Can food allergy be cured? What are the future prospects?

abstract：BACKGROUND:Serum immunoglobulin E (IgE) level is recognized to be under strong genetic control, but the causal and susceptibility genes remain to be identified. We sought to investigate the association between single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway and total serum IgE l...

journal_title：Allergy

authors： Tewfik MA,Bossé Y,Lemire M,Hudson TJ,Vallée-Smejda S,Al-Shemari H,Laprise C,Desrosiers M

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:IgE-independent (pseudoallergic) reactions to food and food ingredients are common in a subgroup of adult patients with chronic urticaria, who have daily spontaneous occurrence of wheals. However, for children with chronic urticaria (duration longer than 6 weeks, no physical influence), no data on the import...

journal_title：Allergy

authors： Ehlers I,Niggemann B,Binder C,Zuberbier T

更新日期：1998-11-01 00:00:00

abstract：:For almost 4 years, the stability of Der p I was assessed by RAST inhibition in house-dust samples incubated under simulated domestic conditions (5 or 25 degrees C and 75% relative humidity). Der p I concentrations were determined before heating dust samples at 60 degrees C to kill the mites, and at 0, 6, 14, 21, and ...

journal_title：Allergy

authors： Kort HS,Kniest FM

更新日期：1994-02-01 00:00:00

abstract：:The yeast Pityrosporum orbiculare (P. orbiculare) is a member of the normal human cutaneous flora, but it is also associated with several clinical manifestations of the skin. We have previously observed IgE-binding components in P. orbiculare extracts, using sera from patients with atopic dermatitis. In the present st...

journal_title：Allergy

authors： Zargari A,Härfast B,Johansson S,Johansson SG,Scheynius A

更新日期：1994-01-01 00:00:00

abstract：:Cocksfoot/orchard grass (Dactylis glomerata) anther cDNA clones encoding the group II allergen Dac g II were previously isolated on the basis of immunoreactivity of human, rabbit, and murine antibodies with a 24-kDa protein expressed as a fusion protein with beta-galactosidase. Nucleotide sequencing reveals an open re...

journal_title：Allergy

authors： Roberts AM,Bevan LJ,Flora PS,Jepson I,Walker MR

更新日期：1993-11-01 00:00:00

abstract：:Ten patients with bronchial asthma reacting with bronchoconstriction after exercise were studied to compare the effect of oral sodium cromoglycate against sodium cromoglycate inhalation and placebo. Only sodium cromoglycate inhalations protected against exercise-induced asthma. The effect of sodium cromoglycate seems ...

journal_title：Allergy

authors： Dahl R,Henriksen JM

更新日期：1980-06-01 00:00:00

abstract：:The mucosal plasma exudate with its proteins, enzymes, derived peptides, and matrix molecules is an important factor in inflammatory airway diseases. This study investigated whether topical glucocorticosteroid treatment influences mucosal exudation of bulk plasma (fibrinogen) and the generation of plasma-derived media...

journal_title：Allergy

authors： Svensson C,Klementsson H,Andersson M,Pipkorn U,Alkner U,Persson CG

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:The inflammation of atopic eczema (AE) is orchestrated not only by T cells predominantly but also B cells, eosinophils and dendritic cells. Recently, a role of invariant natural killer T (NKT) cells has been reported in bronchial asthma and allergy. Natural killer T cells express a restricted repertoire of T...

journal_title：Allergy

authors： Simon D,Kozlowski E,Simon H

更新日期：2009-11-01 00:00:00

abstract：:The pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused an unprecedented global social and economic impact, and high numbers of deaths. Many risk factors have been identified in the progression of COVID-19 into a severe and critical st...

journal_title：Allergy

authors： Gao YD,Ding M,Dong X,Zhang JJ,Kursat Azkur A,Azkur D,Gan H,Sun YL,Fu W,Li W,Liang HL,Cao YY,Yan Q,Cao C,Gao HY,Brüggen MC,van de Veen W,Sokolowska M,Akdis M,Akdis CA

更新日期：2020-11-13 00:00:00

abstract：BACKGROUND:Recent studies showed the presence of a unique dust-mite fauna in the indoor environment of Singapore. Immediate hypersensitivity to these dust mites, along with other known indoor allergens, may play a role in the pathogenesis of allergic respiratory diseases. This study evaluated the sensitization rates of...

journal_title：Allergy

authors： Chew FT,Lim SH,Goh DY,Lee BW

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Filaggrin gene (FLG) mutations contribute to the development of eczema and asthma, but their contribution to sensitization and hay fever remains unclear. METHODS:FLG mutations R501X, 2282del4 and R2447X were genotyped in the Prevention and Incidence of Asthma and Mite Allergy birth cohort (n = 934) to evalu...

journal_title：Allergy

authors： Schuttelaar ML,Kerkhof M,Jonkman MF,Koppelman GH,Brunekreef B,de Jongste JC,Wijga A,McLean WH,Postma DS

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:There is strong evidence that reduced exposures to microbial compounds triggering innate immune responses early in life are critical for the development of allergic illnesses. The underlying mechanisms remain unknown, but will include T-cell responses either along T helper type 1 (Th1)/Th2 pathways or via T ...

journal_title：Allergy

authors： Schaub B,Liu J,Schleich I,Höppler S,Sattler C,von Mutius E

更新日期：2008-11-01 00:00:00

abstract：:Enzymes can cause allergic asthma and rhinitis. Although patients sometimes complain of symptoms in their throat, we have not been able to find any published report of pharyngeal edema caused by exposure to enzymes. We present the case of a maintenance foreman who worked in a factory producing enzymes, and who had pha...

journal_title：Allergy

authors： Hytönen M,Vanhanen M,Keskinen H,Tuomi T,Tupasela O,Nordman H

更新日期：1994-10-01 00:00:00

abstract：:A one-day intensive educational course on allergy and immunology theory and diagnostic procedure significantly increased the competency of allergy and immunology fellows-in-training. ...

journal_title：Allergy

authors： Elizalde A,Perez EE,Sriaroon P,Nguyen D,Lockey RF,Dorsey MJ

更新日期：2012-09-01 00:00:00

abstract：:Airway remodeling is a central feature of asthma. It is exemplified by thickening of the lamina reticularis and structural changes to the epithelium, submucosa, smooth muscle, and vasculature of the airway wall. Airway remodeling may result from persistent airway inflammation. Immunoglobulin E (IgE) is an important me...

journal_title：Allergy

authors： Rabe KF,Calhoun WJ,Smith N,Jimenez P

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Several studies showed that calcium-binding proteins have a fixed place in the spectrum of allergenic substances. Often the binding of a calcium ion induces conformational changes and affects immunoglobulin E-binding to the allergen. Hence, the quantitative characterization of the binding to calcium is of im...

journal_title：Allergy

authors： Hebenstreit D,Ferreira F

更新日期：2005-09-01 00:00:00

abstract：:We measured the IgG subclass antibody levels to wheat flour in 42 bakers and 20 controls with an enzyme immunoassay. The levels of total IgG, IgG1 IgG2 and IgG4 antibodies were significantly higher in the bakers than in the unexposed controls. The presence of anti-wheat flour IgG subclass antibodies in the bakers was ...

journal_title：Allergy

authors： Tiikkainen U,Klockars M

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:The anti-inflammatory peptide, adrenomedullin (AM), and its cognate receptor are expressed in lung tissue, but its pathophysiological significance in airway inflammation is unknown. OBJECTIVES:This study investigated whether allergen-induced airway inflammation involves an impaired local AM response. METHO...

journal_title：Allergy

authors： Hagner S,Welz H,Kicic A,Alrifai M,Marsh LM,Sutanto EN,Ling KM,Stick SM,Müller B,Weissmann N,Renz H

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Clinical tools for predicting poor outcomes in asthma patients are lacking. This study investigated the association of asthma control and subsequent severe asthma-related healthcare events in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. METHODS:The extent of...

journal_title：Allergy

authors： Sullivan SD,Wenzel SE,Bresnahan BW,Zheng B,Lee JH,Pritchard M,Kamath TV,Weiss ST,TENOR Study Group.

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Chronic rhinosinusitis (CRS) epidemiology has been largely studied using symptom-based case definitions, without assessment of objective sinus findings. OBJECTIVE:To describe radiologic sinus opacification and the prevalence of CRS, defined by the co-occurrence of symptoms and sinus opacification, in a gene...

journal_title：Allergy

authors： Hirsch AG,Nordberg C,Bandeen-Roche K,Tan BK,Schleimer RP,Kern RC,Sundaresan A,Pinto JM,Kennedy TL,Greene JS,Kuiper JR,Schwartz BS

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:New therapies are necessary to address inadequate asthma control in many patients. This study sets out to investigate whether hypoxia-inducible factor (HIF) is essential for development of allergic airway inflammation (AAI) and therefore a potential novel target for asthma treatment. METHODS:Mice conditiona...

journal_title：Allergy

authors： Huerta-Yepez S,Baay-Guzman GJ,Bebenek IG,Hernandez-Pando R,Vega MI,Chi L,Riedl M,Diaz-Sanchez D,Kleerup E,Tashkin DP,Gonzalez FJ,Bonavida B,Zeidler M,Hankinson O

更新日期：2011-07-01 00:00:00

abstract：:A total of 109 subjects reporting symptoms indicating type I hypersensitivity reactions to natural rubber latex (NRL) gloves was included in this study, and 66 of them had latex-specific IgE antibodies. They underwent provocation tests by wearing two types of NRL gloves with high (n=103) and low (n=75) allergen conten...

journal_title：Allergy

authors： Baur X,Chen Z,Allmers H,Raulf-Heimsoth M

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:Recent evidence indicates that Staphylococcus aureus, one of the most important human pathogens, secretes vesicles into the extracellular milieu. OBJECTIVE:To evaluate whether inhalation of S. aureus-derived extracellular vesicles (EV) is causally related to the pathogenesis of inflammatory pulmonary diseas...

journal_title：Allergy

authors： Kim MR,Hong SW,Choi EB,Lee WH,Kim YS,Jeon SG,Jang MH,Gho YS,Kim YK

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Exposure to environmental endocrine-disrupting chemicals (EDCs) is associated with allergy, chronic inflammation, and immunodeficiency. Phthalates, the common EDCs used in plastic industry, may act as adjuvants to disrupt immune system and enhance allergy. Plasmacytoid DCs (pDCs) are predominant cells secret...

journal_title：Allergy

authors： Kuo CH,Hsieh CC,Kuo HF,Huang MY,Yang SN,Chen LC,Huang SK,Hung CH

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Skin prick tests (SPTs) play an important role in the diagnosis of baker's asthma and in the investigation of sensitization frequencies in field studies. It was the aim of our study to compare different SPT solutions for wheat and rye flour sensitization and to assess the validity of test results. METHODS:S...

journal_title：Allergy

authors： Sander I,Merget R,Degens PO,Goldscheid N,Brüning T,Raulf-Heimsoth M

更新日期：2004-01-01 00:00:00

abstract：:In recent years, significant attention has been paid to the use of biotechnology to improve the quality and quantity of the food supply due in part to the projected growth in the world population, plus limited options available for increasing the amount of land under cultivation. Alterations in the food supply induced...

journal_title：Allergy

authors： Lehrer SB,Bannon GA

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:We report a series of 24 health-care workers with respiratory symptoms suggestive of occupational asthma due to glutaraldehyde exposure. METHODS:The history of asthmatic symptoms was investigated with peak expiratory flow rate (PEFR) monitoring, and in eight of the subjects, the specific bronchial provocati...

journal_title：Allergy

authors： Di Stefano F,Siriruttanapruk S,McCoach J,Burge PS

更新日期：1999-10-01 00:00:00

abstract：:The prevalence of allergic rhinitis (AR) has witnessed a progressive increase in China. A survey of self-reported AR using validated questionnaire-based telephone interviews in adult subjects conducted between 2004 and 2005 demonstrated that the prevalence of AR in 11 major cities across China was 11.1%1 . A subsequen...

journal_title：Allergy

authors： Xian M,Zhang L

更新日期：2020-08-02 00:00:00

abstract：BACKGROUND:Patients with nonallergic asthma frequently show autoreactivity as do subjects with chronic urticaria (CU). Activation of the coagulation cascade and hyper-expression of vascular endothelial growth factor (VEGF) were recently found in CU, and there is sparse evidence that the same may occur in asthma. OBJEC...

journal_title：Allergy

authors： Asero R,Tedeschi A,Cugno M

更新日期：2011-10-01 00:00:00

abstract：:Eighteen children with perennial asthma and allergy to house-dust mite (HDM) underwent a bronchial challenge with HDM. Before and 24 h after the test, a venous blood sample was taken to determine levels of eosinophils, eosinophil cationic protein (ECP), soluble interleukin-2 receptor (IL-2R), and interleukin-6 (IL-6)....

journal_title：Allergy

authors： Van Bever HP,Moens MM,Bridts CH,De Clerck LS,Mertens AV,Bosmans E,Stevens WJ

更新日期：1993-08-01 00:00:00