Honey allergy is rare in patients sensitive to pollens.


:We challenged in a double-blind manner 46 pollen-allergic patients with 30 g of honey and another 32 patients with a placebo (30 g of syrup). Minor, mostly subjective, symptoms were seen in or reported by 26% of those challenged with honey and 41% of those challenged with placebo. In no case could the symptoms with certainty be related to the challenge. Eight commercially available honeys were examined for allergen activity by RAST inhibition and immunospot methods. Both pollen and insect allergen activity was found in all honeys, and they could cause allergic reactions. However, no serious or even obvious reaction occurred in pollen-allergic patients challenged with honey.






Kiistala R,Hannuksela M,Mäkinen-Kiljunen S,Niinimäki A,Haahtela T




Has Abstract


1995-10-01 00:00:00














  • Placebo-controlled challenges with perfume in patients with asthma-like symptoms.

    abstract::A group of nine patients with respiratory symptoms after nonspecific irritating stimuli, but without any IgE-mediated allergy or demonstrable bronchial obstruction, were referred to the asthma/allergy outpatient department for evaluation of suspected asthma. In order to find a provocation model and objectively assess ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Millqvist E,Löwhagen O

    更新日期:1996-06-01 00:00:00

  • Geographical variations in the prevalence of atopic sensitization in six study sites across Canada.

    abstract:BACKGROUND:Geographical variations in atopic sensitization in Canada have not been described previously. This study used the standardized protocol of the European Community Respiratory Health Survey-1 (ECRHS-1) to investigate the distribution and predictors of atopic sensitization in six sites across Canada and to comp...


    pub_type: 杂志文章,多中心研究


    authors: Chan-Yeung M,Anthonisen NR,Becklake MR,Bowie D,Sonia Buist A,Dimich-Ward H,Ernst P,Sears MR,Siersted HC,Sweet L,Van Til L,Manfreda J

    更新日期:2010-11-01 00:00:00

  • Results of wearing test with two different latex gloves with and without the use of skin-protection cream.

    abstract::A total of 109 subjects reporting symptoms indicating type I hypersensitivity reactions to natural rubber latex (NRL) gloves was included in this study, and 66 of them had latex-specific IgE antibodies. They underwent provocation tests by wearing two types of NRL gloves with high (n=103) and low (n=75) allergen conten...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Baur X,Chen Z,Allmers H,Raulf-Heimsoth M

    更新日期:1998-04-01 00:00:00

  • Selenium and asthma: a complex relationship.

    abstract::Descriptive studies in humans investigating the relationship between selenium (Se) status and asthma have presented inconsistent results. The concept of low Se status as a potential risk factor for increased prevalence or severity of asthma is based on the role that Se, through its incorporation into selenoproteins, p...


    pub_type: 评论,社论


    authors: Hoffmann PR

    更新日期:2008-07-01 00:00:00

  • Inhalation and nasal challenge in the diagnosis of aspirin-induced asthma.

    abstract::Inhalation and nasal aspirin challenge has been investigated in asthma patients with co-existing rhinitis. Eight of 39 asthma patients were diagnosed as aspirin-sensitive on the basis of inhalation challenge. Seven aspirin-sensitive asthmatics were subjected to nasal aspirin provocation. During nasal challenge, all se...


    pub_type: 杂志文章


    authors: Pawlowicz A,Williams WR,Davies BH

    更新日期:1991-08-01 00:00:00

  • The increased number of epithelial mast cells in nasal polyps and adjacent turbinates is not allergy-dependent.

    abstract::Respiratory epithelial mast cells are an expression of airway inflammatory processes. Nasal epithelial mast cells are known to be increased in allergic rhinitis and have now been examined in patients with nasal polyps. Metachromatic cell counts (mean +/- standard error) expressed as the sum of large mast cells, atypic...


    pub_type: 杂志文章


    authors: Ruhno J,Howie K,Anderson M,Andersson B,Vanzieleghem M,Hitch D,Lapp P,Denburg J,Dolovich J

    更新日期:1990-07-01 00:00:00

  • Quantitative analysis of multiple elements in healthy and remodeled epithelium from human upper airway mucosa using nuclear microscopy.

    abstract::Elements are vital in airway mucosal physiology and pathology, but their distribution and levels in the mucosa remain unclear. This study uses the state-of-the-art nuclear microscopy facility to map and quantify multiple elements in the histology sections of nasal mucosa from patients with nasal polyps or inverted pap...


    pub_type: 杂志文章


    authors: Ren MQ,Zhou YT,Chen HX,Li TY,Vajandar SK,Osipowicz T,Watt F,Li CW

    更新日期:2018-03-01 00:00:00

  • IL-33 is a mediator rather than a trigger of the acute allergic response in humans.

    abstract:BACKGROUND:IL-33 enhances FcεRI-induced mediator release in human basophils without inducing degranulation itself. In contrast, studies in mice suggested that in the presence of high IgE levels, IL-33 triggers degranulation and anaphylaxis of similar severity as specific allergen. Consistent with this view, sera of ato...


    pub_type: 杂志文章


    authors: Fux M,Pecaric-Petkovic T,Odermatt A,Hausmann OV,Lorentz A,Bischoff SC,Virchow JC,Dahinden CA

    更新日期:2014-02-01 00:00:00

  • Stratum corneum TARC level is a new indicator of lesional skin inflammation in atopic dermatitis.

    abstract:BACKGROUND:Management of atopic dermatitis (AD) requires judging the symptoms of local skin lesions and prescribing a suitable treatment. However, no method has been established in which objective measures can be used to evaluate the severity of local symptoms. We established a method for measuring thymus and activatio...


    pub_type: 杂志文章


    authors: Morita E,Takahashi H,Niihara H,Dekio I,Sumikawa Y,Murakami Y,Matsunaka H

    更新日期:2010-09-01 00:00:00

  • Multiplexed immunoglobulin E sensitization in relation to exhaled nitric oxide in a population sample of children.

    abstract::This study investigated the relationship between the specific immunoglobulin E (IgE) profile for 40 allergens using a novel microarray technique (BioIC) and fraction of exhaled nitric oxide (FeNO) in a population sample of 1321 children. Significant positive associations were found between FeNO and sensitization to mi...


    pub_type: 杂志文章


    authors: Yao TC,Tsai HJ,Tu YL,Chang SW,Hua MC,Liao SL,Tsai MH,Chiu CY,Lai SH,Yeh KW,Huang JL,PATCH study group.

    更新日期:2014-05-01 00:00:00

  • Chip pile workers and mould exposure. A preliminary clinical and hygienic survey.

    abstract::Chip pile workers are exposed to high concentrations of airborne mould spores. Few sporadic cases of allergic alveolitis have been reported in Finland. Eight non-smoking workers, six on chip piles and two on bark piles, were examined to study the immunological and clinical response to continuous mould spore exposure. ...


    pub_type: 杂志文章


    authors: Jäppinen P,Haahtela T,Liira J

    更新日期:1987-10-01 00:00:00

  • Pseudomonas aeruginosa allergy in cystic fibrosis. Involvement of histamine release in the pathogenesis of lung tissue damage.

    abstract::Basophil histamine release by P. aeruginosa standard antigen was examined in cystic fibrosis patients chronically infected with mucoid P. aeruginosa (CF +P) and with pronounced antibody response against these bacteria, and in patients without P. aeruginosa infection (CF +P). All the patients showed eosinophil counts a...


    pub_type: 杂志文章


    authors: Skov PS,Norn S,Schiøtz PO,Permin H,Høiby N

    更新日期:1980-01-01 00:00:00

  • Eosinophil cationic protein serum levels and allergy in chronic fatigue syndrome.

    abstract::Chronic fatigue syndrome (CFS) is a syndrome of uncertain etiopathogenesis characterized by disabling fatigue associated with a variable number of somatic and/or neuropsychologic symptoms. In patients with CFS, several immunologic abnormalities can be detected, including a higher prevalance of allergy. The aim of this...


    pub_type: 杂志文章


    authors: Conti F,Magrini L,Priori R,Valesini G,Bonini S

    更新日期:1996-02-01 00:00:00

  • Decreased diversity of nasal microbiota and their secreted extracellular vesicles in patients with chronic rhinosinusitis based on a metagenomic analysis.

    abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is an inflammatory process in the nasal cavity and paranasal sinuses, and bacteria have been considered to be a cause. Indeed, recent evidence indicates that bacteria-derived extracellular vesicles (EV) appear to be an important causative agent of inflammatory diseases. Here, we ...


    pub_type: 杂志文章


    authors: Choi EB,Hong SW,Kim DK,Jeon SG,Kim KR,Cho SH,Gho YS,Jee YK,Kim YK

    更新日期:2014-04-01 00:00:00

  • Proteome analysis identifies L1CAM/CD171 and DPP4/CD26 as novel markers of human skin mast cells.

    abstract:BACKGROUND:The function of skin mast cells has been well documented in IgE-mediated allergic reactions, whereas other mast cell functions are poorly defined. This study aimed at identifying novel mast cell proteins by proteome analysis of primary human skin mast cells. METHODS:The proteome of skin mast cells was compa...


    pub_type: 杂志文章


    authors: Gschwandtner M,Paulitschke V,Mildner M,Brunner PM,Hacker S,Eisenwort G,Sperr WR,Valent P,Gerner C,Tschachler E

    更新日期:2017-01-01 00:00:00

  • Naturally occurring human IgA autoantibodies against IgE-DES myeloma protein. Prevalence and specificity.

    abstract::The prevalence and specificity of naturally occurring human IgA anti-IgE autoantibodies (a-E Ab) were studied by ELISA with anti-IgA monoclonal antibodies (mAb) and a purified myeloma IgE as solid-phase protein, i.e., IgE-DES(kappa). Such detected IgA a-E Ab were common among adults, and significantly increased geomet...


    pub_type: 杂志文章


    authors: Magnusson CG

    更新日期:1994-12-01 00:00:00

  • A population-based epidemiologic analysis of deaths from anaphylaxis in Florida.

    abstract:BACKGROUND:Previous US population-based epidemiologic studies of anaphylactic deaths have been limited by small populations and/or few deaths. The objective of this study was to determine the 10-year incidence of death from anaphylaxis in Florida and its descriptive epidemiology. METHODS:Patients who died from anaphyl...


    pub_type: 杂志文章


    authors: Simon MR,Mulla ZD

    更新日期:2008-08-01 00:00:00

  • Asthma in the desert: spectrum of the sensitizing aeroallergens.

    abstract:BACKGROUND:Bronchial asthma is common in Kuwait, a desert country, but the sensitizing allergens are uncertain. This study investigated the sensitizing allergens in Kuwaiti patients with extrinsic asthma. METHODS:A total of 553 asthmatics (male:female ratio: 1.4; mean age: 31.7 years [range 3-76 years]) and 112 matche...


    pub_type: 杂志文章


    authors: Ezeamuzie CI,Thomson MS,Al-Ali S,Dowaisan A,Khan M,Hijazi Z

    更新日期:2000-02-01 00:00:00

  • Advances and novel developments in environmental influences on the development of atopic diseases.

    abstract::Although genetic factors play a role in the etiology of atopic disease, the rapid increases in the prevalence of these diseases over the last few decades suggest that environmental, rather than genetic factors are the driving force behind the increasing prevalence. In modern societies, there is increased time spent in...


    pub_type: 杂志文章,评审


    authors: Alkotob SS,Cannedy C,Harter K,Movassagh H,Paudel B,Prunicki M,Sampath V,Schikowski T,Smith E,Zhao Q,Traidl-Hoffmann C,Nadeau KC

    更新日期:2020-10-09 00:00:00

  • Prevalence and predictors of rhinitis in Danish children and adolescents.

    abstract:BACKGROUND:The prevalence of self-reported symptoms of allergic rhinitis is increasing in many countries, but the reasons for this trend are not well understood. Data from a 6-year follow-up study of a population sample of children and adolescents (n=408), aged 7-17 years at enrolment in 1986, were analyzed to investig...


    pub_type: 杂志文章


    authors: Ulrik CS,von Linstow ML,Backer V

    更新日期:2000-11-01 00:00:00

  • Myeloid-derived suppressor cell-like fibrocytes are increased and associated with preserved lung function in chronic obstructive pulmonary disease.

    abstract:BACKGROUND:The role of fibrocytes in chronic obstructive pulmonary disease (COPD) is unknown. We sought to enumerate blood and tissue fibrocytes in COPD and determine the association of blood fibrocytes with clinical features of disease. METHODS:Utilizing flow cytometry to identify circulating, collagen type 1+ cells,...


    pub_type: 杂志文章


    authors: Wright AK,Newby C,Hartley RA,Mistry V,Gupta S,Berair R,Roach KM,Saunders R,Thornton T,Shelley M,Edwards K,Barker B,Brightling CE

    更新日期:2017-04-01 00:00:00

  • Inhibition of leukotriene (SRS-A)-mediated acute lung anaphylaxis by azelastine in guinea pigs.

    abstract::Azelastine hydrochloride, chemically known as 1(2H)-phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepine-4-yl)-, monohydrochloride, is a novel, orally effective, long-acting, antiallergic/antiasthmatic agent. The ability of azelastine and selected antiallergic drugs to inhibit SRS-A (leukotriene)...


    pub_type: 杂志文章


    authors: Chand N,Nolan K,Diamantis W,Perhach JL Jr,Sofia RD

    更新日期:1986-09-01 00:00:00

  • Prevalence of sensitization to 'improver' enzymes in UK supermarket bakers.

    abstract:BACKGROUND:Supermarket bakers are exposed not only to flour and alpha-amylase but also to other 'improver' enzymes, the nature of which is usually shrouded by commercial sensitivity. We aimed to determine the prevalence of sensitization to 'improver' enzymes in UK supermarket bakers. METHODS:We examined the prevalence...


    pub_type: 杂志文章


    authors: Jones M,Welch J,Turvey J,Cannon J,Clark P,Szram J,Cullinan P

    更新日期:2016-07-01 00:00:00

  • Airway wall geometry in asthma and nonasthmatic eosinophilic bronchitis.

    abstract:BACKGROUND:Variable airflow obstruction and airway hyperresponsiveness (AHR) are features of asthma, which are absent in nonasthmatic eosinophilic bronchitis (EB). Airway remodelling is characteristic of both conditions suggesting that remodelling and airway dysfunction are disassociated, but whether the airway geometr...


    pub_type: 杂志文章


    authors: Siddiqui S,Gupta S,Cruse G,Haldar P,Entwisle J,Mcdonald S,Whithers PJ,Hainsworth SV,Coxson HO,Brightling C

    更新日期:2009-06-01 00:00:00

  • The utility of monitoring trimellitic anhydride (TMA)-specific IgG to predict IgE-mediated sensitization in an immunosurveillance program.

    abstract:BACKGROUND:Workplace exposure to trimellitic anhydride (TMA) can elicit TMA-specific IgE (sIgE), which may lead to occupational asthma (OA). An occupational immunosurveillance program (OISP) has been implemented to monitor TMA exposure and immunologic outcomes. The purpose of this study was to determine whether TMA-spe...


    pub_type: 杂志文章


    authors: Ghosh D,Clay C,Bernstein JA

    更新日期:2018-05-01 00:00:00

  • Allergic rhinitis and inflammation: the effect of nasal corticosteroid therapy.

    abstract::Topical corticosteroids have proved to be effective in the treatment of allergic rhinitis. The symptomatology of allergic rhinitis is considered to be the result of the accumulation and activation of inflammatory cells and cytokine release and hence the efficacy of corticosteroids is associated with their anti-inflamm...


    pub_type: 杂志文章,评审


    authors: Fokkens WJ,Godthelp T,Holm AF,Blom H,Klein-Jan A

    更新日期:1997-01-01 00:00:00

  • Immunological mechanisms of sublingual immunotherapy.

    abstract::Administration of allergen-specific immunotherapy by the oral route, sublingual immunotherapy (SLIT), has been shown to be effective, with an improved safety profile compared with subcutaneous administration. However, the precise mechanisms underlying the induction of immune tolerance by SLIT remain unclear. Contact o...


    pub_type: 杂志文章,评审


    authors: Akdis CA,Barlan IB,Bahceciler N,Akdis M

    更新日期:2006-01-01 00:00:00

  • Comparative detection of mite allergens in house dust of homes in Moscow by enzyme-linked immunosorbent assay and acarologic analysis.

    abstract::The present study revealed that 73% of surveyed apartments in Moscow whose residents included children with the atopic form of bronchial asthma and sensitization to Dermatophagoides pteronyssinus allergens were infested with the pyroglyphid mites D. pteronyssinus and D. farinae. The number of mites in the surveyed apa...


    pub_type: 杂志文章


    authors: Zheltikova TM,Ovsyannikova IG,Gervazieva VB,Platts-Mills TA,Chapman MD,Petrova-Nikitina AD,Stepanova GN

    更新日期:1994-12-01 00:00:00

  • IgE autoantibodies in atopic dermatitis--occurrence of different antibodies against the CH3 and the CH4 epitopes of IgE.

    abstract::Levels of "free" anti-IgE autoantibodies and IgE/anti-IgE immune complexes were measured in the sera of patients with atopic dermatitis before and after treatment, psoriasis patients, and nonatopic controls. In this measurement, we used two monoclonal antibodies with distinct in vitro functions (LE 27, BSW 17), direct...


    pub_type: 杂志文章


    authors: Czech W,Stadler BM,Schôpf E,Kapp A

    更新日期:1995-03-01 00:00:00

  • Specificity of ELISA for IgG subclass antibodies against inhalant antigens in early childhood.

    abstract::ELISA is increasingly used to measure antibodies in new circumstances. Recently, it has been applied to the measurement of IgG subclass antibodies against common antigens in early childhood. These studies have raised concerns about the specificity of some of these assays. This paper details the results of experiments ...


    pub_type: 杂志文章


    authors: Ruiz RG,Price JF,Kemeny DM

    更新日期:1994-10-01 00:00:00