Abstract:
:Standardized bronchial allergen provocation with the same individual allergen dose was performed 3-9 times in 20 symptomless adult asthmatic patients at intervals of 1 week or more during 1/2-22 months in order to study variations in bronchial response. The immediate type reaction was recorded by monitoring FEV1, FVC, PEFR and MEF50% for 30-40 min after provocation. FEV1 was highly significantly correlated to the other variables. The coefficient of variation corresponding to maximum decrease in FEV1 was 23%. All provocations were followed by a bronchial reaction within clinically acceptable limits. There was no indication of hypo- or hypersensitization. It is concluded that although many different factors influence the bronchial response, careful standardization of the provocation procedure leads to a moderate variation in bronchial response, making the allergen provocation test suitable for pathophysiological studies and clinical evaluation of anti-asthmatic drugs.
journal_name
Allergyjournal_title
Allergyauthors
Loẅhagen O,Lindholm NBdoi
10.1111/j.1398-9995.1980.tb01777.xsubject
Has Abstractpub_date
1980-06-01 00:00:00pages
349-56issue
4eissn
0105-4538issn
1398-9995journal_volume
35pub_type
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