Lymphocyte proliferative responses to the purified Dermatophagoides farinae major allergen in untreated and hyposensitized atopic patients.

Abstract:

:We investigated the proliferative response of lymphocytes from mite-sensitive patients (RAST D.far greater than 3.5 PRU/ml) in the presence of the major allergen Der.f.I purified from Dermatophagoides farinae. Comparative studies were carried out with peripheral blood mononuclear cells from non-atopic donors (RAST = 0), and from patients undergoing hyposensitization treatment (5 to 24 months). According to Student's t-test, there was no significant difference in the Der.f.I-induced proliferation of peripheral blood mononuclear cells from normal donors, untreated atopic patients and hyposensitized patients. In conclusion, it was impossible to discriminate between normal donors, atopic patients and hyposensitized patients with regard to their circulating lymphocyte responses to the purified major allergen Der.f.I.

journal_name

Allergy

journal_title

Allergy

authors

Cavaillon JM,Fitting C,Guinnepain MT,Rassemont R,David B

doi

10.1111/j.1398-9995.1988.tb00409.x

subject

Has Abstract

pub_date

1988-02-01 00:00:00

pages

146-51

issue

2

eissn

0105-4538

issn

1398-9995

journal_volume

43

pub_type

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