Incidence and natural history of hen's egg allergy in the first 2 years of life-the EuroPrevall birth cohort study.


BACKGROUND:Parents and health staff perceive hen's egg allergy (HEA) as a common food allergy in early childhood, but the true incidence is unclear because population-based studies with gold-standard diagnostic criteria are lacking. OBJECTIVE:To establish the incidence and course of challenge-confirmed HEA in children, from birth until the age of 24 months, in different European regions. METHODS:In the EuroPrevall birth cohort study, children with a suspected HEA and their age-matched controls were evaluated in 9 countries, using a standardized protocol including measurement of HE-specific immunoglobulin E-antibodies in serum, skin prick tests, and double-blind, placebo-controlled food challenges (DBPCFC). RESULTS:Across Europe, 12 049 newborns were enrolled, and 9336 (77.5%) were followed up to 2 years of age. In 298 children, HEA was suspected and DBPCFC was offered. HEA by age two was confirmed in 86 of 172 challenged children (mean raw incidence 0.84%, 95% confidence interval (95% CI) 0.67-1.03). Adjusted mean incidence of HEA was 1.23% (95% CI 0.98-1.51) considering possible cases among eligible children who were not challenged. Centre-specific incidence ranged from United Kingdom (2.18%, 95% CI 1.27-3.47) to Greece (0.07%). Half of the HE-allergic children became tolerant to HE within 1 year after the initial diagnosis. CONCLUSIONS:The largest multinational European birth cohort study on food allergy with gold-standard diagnostic methods showed that the mean adjusted incidence of HEA was considerably lower than previously documented, although differences in incidence rates among countries were noted. Half of the children with documented HEA gained tolerance within 1 year postdiagnosis.






Xepapadaki P,Fiocchi A,Grabenhenrich L,Roberts G,Grimshaw KE,Fiandor A,Larco JI,Sigurdardottir S,Clausen M,Papadopoulos NG,Dahdah L,Mackie A,Sprikkelman AB,Schoemaker AA,Dubakiene R,Butiene I,Kowalski ML,Zeman K,Gavri




Has Abstract


2016-03-01 00:00:00














  • Epicutaneous aeroallergen sensitization in atopic dermatitis infants - determining the role of epidermal barrier impairment.

    abstract:BACKGROUND:Sensitization to atopens is an early phenomenon that overlaps with the onset of atopic dermatitis (AD) in infancy. Early epidermal barrier impairment may facilitate the epicutaneous penetration of atopens. OBJECTIVE:To correlate transepidermal water loss (TEWL) and aeroallergen sensitization in infants with...


    pub_type: 杂志文章


    authors: Boralevi F,Hubiche T,Léauté-Labrèze C,Saubusse E,Fayon M,Roul S,Maurice-Tison S,Taïeb A

    更新日期:2008-02-01 00:00:00

  • Determinants of cord-blood IgE concentrations in 6401 German neonates.

    abstract::For screening atopy risk in 6401 (84%) of all infants born during the year 1990 in six obstetric departments of five German cities, cord-blood IgE values were determined with CAP-RAST-FEIA. After cases with elevated IgA values had been excluded, 25% of the values were above the detection limit of 0.35 kU/l, and 8.5% w...


    pub_type: 杂志文章


    authors: Bergmann RL,Schulz J,Günther S,Dudenhausen JW,Bergmann KE,Bauer CP,Dorsch W,Schmidt E,Luck W,Lau S

    更新日期:1995-01-01 00:00:00

  • Anaphylactic shock after skin test with phytohaemoagglutinin.

    abstract::A young woman (26 years old), with gastrointestinal candidosis of 8 months duration, was hospitalized in our department to study her cell immunity. Five minutes after an id injection of PHA (bactophytohaemoagglutinin M, Difco, 1 mg), mix monilieae, mix tricophyton and PPD Berna, she showed an extensive wheal and flare...


    pub_type: 杂志文章


    authors: Schiavino D,Nucera E,Murzilli F,Schinco G,Papa G,Fais G,Patriarca G

    更新日期:1992-04-01 00:00:00

  • The atopy patch test (APT)-- a useful tool for the diagnosis of food allergy in children with atopic dermatitis.

    abstract:BACKGROUND:While immediate-type clinical reactions to food can quite easily be identified by history or measurement of specific IgE in combination with positive oral food challenges, the evaluation of food allergy in the absence of immediate clinical reactions still presents diagnostic difficulties--particularly in chi...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Niggemann B,Reibel S,Wahn U

    更新日期:2000-03-01 00:00:00

  • Prevalence of celiac disease in patients with severe food allergy.

    abstract::The association between food allergy and celiac disease (CD) is still to be clarified. We screened for CD 319 patients with severe food allergy (IgE > 85 kU/l against food proteins and a history of severe allergic reactions) who underwent specific food oral immunotherapy (OIT), together with 128 children with mild all...


    pub_type: 杂志文章


    authors: Pillon R,Ziberna F,Badina L,Ventura A,Longo G,Quaglia S,De Leo L,Vatta S,Martelossi S,Patano G,Not T,Berti I

    更新日期:2015-10-01 00:00:00

  • n-Nonanoyl-CCL14 (NNY-CCL14), a novel inhibitor of allergic airway inflammation is a partial agonist of human CCR2.

    abstract:BACKGROUND:Modulation of leukocyte recruitment through blocking of chemokine receptors has been proposed as an attractive therapeutic strategy. We have previously demonstrated that n-Nonanoyl-CC chemokine ligand 14 (NNY-CCL14), a modified analog of the naturally occurring chemokine CCL14(9-74) internalizes and desensit...


    pub_type: 杂志文章


    authors: Gupta S,Erdmann G,Schulz-Maronde S,Escher SE,Richter R,Forssmann WG,Elsner J,Forssmann U

    更新日期:2008-10-01 00:00:00

  • Skin tests in patients with hypersensitivity reaction to iodinated contrast media: a meta-analysis.

    abstract:BACKGROUND:Patients with a previous history of hypersensitivity reaction (HSR) to iodinated contrast media (ICM) are at high risk of the development of HSR to ICM. Many studies have tried to evaluate the diagnostic potential of skin tests in this population but have not yet reached a common conclusion. We investigated ...


    pub_type: 杂志文章,meta分析


    authors: Yoon SH,Lee SY,Kang HR,Kim JY,Hahn S,Park CM,Chang YS,Goo JM,Cho SH

    更新日期:2015-06-01 00:00:00

  • Health economics of asthma: assessing the value of asthma interventions.

    abstract::The aim of this systematic review was to summarize and assess the quality of asthma intervention health economic studies from 2002 to 2007, compare the study findings with clinical management guidelines, and suggest avenues for future improvement of asthma health economic studies. Forty of the 177 studies met our incl...


    pub_type: 杂志文章,评审


    authors: Campbell JD,Spackman DE,Sullivan SD

    更新日期:2008-12-01 00:00:00

  • IgE-mediated anaphylactoid reactions to rubber.

    abstract::Delayed hypersensitivity to rubber chemicals is well known, but there are only a limited number of case reports on an immediate type of hypersensitivity inducing contact urticaria. We have recently seen several patients with rubber glove-induced contact urticaria who have had both positive skin prick tests and positiv...


    pub_type: 杂志文章


    authors: Axelsson JG,Johansson SG,Wrangsjö K

    更新日期:1987-01-01 00:00:00

  • Epidermal Langerhans cells in patients with primary Sjögren's syndrome.

    abstract::IgG-binding to the surface of Langerhans cells (LC) is a feature of primary Sjögren's syndrome and might be associated with qualitative and quantitative defects in LC. Fifteen patients with primary Sjögren's syndrome and 15 healthy controls had a punch biopsy performed from clinically unaffected skin. LC were enumerat...


    pub_type: 杂志文章


    authors: Oxholm P,Oxholm A,Manthorpe R

    更新日期:1986-08-01 00:00:00

  • Involvement of arachidonate cyclooxygenase products in bronchial hyperresponsiveness induced by subthreshold concentration of aerosolized thromboxane A2 analogue (STA2) in guinea pigs.

    abstract::Effects of a thromboxane synthetase inhibitor (OKY-046) and a cyclooxygenase inhibitor (indomethacin) on bronchial hyperresponsiveness induced by subthreshold concentration of aerosolized thromboxane A2 analogue (STA2) were investigated in anesthetized, artificially ventilated guinea pigs in order to examine the role ...


    pub_type: 杂志文章


    authors: Saito M,Fujimura M,Sakamoto S,Miyake Y,Shintani H,Yasui M,Matsuda T

    更新日期:1992-04-01 00:00:00

  • The influence of air conditioning, humidity, temperature and other household characteristics on mite allergen concentrations in the northeastern United States.

    abstract:BACKGROUND:Information about the influence of housing and occupant characteristics on mite allergen concentrations is crucial to determine which methods could be used to decrease exposure of susceptible subjects. OBJECTIVES:To identify housing and occupant characteristics that are associated with mite allergen concent...


    pub_type: 杂志文章


    authors: van Strien RT,Gehring U,Belanger K,Triche E,Gent J,Bracken MB,Leaderer BP

    更新日期:2004-06-01 00:00:00

  • IgE-binding components of cultured human keratinocytes in atopic eczema/dermatitis syndrome and their crossreactivity with Malassezia furfur.

    abstract:BACKGROUND:Atopic eczema/dermatitis syndrome (AEDS) patients display immunoglobulin E (IgE) reactivity to several antigens, e.g. saprophytic yeasts as Malassezia furfur. AEDS patients also show IgE autoreactivity towards cells of their own tissue including epidermis. PURPOSE OF THE STUDY:The aim of this study was to i...


    pub_type: 杂志文章


    authors: Kortekangas-Savolainen O,Peltonen S,Pummi K,Kalimo K,Savolainen J

    更新日期:2004-02-01 00:00:00

  • Regulatory T cells and type 2 innate lymphoid cell-dependent asthma.

    abstract::Group 2 innate lymphoid cells (ILC2s) are a recently identified group of cells with the potent capability to produce Th2-type cytokines such as interleukin (IL)-5 and IL-13. Several studies suggest that ILC2s play an important role in the development of allergic diseases and asthma. Activation of pulmonary ILC2s in mu...


    pub_type: 杂志文章,评审


    authors: Aron JL,Akbari O

    更新日期:2017-08-01 00:00:00

  • The effect of immediate-hypersensitivity reactions on the level of SLPI, granulocyte elastase, alpha1-antitrypsin, and albumin in nasal secretions, by the method of unilateral antigen challenge.

    abstract:BACKGROUND:The aim of this paper was to investigate the role of SLPI in patients with allergic rhinitis. From this point of view, we also examined leukocyte elastase, alpha1-antitrypsin, and albumin. SLPI is an inhibitor of serine proteases such as leukocyte elastase, cathepsin G, and mast-cell chymase. Since chymase i...


    pub_type: 杂志文章


    authors: Westin U,Lundberg E,Wihl JA,Ohlsson K

    更新日期:1999-08-01 00:00:00

  • Perennial allergic rhinitis and chronic sinusitis: correlation with rhinologic risk factors.

    abstract:BACKGROUND:The reported association of allergy and sinusitis varies greatly between study, and the exact role of allergy in predisposing to sinusitis is not clear. We attempted to determine whether patients with perennial allergic rhinitis are at greater risk of developing sinusitis with respect to a control group, and...


    pub_type: 杂志文章


    authors: Berrettini S,Carabelli A,Sellari-Franceschini S,Bruschini L,Abruzzese A,Quartieri F,Sconosciuto F

    更新日期:1999-03-01 00:00:00

  • Antigen-induced bronchial anaphylaxis in actively sensitized SD rats. Effects of local treatment with anti-asthmatic drugs.

    abstract::We studied the effects of anti-asthmatic and anti-inflammatory drugs on antigen-induced bronchial anaphylactic reactions (BAR) in Sprague Dawley (SD) rats immunized with ovalbumin (OA) and alum. The animals were treated locally (intratracheal instillation (i.t.) or by aerosol) with terbutaline (TERB), disodium cromogl...


    pub_type: 杂志文章


    authors: Dahlbäck M,Brattsand R

    更新日期:1986-11-01 00:00:00

  • Nasal sensitization.

    abstract::Because humans breathe through the nose, the nasal mucosa becomes sensitized to inhalant allergens. Allergic rhinitis is, together with allergic conjunctivitis, the best example of a type I hypersensitivity reaction. It is an inflammation of the nasal mucosa induced by specific immune recognition of exogenous allergen...


    pub_type: 杂志文章,评审


    authors: Van Cauwenberge PB

    更新日期:1997-01-01 00:00:00

  • Differential expression of interleukin-32 in chronic rhinosinusitis with and without nasal polyps.

    abstract:BACKGROUND:  Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by local inflammation of the upper airways and sinuses and is frequently divided into polypoid CRS (CRSwNP) and nonpolypoid CRS (CRSsNP). However, the mechanism of inflammation in CRS has still not been fully elucidated. The aim of the s...


    pub_type: 杂志文章


    authors: Keswani A,Chustz RT,Suh L,Carter R,Peters AT,Tan BK,Chandra R,Kim SH,Azam T,Dinarello CA,Kern RC,Schleimer RP,Kato A

    更新日期:2012-01-01 00:00:00

  • Comparison of quantitative ELISA and semiquantitative Dustscreen for determination of Der p 1, Der f 1, and Fel d 1 in domestic dust samples.

    abstract:BACKGROUND:Quantitative ELISA kits used for the measurement of indoor allergens are time-consuming. Therefore, an immunodot assay (Dustscreen) has been introduced, so that results can be obtained within 4 h. In order to assess the potential applications of the new method, we compared quantitative ELISA methods and Dust...


    pub_type: 杂志文章


    authors: Lau S,Schulz G,Sommerfeld C,Wahn U

    更新日期:2001-10-01 00:00:00

  • The non-specific enhancement of allergy. II. Precipitation of anaphylactic in vitro response capacity and serum IgE and IgG2a antibody synthesis in primed but non-responding rats by injection of alum.

    abstract::PVG rats given injections of 1 microgram ovalbumin (OA) together with 10 mg Silica gel failed to provide serosal mast cells or lung tissue with the capacity to release histamine on in vitro challenge with the antigen. However, if such animals were injected i.p. with 100 mg of alum (without any further antigen addition...


    pub_type: 杂志文章


    authors: Bergstrand H,Andersson I,Nyström I,Pauwels R,Bazin H

    更新日期:1983-05-01 00:00:00

  • Prevalence and features of allergic rhinitis in Italy.

    abstract:BACKGROUND:Italian data on the prevalence of allergic rhinitis are sparse and with wide variations, maybe because of different diagnostic criteria and methods of investigation. This study analyzes the information on rhinitis collected in northern Italy through standardized methods within the European Community Respirat...


    pub_type: 杂志文章


    authors: Olivieri M,Verlato G,Corsico A,Lo Cascio V,Bugiani M,Marinoni A,de Marco R,Italian European Community Respiratory Health Survey group.

    更新日期:2002-07-01 00:00:00

  • Comparision of two-flow cytometry methods for basophil degranulation in patients sensitized to grass pollen.

    abstract:BACKGROUND:Two-flow cytometry methods for quantification of degranulated basophil after allergen-specific activation were discussed. The methods are discerned by used membrane receptors--FcepsilonRI or IL-3Ralpha Our goal was to evaluate the diagnostic potential of the methods and to correlate them to allergen-specific...


    pub_type: 杂志文章


    authors: Michova A,Abugalia M,Ivanova Ts,Nikolov G,Taskov H,Petrunov B

    更新日期:2006-09-01 00:00:00

  • Evaluation of cytokine mRNA in induced sputum from patients with allergic rhinitis: relationship to airway hyperresponsiveness.

    abstract:BACKGROUND:Although airway hyperresponsiveness (AHR) is a characteristic feature of asthma, it is also frequently present in allergic rhinitis (AR). However, the pathogenesis of AHR is unclear and the roles of cytokines in the airway have not been well established in AR. We sought to compare cytokine mRNA levels in the...


    pub_type: 杂志文章


    authors: Sohn SW,Lee HS,Park HW,Chang YS,Kim YK,Cho SH,Kim YY,Min KU

    更新日期:2008-03-01 00:00:00

  • Cell type-dependent effects of corticosteroid on periostin production by primary human tissue cells.

    abstract::Overproduction of periostin, an IL-13-inducible matricellular protein, despite corticosteroid treatment is thought to be involved in the chronicity of allergic inflammation seen in corticosteroid-refractory tissue fibrosis. Therefore, we hypothesized that some tissue cells must produce periostin in a corticosteroid-in...


    pub_type: 杂志文章


    authors: Shoda T,Futamura K,Kobayashi F,Saito H,Matsumoto K,Matsuda A

    更新日期:2013-11-01 00:00:00

  • Symptoms and immunologic markers induced by exposure to methyltetrahydrophthalic anhydride.

    abstract::A study was performed in 43 workers exposed to methyltetrahydrophthalic anhydride (MTHPA) used as a hardener in an epoxy resin system. Ten workers sensitized to MTHPA (group SS; presence of serum IgE antibodies against a conjugate of MTHPA and human serum albumin (HSA) detected by RAST) had significantly higher levels...


    pub_type: 杂志文章


    authors: Nielsen J,Welinder H,Bensryd I,Andersson P,Skerfving S

    更新日期:1994-04-01 00:00:00

  • A high-positive patch test load correlates with further positive patch test reactions irrespective of their location.

    abstract:BACKGROUND:Patch testing is the standard clinical procedure to prove contact sensitization. It is a common practice to attach multiple patch tests at the same time. However, synchronous reactions to unrelated allergens may not be completely unassociated. If so, the reaction in a given test field might be influenced by ...


    pub_type: 杂志文章


    authors: Brasch J,Geier J,Schnuch A,Uter W,German Contact Dermatitis Research Group (DKG).,Information Network of Departments of Dermatology (IVDK).

    更新日期:2006-12-01 00:00:00

  • Th17 cells: new players in asthma pathogenesis.

    abstract::CD4+ T effector lymphocytes are distinguished in different subsets on the basis of their patterns of cytokine secretion. Th1 cells, thank to IFN-γ production, are responsible for cell-mediated immunity against intracellular pathogens, Th2 cells, through the production of IL-4, provide some degree of protection against...


    pub_type: 杂志文章,评审


    authors: Cosmi L,Liotta F,Maggi E,Romagnani S,Annunziato F

    更新日期:2011-08-01 00:00:00

  • Release of prostaglandin D2 and leukotriene C4 in response to hyperosmolar stimulation of mast cells.

    abstract:BACKGROUND:Mannitol-induced bronchoconstriction in subjects with exercise-induced asthma is associated with increased urinary excretion of 9alpha, 11beta-PGF(2), a metabolite of prostaglandin D(2) (PGD(2)) serving as a mast cell marker. It has however been questioned whether or not human mast cells release PGD(2) and l...


    pub_type: 杂志文章


    authors: Gulliksson M,Palmberg L,Nilsson G,Ahlstedt S,Kumlin M

    更新日期:2006-12-01 00:00:00

  • The effect of fluticasone propionate aqueous nasal spray on nasal mucosal inflammation in perennial allergic rhinitis.

    abstract::Mast cell degranulation, and the subsequent recruitment of infiltrating inflammatory cells, such as eosinophils, into the nasal mucosa has long been considered the most important model to explain allergic rhinitis. Several studies show a decrease in the number of eosinophils and possibly also mast cells during local c...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Godthelp T,Holm AF,Blom H,Klein-Jan A,Rijntjes E,Fokkens WJ

    更新日期:1995-01-01 00:00:00