Endocrine disrupters--potential modulators of the immune system and allergic response.

Abstract:

:Endocrine disrupters (EDs) are environmental pollutants of industrial or agricultural origin (e.g. herbicides, fungicides, insecticides, industrial chemicals) that may influence health of wildlife and human. Endocrine-disrupting effect is obtained by mimicking the action of the steroid hormones and has been associated with several reproductive disorders as well as cancerogenesis both in animals and humans. EDs can also influence synthesis of cytokines, immunoglobulins, and cell mediators as well as immune cell activation and survival. Modulation by EDs of interleukin-4 production, Th1/Th2 balance and IgE production suggest their potential effect on allergic immune responses. The aim of this review was to summarize data indicating a potential effect of EDs exposure on the immune system and allergic responses.

journal_name

Allergy

journal_title

Allergy

authors

Chalubinski M,Kowalski ML

doi

10.1111/j.1398-9995.2006.01135.x

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

1326-35

issue

11

eissn

0105-4538

issn

1398-9995

pii

ALL1135

journal_volume

61

pub_type

杂志文章,评审

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