Abstract:
:Airways inflammation involves accumulation of inflammatory cells such as eosinophils, basophils and mast cells, which are derived from progenitors in marrow and blood. The inflamed tissue of the airways, through its structural (epithelium, stroma) and inflammatory cell components, produces an array of cytokines which can influence the differentiation of inflammatory cell progenitors. It is particular mechanism that we have investigated, showing that molecules such as GM-CSF, G-CSF, IL-6, IL-8 and SCF can be produced by airways epithelial cells and fibroblasts in quantities sufficient to induce hemopoietic events, either systemically or locally. Corticosteriods may act therapeutically, at least in part, to block inflammatory cell differentiation, and thus recruitment, into the allergic inflammatory process in the airways.
journal_name
Allergyjournal_title
Allergyauthors
Denburg JAdoi
10.1111/j.1398-9995.1995.tb04272.xsubject
Has Abstractpub_date
1995-01-01 00:00:00pages
25-8issue
25 Suppleissn
0105-4538issn
1398-9995journal_volume
50pub_type
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