Abstract:
:Endocrine disrupters (EDs) are environmental pollutants of industrial or agricultural origin (e.g. herbicides, fungicides, insecticides, industrial chemicals) that may influence health of wildlife and human. Endocrine-disrupting effect is obtained by mimicking the action of the steroid hormones and has been associated with several reproductive disorders as well as cancerogenesis both in animals and humans. EDs can also influence synthesis of cytokines, immunoglobulins, and cell mediators as well as immune cell activation and survival. Modulation by EDs of interleukin-4 production, Th1/Th2 balance and IgE production suggest their potential effect on allergic immune responses. The aim of this review was to summarize data indicating a potential effect of EDs exposure on the immune system and allergic responses.
journal_name
Allergyjournal_title
Allergyauthors
Chalubinski M,Kowalski MLdoi
10.1111/j.1398-9995.2006.01135.xsubject
Has Abstractpub_date
2006-11-01 00:00:00pages
1326-35issue
11eissn
0105-4538issn
1398-9995pii
ALL1135journal_volume
61pub_type
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