Incidence and natural history of hen's egg allergy in the first 2 years of life-the EuroPrevall birth cohort study.


BACKGROUND:Parents and health staff perceive hen's egg allergy (HEA) as a common food allergy in early childhood, but the true incidence is unclear because population-based studies with gold-standard diagnostic criteria are lacking. OBJECTIVE:To establish the incidence and course of challenge-confirmed HEA in children, from birth until the age of 24 months, in different European regions. METHODS:In the EuroPrevall birth cohort study, children with a suspected HEA and their age-matched controls were evaluated in 9 countries, using a standardized protocol including measurement of HE-specific immunoglobulin E-antibodies in serum, skin prick tests, and double-blind, placebo-controlled food challenges (DBPCFC). RESULTS:Across Europe, 12 049 newborns were enrolled, and 9336 (77.5%) were followed up to 2 years of age. In 298 children, HEA was suspected and DBPCFC was offered. HEA by age two was confirmed in 86 of 172 challenged children (mean raw incidence 0.84%, 95% confidence interval (95% CI) 0.67-1.03). Adjusted mean incidence of HEA was 1.23% (95% CI 0.98-1.51) considering possible cases among eligible children who were not challenged. Centre-specific incidence ranged from United Kingdom (2.18%, 95% CI 1.27-3.47) to Greece (0.07%). Half of the HE-allergic children became tolerant to HE within 1 year after the initial diagnosis. CONCLUSIONS:The largest multinational European birth cohort study on food allergy with gold-standard diagnostic methods showed that the mean adjusted incidence of HEA was considerably lower than previously documented, although differences in incidence rates among countries were noted. Half of the children with documented HEA gained tolerance within 1 year postdiagnosis.






Xepapadaki P,Fiocchi A,Grabenhenrich L,Roberts G,Grimshaw KE,Fiandor A,Larco JI,Sigurdardottir S,Clausen M,Papadopoulos NG,Dahdah L,Mackie A,Sprikkelman AB,Schoemaker AA,Dubakiene R,Butiene I,Kowalski ML,Zeman K,Gavri




Has Abstract


2016-03-01 00:00:00














  • The burden of atopy and asthma in children.

    abstract:BACKGROUND:There has been a world-wide increase in the prevalence of atopic diseases. These atopic diseases, including asthma, allergic rhinoconjunctivitis and atopic eczema/dermatitis, are common in childhood and create a challenge of management for physicians and parents. METHODS:MEDLINE was searched for articles re...


    pub_type: 杂志文章,评审


    authors: O'Connell EJ

    更新日期:2004-08-01 00:00:00

  • Beer-induced anaphylaxis: identification of allergens.

    abstract:BACKGROUND:We report on a 21-year-old atopic woman who developed urticaria, angioedema of the face, and wheezy dyspnea shortly after drinking beer and after eating a corn-made snack. METHODS:Skin prick tests and specific IgE determinations to beer ingredients and cereal extracts were performed. Immunoblotting inhibiti...


    pub_type: 杂志文章


    authors: Figueredo E,Quirce S,del Amo A,Cuesta J,Arrieta I,Lahoz C,Sastre J

    更新日期:1999-06-01 00:00:00

  • The influence of air conditioning, humidity, temperature and other household characteristics on mite allergen concentrations in the northeastern United States.

    abstract:BACKGROUND:Information about the influence of housing and occupant characteristics on mite allergen concentrations is crucial to determine which methods could be used to decrease exposure of susceptible subjects. OBJECTIVES:To identify housing and occupant characteristics that are associated with mite allergen concent...


    pub_type: 杂志文章


    authors: van Strien RT,Gehring U,Belanger K,Triche E,Gent J,Bracken MB,Leaderer BP

    更新日期:2004-06-01 00:00:00

  • Prolactin and contact sensitivity.

    abstract::Hypophysectomized (Hypo-X) rats did not develop contact dermatitis in response to dinitrochlorobenzene (DNCB). Syngeneic pituitary grafts placed under the kidney capsule or daily treatment with prolactin restored the DNCB-reactivity of Hypo-X animals. Combined treatment with other pituitary hormones was ineffective. T...


    pub_type: 杂志文章


    authors: Nagy E,Berczi I

    更新日期:1981-08-01 00:00:00

  • Damage-associated molecular pattern and innate cytokine release in the airways of competitive swimmers.

    abstract:BACKGROUND:Daily intensive exercise by elite athletes can result in exercise-induced asthma especially in elite swimmers and this may be linked to epithelial damage. OBJECTIVE:To study airway epithelial damage and release of damage-associated molecular patterns (DAMPs) after intensive exercise in elite athletes and co...


    pub_type: 杂志文章


    authors: Seys SF,Hox V,Van Gerven L,Dilissen E,Marijsse G,Peeters E,Dekimpe E,Kasran A,Aertgeerts S,Troosters T,Vanbelle V,Peers K,Ceuppens JL,Hellings PW,Dupont LJ,Bullens DM

    更新日期:2015-02-01 00:00:00

  • Validation of basophil histamine release against the autologous serum skin test and outcome of serum-induced basophil histamine release studies in a large population of chronic urticaria patients.

    abstract:BACKGROUND:Endogenous histamine-releasing factors (HRFs) are involved in 30-60% of patients with chronic urticaria (CU). Evidence for their existence comes from in vivo studies of autoreactivity with the autologous serum skin test (ASST), in vitro immunoassays demonstrating autoantibodies against the immunoglobulin E (...


    pub_type: 杂志文章


    authors: Platzer MH,Grattan CE,Poulsen LK,Skov PS

    更新日期:2005-09-01 00:00:00

  • Misdiagnosis of exercise-induced bronchoconstriction in professional soccer players.

    abstract:BACKGROUND:Physicians typically rely heavily on self-reported symptoms to make a diagnosis of exercise-induced bronchoconstriction (EIB). However, in elite sport, respiratory symptoms have poor diagnostic value. In 2009, following a change in international sports regulations, all elite athletes suspected of asthma and/...


    pub_type: 杂志文章


    authors: Ansley L,Kippelen P,Dickinson J,Hull JH

    更新日期:2012-03-01 00:00:00

  • Nasal sensitization.

    abstract::Because humans breathe through the nose, the nasal mucosa becomes sensitized to inhalant allergens. Allergic rhinitis is, together with allergic conjunctivitis, the best example of a type I hypersensitivity reaction. It is an inflammation of the nasal mucosa induced by specific immune recognition of exogenous allergen...


    pub_type: 杂志文章,评审


    authors: Van Cauwenberge PB

    更新日期:1997-01-01 00:00:00

  • Intensive educational course in allergy and immunology.

    abstract::A one-day intensive educational course on allergy and immunology theory and diagnostic procedure significantly increased the competency of allergy and immunology fellows-in-training. ...


    pub_type: 杂志文章


    authors: Elizalde A,Perez EE,Sriaroon P,Nguyen D,Lockey RF,Dorsey MJ

    更新日期:2012-09-01 00:00:00

  • Diagnostic workup including CD203c-based basophil activation test in immediate hypersensitivity due to metronidazole and ornidazole and evaluation of cross-reactivity in between.

    abstract:BACKGROUND:Little is known about the diagnostic approaches for immediate hypersensitivity reactions (IHRs) due to 5-nitroimidazole antibiotics. The aim was to evaluate the usefulness of in vivo tests and basophil activation test (BAT) for the diagnosis of IHRs due to metronidazole and ornidazole and to determine possib...


    pub_type: 杂志文章


    authors: Beyaz Ş,Akdeniz N,Yılmaz A,Demir S,Öztop N,Çolakoğlu B,Büyüköztürk S,Deniz G,Gelincik A

    更新日期:2020-08-05 00:00:00

  • Astemizole in the treatment of hay fever.

    abstract::A double-blind parallel trial of astemizole, pheniramine and placebo was carried out in 51 patients with hay fever. Astemizole is a new potent H1-antihistamine with long duration of action but devoid of central activity. Evaluation criteria were daily symptom- and side effect score cards, daily nasal peak flow measure...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Malmberg H,Holopainen E,Grahne B,Binder E,Savolainen S,Sundberg S

    更新日期:1983-05-01 00:00:00

  • Stability of phenotypes defined by physiological variables and biomarkers in adults with asthma.

    abstract:BACKGROUND:Although asthma is characterized by variable airways obstruction, most studies of asthma phenotypes are cross-sectional. The stability of phenotypes defined either by biomarkers or by physiological variables was assessed by repeated measures over 1 year in the Pan-European BIOAIR cohort of adult asthmatics. ...


    pub_type: 杂志文章,随机对照试验


    authors: Kupczyk M,Dahlén B,Sterk PJ,Nizankowska-Mogilnicka E,Papi A,Bel EH,Chanez P,Howarth PH,Holgate ST,Brusselle G,Siafakas NM,Gjomarkaj M,Dahlén SE,BIOAIR investigators.

    更新日期:2014-09-01 00:00:00

  • Radiologic sinus inflammation and symptoms of chronic rhinosinusitis in a population-based sample.

    abstract:BACKGROUND:Chronic rhinosinusitis (CRS) epidemiology has been largely studied using symptom-based case definitions, without assessment of objective sinus findings. OBJECTIVE:To describe radiologic sinus opacification and the prevalence of CRS, defined by the co-occurrence of symptoms and sinus opacification, in a gene...


    pub_type: 杂志文章


    authors: Hirsch AG,Nordberg C,Bandeen-Roche K,Tan BK,Schleimer RP,Kern RC,Sundaresan A,Pinto JM,Kennedy TL,Greene JS,Kuiper JR,Schwartz BS

    更新日期:2020-04-01 00:00:00

  • IgE antibodies to omega-5 gliadin associate with immediate symptoms on oral wheat challenge in Japanese children.

    abstract:BACKGROUND:Gliadins have been implicated in immunoglobulin E (IgE)-mediated allergy to ingested wheat and omega-5-gliadin is known to represent a major allergen in wheat-dependent exercise-induced anaphylaxis. Less known is whether omega-5-gliadin is a clinically relevant allergen in children with immediate allergy to ...


    pub_type: 杂志文章


    authors: Ito K,Futamura M,Borres MP,Takaoka Y,Dahlstrom J,Sakamoto T,Tanaka A,Kohno K,Matsuo H,Morita E

    更新日期:2008-11-01 00:00:00

  • Onset of action and duration of effect of formoterol and salmeterol compared to salbutamol in isolated guinea pig trachea with or without epithelium.

    abstract::Formoterol and salmeterol are 2 newly developed beta 2-adrenoceptor agonists for inhalation with prolonged duration of effect compared with currently available beta 2-agonists. The clinical duration of effect has been suggested to be correlated to a decreased washability in vitro, i.e. decreased effect due to continuo...


    pub_type: 杂志文章


    authors: Ullman A,Bergendal A,Lindén A,Waldeck B,Skoogh BE,Löfdahl CG

    更新日期:1992-08-01 00:00:00

  • Airway wall geometry in asthma and nonasthmatic eosinophilic bronchitis.

    abstract:BACKGROUND:Variable airflow obstruction and airway hyperresponsiveness (AHR) are features of asthma, which are absent in nonasthmatic eosinophilic bronchitis (EB). Airway remodelling is characteristic of both conditions suggesting that remodelling and airway dysfunction are disassociated, but whether the airway geometr...


    pub_type: 杂志文章


    authors: Siddiqui S,Gupta S,Cruse G,Haldar P,Entwisle J,Mcdonald S,Whithers PJ,Hainsworth SV,Coxson HO,Brightling C

    更新日期:2009-06-01 00:00:00

  • Genetic determinants of paediatric food allergy: A systematic review.

    abstract:BACKGROUND:The genetic determinants of food allergy have not been systematically reviewed. We therefore systematically reviewed the literature on the genetic basis of food allergy, identifying areas for further investigation. METHODS:We searched three electronic databases (MEDLINE, EMBASE and PubMed) on 9 January 2018...


    pub_type: 杂志文章,meta分析


    authors: Suaini NHA,Wang Y,Soriano VX,Martino DJ,Allen KJ,Ellis JA,Koplin JJ

    更新日期:2019-09-01 00:00:00

  • A microtiter assay for activation of eosinophils. Simultaneous monitoring of eosinophil adhesion and degranulation.

    abstract::A simple microtiter assay for eosinophil activation is described. The assay used 1000-4000 eosinophils/microtiter well, and the design allows for a separate or simultaneous quantitative assessment of eosinophil adhesion to protein-coated microtiter wells and degranulation after stimulation with eosinophil-activating f...


    pub_type: 杂志文章


    authors: Reimert CM,Skov PS,Poulsen LK

    更新日期:1998-02-01 00:00:00

  • Allergy to date fruits: characterization of antigens and allergens of fruits of the date palm (Phoenix dactylifera L.).

    abstract:BACKGROUND:Date-palm (Phoenix dactylifera L.) fruits are eaten daily by most inhabitants of the Middle East and the neighboring countries. Recent reports have indicated that dates are allergenic. This study aimed to investigate the antigenic and allergenic potential of date fruits. METHODS:Date-fruit extracts from eig...


    pub_type: 杂志文章


    authors: Kwaasi AA,Harfi HA,Parhar RS,Al-Sedairy ST,Collison KS,Panzani RC,Al-Mohanna FA

    更新日期:1999-12-01 00:00:00

  • Nasal and exhaled nitric oxide in response to occupational latex exposure.

    abstract:BACKGROUND:Latex sensitivity is an increasing problem among health-care workers. Allergic responses are associated with changes in nitric oxide (NO) generation and the changes secondary to latex have not been described. METHODS:A total of 22 subjects comprising equal numbers of control volunteers and subjects with sel...


    pub_type: 杂志文章


    authors: Tan K,Bruce C,Birkhead A,Thomas PS

    更新日期:2001-07-01 00:00:00

  • Inhibition of anti-IgE induced skin response in normals by formoterol, a new beta 2-adrenoceptor agonist, and terbutaline. 2. Effect on the late phase reaction.

    abstract::Formoterol, a new beta 2-selective long-acting bronchodilator, was compared with terbutaline in terms of ability to inhibit dual phase skin reactions to anti-human IgE in volunteers. Anti-IgE induced an early wheal and flare reaction (WFR) followed by a progressively increasing induration, the late phase reaction (LCR...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Grönneberg R,Zetterström O

    更新日期:1990-07-01 00:00:00

  • EAACI/GA2LEN/EDF guideline: definition, classification and diagnosis of urticaria.

    abstract::This guideline is the result of a consensus reached during a panel discussion at the 2nd International Consensus Meeting on Urticaria, Urticaria 2004, a joint initiative of the European Academy of Allergology and Clinical Immunology Dermatology Section and the European Union (EU)-funded network of excellence, GA2LEN. ...


    pub_type: 杂志文章,实务指引,评审


    authors: Zuberbier T,Bindslev-Jensen C,Canonica W,Grattan CE,Greaves MW,Henz BM,Kapp A,Kozel MM,Maurer M,Merk HF,Schäfer T,Simon D,Vena GA,Wedi B,EAACI\/GA2LEN\/EDF.

    更新日期:2006-03-01 00:00:00

  • Cytodestructive mechanisms provoked by food antigens. II. Antibody-dependent, allergic autocytotoxicity.

    abstract::Antibody-dependent, allergic autocytotoxicity (ACT) is an in vitro process through which WBC from patients and/or controls, passively sensitized with RAST positive serum, are damaged in the presence of corresponding food antigens. Studies among 13 patients, sensitive to cow milk, corn and wheat, and 13 asymptomatic co...


    pub_type: 杂志文章


    authors: Podleski WK

    更新日期:1985-04-01 00:00:00

  • Association of interleukin 18 (IL18) polymorphisms with specific IgE levels to mite allergens among asthmatic patients.

    abstract:BACKGROUND:Allergy is regarded as a multifactorial condition. Its onset and severity are influenced by both genetic and environmental factors. Identification of genetic factors involved in asthma development and related phenotypes is a major task in understanding the genetic background of asthma. The possible involveme...


    pub_type: 杂志文章


    authors: Shin HD,Kim LH,Park BL,Choi YH,Park HS,Hong SJ,Choi BW,Lee JH,Park CS

    更新日期:2005-07-01 00:00:00

  • Mattresses as a winter refuge for house-dust mite populations.

    abstract::House-dust mites are a major source of allergens. Beds are often heavily infested. It is conceivable that, during the winter period in temperate climates, the ambient indoor air is too dry for their survival, but that mites can still survive in beds where the humidity is raised when the bed is occupied. To investigate...


    pub_type: 杂志文章


    authors: de Boer R,Kuller K

    更新日期:1997-03-01 00:00:00

  • Atopy and intolerance of antimicrobial drugs increase the risk of reactions to acetaminophen and nimesulide in patients allergic to nonsteroidal anti-inflammatory drugs.

    abstract::This study evaluated the risk factors for developing allergic reactions to alternative drugs such as acetaminophen and nimesulide in 367 patients intolerant of nonsteroidal anti-inflammatory drugs (NSAID) compared to 243 healthy controls. All subjects were given test doses (TD) of acetaminophen and nimesulide, and age...


    pub_type: 杂志文章


    authors: Pastorello EA,Zara C,Riario-Sforza GG,Pravettoni V,Incorvaia C

    更新日期:1998-09-01 00:00:00

  • Up-regulation of IL-18 in allergic rhinitis.

    abstract:BACKGROUND:This paper reports a study on the concentrations of the pro-inflammatory cytokines IL-18 and IL-1beta in nasal secretions of allergic rhinitis patients in relation to ECP and nasal symptoms. METHODS:We measured IL-18 and IL-1beta concentrations using ELISA, and eosinophilic cationic protein (ECP) using the ...


    pub_type: 杂志文章


    authors: Verhaeghe B,Gevaert P,Holtappels G,Lukat KF,Lange B,Van Cauwenberge P,Bachert C

    更新日期:2002-09-01 00:00:00

  • Impact of (bio)chemical and physical procedures on food allergen stability.

    abstract::A variety of methods have been used to attempt to decrease the allergenicity of food products, with highly variable success. Limited knowledge of allergen and epitope structures and the factors governing their stability may explain this, and the ensuing need for an empirical approach. A combined effort from a processi...


    pub_type: 杂志文章,评审


    authors: Soler-Rivas C,Wichers HJ

    更新日期:2001-01-01 00:00:00

  • Long-term reduction in local inflammation by a lipid raft molecule in atopic dermatitis.

    abstract:BACKGROUND:The complex pathogenesis of atopic dermatitis (AD) is guided by cell surface receptor-mediated signal transduction regulated in lipid rafts. Miltefosine is a raft-modulating molecule targeting cell membranes. With this controlled clinical study, the clinical and immunomodulatory efficacy of miltefosine was i...


    pub_type: 杂志文章,随机对照试验


    authors: Dölle S,Hoser D,Rasche C,Loddenkemper C,Maurer M,Zuberbier T,Worm M

    更新日期:2010-09-01 00:00:00

  • Sinus CT scans and mediator release in nasal secretions after nasal challenge with cypress pollens.

    abstract:BACKGROUND:Involvement of paranasal sinuses has been suggested in allergic rhinitis but not clearly demonstrated. AIMS:To investigate the relationship between intermittent allergic rhinitis and computerized tomography (CT). METHODS:Twenty patients with intermittent rhinitis and sensitized to cypress pollens underwent...


    pub_type: 杂志文章


    authors: Piette V,Bousquet C,Kvedariene V,Dhivert-Donnadieu H,Crampette L,Senac JP,Bousquet J,Demoly P

    更新日期:2004-08-01 00:00:00