Microenvironmental influences on inflammatory cell differentiation.

Abstract:

:Airways inflammation involves accumulation of inflammatory cells such as eosinophils, basophils and mast cells, which are derived from progenitors in marrow and blood. The inflamed tissue of the airways, through its structural (epithelium, stroma) and inflammatory cell components, produces an array of cytokines which can influence the differentiation of inflammatory cell progenitors. It is particular mechanism that we have investigated, showing that molecules such as GM-CSF, G-CSF, IL-6, IL-8 and SCF can be produced by airways epithelial cells and fibroblasts in quantities sufficient to induce hemopoietic events, either systemically or locally. Corticosteriods may act therapeutically, at least in part, to block inflammatory cell differentiation, and thus recruitment, into the allergic inflammatory process in the airways.

journal_name

Allergy

journal_title

Allergy

authors

Denburg JA

doi

10.1111/j.1398-9995.1995.tb04272.x

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

25-8

issue

25 Suppl

eissn

0105-4538

issn

1398-9995

journal_volume

50

pub_type

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