Abstract:
:Twenty-nine patients with asthma and aspirin-sensitivity were studied in an attempt to induce tolerance to aspirin (ASA). Starting with the smallest ASA doses eliciting bronchial obstruction (threshold doses) we doubled the doses on subsequent days and finally achieved good tolerance of 600 mg ASA per day in 27 patients. It was more difficult to achieve tolerance in patients with low ASA-thresholds than in patients with high ones. Daily ASA administration led to prolongation of the refractory state but when the intervals between consecutive doses were increased, aspirin hypersensitivity recurred. The pause sufficient for a recurrence of sensitivity to ASA was measured in 16 patients and ranged from 24 h to 9 days. Twelve patients challenged with indomethacin after ASA-desensitisation showed good drug tolerance.
journal_name
Allergyjournal_title
Allergyauthors
Kowalski ML,Grzelewska-Rzymowska I,Rozniecki J,Szmidt Mdoi
10.1111/j.1398-9995.1984.tb02621.xsubject
Has Abstractpub_date
1984-04-01 00:00:00pages
171-8issue
3eissn
0105-4538issn
1398-9995journal_volume
39pub_type
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