Sub-lethal exposure of cockroaches to boric acid pesticide contributes to increased Bla g 2 excretion.

Abstract:

BACKGROUND:Several epidemiology studies have found an increase in the major cockroach allergen Bla g 2 with reported pesticide use. AIMS OF THE STUDY:Our aim was to investigate the effect on the excretion of Bla g 1 and Bla g 2 allergens by cockroaches exposed to sub-lethal doses of the pesticides, boric acid and hydramethylnon gel. METHODS:German cockroaches in separate colonies were fed either boric acid or hydramethylnon gel at concentrations of 0.2, 0.1 and 0.01% in their water supply over a 2 week period. Ten colonies were exposed to each treatment concentration. Bla g 1 and Bla g 2 in fecal pellets were measured by ELISA. RESULTS:Cockroaches exposed to boric acid excreted fecal pellets with significantly higher concentrations of Bla g 2 (35,400 U/g) than did controls (12,700 U/g) (P = 0.001). Bla g 1 concentrations were not significantly different. There was no difference in either Bla g 1 or Bla g 2 concentrations between cockroaches that ingested hydramethylnon gel and those in the controls colonies. CONCLUSIONS:The application of boric acid, a common pesticide, appears to paradoxically increase the production of Bla g 2, a major allergen, by the surviving cockroaches. This may have important implications in avoidance strategies.

journal_name

Allergy

journal_title

Allergy

authors

Zhang YC,Perzanowski MS,Chew GL

doi

10.1111/j.1398-9995.2005.00814.x

keywords:

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

965-8

issue

7

eissn

0105-4538

issn

1398-9995

pii

ALL814

journal_volume

60

pub_type

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