Identification of B-cell epitopes of Bet v 1 involved in cross-reactivity with food allergens.

abstract：:We investigated the proliferative response of lymphocytes from mite-sensitive patients (RAST D.far greater than 3.5 PRU/ml) in the presence of the major allergen Der.f.I purified from Dermatophagoides farinae. Comparative studies were carried out with peripheral blood mononuclear cells from non-atopic donors (RAST = 0...

journal_title：Allergy

authors： Cavaillon JM,Fitting C,Guinnepain MT,Rassemont R,David B

更新日期：1988-02-01 00:00:00

abstract：:The mucosal plasma exudate with its proteins, enzymes, derived peptides, and matrix molecules is an important factor in inflammatory airway diseases. This study investigated whether topical glucocorticosteroid treatment influences mucosal exudation of bulk plasma (fibrinogen) and the generation of plasma-derived media...

journal_title：Allergy

authors： Svensson C,Klementsson H,Andersson M,Pipkorn U,Alkner U,Persson CG

更新日期：1994-03-01 00:00:00

abstract：:The association between food allergy and celiac disease (CD) is still to be clarified. We screened for CD 319 patients with severe food allergy (IgE > 85 kU/l against food proteins and a history of severe allergic reactions) who underwent specific food oral immunotherapy (OIT), together with 128 children with mild all...

journal_title：Allergy

authors： Pillon R,Ziberna F,Badina L,Ventura A,Longo G,Quaglia S,De Leo L,Vatta S,Martelossi S,Patano G,Not T,Berti I

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Farm environment in childhood may protect against sensitization, allergic rhinitis, and asthma. METHODS:Subjects were obtained from 10 667 Finnish first-year university students who responded to a questionnaire survey on IgE-mediated diseases. Two random samples were selected from 1631 respondents in Turku:...

journal_title：Allergy

authors： Kilpeläinen M,Terho EO,Helenius H,Koskenvuo M

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:IL-31 is a cytokine expressed by T cells following activation with cytokines or staphylococcal exotoxins. A major function of IL-31 in atopic dermatitis (AD) is the induction of pruritus in the skin via the IL-31 receptor on sensory nerve cells. However, the regulation of the IL-31 receptor and pro-inflammat...

journal_title：Allergy

authors： Kasraie S,Niebuhr M,Werfel T

更新日期：2010-06-01 00:00:00

abstract：:We investigated whether exine-free pollen allergen particles exist together with the intact pollen grains of Japanese cedar (Cryptomeria japonica) in the air during the pollen season in Yamagata City. First, we separated the allergen particles in an Andersen multi-stage air-sampler according to their aerodynamic diame...

journal_title：Allergy

authors： Takahashi Y,Sakaguchi M,Inouye S,Miyazawa H,Imaoka K,Katagiri S

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Chronic urticaria (CU) is a common skin disorder that causes a substantial burden on patients' quality-of-life (QoL). The aim of this work was to generate and validate a German version of the Chronic Urticaria Quality of Life Questionnaire (CU-Q(2)oL) and to provide reference assessments of QoL. METHODS:The...

journal_title：Allergy

authors： Młynek A,Magerl M,Hanna M,Lhachimi S,Baiardini I,Canonica GW,Brzoza Z,Kasperska-Zajac A,Rogala B,Zalewska-Janowska A,Zuberbier T,Maurer M

更新日期：2009-06-01 00:00:00

abstract：:Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient empowerment. MASK-rh...

journal_title：Allergy

authors： Bousquet J,Schunemann HJ,Fonseca J,Samolinski B,Bachert C,Canonica GW,Casale T,Cruz AA,Demoly P,Hellings P,Valiulis A,Wickman M,Zuberbier T,Bosnic-Anticevitch S,Bedbrook A,Bergmann KC,Caimmi D,Dahl R,Fokkens WJ,Gris

更新日期：2015-11-01 00:00:00

abstract：:Airway remodeling is a central feature of asthma. It is exemplified by thickening of the lamina reticularis and structural changes to the epithelium, submucosa, smooth muscle, and vasculature of the airway wall. Airway remodeling may result from persistent airway inflammation. Immunoglobulin E (IgE) is an important me...

journal_title：Allergy

authors： Rabe KF,Calhoun WJ,Smith N,Jimenez P

更新日期：2011-09-01 00:00:00

abstract：:Hyposmia is a common symptom in allergic rhinitis. However, little is known about differences in the olfactory function of patients with seasonal or perennial allergy. A prospective controlled study was performed on 28 patients with allergic rhinitis to grass pollen and on 47 patients with allergic rhinitis to mites. ...

journal_title：Allergy

authors： Moll B,Klimek L,Eggers G,Mann W

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Differential leukocyte counts are of proven clinical value, but information about basophil counts in normal and disease conditions is scarce although basophils are regarded as key effector cells in allergy. AIMS:To establish and validate flowcytometric methods for counting basophils in peripheral human bloo...

journal_title：Allergy

authors： Ducrest S,Meier F,Tschopp C,Pavlovic R,Dahinden CA

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Genetic modification of allergenic foods such as apple has the potential to reduce their clinical allergenicity, but this has never been studied by oral challenges in allergic individuals. METHODS:We performed oral food challenges in 21 apple-allergic individuals with Elstar apples which had undergone gene ...

journal_title：Allergy

authors： Dubois AE,Pagliarani G,Brouwer RM,Kollen BJ,Dragsted LO,Eriksen FD,Callesen O,Gilissen LJ,Krens FA,Visser RG,Smulders MJ,Vlieg-Boerstra BJ,Flokstra-de Blok BJ,van de Weg WE

更新日期：2015-11-01 00:00:00

abstract：:There is now extensive evidence that asthma results from inflammation in large and small airways, and that the degree of inflammation reflects the clinical severity of the disease. Most of this evidence, however, has come from studies in adult patients. Evidence in children comes largely from indirect studies such as ...

journal_title：Allergy

authors： van Aalderen WM,Sprikkelman AB,Hoekstra MO

更新日期：1999-01-01 00:00:00

abstract：:Airways inflammation involves accumulation of inflammatory cells such as eosinophils, basophils and mast cells, which are derived from progenitors in marrow and blood. The inflamed tissue of the airways, through its structural (epithelium, stroma) and inflammatory cell components, produces an array of cytokines which ...

journal_title：Allergy

authors： Denburg JA

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:It is commonly acknowledged that asthma is exacerbated by viral infections. On the other hand, basophil infiltration of lung tissues has been evidenced postmortem in cases of fatal disease, raising the question of a possible link between these two observations. OBJECTIVES:Herein, we addressed the relationsh...

journal_title：Allergy

authors： Ramadan A,Pham Van L,Machavoine F,Dietrich C,Alkan M,Karasuyama H,Schneider E,Dy M,Thieblemont N

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Genomewide association studies (GWASs) of asthma have identified single-nucleotide polymorphisms (SNPs) that modestly increase the risk for asthma. This could be due to phenotypic heterogeneity of asthma. Bronchial hyperresponsiveness (BHR) is a phenotypic hallmark of asthma. We aim to identify susceptibilit...

journal_title：Allergy

authors： Nieuwenhuis MA,Siedlinski M,van den Berge M,Granell R,Li X,Niens M,van der Vlies P,Altmüller J,Nürnberg P,Kerkhof M,van Schayck OC,Riemersma RA,van der Molen T,de Monchy JG,Bossé Y,Sandford A,Bruijnzeel-Koomen CA,Gerth

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Glucocorticoids (GCs) may affect the expression of hundreds of genes in different cells and tissues from patients with intermittent allergic rhinitis (IAR). It is a formidable challenge to understand these complex changes by studying individual genes. In this study, we aimed to identify (i) pathways affected...

journal_title：Allergy

authors： Wang H,Chavali S,Mobini R,Muraro A,Barbon F,Boldrin D,Aberg N,Benson M

更新日期：2011-01-01 00:00:00

abstract：:Overproduction of periostin, an IL-13-inducible matricellular protein, despite corticosteroid treatment is thought to be involved in the chronicity of allergic inflammation seen in corticosteroid-refractory tissue fibrosis. Therefore, we hypothesized that some tissue cells must produce periostin in a corticosteroid-in...

journal_title：Allergy

authors： Shoda T,Futamura K,Kobayashi F,Saito H,Matsumoto K,Matsuda A

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Food allergy in children can be life-threatening. Component-resolved diagnostics approach to food anaphylaxis is rarely assessed in children. The aim of the study was to identify the food allergen components as the triggers responsible for severe anaphylaxis, with regard to characteristics and associated ris...

journal_title：Allergy

authors： Blazowski L,Majak P,Kurzawa R,Kuna P,Jerzynska J

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Histamine intolerance is thought to trigger manifold clinical symptoms after ingesting histamine-rich food due to reduced activity of diamine oxidase (DAO). No study has hitherto systematically assessed daily fluctuations of histamine levels and DAO activities in symptomatic patients. The aim of the study wa...

journal_title：Allergy

authors： Pinzer TC,Tietz E,Waldmann E,Schink M,Neurath MF,Zopf Y

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:In a previous controlled study we demonstrated that preseasonal grass pollen immunotherapy for three years was effective in children. In the current study we examined the same group of patients to see if there is still a benefit six years after discontinuation of treatment. METHODS:Thirteen of 14 patients w...

journal_title：Allergy

authors： Eng PA,Reinhold M,Gnehm HP

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:Airway ecology is altered in asthma and chronic obstructive pulmonary disease (COPD). Anti-microbial interventions might have benefit in subgroups of airway disease. Differences in sputum microbial profiles at acute exacerbation of airways disease are reflected by the γProteobacteria:Firmicutes (γP:F) ratio....

journal_title：Allergy

authors： Diver S,Richardson M,Haldar K,Ghebre MA,Ramsheh MY,Bafadhel M,Desai D,Cohen ES,Newbold P,Rapley L,Rugman P,Pavord ID,May RD,Barer M,Brightling CE

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:We have previously demonstrated the presence of toll-like receptor 9 in the nasal mucosa of both healthy and allergic individuals. CpG motifs, found in bacterial and viral DNA, elicit strong immunostimulatory effects via this receptor. CpG is known to skew the immune system towards a T helper 1 (Th1) profile...

journal_title：Allergy

authors： Månsson A,Bachar O,Adner M,Cardell LO

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:The diagnosis of allergic reactions to drugs is difficult. Most skin tests are not standardized, and in vitro tests are needed to avoid provocation tests. Cross-linking of IgE on basophils is known to cause the release of both cysteinyl leukotriene (Cys-LT) and histamine. We aimed to evaluate the diagnostic ...

journal_title：Allergy

authors： Lebel B,Messaad D,Kvedariene V,Rongier M,Bousquet J,Demoly P

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:The complex pathogenesis of atopic dermatitis (AD) is guided by cell surface receptor-mediated signal transduction regulated in lipid rafts. Miltefosine is a raft-modulating molecule targeting cell membranes. With this controlled clinical study, the clinical and immunomodulatory efficacy of miltefosine was i...

journal_title：Allergy

authors： Dölle S,Hoser D,Rasche C,Loddenkemper C,Maurer M,Zuberbier T,Worm M

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Several studies have shown that allergy to natural rubber latex is associated with cross-reactivity to certain foods such as tomato and potato. The objective was to investigate the clinical and immunologic differences between a group of patients with clinical allergy to tomato and latex and another which had...

journal_title：Allergy

authors： Reche M,Pascual CY,Vicente J,Caballero T,Martín-Muñoz F,Sanchez S,Martín-Esteban M

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Mastocytosis is a heterogeneous disease characterized by a clonal expansion of mast cells in various organs. The vast majority of patients suffer from signs and symptoms caused by mediator release from mast cells. Although the disease burden is high, there is currently no specific and validated instrument to...

journal_title：Allergy

authors： Siebenhaar F,Sander B,Ho LHT,Ellrich A,Maurer M,Weller K

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:The genetic determinants of food allergy have not been systematically reviewed. We therefore systematically reviewed the literature on the genetic basis of food allergy, identifying areas for further investigation. METHODS:We searched three electronic databases (MEDLINE, EMBASE and PubMed) on 9 January 2018...

journal_title：Allergy

authors： Suaini NHA,Wang Y,Soriano VX,Martino DJ,Allen KJ,Ellis JA,Koplin JJ

更新日期：2019-09-01 00:00:00

abstract：:We investigated the relationship between residence in the neighbourhood of an aluminium smelter and the prevalence of atopy in schoolchildren (7-13 years of age). Atopy was assessed in 556 of the 620 participants by a skin prick test with eight common aeroallergens. The median exposures to sulphur dioxide and fluoride...

journal_title：Allergy

authors： Søyseth V,Kongerud J,Boe J

更新日期：1996-10-01 00:00:00

abstract：:All eight production workers from a small trout-processing factory were studied because of respiratory or rhinitis symptoms when working next to the automatic gutting machine. Seven of the eight had positive histamine provocation tests. Four patients had elevated total IgE levels while one had a slightly elevated eosi...

journal_title：Allergy

authors： Sherson D,Hansen I,Sigsgaard T

更新日期：1989-07-01 00:00:00