Aspirin tolerance induced in aspirin-sensitive asthmatics.

Abstract:

:Twenty-nine patients with asthma and aspirin-sensitivity were studied in an attempt to induce tolerance to aspirin (ASA). Starting with the smallest ASA doses eliciting bronchial obstruction (threshold doses) we doubled the doses on subsequent days and finally achieved good tolerance of 600 mg ASA per day in 27 patients. It was more difficult to achieve tolerance in patients with low ASA-thresholds than in patients with high ones. Daily ASA administration led to prolongation of the refractory state but when the intervals between consecutive doses were increased, aspirin hypersensitivity recurred. The pause sufficient for a recurrence of sensitivity to ASA was measured in 16 patients and ranged from 24 h to 9 days. Twelve patients challenged with indomethacin after ASA-desensitisation showed good drug tolerance.

journal_name

Allergy

journal_title

Allergy

authors

Kowalski ML,Grzelewska-Rzymowska I,Rozniecki J,Szmidt M

doi

10.1111/j.1398-9995.1984.tb02621.x

subject

Has Abstract

pub_date

1984-04-01 00:00:00

pages

171-8

issue

3

eissn

0105-4538

issn

1398-9995

journal_volume

39

pub_type

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