Abstract:
:Slow-reacting substance of anaphylaxis (SRS-A) is an important factor mediating bronchoconstriction in asthma. We developed a guinea pig model for SRS-A mediated bronchoconstriction induced by antigen inhalation. Using this model, we investigated the effect of inhaled WP871, a new anti-allergic drug, on bronchoconstriction. Aerosol WP871 (0.01 and 0.033%) to some extent inhibited the antigen-induced bronchoconstriction in a dose-dependent fashion, but high-dose WP871 (0.1%) inhalation itself produced a non-specific bronchoconstriction. However, aerosol WP871 (0.033%) showed no inhibitory effect on bronchoconstriction caused by direct inhalation of leukotriene C4, a component of SRS-A. These findings indicate that aerosol WP871 does not antagonize SRS-A, but inhibits synthesis and/or release of SRS-A and has some non-specific bronchoconstrictive effect in high concentration.
journal_name
Allergyjournal_title
Allergyauthors
Kurashima K,Fujimura M,Saito M,Sakamoto S,Miyake Y,Nishi K,Matsuda Tdoi
10.1111/j.1398-9995.1990.tb00492.xsubject
Has Abstractpub_date
1990-05-01 00:00:00pages
249-53issue
4eissn
0105-4538issn
1398-9995journal_volume
45pub_type
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