Allergy to jackfruit: a novel example of Bet v 1-related food allergy.


BACKGROUND:Jackfruit allergy has been reported just once. It is unknown whether this food allergy is caused by direct sensitization or cross-sensitization to pollen allergens. OBJECTIVE:Establish whether jackfruit allergy is linked to birchpollen allergy. METHODS:Two jackfruit allergic patients and five patients with birchpollen-related apple allergy were recruited. Sensitization to pollen and plant foods was assessed by skin prick test (SPT), radio-allergosorbent test (RAST) and immunoblot. RAST analysis was performed for Bet v 1 and Mal d 1. Cross-reactivity was evaluated by RAST and immunoblot-inhibition. Biological activity of immunoglobulin E (IgE) was measured by basophil histamine release. Allergy to jackfruit was evaluated by double-blind placebo-controlled food challenge (DBPCFC) or open challenge (OC). RESULTS:In both patients DBPCFC confirmed the reported jackfruit allergy. SPT was 41 and 27 mm2 and specific IgE to jackfruit was 5.9 and 0.8 IU/ml, respectively. Immunoblot analysis revealed IgE reactivity at Mr of approximately 17 kDa. The Bet v 1-related nature of this allergen in jackfruit was demonstrated by RAST and immunoblot inhibition. To assess whether jackfruit allergy might be common in patients with combined birchpollen-fruit allergy, five such patients underwent an OC with jackfruit. All five had OA-like symptoms. CONCLUSIONS:Jackfruit allergy can be added to the list of birchpollen-related food allergies. Increased consumption of this fruit will result in a rise in allergic reactions.






Bolhaar ST,Ree R,Bruijnzeel-Koomen CA,Knulst AC,Zuidmeer L





Has Abstract


2004-11-01 00:00:00
















  • The association between synthetic bedding and adverse respiratory outcomes among skin-prick test positive and skin-prick test negative children.

    abstract:BACKGROUND:Synthetic bedding has been associated with increased child wheeze and also higher allergen levels in several studies. We aimed to examine whether the association between synthetic bedding and adverse respiratory outcomes was more evident among skin-prick test (SPT) positive children. METHODS:A cross-section...


    pub_type: 杂志文章


    authors: Ponsonby AL,Gatenby P,Glasgow N,Mullins R,Hurwitz M,McDonald T

    更新日期:2002-03-01 00:00:00

  • Allergy to date fruits: characterization of antigens and allergens of fruits of the date palm (Phoenix dactylifera L.).

    abstract:BACKGROUND:Date-palm (Phoenix dactylifera L.) fruits are eaten daily by most inhabitants of the Middle East and the neighboring countries. Recent reports have indicated that dates are allergenic. This study aimed to investigate the antigenic and allergenic potential of date fruits. METHODS:Date-fruit extracts from eig...


    pub_type: 杂志文章


    authors: Kwaasi AA,Harfi HA,Parhar RS,Al-Sedairy ST,Collison KS,Panzani RC,Al-Mohanna FA

    更新日期:1999-12-01 00:00:00

  • Single-dose inhaled budesonide in subjects with chronic asthma.

    abstract::In 30 stable asthmatics, a comparison was made between the changes in pulmonary function (FEV1, FVC, PEF, MEF75, MEF50 and MEF25) hourly for 9 h after a single dose of inhaled budesonide 1,600 micrograms, and placebo. All subjects used inhaled steroids daily; this medication was, however, withheld 8 days prior to the ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Engel T,Dirksen A,Heinig JH,Nielsen NH,Weeke B,Johansson SA

    更新日期:1991-10-01 00:00:00

  • Comparative efficacy of azelastine nasal spray and terfenadine in seasonal and perennial rhinitis.

    abstract::The efficacy and tolerability of intranasal azelastine (0.14 mg/nostril twice daily) and oral terfenadine (60 mg twice daily) were compared under double-blind conditions in two 6-week, multicenter, parallel-group studies, including 167 patients suffering from seasonal and 52 patients suffering from perennial allergic ...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Gastpar H,Nolte D,Aurich R,Brendt P,Enzmann H,Giesemann G,Kunkel G,Petzold U,Renz W,Schata M

    更新日期:1994-03-01 00:00:00

  • Influence of food on the absorption rate and bioavailability of a sustained release theophylline preparation.

    abstract::Six children and six adults were given a single dose of a sustained release theophylline preparation (Nuelin Retard) after an overnight fast and later after a standardized breakfast. Food significantly reduced the absorption rate of theophylline whereas the extent of absorption of theophylline was unaffected by food. ...


    pub_type: 杂志文章


    authors: Pedersen S,Moeller-Petersen J

    更新日期:1982-10-01 00:00:00

  • Artemisia annua- sublingual immunotherapy: first step to cross the chasm.

    abstract::The prevalence of allergic rhinitis (AR) has witnessed a progressive increase in China. A survey of self-reported AR using validated questionnaire-based telephone interviews in adult subjects conducted between 2004 and 2005 demonstrated that the prevalence of AR in 11 major cities across China was 11.1%1 . A subsequen...


    pub_type: 社论


    authors: Xian M,Zhang L

    更新日期:2020-08-02 00:00:00

  • Contrasting microbiotas between Finnish and Estonian infants: Exposure to Acinetobacter may contribute to the allergy gap.

    abstract:BACKGROUND:Allergic diseases are more common in Finland than in Estonia, which-according to the biodiversity hypothesis-could relate to differences in early microbial exposures. METHODS:We aimed at defining possible microbial perturbations preceding early atopic sensitization. Stool, nasal and skin samples of 6-month-...


    pub_type: 杂志文章


    authors: Ruokolainen L,Parkkola A,Karkman A,Sinkko H,Peet A,Hämäläinen AM,von Hertzen L,Tillmann V,Koski K,Virtanen SM,Niemelä O,Haahtela T,Knip M

    更新日期:2020-09-01 00:00:00

  • Acute autoimmune response in a case of pyromellitic acid dianhydride-induced hemorrhagic alveolitis.

    abstract::A 17-year-old man was occupationally exposed to pyromellitic acid dianhydride dust during the production of epoxy resin in a chemical factory. He was clinically diagnosed as having acute hemorrhagic alveolitis associated with anemia. The serologic analysis revealed a high concentration of IgG antibodies against pyrome...


    pub_type: 杂志文章


    authors: Czuppon AB,Kaplan V,Speich R,Baur X

    更新日期:1994-05-01 00:00:00

  • Food allergy endotype with high risk of severe anaphylaxis in children-Monosensitization to cashew 2S albumin Ana o 3.

    abstract:BACKGROUND:Food allergy in children can be life-threatening. Component-resolved diagnostics approach to food anaphylaxis is rarely assessed in children. The aim of the study was to identify the food allergen components as the triggers responsible for severe anaphylaxis, with regard to characteristics and associated ris...


    pub_type: 杂志文章


    authors: Blazowski L,Majak P,Kurzawa R,Kuna P,Jerzynska J

    更新日期:2019-10-01 00:00:00

  • Impairment of T helper and T regulatory cell responses at birth.

    abstract:BACKGROUND:There is strong evidence that reduced exposures to microbial compounds triggering innate immune responses early in life are critical for the development of allergic illnesses. The underlying mechanisms remain unknown, but will include T-cell responses either along T helper type 1 (Th1)/Th2 pathways or via T ...


    pub_type: 杂志文章


    authors: Schaub B,Liu J,Schleich I,Höppler S,Sattler C,von Mutius E

    更新日期:2008-11-01 00:00:00

  • Management of ocular allergy.

    abstract::The treatment and management of ocular allergy (OA) remain a major concern for different specialties, including allergists, ophthalmologists, primary care physicians, rhinologists, pediatricians, dermatologists, clinical immunologists, and pharmacists. We performed a systematic review of all relevant publications in M...


    pub_type: 杂志文章,meta分析


    authors: Leonardi A,Silva D,Perez Formigo D,Bozkurt B,Sharma V,Allegri P,Rondon C,Calder V,Ryan D,Kowalski ML,Delgado L,Doan S,Fauquert JL

    更新日期:2019-09-01 00:00:00

  • Neonatal leukocyte cAMP-phosphodiesterase determination is not suitable for allergy prediction.

    abstract::The atopy-predictive value of cord blood (CB) cyclic adenosine monophosphate-phosphodiesterase (cAMP-PDE) in mononuclear leukocytes (MN) was studied prospectively in 57 neonates. Reliable determination of cAMP-PDE was achieved in only 20 CB samples. The levels tended to be higher in infants developing signs of atopy u...


    pub_type: 杂志文章


    authors: Odelram H,Björkstén B,Chan SC,Hanifin JM,Kjellman NI

    更新日期:1994-09-01 00:00:00

  • Risk assessment for food allergy--the industry viewpoint.

    abstract::A safe food supply is a legitimate expectation of consumers, which the food industry must meet. Allergic reactions to food are recognised as a significant public health problem. Protecting allergic consumers against such reactions, while minimising the impact of food allergy on their quality of life, poses a challenge...


    pub_type: 杂志文章


    authors: Crevel RW

    更新日期:2001-01-01 00:00:00

  • Specific oral tolerance induction in food allergy in children: efficacy and clinical patterns of reaction.

    abstract:BACKGROUND:Specific oral tolerance induction (SOTI) seems to be a promising treatment of food allergy. Specific oral tolerance induction and elimination diet were compared with respect to efficacy rate and patterns of clinical reaction. METHODS:Children with challenge proven immunoglobulin E (IgE)-mediated cow's milk ...


    pub_type: 杂志文章,随机对照试验


    authors: Staden U,Rolinck-Werninghaus C,Brewe F,Wahn U,Niggemann B,Beyer K

    更新日期:2007-11-01 00:00:00

  • Sublingual immunotherapy with a standardized cat dander extract: evaluation of efficacy in a double blind placebo controlled study.

    abstract:BACKGROUND:Little information is available on the clinical efficacy of sublingual immunotherapy (SLIT) using extracts derived from mammalian epithelia. OBJECTIVES:To assess clinical efficacy of cat SLIT based on natural exposure challenge test (NCT). MATERIAL AND METHODS:Fifty cat allergic patients with rhinoconjunct...


    pub_type: 杂志文章,随机对照试验


    authors: Alvarez-Cuesta E,Berges-Gimeno P,González-Mancebo E,Fernández-Caldas E,Cuesta-Herranz J,Casanovas M

    更新日期:2007-07-01 00:00:00

  • Pharyngeal edema caused by occupational exposure to cellulase enzyme.

    abstract::Enzymes can cause allergic asthma and rhinitis. Although patients sometimes complain of symptoms in their throat, we have not been able to find any published report of pharyngeal edema caused by exposure to enzymes. We present the case of a maintenance foreman who worked in a factory producing enzymes, and who had pha...


    pub_type: 杂志文章


    authors: Hytönen M,Vanhanen M,Keskinen H,Tuomi T,Tupasela O,Nordman H

    更新日期:1994-10-01 00:00:00

  • Effects of immunotherapy on symptoms, PEFR, spirometry, and airway responsiveness in patients with allergic asthma to house-dust mites (D. pteronyssinus) on inhaled steroid therapy.

    abstract::The present study was designed to investigate the effects of immunotherapy (IT) with an extract of Dermatophagoides pteronyssinus (Alergo-Merck Depot) during a 27-month period in patients with allergic asthma to house-dust mites. We included 11 patients (mean age 18 years) treated with a combination of IT and inhaled ...


    pub_type: 杂志文章


    authors: Costa JC,Plácido JL,Silva JP,Delgado L,Vaz M

    更新日期:1996-04-01 00:00:00

  • Aluminium per se and in the anti-acid drug sucralfate promotes sensitization via the oral route.

    abstract:BACKGROUND:Aluminium (ALUM) is used as experimental and clinical adjuvant for parenteral vaccine formulation. It is also contained in anti-acid drugs like sucralfate (SUC). These anti-acids have been shown to cause sensitization to food proteins via elevation of the gastric pH. The aim of this study was to assess the o...


    pub_type: 杂志文章


    authors: Brunner R,Wallmann J,Szalai K,Karagiannis P,Altmeppen H,Riemer AB,Jensen-Jarolim E,Pali-Schöll I

    更新日期:2009-06-01 00:00:00

  • The differences of tear function and ocular surface findings in patients with atopic keratoconjunctivitis and vernal keratoconjunctivitis.

    abstract:BACKGROUND:The pathogenesis of the ocular surface disease in atopic keratoconjunctivitis (AKC) and vernal keratoconjunctivitis (VKC) has not been fully understood. We tried to clarify the differences in the ocular surface status in patients with AKC, VKC, and healthy control subjects. METHODS:Twenty-four eyes of 12 AK...


    pub_type: 杂志文章


    authors: Hu Y,Matsumoto Y,Dogru M,Okada N,Igarashi A,Fukagawa K,Tsubota K,Fujishima H

    更新日期:2007-08-01 00:00:00

  • The structural basis of allergenicity: recombinant DNA-based strategies for the study of allergens.

    abstract::The use of recombinant DNA techniques for the study of allergenicity of proteins is a viable, and in many ways a preferred, alternative to the traditional procedures of protein purification, digestion and analysis of peptides for both allergenicity and amino acid sequence. The process of protein purification can be di...


    pub_type: 杂志文章,评审


    authors: Baldo BA,Donovan GR

    更新日期:1989-02-01 00:00:00

  • Occupationally related respiratory symptoms in trout-processing workers.

    abstract::All eight production workers from a small trout-processing factory were studied because of respiratory or rhinitis symptoms when working next to the automatic gutting machine. Seven of the eight had positive histamine provocation tests. Four patients had elevated total IgE levels while one had a slightly elevated eosi...


    pub_type: 杂志文章


    authors: Sherson D,Hansen I,Sigsgaard T

    更新日期:1989-07-01 00:00:00

  • Efficacy of the topical nasal steroid budesonide on improving sleep and daytime somnolence in patients with perennial allergic rhinitis.

    abstract:BACKGROUND:Improving quality of life is considered to be a major endpoint and motivation for clinical intervention in patients with perennial allergic rhinitis (PAR). In addition to classical symptoms of congestion, pruritus, and rhinorrhea, patients will often complain of not being able to sleep well at night and of f...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hughes K,Glass C,Ripchinski M,Gurevich F,Weaver TE,Lehman E,Fisher LH,Craig TJ

    更新日期:2003-05-01 00:00:00

  • Up-regulation of IL-18 in allergic rhinitis.

    abstract:BACKGROUND:This paper reports a study on the concentrations of the pro-inflammatory cytokines IL-18 and IL-1beta in nasal secretions of allergic rhinitis patients in relation to ECP and nasal symptoms. METHODS:We measured IL-18 and IL-1beta concentrations using ELISA, and eosinophilic cationic protein (ECP) using the ...


    pub_type: 杂志文章


    authors: Verhaeghe B,Gevaert P,Holtappels G,Lukat KF,Lange B,Van Cauwenberge P,Bachert C

    更新日期:2002-09-01 00:00:00

  • Regulatory T cells and type 2 innate lymphoid cell-dependent asthma.

    abstract::Group 2 innate lymphoid cells (ILC2s) are a recently identified group of cells with the potent capability to produce Th2-type cytokines such as interleukin (IL)-5 and IL-13. Several studies suggest that ILC2s play an important role in the development of allergic diseases and asthma. Activation of pulmonary ILC2s in mu...


    pub_type: 杂志文章,评审


    authors: Aron JL,Akbari O

    更新日期:2017-08-01 00:00:00

  • Fexofenadine reduces nasal congestion in perennial allergic rhinitis.

    abstract:BACKGROUND:Nasal congestion is the predominant symptom in perennial allergic rhinitis (PAR), and it seems to be mainly related to the late-phase inflammatory events. The present pilot study aimed to evaluate the therapeutic effect exerted by fexofenadine in patients with PAR due to mite allergy. METHODS:This study was...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ciprandi G,Cosentino C,Milanese M,Mondino C,Canonica GW

    更新日期:2001-11-01 00:00:00

  • Risk factors for severe and critically ill COVID-19 patients: A review.

    abstract::The pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused an unprecedented global social and economic impact, and high numbers of deaths. Many risk factors have been identified in the progression of COVID-19 into a severe and critical st...


    pub_type: 杂志文章,评审


    authors: Gao YD,Ding M,Dong X,Zhang JJ,Kursat Azkur A,Azkur D,Gan H,Sun YL,Fu W,Li W,Liang HL,Cao YY,Yan Q,Cao C,Gao HY,Brüggen MC,van de Veen W,Sokolowska M,Akdis M,Akdis CA

    更新日期:2020-11-13 00:00:00

  • Streptomycin-induced anaphylactic reaction during in vitro fertilization (IVF).

    abstract::Indications for in vitro fertilization (IVF) have been cautiously extended over the years. IVF is usually considered to be a technically complex method with only minimal side-effects. We report the case of a woman who developed an anaphylactic reaction during IVF immediately after the embryo transfer. ...


    pub_type: 杂志文章


    authors: Abeck D,Kuwert C,Segnini-Torres M,Przybilla B,Ring J

    更新日期:1994-05-01 00:00:00

  • Is atopic disease a risk factor for attention-deficit/hyperactivity disorder? A systematic review.

    abstract::The increase in prevalence and burden of atopic diseases, i.e. eczema, rhinitis, and asthma over the past decades was paralleled by a worldwide increase in attention-deficit/hyperactivity disorder (ADHD) diagnoses. We systematically reviewed epidemiologic studies investigating the relationship between atopic diseases ...


    pub_type: 杂志文章,评审


    authors: Schmitt J,Buske-Kirschbaum A,Roessner V

    更新日期:2010-12-01 00:00:00

  • Seasonal allergic rhinitis and depot injection of a corticosteroid. Evaluation of the efficacy of medication early and late in the season based on detailed symptom recording.

    abstract::It was the aim of this investigation to study the efficacy of a corticosteroid given as a depot injection in seasonal allergic rhinitis, the efficacy profile with regard to specific symptoms, and whether the injection is best given early in the season or later at the peak of the pollen count. An injection of 80 mg met...


    pub_type: 临床试验,杂志文章


    authors: Borum P,Grønborg H,Mygind N

    更新日期:1987-01-01 00:00:00

  • Mattresses as a winter refuge for house-dust mite populations.

    abstract::House-dust mites are a major source of allergens. Beds are often heavily infested. It is conceivable that, during the winter period in temperate climates, the ambient indoor air is too dry for their survival, but that mites can still survive in beds where the humidity is raised when the bed is occupied. To investigate...


    pub_type: 杂志文章


    authors: de Boer R,Kuller K

    更新日期:1997-03-01 00:00:00