Incidence and natural history of hen's egg allergy in the first 2 years of life-the EuroPrevall birth cohort study.

Abstract:

BACKGROUND:Parents and health staff perceive hen's egg allergy (HEA) as a common food allergy in early childhood, but the true incidence is unclear because population-based studies with gold-standard diagnostic criteria are lacking. OBJECTIVE:To establish the incidence and course of challenge-confirmed HEA in children, from birth until the age of 24 months, in different European regions. METHODS:In the EuroPrevall birth cohort study, children with a suspected HEA and their age-matched controls were evaluated in 9 countries, using a standardized protocol including measurement of HE-specific immunoglobulin E-antibodies in serum, skin prick tests, and double-blind, placebo-controlled food challenges (DBPCFC). RESULTS:Across Europe, 12 049 newborns were enrolled, and 9336 (77.5%) were followed up to 2 years of age. In 298 children, HEA was suspected and DBPCFC was offered. HEA by age two was confirmed in 86 of 172 challenged children (mean raw incidence 0.84%, 95% confidence interval (95% CI) 0.67-1.03). Adjusted mean incidence of HEA was 1.23% (95% CI 0.98-1.51) considering possible cases among eligible children who were not challenged. Centre-specific incidence ranged from United Kingdom (2.18%, 95% CI 1.27-3.47) to Greece (0.07%). Half of the HE-allergic children became tolerant to HE within 1 year after the initial diagnosis. CONCLUSIONS:The largest multinational European birth cohort study on food allergy with gold-standard diagnostic methods showed that the mean adjusted incidence of HEA was considerably lower than previously documented, although differences in incidence rates among countries were noted. Half of the children with documented HEA gained tolerance within 1 year postdiagnosis.

journal_name

Allergy

journal_title

Allergy

authors

Xepapadaki P,Fiocchi A,Grabenhenrich L,Roberts G,Grimshaw KE,Fiandor A,Larco JI,Sigurdardottir S,Clausen M,Papadopoulos NG,Dahdah L,Mackie A,Sprikkelman AB,Schoemaker AA,Dubakiene R,Butiene I,Kowalski ML,Zeman K,Gavri

doi

10.1111/all.12801

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

350-7

issue

3

eissn

0105-4538

issn

1398-9995

journal_volume

71

pub_type

杂志文章

相关文献

ALLERGY文献大全
  • Repeatability of peak nasal inspiratory flow measurements and utility for assessing the severity of rhinitis.

    abstract:BACKGROUND:The measurement of peak nasal inspiratory flow (PNIF) provides a simple, cheap, fast and readily available tool for determining the extent of nasal airway patency. However, there are questions regarding its repeatability when used to assess the degree of nasal obstruction in large populations. Therefore, thi...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2005.00779.x

    authors: Starling-Schwanz R,Peake HL,Salome CM,Toelle BG,Ng KW,Marks GB,Lean ML,Rimmer SJ

    更新日期:2005-06-01 00:00:00

  • Comparative immunophenotyping of monocytes from symptomatic and asymptomatic atopic individuals.

    abstract:BACKGROUND:Allergy has at least two components - a genetic predisposition referred to as atopy and the progress from an atopic state to clinically apparent disease. Peripheral blood monocytes are circulating myeloid precursors of antigen-presenting cells. The expression of cell surface proteins on monocytes may therefo...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2004.00546.x

    authors: von Bubnoff D,Scheler M,Hinz T,Matz H,Koch S,Bieber T

    更新日期:2004-09-01 00:00:00

  • Prevention of allergy by virus-like nanoparticles (VNP) delivering shielded versions of major allergens in a humanized murine allergy model.

    abstract:BACKGROUND:In high-risk populations, allergen-specific prophylaxis could protect from sensitization and subsequent development of allergic disease. However, such treatment might itself induce sensitization and allergies, thus requiring hypoallergenic vaccine formulations. We here characterized the preventive potential ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.13573

    authors: Kratzer B,Köhler C,Hofer S,Smole U,Trapin D,Iturri J,Pum D,Kienzl P,Elbe-Bürger A,Gattinger P,Mittermann I,Linhart B,Gadermaier G,Jahn-Schmid B,Neunkirchner A,Valenta R,Pickl WF

    更新日期:2019-02-01 00:00:00

  • Distinct eosinophil cytokine expression patterns in skin diseases - the possible existence of functionally different eosinophil subpopulations.

    abstract:BACKGROUND:The function of eosinophils has been attributed to host defense, immunomodulation, and fibrosis. Although eosinophils are found among infiltrating cells in a broad spectrum of skin diseases, their pathogenic role remains uncertain. This study aimed to analyze the cytokine expression by eosinophils in differe...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2011.02694.x

    authors: Roth N,Städler S,Lemann M,Hösli S,Simon HU,Simon D

    更新日期:2011-11-01 00:00:00

  • Treatment of acute bronchoconstriction in children with use of a tube spacer aerosol and a dry powder inhaler.

    abstract::In a double blind cross-over study 24 children suffering from acute bronchoconstriction were treated with either placebo, or terbutaline delivered by a pressurized aerosol with a tube spacer (TS), or salbutamol from a dry powder inhaler (Rotahaler = RO). Both active treatments resulted in a significant increase in FEV...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1985.tb00236.x

    authors: Pedersen S

    更新日期:1985-05-01 00:00:00

  • Stratum corneum TARC level is a new indicator of lesional skin inflammation in atopic dermatitis.

    abstract:BACKGROUND:Management of atopic dermatitis (AD) requires judging the symptoms of local skin lesions and prescribing a suitable treatment. However, no method has been established in which objective measures can be used to evaluate the severity of local symptoms. We established a method for measuring thymus and activatio...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2010.02361.x

    authors: Morita E,Takahashi H,Niihara H,Dekio I,Sumikawa Y,Murakami Y,Matsunaka H

    更新日期:2010-09-01 00:00:00

  • Interpretation of subjective symptoms in double-blind placebo-controlled food challenges - interobserver reliability.

    abstract:BACKGROUND:Subjective symptoms after food challenges are difficult to interpret and no standard is available. We discuss a strategy for how to interpret a diary. Furthermore, the interobserver reliability is evaluated. METHODS:Diaries for 32 patients with subjective symptoms were used. The diaries were re-evaluated wi...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2003.00437.x

    authors: Gellerstedt M,Magnusson J,Gråjö U,Ahlstedt S,Bengtsson U

    更新日期:2004-03-01 00:00:00

  • Safety of triflusal (antiplatelet drug) in patients with aspirin-exacerbated respiratory diseases.

    abstract:BACKGROUND AND AIMS:Aspirin, a cyclo-oxygenase (COX)-1 and COX-2 inhibitor, is the antiplatelet drug of choice to prevent serious vascular events. Adverse reactions to aspirin are frequent particularly among patients with asthma, chronic rhinosinusitis and nasal polyps. COX-1 inhibitors but not COX-2 inhibitors precipi...

    journal_title:Allergy

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.2007.01473.x

    authors: Fraj J,Valero A,Vives R,Pérez I,Borja J,Izquierdo I,Picado C

    更新日期:2008-01-01 00:00:00

  • Arizona cypress (Cupressus arizonica) pollen allergens. Identification of cross-reactive periodate-resistant and -sensitive epitopes with monoclonal antibodies.

    abstract::Species of the Cupressaceae family are a worldwide cause of respiratory allergies. We used monoclonal antibodies (mAbs) to investigate the presence and the nature of cross-reacting epitopes shared by various components within Cupressus arizonica pollen extract (CaE) or by CaE and pollen extract from C. sempervirens (C...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1998.tb03934.x

    authors: Barletta B,Tinghino R,Corinti S,Afferni C,Iacovacci P,Mari A,Pini C,Di Felice G

    更新日期:1998-06-01 00:00:00

  • Onset of action and duration of effect of formoterol and salmeterol compared to salbutamol in isolated guinea pig trachea with or without epithelium.

    abstract::Formoterol and salmeterol are 2 newly developed beta 2-adrenoceptor agonists for inhalation with prolonged duration of effect compared with currently available beta 2-agonists. The clinical duration of effect has been suggested to be correlated to a decreased washability in vitro, i.e. decreased effect due to continuo...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1992.tb02076.x

    authors: Ullman A,Bergendal A,Lindén A,Waldeck B,Skoogh BE,Löfdahl CG

    更新日期:1992-08-01 00:00:00

  • Once daily fluticasone propionate aqueous nasal spray controls symptoms of most patients with seasonal allergic rhinitis.

    abstract::This multicentre, randomized, double-blind, parallel-group study was designed to compare the efficacy and tolerability of fluticasone propionate aqueous nasal spray 200 micrograms once daily (FPANS 200 micrograms od) with FPANS 200 micrograms twice daily (bd) in patients whose seasonal rhinitis symptoms were not compl...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1398-9995.1995.tb05051.x

    authors: Pedersen B,Dahl R,Richards DH,Jacques LA,Larsen BB,Pichler W,Nykanen KN

    更新日期:1995-10-01 00:00:00

  • Design, engineering and in vitro evaluation of MHC class-II targeting allergy vaccines.

    abstract:BACKGROUND:The worldwide increasing incidence of allergic diseases requires the development of new, efficient vaccination strategies, the only curative treatment with a long-lasting effect. Current allergen-specific immunotherapy protocols suffer from limited efficacy and a long treatment time. METHODS:We engineered m...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2006.01292.x

    authors: Crameri R,Flückiger S,Daigle I,Kündig T,Rhyner C

    更新日期:2007-02-01 00:00:00

  • Existence of exine-free airborne allergen particles of Japanese cedar (Cryptomeria japonica) pollen.

    abstract::We investigated whether exine-free pollen allergen particles exist together with the intact pollen grains of Japanese cedar (Cryptomeria japonica) in the air during the pollen season in Yamagata City. First, we separated the allergen particles in an Andersen multi-stage air-sampler according to their aerodynamic diame...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1991.tb00628.x

    authors: Takahashi Y,Sakaguchi M,Inouye S,Miyazawa H,Imaoka K,Katagiri S

    更新日期:1991-11-01 00:00:00

  • Bee moth (Galleria mellonella) allergic reactions are caused by several thermolabile antigens.

    abstract:BACKGROUND:Exposure and contact with bee moth (Galleria mellonella) larvae (Gm) can cause an allergic reaction both in anglers and breeders. We described the case of an amateur fisherman who experienced an allergic reaction using Gm but not using heat-treated Gm (h-Gm) (mummies). The aim of this study was to demonstrat...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2004.00446.x

    authors: Villalta D,Martelli P,Mistrello G,Roncarolo D,Zanoni D

    更新日期:2004-09-01 00:00:00

  • Anti-IgG antibodies and antinuclear antibodies in allergic patients.

    abstract::With an indirect immunofluorescence technique 77% of 96 patients with type I allergy and 40% of 20 patients with intrinsic bronchial asthma showed positive reactions for IgG anti-IgG antibodies in serum. They were present partly in an aggregated state not directly detectable before treatment with dithiothreitol. The a...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1981.tb01875.x

    authors: Egeskjold EM,Permin H,Nielsen I,Sørensen HJ,Osterballe O,Kallerup HE

    更新日期:1981-11-01 00:00:00

  • Characterization of genetic variation in TLR8 in relation to allergic rhinitis.

    abstract:BACKGROUND:A previous investigation of all 10 TLR genes for associations with allergic rhinitis (AR) detected a number of significant SNPs in the TLR8 locus. The associations indicated that an accumulation of rare variants could explain the signal. This study therefore searches for rare variants in the TLR8 region and ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.12805

    authors: Henmyr V,Lind-Halldén C,Carlberg D,Halldén C,Melén E,Wickman M,Bergström A,Säll T,Cardell LO

    更新日期:2016-03-01 00:00:00

  • Gene expression analysis predicts insect venom anaphylaxis in indolent systemic mastocytosis.

    abstract:BACKGROUND:Anaphylaxis to insect venom (Hymenoptera) is most severe in patients with mastocytosis and may even lead to death. However, not all patients with mastocytosis suffer from anaphylaxis. The aim of the study was to analyze differences in gene expression between patients with indolent systemic mastocytosis (ISM)...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2010.02521.x

    authors: Niedoszytko M,Bruinenberg M,van Doormaal JJ,de Monchy JG,Nedoszytko B,Koppelman GH,Nawijn MC,Wijmenga C,Jassem E,Elberink JN

    更新日期:2011-05-01 00:00:00

  • European birth cohort studies on asthma and atopic diseases: I. Comparison of study designs -- a GALEN initiative.

    abstract:BACKGROUND:The reasons for the rise in asthma and allergies remain unclear. To identify risk or protective factors, it is essential to carry out longitudinal epidemiological studies, preferably birth cohort studies. In Europe, several birth cohort studies on asthma and atopic diseases have been initiated over the last ...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.2006.00989.x

    authors: Keil T,Kulig M,Simpson A,Custovic A,Wickman M,Kull I,Lødrup Carlsen KC,Carlsen KH,Smit HA,Wijga AH,Schmid S,Berg A,Bollrath C,Eller E,Bindslev-Jensen C,Halken S,Høst A,Heinrich J,Porta D,Forastiere F,Brunekreef B

    更新日期:2006-02-01 00:00:00

  • Quantification of a major bovine allergen by a two-site immunometric assay based on monoclonal antibodies.

    abstract::A two-site immunometric assay based on monoclonal antibodies (mAb) was developed for the measurement of a 20-kDa major allergen of cow. The sensitivity of this assay was (BDA20) 1 ng/ml. It was used to measure airborne allergen concentrations in 10 Finnish cowsheds. The mean concentration of the BDA20 measured at two ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1994.tb02091.x

    authors: Ylönen J,Virtanen T,Rytkönen M,Mäntyjärvi R

    更新日期:1994-10-01 00:00:00

  • Major allergens of date palm (Phoenix dactylifera L.) pollen. Identification of IgE-binding components by ELISA and immunoblot analysis.

    abstract::The IgE-binding components of date palm (Phoenix dactylifera L.) pollen were determined by ELISA and Western blotting in atopic patients in order to identify its major allergens. From a pool of previously identified allergenic fractions and sera from 15 skin-test-positive, atopic subjects, four components of 12, 14.4,...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1993.tb01107.x

    authors: Kwaasi AA,Parhar RS,Tipirneni P,Harfi H,al-Sedairy ST

    更新日期:1993-10-01 00:00:00

  • Lack of control of severe asthma is associated with co-existence of moderate-to-severe rhinitis.

    abstract:BACKGROUND:Retrospective studies provide evidence that rhinitis is associated with more severe asthma. The aim of this study was to evaluate prospectively whether rhinitis is a predictor of increased asthma severity. METHODS:Five hundred and fifty-seven patients with severe asthma were enrolled. During 1 year of follo...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2007.01624.x

    authors: Ponte EV,Franco R,Nascimento HF,Souza-Machado A,Cunha S,Barreto ML,Naspitz C,Cruz AA

    更新日期:2008-05-01 00:00:00

  • CD40 and OX40 ligand are differentially regulated on asthmatic airway smooth muscle.

    abstract:BACKGROUND:CD40 and OX40 Ligand (OX40L) are cell-surface molecules expressed on airway smooth muscle (ASM) that can enhance inflammatory cell activation and survival. The aim of this study was to examine the effect of tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on ASM CD40 and OX40L expres...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2009.01959.x

    authors: Krimmer DI,Loseli M,Hughes JM,Oliver BG,Moir LM,Hunt NH,Black JL,Burgess JK

    更新日期:2009-07-01 00:00:00

  • Preparation of patient-related allergens for hyposensitization. Qualitative aspects.

    abstract::An affinity chromatography method for preparation of patient-related antigens from commercially available allergen extracts has been investigated. IgG1,2,4 from a patient previously hyposensitized with dog hair and dandruff allergen was bound to protein A-sepharose. Secondly, commercial allergen extract was applied to...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1988.tb00927.x

    authors: Poulsen LK,Søndergaard I,Weeke B

    更新日期:1988-11-01 00:00:00

  • Respiratory symptoms in ispaghula-allergic nurses after oral challenge with ispaghula suspension.

    abstract::Ispaghula powder, which is used as a component in bulk laxatives, is known to induce allergic reactions when inhaled by occupationally exposed persons. We have tested whether nurses sensitized by inhalation could get allergic symptoms when challenged by eating ispaghula. Of six nurses tested, all developed symptoms fr...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1984.tb01934.x

    authors: Machado L,Stålenheim G

    更新日期:1984-01-01 00:00:00

  • Reduction of side-effects from ultrarush immunotherapy with honeybee venom by pretreatment with fexofenadine: a double-blind, placebo-controlled trial.

    abstract:BACKGROUND:Immunotherapy with Hymenoptera venoms is highly effective but causes allergic side-effects frequently, especially when honeybee venom is used. Therefore, our objective was to investigate the effect of pretreatment with the antihistamine fexofenadine on the incidence of allergic side-effects during ultrarush ...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1398-9995.2000.00520.x

    authors: Reimers A,Hari Y,Müller U

    更新日期:2000-05-01 00:00:00

  • Eosinophil activities modulate the immune/inflammatory character of allergic respiratory responses in mice.

    abstract:BACKGROUND:The importance and specific role(s) of eosinophils in modulating the immune/inflammatory phenotype of allergic pulmonary disease remain to be defined. Established animal models assessing the role(s) of eosinophils as contributors and/or causative agents of disease have relied on congenitally deficient mice w...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.12321

    authors: Jacobsen EA,Lesuer WE,Willetts L,Zellner KR,Mazzolini K,Antonios N,Beck B,Protheroe C,Ochkur SI,Colbert D,Lacy P,Moqbel R,Appleton J,Lee NA,Lee JJ

    更新日期:2014-03-01 00:00:00

  • Decreased intercellular adhesion molecule-1 (CD54) and L-selectin (CD62L) expression on peripheral blood natural killer cells in asthmatic children with acute exacerbation.

    abstract:BACKGROUND:The capacity of inflammatory cells to adhere involves an array of adhesion molecules, and is critical to the inflammatory responses seen in childhood asthma. We aimed to determine the changes of intercellular adhesion molecule-1 (ICAM-1) and L-selectin expressed on peripheral blood (PB) T lymphocytes and nat...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2003.t01-1-23697.x

    authors: Lin SJ,Chang LY,Yan DC,Huang YJ,Lin TJ,Lin TY

    更新日期:2003-01-01 00:00:00

  • Monitoring of mite Dermatophagoides farinae allergen-specific IgG and IgG subclass distribution in patients on immunotherapy.

    abstract::House dust mite D. farinae and Der f II-specific IgG and IgG subclass responses were evaluated in 32 adults with perennial rhinitis undergoing immunotherapy for 1 year by means of IgG-RAST and ELISA. The ELISA method, which is based on subclass-specific monoclonal antibodies, could detect 0.5-1.5 ng/ml of specific ant...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1992.tb05092.x

    authors: Einarsson R,Dreborg S,Hammarström L,Löfkvist T,Smith CI,Svensson G

    更新日期:1992-04-01 00:00:00

  • Combined skin prick and patch testing enhances identification of peanut-allergic patients with atopic dermatitis.

    abstract:BACKGROUND:Food atopy patch tests (APTs) are considered a useful tool for the diagnosis of food allergy. Hypersensitivity to peanuts has not been investigated by means of APTs so far. METHODS:APTs and skin prick tests (SPTs) with peanuts were performed in 136 atopic dermatitis (AD) patients. Relevance of positive and ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2003.00153.x

    authors: Seidenari S,Giusti F,Bertoni L,Mantovani L

    更新日期:2003-06-01 00:00:00

  • Prevalence and predictors of rhinitis in Danish children and adolescents.

    abstract:BACKGROUND:The prevalence of self-reported symptoms of allergic rhinitis is increasing in many countries, but the reasons for this trend are not well understood. Data from a 6-year follow-up study of a population sample of children and adolescents (n=408), aged 7-17 years at enrolment in 1986, were analyzed to investig...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2000.00630.x

    authors: Ulrik CS,von Linstow ML,Backer V

    更新日期:2000-11-01 00:00:00