilahti R,Uitti J,Roto P,Laippala P,Husman T

    更新日期:2001-02-01 00:00:00

  • Downregulation of polymeric immunoglobulin receptor and secretory IgA antibodies in eosinophilic upper airway diseases.

    abstract:BACKGROUND:Immunoglobulin (Ig) A represents a first-line defence mechanism in the airways, but little is known regarding its implication in upper airway disorders. This study aimed to address the hypothesis that polymeric Ig receptor (pIgR)-mediated secretory IgA immunity could be impaired in chronic upper airway disea...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.12274

    authors: Hupin C,Rombaux P,Bowen H,Gould H,Lecocq M,Pilette C

    更新日期:2013-12-01 00:00:00

  • Heat treatment modifies the allergenicity of beef and bovine serum albumin.

    abstract::The effect of heat on the allergenicity of beef and bovine serum albumin was investigated among 10 toddlers skin prick test (SPT)-positive to raw and cooked beef. The meat-allergy diagnosis was confirmed during double-blind, placebo-controlled food challenge (DBPCFC) with 180 g of beef cooked for 5 min at 100 degrees ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1998.tb03977.x

    authors: Fiocchi A,Restani P,Riva E,Mirri GP,Santini I,Bernardo L,Galli CL

    更新日期:1998-08-01 00:00:00

  • A potential new target for asthma therapy: a disintegrin and metalloprotease 10 (ADAM10) involvement in murine experimental asthma.

    abstract:BACKGROUND:Elevated levels of CD23, a natural regulator of IgE production, have been shown to decrease the signs of lung inflammation in mice. The aim of this study was to study the involvement of ADAM10, the primary CD23 sheddase, in experimental asthma. METHODS:ADAM10 was blocked either by using mice with a B-cell-s...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2011.02614.x

    authors: Mathews JA,Ford J,Norton S,Kang D,Dellinger A,Gibb DR,Ford AQ,Massay H,Kepley CL,Scherle P,Keegan AD,Conrad DH

    更新日期:2011-09-01 00:00:00