Role of comorbid conditions in asthma hospitalizations in the south of France.


BACKGROUND:Reasons for asthma hospitalizations are dynamic and complex. Comorbid conditions are important contributors to most chronic diseases today. We aim to characterize and describe risk factors associated with hospitalizations due to asthma in the Languedoc-Roussillon region (France) in 2009. METHODS:Programme de Médicalisation des Systèmes d'Information (PMSI) data records from 2009 were sorted using selected International Classification of Diseases (ICD10) codes eliciting three groups of asthma hospitalizations according to acute severity. All available data including demographics, comorbid conditions, past hospitalizations either related or unrelated to asthma, seasonality and distance to medical facilities were used to compare the subjects within the three groups. RESULTS:One thousand two hundred and eighty-nine hospitalizations due to asthma exacerbation were found, concerning 1122 patients. We observed significant differences within the groups, using univariate analysis, concerning duration of hospitalizations (mean ± SD, 4.9 ± 5.9 days vs 6.4 ± 6.8 vs 15.8 ± 16.8, P < 0.001), deaths (percentage, 0.03% vs 1.50% vs 9.20%, P < 0.001) and numbers of comorbid conditions (0.80 ± 0.95 vs 0.75 ± 0.97 vs 1.74 ± 1.36, P < 0.001). Recurrent admissions for asthma during the period 2006-2008 were significantly more frequent in the more severe group (1.93 ± 3.91 vs 2.56 ± 4.47 vs 2.81 ± 3.97, P = 0.006). In the multivariate model, age and number of comorbid conditions were independently associated with severe hospitalizations and deaths. CONCLUSIONS:Asthma hospitalizations can be appropriately assessed using PMSI coding databases. In this study, age and the presence of comorbid conditions are the major risk factors for asthma hospitalizations and deaths.






Aubas C,Bourdin A,Aubas P,Gamez AS,Halimi L,Vachier I,Malafaye N,Chanez P,Molinari N




Has Abstract


2013-01-01 00:00:00














  • Atopy and asthma in rural Poland: a paradigm for the emergence of childhood respiratory allergies in Europe.

    abstract:BACKGROUND:We hypothesized that, in south-west Poland, a 'rural' protective effect on atopy and respiratory allergies would be most pronounced among children but that at all ages would be stronger among those with a rural background. METHODS:A cross-sectional survey of the inhabitants (age >5 years, n = 1657) of Sobot...


    pub_type: 杂志文章


    authors: Sozanska B,Macneill SJ,Kajderowicz-Kowalik M,Danielewicz H,Wheatley M,Newman Taylor AJ,Boznanski A,Cullinan P

    更新日期:2007-04-01 00:00:00

  • Safety of triflusal (antiplatelet drug) in patients with aspirin-exacerbated respiratory diseases.

    abstract:BACKGROUND AND AIMS:Aspirin, a cyclo-oxygenase (COX)-1 and COX-2 inhibitor, is the antiplatelet drug of choice to prevent serious vascular events. Adverse reactions to aspirin are frequent particularly among patients with asthma, chronic rhinosinusitis and nasal polyps. COX-1 inhibitors but not COX-2 inhibitors precipi...


    pub_type: 杂志文章,随机对照试验


    authors: Fraj J,Valero A,Vives R,Pérez I,Borja J,Izquierdo I,Picado C

    更新日期:2008-01-01 00:00:00

  • Comparison of sputum-ECP levels in bronchial asthma and chronic bronchitis.

    abstract::Eosinophil cationic protein (ECP) is a cationic protein secreted by eosinophils with toxic properties for the respiratory epithelium. Sputum-ECP levels have been shown to correlate inversely with airflow obstruction in asthma. In the present study we investigated whether ECP concentrations are different between asthma...


    pub_type: 杂志文章


    authors: Virchow JC Jr,Kroegel C,Hage U,Kortsik C,Matthys H,Werner P

    更新日期:1993-01-01 00:00:00

  • Allergen-induced mediator release tests.

    abstract::The diagnosis of allergic reactions in clinical practice is based on both clinical history and the determination of specific immunoglobulin E (IgE), either in the serum or on skin mast cells. However, for various reasons, identification of the causative factors is not possible in all the cases. Moreover, not all aller...


    pub_type: 杂志文章,评审


    authors: Demoly P,Lebel B,Arnoux B

    更新日期:2003-07-01 00:00:00

  • Differential pattern of CCR1 internalization in human eosinophils: prolonged internalization by CCL5 in contrast to CCL3.

    abstract:BACKGROUND:Whereas recent studies underlie the fundamental importance of the CC chemokine receptor 3 (CCR3) for the recruitment of eosinophils in allergic diseases, controversial data exist about the relevance of CCR1 on eosinophils. Therefore, the purpose of this study was to investigate the expression and regulation ...


    pub_type: 杂志文章


    authors: Elsner J,Dulkys Y,Gupta S,Escher SE,Forssmann WG,Kapp A,Forssmann U

    更新日期:2005-11-01 00:00:00

  • Ragweed pollen collected along high-traffic roads shows a higher allergenicity than pollen sampled in vegetated areas.

    abstract:BACKGROUND:Pollutants may affect pollen allergenicity and thus the prevalence of allergies. Although a few studies are available in literature, the connection between pollution and the allergenic potential of pollen has yet to be clearly defined. The objective of this study was to evaluate the effect of traffic-related...


    pub_type: 杂志文章


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    更新日期:2012-07-01 00:00:00

  • Structural changes in calcium-binding allergens: use of circular dichroism to study binding characteristics.

    abstract:BACKGROUND:Several studies showed that calcium-binding proteins have a fixed place in the spectrum of allergenic substances. Often the binding of a calcium ion induces conformational changes and affects immunoglobulin E-binding to the allergen. Hence, the quantitative characterization of the binding to calcium is of im...


    pub_type: 杂志文章


    authors: Hebenstreit D,Ferreira F

    更新日期:2005-09-01 00:00:00

  • New European Academy of Allergy and Clinical Immunology definition on pollen season mirrors symptom load for grass and birch pollen-induced allergic rhinitis.

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    pub_type: 杂志文章


    authors: Karatzas K,Katsifarakis N,Riga M,Werchan B,Werchan M,Berger U,Pfaar O,Bergmann KC

    更新日期:2018-09-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Breiteneder H,Peng YQ,Agache I,Diamant Z,Eiwegger T,Fokkens WJ,Traidl-Hoffmann C,Nadeau K,O'Hehir RE,O'Mahony L,Pfaar O,Torres MJ,Wang DY,Zhang L,Akdis CA

    更新日期:2020-09-07 00:00:00

  • Protein phosphatase 5 mediates corticosteroid insensitivity in airway smooth muscle in patients with severe asthma.

    abstract:BACKGROUND:The mechanisms driving glucocorticoid (GC) insensitivity in patients with severe asthma are still unknown. Recent evidence suggests the existence of GC-insensitive pathways in airway smooth muscle (ASM) caused by a defect in GC receptor (GRα) function. We examined whether other mechanisms could potentially e...


    pub_type: 杂志文章


    authors: Chachi L,Abbasian M,Gavrila A,Alzahrani A,Tliba O,Bradding P,Wardlaw AJ,Brightling C,Amrani Y

    更新日期:2017-01-01 00:00:00

  • MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation.

    abstract::Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient empowerment. MASK-rh...


    pub_type: 杂志文章,评审


    authors: Bousquet J,Schunemann HJ,Fonseca J,Samolinski B,Bachert C,Canonica GW,Casale T,Cruz AA,Demoly P,Hellings P,Valiulis A,Wickman M,Zuberbier T,Bosnic-Anticevitch S,Bedbrook A,Bergmann KC,Caimmi D,Dahl R,Fokkens WJ,Gris

    更新日期:2015-11-01 00:00:00

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    abstract:BACKGROUND:The differential diagnosis of eosinophilic gastroenteritis (EG) includes, among other diseases, parasitic infections such as anisakiasis, which has acquired worldwide importance. METHODS:We reviewed all patients referred to our allergy service who had been diagnosed as having primary EG to determine the pos...


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    authors: Gómez B,Tabar AI,Tuñón T,Larrínaga B,Alvarez MJ,García BE,Olaguibel JM

    更新日期:1998-12-01 00:00:00

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    authors: Pignatti P,Perfetti L,Galdi E,Pozzi V,Bossi A,Biale C,Moscato G

    更新日期:2002-05-01 00:00:00

  • Occupational anaphylaxis--an EAACI task force consensus statement.

    abstract::Anaphylaxis is a systemic allergic reaction, potentially life-threatening that can be due to nonoccupational or, less commonly, to occupational triggers. Occupational anaphylaxis (OcAn) could be defined as anaphylaxis arising out of triggers and conditions attributable to a particular work environment. Hymenoptera sti...


    pub_type: 杂志文章,meta分析,评审


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    pub_type: 杂志文章


    authors: Wilkinson P,Taudorf E

    更新日期:1984-08-01 00:00:00

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    authors: Liccardi G,Mistrello G,Noschese P,Falagiani P,D'Amato M,D'Amato G

    更新日期:1996-12-01 00:00:00

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    pub_type: 杂志文章


    authors: Weller K,Groffik A,Magerl M,Tohme N,Martus P,Krause K,Metz M,Staubach P,Maurer M

    更新日期:2013-09-01 00:00:00

  • Multiple roles of Bet v 1 ligands in allergen stabilization and modulation of endosomal protease activity.

    abstract:BACKGROUND:Over 100 million people worldwide suffer from birch pollen allergy. Bet v 1 has been identified as the major birch pollen allergen. However, the molecular mechanisms of birch allergic sensitization, including the roles of Bet v 1 and other components of the birch pollen extract, remain incompletely understoo...


    pub_type: 杂志文章


    authors: Soh WT,Aglas L,Mueller GA,Gilles S,Weiss R,Scheiblhofer S,Huber S,Scheidt T,Thompson PM,Briza P,London RE,Traidl-Hoffmann C,Cabrele C,Brandstetter H,Ferreira F

    更新日期:2019-12-01 00:00:00

  • Prenatal allergen exposures prevent allergen-induced sensitization and airway inflammation in young mice.

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    pub_type: 杂志文章


    authors: Gerhold K,Avagyan A,Reichert E,Seib C,Van DV,Luger EO,Hutloff A,Hamelmann E

    更新日期:2012-03-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2009-06-01 00:00:00

  • Glucocorticoid-induced attenuation of mucosal exudation of fibrinogen and bradykinins in seasonal allergic rhinitis.

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    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:1994-03-01 00:00:00

  • Excess subcutaneous tissue may preclude intramuscular delivery when using adrenaline autoinjectors in patients with anaphylaxis.

    abstract::Intramuscular adrenaline is the gold standard treatment for anaphylaxis. Intramuscular injection provides more rapid and higher plasma concentrations than subcutaneous routes. Given the increasing epidemic of obesity patients are at increased risk of subcutaneous delivery, we therefore assessed the depth of subcutaneo...


    pub_type: 杂志文章


    authors: Johnstone J,Hobbins S,Parekh D,O'Hickey S

    更新日期:2015-06-01 00:00:00

  • Allergic rhinitis and inflammation: the effect of nasal corticosteroid therapy.

    abstract::Topical corticosteroids have proved to be effective in the treatment of allergic rhinitis. The symptomatology of allergic rhinitis is considered to be the result of the accumulation and activation of inflammatory cells and cytokine release and hence the efficacy of corticosteroids is associated with their anti-inflamm...


    pub_type: 杂志文章,评审


    authors: Fokkens WJ,Godthelp T,Holm AF,Blom H,Klein-Jan A

    更新日期:1997-01-01 00:00:00

  • The effect of immediate-hypersensitivity reactions on the level of SLPI, granulocyte elastase, alpha1-antitrypsin, and albumin in nasal secretions, by the method of unilateral antigen challenge.

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    pub_type: 杂志文章


    authors: Westin U,Lundberg E,Wihl JA,Ohlsson K

    更新日期:1999-08-01 00:00:00

  • Alpine climate treatment of atopic dermatitis: a systematic review.

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    pub_type: 杂志文章,meta分析,评审


    authors: Fieten KB,Weststrate AC,van Zuuren EJ,Bruijnzeel-Koomen CA,Pasmans SG

    更新日期:2015-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Roth N,Städler S,Lemann M,Hösli S,Simon HU,Simon D

    更新日期:2011-11-01 00:00:00

  • STAT1 gene variations, IgE regulation and atopy.

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    pub_type: 杂志文章


    authors: Pinto LA,Steudemann L,Depner M,Klopp N,Illig T,Weiland SK,von Mutius E,Kabesch M

    更新日期:2007-12-01 00:00:00

  • Nasal inhalation of budesonide from a spacer in children with perennial rhinitis and asthma.

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    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:1998-04-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:1992-10-01 00:00:00

  • Immune mechanisms of allergen-specific sublingual immunotherapy.

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    pub_type: 杂志文章,评审


    authors: Moingeon P,Batard T,Fadel R,Frati F,Sieber J,Van Overtvelt L

    更新日期:2006-02-01 00:00:00