Dominant atopy risk mutations identified by mouse forward genetic analysis.

abstract：BACKGROUND:Air-pollution levels have been shown to be associated with increased morbidity of respiratory diseases. METHODS:Data for ambient air-pollutant levels, meteorologic factors, and hospitalization or emergency room (ER) visits for acute asthma in Singapore children over a 5-year period (1990-4) were obtained an...

journal_title：Allergy

authors： Chew FT,Goh DY,Ooi BC,Saharom R,Hui JK,Lee BW

更新日期：1999-04-01 00:00:00

abstract：:Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report, we provide eviden...

journal_title：Allergy

authors： Yousefi S,Morshed M,Amini P,Stojkov D,Simon D,von Gunten S,Kaufmann T,Simon HU

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Aspirin, a cyclo-oxygenase (COX)-1 and COX-2 inhibitor, is the antiplatelet drug of choice to prevent serious vascular events. Adverse reactions to aspirin are frequent particularly among patients with asthma, chronic rhinosinusitis and nasal polyps. COX-1 inhibitors but not COX-2 inhibitors precipi...

journal_title：Allergy

authors： Fraj J,Valero A,Vives R,Pérez I,Borja J,Izquierdo I,Picado C

更新日期：2008-01-01 00:00:00

abstract：:Allergic rhinitis is an inflammatory disorder of the nasal mucosa typified by the symptoms of nasal itch, sneeze, anterior nasal secretions, and nasal blockage. These symptoms arise from the interaction between mediators and neural, vascular, and glandular structures within the nose. Nasal itch, sneezes, and rhinorrho...

journal_title：Allergy

authors： Howarth PH,Salagean M,Dokic D

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Allergic asthma is associated with airway inflammation and dysfunction of pulmonary surfactant. Because surfactant proteins (SP) account for immunomodulatory functions as well as biophysical functions, we hypothesized that the allergic response in asthma might be accompanied by a dysregulation of SPs. METHO...

journal_title：Allergy

authors： Erpenbeck VJ,Schmidt R,Günther A,Krug N,Hohlfeld JM

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Histamine intolerance is thought to trigger manifold clinical symptoms after ingesting histamine-rich food due to reduced activity of diamine oxidase (DAO). No study has hitherto systematically assessed daily fluctuations of histamine levels and DAO activities in symptomatic patients. The aim of the study wa...

journal_title：Allergy

authors： Pinzer TC,Tietz E,Waldmann E,Schink M,Neurath MF,Zopf Y

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:We hypothesized that, in south-west Poland, a 'rural' protective effect on atopy and respiratory allergies would be most pronounced among children but that at all ages would be stronger among those with a rural background. METHODS:A cross-sectional survey of the inhabitants (age >5 years, n = 1657) of Sobot...

journal_title：Allergy

authors： Sozanska B,Macneill SJ,Kajderowicz-Kowalik M,Danielewicz H,Wheatley M,Newman Taylor AJ,Boznanski A,Cullinan P

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:The hygiene hypothesis proposes that reduced exposure to infectious agents in early life would explain the increase of allergic and autoimmune diseases observed over the past decades in high-income countries. METHODS:We conducted a matched case-control study on incident atopic dermatitis (AD). Cases were 42...

journal_title：Allergy

authors： Chatenoud L,Bertuccio P,Turati F,Galeone C,Naldi L,Chatenoud L,La Vecchia C,Bach JF,HYGIENE Study Group.

更新日期：2020-01-01 00:00:00

abstract：:Olea europaea (olive) pollen extract was prepared by aqueous extraction and characterized by biochemical and immunochemical methods. Two components, displaying respective mol. wt. of 17,000 and 19,000, were the most reactive allergens, being the doublet (designated Ole e I) recognized by most sera tested. The 19,000 m...

journal_title：Allergy

authors： De Cesare F,Pini C,Di Felice G,Caiaffa MF,Macchia L,Tursi A,Tinghino R,Palumbo S,Sallusto F,Federico R

更新日期：1993-05-01 00:00:00

abstract：:This is a description of the Study of Asthma, Genes and the Environment (SAGE), a novel birth cohort created from provincial healthcare administrative records. It is a general population-based cohort, composed of children at high and low risk for asthma, living in urban and rural environments in Manitoba, Canada. The ...

journal_title：Allergy

authors： Kozyrskyj AL,HayGlass KT,Sandford AJ,Paré PD,Chan-Yeung M,Becker AB

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Allergic diseases are more common in Finland than in Estonia, which-according to the biodiversity hypothesis-could relate to differences in early microbial exposures. METHODS:We aimed at defining possible microbial perturbations preceding early atopic sensitization. Stool, nasal and skin samples of 6-month-...

journal_title：Allergy

authors： Ruokolainen L,Parkkola A,Karkman A,Sinkko H,Peet A,Hämäläinen AM,von Hertzen L,Tillmann V,Koski K,Virtanen SM,Niemelä O,Haahtela T,Knip M

更新日期：2020-09-01 00:00:00

abstract：:Epicutaneous allergen-specific immunotherapy (EPIT) is proposed as an alternative route for allergen-specific immunotherapy (AIT). The induction of allergen-specific blocking IgG antibodies represents an important mechanism underlying AIT, but has not been investigated for EPIT. Here, we compared the induction of alle...

journal_title：Allergy

authors： Cabauatan CR,Campana R,Niespodziana K,Reinisch C,Lundberg U,Meinke A,Henning R,Neubauer A,Valenta R

更新日期：2017-01-01 00:00:00

abstract：:Innate immunity is a pivotal defence system of higher organisms. Based on a limited number of receptors, it is capable of recognizing pathogens and to initiate immune responses. Major components of these innate immunity pathogen recognition receptors are the toll-like receptors (TLRs), a family of 11 in humans. They a...

journal_title：Allergy

authors： Tesse R,Pandey RC,Kabesch M

更新日期：2011-03-01 00:00:00

abstract：:To determine the effects of anthropogenic pollution on water-soluble proteins and specifically allergens in birch (Betula pendula and B. pubescens) pollen, we analyzed extracts of pollen from the pollution gradient around a factory complex (emitting sulfur oxides and heavy metals) by sodium dodecyl sulfate (SDS)--poly...

journal_title：Allergy

authors： Helander ML,Savolainen J,Ahlholm J

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:The differential diagnosis of eosinophilic gastroenteritis (EG) includes, among other diseases, parasitic infections such as anisakiasis, which has acquired worldwide importance. METHODS:We reviewed all patients referred to our allergy service who had been diagnosed as having primary EG to determine the pos...

journal_title：Allergy

authors： Gómez B,Tabar AI,Tuñón T,Larrínaga B,Alvarez MJ,García BE,Olaguibel JM

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Food allergy may present with a plethora of gastrointestinal and extraintestinal symptoms such as abdominal pain, diarrhea, cardiocirculatory symptoms, cutaneous reactions, or rhinitis. Macropathological lesions like lymphofollicular hyperplasia and erosive or ulcerative lesions have seldom been described in...

journal_title：Allergy

authors： Hagel AF,de Rossi TM,Zopf Y,Lindner AS,Dauth W,Neurath MF,Raithel M

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Nasopharynx-associated lymphoid tissue (NALT) serves as an important inductive site for mucosal immunity in the upper respiratory tract. Despite its importance in the mucosal immune system, little is known regarding the role of NALT in airway allergic immune responses. We aimed to elucidate the role of NALT ...

journal_title：Allergy

authors： Kim DY,Fukuyama S,Nagatake T,Takamura K,Kong IG,Yokota Y,Lee CH,Kiyono H

更新日期：2012-04-01 00:00:00

abstract：:It was the aim of this investigation to study the efficacy of a corticosteroid given as a depot injection in seasonal allergic rhinitis, the efficacy profile with regard to specific symptoms, and whether the injection is best given early in the season or later at the peak of the pollen count. An injection of 80 mg met...

journal_title：Allergy

authors： Borum P,Grønborg H,Mygind N

更新日期：1987-01-01 00:00:00

abstract：:An atopic girl experienced an anaphylactic reaction after eating cookies containing pecan nuts. Investigations revealed that she had developed IgE antibodies exclusively specific against allergenic determinants present in aged or heated pecan nuts, but not in fresh pecans. These neoallergenic determinants were located...

journal_title：Allergy

authors： Malanin K,Lundberg M,Johansson SG

更新日期：1995-12-01 00:00:00

abstract：:We investigated the relationship between residence in the neighbourhood of an aluminium smelter and the prevalence of atopy in schoolchildren (7-13 years of age). Atopy was assessed in 556 of the 620 participants by a skin prick test with eight common aeroallergens. The median exposures to sulphur dioxide and fluoride...

journal_title：Allergy

authors： Søyseth V,Kongerud J,Boe J

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Skin prick tests (SPTs) play an important role in the diagnosis of baker's asthma and in the investigation of sensitization frequencies in field studies. It was the aim of our study to compare different SPT solutions for wheat and rye flour sensitization and to assess the validity of test results. METHODS:S...

journal_title：Allergy

authors： Sander I,Merget R,Degens PO,Goldscheid N,Brüning T,Raulf-Heimsoth M

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Asthma is a complex disorder, which is known to be affected by interactions between genetic and environmental factors. The human Eotaxin 1 and CCR3 attract eosinophils and Th2-lymphocytes to migrate to the inflammatory foci that could represent a key mechanism in allergy and asthma. OBJECTIVE:We hypothesize...

journal_title：Allergy

authors： Wang TN,Chiang W,Tseng HI,Chu YT,Chen WY,Shih NH,Ko YC

更新日期：2007-10-01 00:00:00

abstract：:Dose- and pH- dependent carbodiimide-mediated coupling of Penicillin-G to polystyrene microtiter-plates that leaves the beta-lactam ring unchanged is described. A new ELISA method was developed using Penicillin-G coated plates. The binding of 3 different monoclonal antibodies as well as human IgG antibodies of the IgG...

journal_title：Allergy

authors： Klein GF,Stanzl U,Fritsch PO,Varga JM

更新日期：1993-04-01 00:00:00

abstract：:In 30 stable asthmatics, a comparison was made between the changes in pulmonary function (FEV1, FVC, PEF, MEF75, MEF50 and MEF25) hourly for 9 h after a single dose of inhaled budesonide 1,600 micrograms, and placebo. All subjects used inhaled steroids daily; this medication was, however, withheld 8 days prior to the ...

journal_title：Allergy

authors： Engel T,Dirksen A,Heinig JH,Nielsen NH,Weeke B,Johansson SA

更新日期：1991-10-01 00:00:00

abstract：:Two methods of relating daily pollen counts to patients' symptom scores in clinical trials of hyposensitisation in hay fever are described. The problems involved in comparing results from different centres and years of a trial are discussed with particular reference to symptoms which are not pollen related. The Normal...

journal_title：Allergy

authors： Wilkinson P,Taudorf E

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND:Exposure to acrylates may give rise to rhinitis and asthma in both industrial and domestic environments. The mechanisms underlying these respiratory conditions caused by acrylates remain largely unknown. METHODS:We studied two assembly operators exposed to cyanoacrylate glue who developed rhinitis and asthm...

journal_title：Allergy

authors： Quirce S,Baeza ML,Tornero P,Blasco A,Barranco R,Sastre J

更新日期：2001-05-01 00:00:00

abstract：:Soluble interleukin-2 receptor (sIL-2R), eosinophil cationic protein (ECP), the lymphoproliferative response to house-dust mite (HDM), adhesion to human umbilical vein endothelial cells (HUVEC), and lymphocyte membrane markers were studied in three groups of children: healthy children, asthmatic children without hypos...

journal_title：Allergy

authors： Moens MM,Van Bever HP,Stevens WJ,Mertens AV,Bridts CH,De Clerck LS

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Daily intensive exercise by elite athletes can result in exercise-induced asthma especially in elite swimmers and this may be linked to epithelial damage. OBJECTIVE:To study airway epithelial damage and release of damage-associated molecular patterns (DAMPs) after intensive exercise in elite athletes and co...

journal_title：Allergy

authors： Seys SF,Hox V,Van Gerven L,Dilissen E,Marijsse G,Peeters E,Dekimpe E,Kasran A,Aertgeerts S,Troosters T,Vanbelle V,Peers K,Ceuppens JL,Hellings PW,Dupont LJ,Bullens DM

更新日期：2015-02-01 00:00:00

abstract：:Twenty-nine patients with asthma and aspirin-sensitivity were studied in an attempt to induce tolerance to aspirin (ASA). Starting with the smallest ASA doses eliciting bronchial obstruction (threshold doses) we doubled the doses on subsequent days and finally achieved good tolerance of 600 mg ASA per day in 27 patien...

journal_title：Allergy

authors： Kowalski ML,Grzelewska-Rzymowska I,Rozniecki J,Szmidt M

更新日期：1984-04-01 00:00:00

abstract：BACKGROUND:Endogenous histamine-releasing factors (HRFs) are involved in 30-60% of patients with chronic urticaria (CU). Evidence for their existence comes from in vivo studies of autoreactivity with the autologous serum skin test (ASST), in vitro immunoassays demonstrating autoantibodies against the immunoglobulin E (...

journal_title：Allergy

authors： Platzer MH,Grattan CE,Poulsen LK,Skov PS

更新日期：2005-09-01 00:00:00