Abstract:
:Busereline acetate is an LH-RH agonist that was found to induce local reactions at the injection site or generalized minor skin reactions in some patients. Since these reactions may represent the first reaction of systemic anaphylaxis, we tested the non-specific histamine releasing activity of this drug by intradermal skin tests. It was found that all subjects tested had a positive wheal and flare reaction, the flare being significantly decreased by terfenadine. Benzyl alcohol, the preservative used in commercial preparation of busereline acetate, did not elicit a positive wheal and flare reaction in two patients who had experienced a clinically noticeable reaction. It is concluded that busereline is likely to be a non-specific histamine releasing compound.
journal_name
Allergyjournal_title
Allergyauthors
Bousquet J,Hédon B,Hejjaoui A,Chanal I,Michel FBdoi
10.1111/j.1398-9995.1988.tb01634.xsubject
Has Abstractpub_date
1988-10-01 00:00:00pages
540-1issue
7eissn
0105-4538issn
1398-9995journal_volume
43pub_type
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