Incidence and natural history of hen's egg allergy in the first 2 years of life-the EuroPrevall birth cohort study.


BACKGROUND:Parents and health staff perceive hen's egg allergy (HEA) as a common food allergy in early childhood, but the true incidence is unclear because population-based studies with gold-standard diagnostic criteria are lacking. OBJECTIVE:To establish the incidence and course of challenge-confirmed HEA in children, from birth until the age of 24 months, in different European regions. METHODS:In the EuroPrevall birth cohort study, children with a suspected HEA and their age-matched controls were evaluated in 9 countries, using a standardized protocol including measurement of HE-specific immunoglobulin E-antibodies in serum, skin prick tests, and double-blind, placebo-controlled food challenges (DBPCFC). RESULTS:Across Europe, 12 049 newborns were enrolled, and 9336 (77.5%) were followed up to 2 years of age. In 298 children, HEA was suspected and DBPCFC was offered. HEA by age two was confirmed in 86 of 172 challenged children (mean raw incidence 0.84%, 95% confidence interval (95% CI) 0.67-1.03). Adjusted mean incidence of HEA was 1.23% (95% CI 0.98-1.51) considering possible cases among eligible children who were not challenged. Centre-specific incidence ranged from United Kingdom (2.18%, 95% CI 1.27-3.47) to Greece (0.07%). Half of the HE-allergic children became tolerant to HE within 1 year after the initial diagnosis. CONCLUSIONS:The largest multinational European birth cohort study on food allergy with gold-standard diagnostic methods showed that the mean adjusted incidence of HEA was considerably lower than previously documented, although differences in incidence rates among countries were noted. Half of the children with documented HEA gained tolerance within 1 year postdiagnosis.






Xepapadaki P,Fiocchi A,Grabenhenrich L,Roberts G,Grimshaw KE,Fiandor A,Larco JI,Sigurdardottir S,Clausen M,Papadopoulos NG,Dahdah L,Mackie A,Sprikkelman AB,Schoemaker AA,Dubakiene R,Butiene I,Kowalski ML,Zeman K,Gavri




Has Abstract


2016-03-01 00:00:00














  • Heat treatment modifies the allergenicity of beef and bovine serum albumin.

    abstract::The effect of heat on the allergenicity of beef and bovine serum albumin was investigated among 10 toddlers skin prick test (SPT)-positive to raw and cooked beef. The meat-allergy diagnosis was confirmed during double-blind, placebo-controlled food challenge (DBPCFC) with 180 g of beef cooked for 5 min at 100 degrees ...


    pub_type: 杂志文章


    authors: Fiocchi A,Restani P,Riva E,Mirri GP,Santini I,Bernardo L,Galli CL

    更新日期:1998-08-01 00:00:00

  • Barrier function of the nasal mucosa in health and type-2 biased airway diseases.

    abstract::The mucosal lining of the upper airways represents the outer surface of the body to the ambient air and its contents and is prepared for it as the first line of defense. Apart from the well-described physical barrier and the mucociliary clearance, a variety of systems, including the airway microbiome, antimicrobial pr...


    pub_type: 杂志文章,评审


    authors: Zhang N,Van Crombruggen K,Gevaert E,Bachert C

    更新日期:2016-03-01 00:00:00

  • Rhinitis symptoms and IgE sensitization as risk factors for development of later allergic rhinitis in adults.

    abstract:BACKGROUND:Rhinitis symptoms and IgE-sensitization often mismatch. Asymptomatic sensitization is an established risk factor for later rhinitis, whereas it is not clear whether rhinitis is a risk factor for later development of IgE-sensitization. OBJECTIVE:To investigate whether nonallergic rhinitis is a risk factor fo...


    pub_type: 杂志文章


    authors: Bodtger U,Poulsen LK,Linneberg A

    更新日期:2006-06-01 00:00:00

  • Allergic rhinitis: not purely a histamine-related disease.

    abstract::Allergic rhinitis is an inflammatory disorder of the nasal mucosa typified by the symptoms of nasal itch, sneeze, anterior nasal secretions, and nasal blockage. These symptoms arise from the interaction between mediators and neural, vascular, and glandular structures within the nose. Nasal itch, sneezes, and rhinorrho...


    pub_type: 杂志文章,评审


    authors: Howarth PH,Salagean M,Dokic D

    更新日期:2000-01-01 00:00:00

  • The structural basis of allergenicity: recombinant DNA-based strategies for the study of allergens.

    abstract::The use of recombinant DNA techniques for the study of allergenicity of proteins is a viable, and in many ways a preferred, alternative to the traditional procedures of protein purification, digestion and analysis of peptides for both allergenicity and amino acid sequence. The process of protein purification can be di...


    pub_type: 杂志文章,评审


    authors: Baldo BA,Donovan GR

    更新日期:1989-02-01 00:00:00

  • Effect of tea polyphenols on histamine release from rat basophilic leukemia (RBL-2H3) cells: the structure-inhibitory activity relationship.

    abstract::We studied the effect of tea polyphenols on histamine release from rat basophilic leukemia (RBL-2H3) cells. Among tea polyphenols, (-)- epigallocatechin gallate (EGCG) most strongly and dose-dependently inhibited histamine release from cells stimulated with a calcium ionophore, A23187. (-)-Epigallocatechin (EGC) and (...


    pub_type: 杂志文章


    authors: Matsuo N,Yamada K,Shoji K,Mori M,Sugano M

    更新日期:1997-01-01 00:00:00

  • The role of diesel exhaust particles and their associated polyaromatic hydrocarbons in the induction of allergic airway disease.

    abstract::The increase in allergic airway disease has paralleled the increase in the use of fossil fuels. Studies were undertaken to examine whether extracts of polyaromatic hydrocarbons (PAH) from diesel exhaust particles (DEP) (PAH-DEP) acted as mucosal adjuvants to help initiate or enhance immunoglobulin E (IgE) production i...


    pub_type: 杂志文章,评审


    authors: Diaz-Sanchez D

    更新日期:1997-01-01 00:00:00

  • Chaperone patterns in vernal keratoconjunctivitis are distinctive of cell and Hsp type and are modified by inflammatory stimuli.

    abstract:BACKGROUND:Vernal keratoconjunctivitis (VKC) is a severe ocular allergy with pathogenic mechanism poorly understood and no efficacious treatment. The aims of the study were to determine quantities and distribution of Hsp chaperones in the conjunctiva of VKC patients and assess their levels in conjunctival epithelial an...


    pub_type: 杂志文章


    authors: Leonardi A,Tarricone E,Corrao S,Alaibac M,Corso AJ,Zavan B,Venier P,Conway de Macario E,Macario AJ,Di Stefano A,Cappello F,Brun P

    更新日期:2016-03-01 00:00:00

  • No consumption of IgE antibody in serum during allergic drug anaphylaxis.

    abstract:BACKGROUND:The general understanding is that a blood sample for analysis of immunoglobulin (Ig) E antibodies to an allergen suspected to cause an anaphylaxis cannot be drawn until several weeks after the reaction. As this is most unpractical, the changes in IgE antibody levels during anaphylaxis were studied to evaluat...


    pub_type: 杂志文章


    authors: Guttormsen AB,Johansson SG,Oman H,Wilhelmsen V,Nopp A

    更新日期:2007-11-01 00:00:00

  • Evidence for an asthma risk locus on chromosome Xp: a replication linkage study.

    abstract:BACKGROUND:Asthma is a complex genetic disorder characterized by chronic inflammation in the airways. Identification of genetic risk factors for asthma has been complicated due to genetic heterogeneity and influence from environmental risk factors. Despite the fact that multiple genetic linkage studies have been carrie...


    pub_type: 杂志文章


    authors: Brasch-Andersen C,Møller MU,Haagerup A,Vestbo J,Kruse TA

    更新日期:2008-09-01 00:00:00

  • Clinical cross-reactivity between amoxicillin and cephadroxil in patients allergic to amoxicillin and with good tolerance of penicillin.

    abstract::In recent years, patients allergic to amoxicillin (AX) but with good tolerance of penicillin G (PG) have been described. It has been suggested that the epitope implicated in this type of sensitization might be located on the side-chain of the AX molecule. Thus, cross-reactivity between AX and cephadroxil (CEPH), a cep...


    pub_type: 杂志文章


    authors: Sastre J,Quijano LD,Novalbos A,Hernandez G,Cuesta J,de las Heras M,Lluch M,Fernandez M

    更新日期:1996-06-01 00:00:00

  • Comparative evaluation between two immunoenzymatic techniques (FAST and Phadezym) and the Phadebas RAST in food allergy.

    abstract::The diagnosis of food IgE-dependent hypersensitivity is based on the demonstration of specific IgE, completed by provocation tests. Two immunoenzymatic techniques, the Phadezym and the FAST, are compared with the Phadebas RAST, in 86 sera (23 controls, 28 from patients with a reported food allergy and 35 with a positi...


    pub_type: 杂志文章


    authors: Moneret-Vautrin DA,Gueant JL,Abdel-Ghani A,Maria Y,Nicolas JP

    更新日期:1990-02-01 00:00:00

  • Gastroesophageal reflux and asthma: a review of pathogenesis, diagnosis, and therapy.

    abstract::Gastroesophageal reflux disease (GERD) occurs in up to one-third of the adult US population. Most affected individuals are either unaware of their condition or do not seek medical help, relying on nonprescription acid suppressants and antacids for relief. GERD, a common disorder of infancy, old age, and pregnancy, is ...


    pub_type: 杂志文章,评审


    authors: Theodoropoulos DS,Lockey RF,Boyce HW Jr,Bukantz SC

    更新日期:1999-07-01 00:00:00

  • Release of prostaglandin D2 and leukotriene C4 in response to hyperosmolar stimulation of mast cells.

    abstract:BACKGROUND:Mannitol-induced bronchoconstriction in subjects with exercise-induced asthma is associated with increased urinary excretion of 9alpha, 11beta-PGF(2), a metabolite of prostaglandin D(2) (PGD(2)) serving as a mast cell marker. It has however been questioned whether or not human mast cells release PGD(2) and l...


    pub_type: 杂志文章


    authors: Gulliksson M,Palmberg L,Nilsson G,Ahlstedt S,Kumlin M

    更新日期:2006-12-01 00:00:00

  • Influenza A virus enhances basophil histamine release and the enhancement is abolished by carbohydrates.

    abstract::Basophil histamine release was studied in leukocyte suspensions from normal individuals and from patients allergic to house dust mite or birch pollen. Mediator release caused by IgE-mediated reactions was examined by stimulating the cells with anti-IgE or specific antigens, and the calcium ionophore A23187 was used fo...


    pub_type: 杂志文章


    authors: Clementsen P,Norn S,Kristensen KS,Hannoun C

    更新日期:1990-08-01 00:00:00

  • Gender and occupational allergy: Report from the task force of the EAACI Environmental and Occupational Allergy Interest Group.

    abstract::Women's work has traditionally been considered less hazardous to health in comparison with men's work. The increased women's participation in the workforce has led to an increased attention to women's working conditions. Women and men are unequally represented in individual professions or sectors (horizontal segregati...


    pub_type: 杂志文章


    authors: Moscato G,Apfelbacher C,Brockow K,Eberle C,Genuneit J,Mortz CG,Quecchia C,Quirce S,Siracusa A,Tarlo SM,van Kampen V,Walusiak-Skorupa J,Raulf M

    更新日期:2020-11-01 00:00:00

  • Stratum corneum TARC level is a new indicator of lesional skin inflammation in atopic dermatitis.

    abstract:BACKGROUND:Management of atopic dermatitis (AD) requires judging the symptoms of local skin lesions and prescribing a suitable treatment. However, no method has been established in which objective measures can be used to evaluate the severity of local symptoms. We established a method for measuring thymus and activatio...


    pub_type: 杂志文章


    authors: Morita E,Takahashi H,Niihara H,Dekio I,Sumikawa Y,Murakami Y,Matsunaka H

    更新日期:2010-09-01 00:00:00

  • Biological assays for interleukin 1 detection. Comparison of human T lymphocyte, murine thymocyte and NOB-1 assays.

    abstract::Various biological assays are used for qualitative and quantitative measurements of interleukin 1 (IL-1) in supernatants from cell cultures. The purpose of the present study was to compare the specificity and variability of three cellular IL-1 bioassays: the PHA co-stimulatory human T lymphocyte proliferation assay, t...


    pub_type: 杂志文章


    authors: Remvig L,Vibe-Petersen J,Svenson M,Enk C,Bendtzen K

    更新日期:1991-01-01 00:00:00

  • Measurement of natural rubber latex allergen levels in medical gloves by allergen-specific IgE-ELISA inhibition, RAST inhibition, and skin prick test.

    abstract::Exposure to natural rubber latex (NRL) medical gloves poses risks to patients sensitized to NRL and to users of protective gloves. Previous studies have shown that extractable allergen levels of the gloves vary widely. Since most of the available laboratory methods of NRL allergen measurement lack adequate validation,...


    pub_type: 杂志文章


    authors: Palosuo T,Mäkinen-Kiljunen S,Alenius H,Reunala T,Yip E,Turjanmaa K

    更新日期:1998-01-01 00:00:00

  • Angioedema induced by cardiovascular drugs: new players join old friends.

    abstract::During the last years, two new cardiovascular drug classes, namely inhibitors of DPP IV or neprilysin, have been developed. In both cases, there is clinical evidence for their potential to induce angioedema as known already from blockers of the renin-angiotensin-aldosterone system (RAAS). The majority of angioedema in...


    pub_type: 杂志文章,评审


    authors: Bas M,Greve J,Strassen U,Khosravani F,Hoffmann TK,Kojda G

    更新日期:2015-10-01 00:00:00

  • Breast milk fatty acid composition has a long-term effect on the risk of asthma, eczema, and sensitization.

    abstract:BACKGROUND:Levels of n-3 polyunsaturated fatty acids (PUFAs) and n-6 PUFAs in breast milk are associated with the development of allergic diseases up to school age. However, it is unknown whether this relationship persists when the child becomes older. We therefore studied the association between levels of n-3 PUFAs an...


    pub_type: 杂志文章


    authors: van Elten TM,van Rossem L,Wijga AH,Brunekreef B,de Jongste JC,Koppelman GH,Smit HA

    更新日期:2015-11-01 00:00:00

  • Recommendations for standardization of clinical trials with Allergen Specific Immunotherapy for respiratory allergy. A statement of a World Allergy Organization (WAO) taskforce.

    abstract::Specific Immunotherapy for respiratory allergy is used since about one century and there is now solid documentation of its efficacy. Nevertheless, the methods and experimental designs used in clinical trials are quite heterogeneous and there is no unanimously accepted methodological standard. Many studies are planned ...


    pub_type: 杂志文章,评审


    authors: Canonica GW,Baena-Cagnani CE,Bousquet J,Bousquet PJ,Lockey RF,Malling HJ,Passalacqua G,Potter P,Valovirta E

    更新日期:2007-03-01 00:00:00

  • Skin tests in patients with hypersensitivity reaction to iodinated contrast media: a meta-analysis.

    abstract:BACKGROUND:Patients with a previous history of hypersensitivity reaction (HSR) to iodinated contrast media (ICM) are at high risk of the development of HSR to ICM. Many studies have tried to evaluate the diagnostic potential of skin tests in this population but have not yet reached a common conclusion. We investigated ...


    pub_type: 杂志文章,meta分析


    authors: Yoon SH,Lee SY,Kang HR,Kim JY,Hahn S,Park CM,Chang YS,Goo JM,Cho SH

    更新日期:2015-06-01 00:00:00

  • Full automation in allergy testing: measurement of specific IgE by the ENEA System.

    abstract:UNLABELLED:We evaluated the ENEA System, a fully automated instrument for the measurement of specific IgE antibodies. The instrument dispenses sera and reagents, incubates, washes, and reads and prints results automatically. The "core" of the instrument is the reactive unit called ACE (Allergy Chamber Enzymatic), which...


    pub_type: 杂志文章


    authors: Plebani M,Faggian D,Borghesan F

    更新日期:1995-03-01 00:00:00

  • Decongestant efficacy of desloratadine in patients with seasonal allergic rhinitis.

    abstract::Recent advances in experimental immunologic approaches to seasonal allergic rhinitis (SAR) have led to a shift in the concepts of its pathogenesis. The conventional view of SAR as a local response to inhaled allergens has largely given way to a new view of this disorder as a systemic condition with local tissue manife...


    pub_type: 杂志文章,评审


    authors: Bachert C

    更新日期:2001-01-01 00:00:00

  • Major allergens of date palm (Phoenix dactylifera L.) pollen. Identification of IgE-binding components by ELISA and immunoblot analysis.

    abstract::The IgE-binding components of date palm (Phoenix dactylifera L.) pollen were determined by ELISA and Western blotting in atopic patients in order to identify its major allergens. From a pool of previously identified allergenic fractions and sera from 15 skin-test-positive, atopic subjects, four components of 12, 14.4,...


    pub_type: 杂志文章


    authors: Kwaasi AA,Parhar RS,Tipirneni P,Harfi H,al-Sedairy ST

    更新日期:1993-10-01 00:00:00

  • Activation of basophils by the double-stranded RNA poly(A:U) exacerbates allergic inflammation.

    abstract:BACKGROUND:It is commonly acknowledged that asthma is exacerbated by viral infections. On the other hand, basophil infiltration of lung tissues has been evidenced postmortem in cases of fatal disease, raising the question of a possible link between these two observations. OBJECTIVES:Herein, we addressed the relationsh...


    pub_type: 杂志文章


    authors: Ramadan A,Pham Van L,Machavoine F,Dietrich C,Alkan M,Karasuyama H,Schneider E,Dy M,Thieblemont N

    更新日期:2013-06-01 00:00:00

  • Low-dose inhaled budesonide once or twice daily for 27 months in children with mild asthma.

    abstract::This study is an extended follow-up for 24 months of a 12-week trial to study the long-term clinical efficacy of low-dose inhaled budesonide (BUD) once or twice daily in children with mild asthma. A total of 122 children (mean age 9.7 years, girls/boys; 42/80) with mild asthma (FEV1 103.7% of predicted, reversibility ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jónasson G,Carlsen KH,Jonasson C,Mowinckel P

    更新日期:2000-08-01 00:00:00

  • Fungal propagules in house dust. I. Comparison of analytic methods and their value as estimators of potential exposure.

    abstract::The presence of viable mold propagules in house dust was investigated by 10 different analytic methods, in order to determine to what extent different results are obtained when different analytic methods are used. Moreover, the value of this measurement as an estimator of the potential exposure to fungi in epidemiolog...


    pub_type: 杂志文章


    authors: Verhoeff AP,van Reenen-Hoekstra ES,Samson RA,Brunekreef B,van Wijnen JH

    更新日期:1994-08-01 00:00:00

  • Evaluating the efficacy of breastfeeding guidelines on long-term outcomes for allergic disease.

    abstract:BACKGROUND:WHO guidelines advocate breastfeeding for 6 months, and EAACI guideline recommends exclusive breastfeeding for 4-6 months. However, evidence for breastfeeding to prevent asthma and allergic disease is conflicting. We examined whether following recommended breastfeeding guidelines alters the long-term risks o...


    pub_type: 杂志文章


    authors: Bion V,Lockett GA,Soto-Ramírez N,Zhang H,Venter C,Karmaus W,Holloway JW,Arshad SH

    更新日期:2016-05-01 00:00:00