Inhibitory effect of aerosol WP871 on SRS-A mediated bronchoconstriction in the guinea pig in vivo.

Abstract:

:Slow-reacting substance of anaphylaxis (SRS-A) is an important factor mediating bronchoconstriction in asthma. We developed a guinea pig model for SRS-A mediated bronchoconstriction induced by antigen inhalation. Using this model, we investigated the effect of inhaled WP871, a new anti-allergic drug, on bronchoconstriction. Aerosol WP871 (0.01 and 0.033%) to some extent inhibited the antigen-induced bronchoconstriction in a dose-dependent fashion, but high-dose WP871 (0.1%) inhalation itself produced a non-specific bronchoconstriction. However, aerosol WP871 (0.033%) showed no inhibitory effect on bronchoconstriction caused by direct inhalation of leukotriene C4, a component of SRS-A. These findings indicate that aerosol WP871 does not antagonize SRS-A, but inhibits synthesis and/or release of SRS-A and has some non-specific bronchoconstrictive effect in high concentration.

journal_name

Allergy

journal_title

Allergy

authors

Kurashima K,Fujimura M,Saito M,Sakamoto S,Miyake Y,Nishi K,Matsuda T

doi

10.1111/j.1398-9995.1990.tb00492.x

subject

Has Abstract

pub_date

1990-05-01 00:00:00

pages

249-53

issue

4

eissn

0105-4538

issn

1398-9995

journal_volume

45

pub_type

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