First successful reduction of clinical allergenicity of food by genetic modification: Mal d 1-silenced apples cause fewer allergy symptoms than the wild-type cultivar.

abstract：BACKGROUND:Management of atopic dermatitis (AD) requires judging the symptoms of local skin lesions and prescribing a suitable treatment. However, no method has been established in which objective measures can be used to evaluate the severity of local symptoms. We established a method for measuring thymus and activatio...

journal_title：Allergy

authors： Morita E,Takahashi H,Niihara H,Dekio I,Sumikawa Y,Murakami Y,Matsunaka H

更新日期：2010-09-01 00:00:00

abstract：:The scarce data published on mite sensitization and mite-allergen levels in Norway indicate that the mites may not be of the same importance in allergic disease in Norway as in countries such as the UK and the rest of Europe. The problem also involves the low allergen levels and small amounts of dust collected for all...

journal_title：Allergy

authors： Gaarder PI

更新日期：1998-01-01 00:00:00

abstract：:An egg protein, lysozyme, is a still unlabeled additive currently used in cheese preparation. Furthermore, the WHO-FAO committee considers it innocuous. However, 31% of children and 8% of adults with food allergies are allergic to eggs. This work aimed to determine the percentage of patients sensitized to lysozyme fro...

journal_title：Allergy

authors： Frémont S,Kanny G,Nicolas JP,Moneret-Vautrin DA

更新日期：1997-02-01 00:00:00

abstract：:708 unselected adolescents 15-17 years old were studied. They were physically examined, interviewed and skin prick tested with 12 common allergens. Questionnaires were distributed to the adolescents and their parents to investigate past and present symptoms and environmental influences. Emphasis was on the first year ...

journal_title：Allergy

authors： Suoniemi I,Björkstén F,Haahtela T

更新日期：1981-05-01 00:00:00

abstract：BACKGROUND:The function of eosinophils has been attributed to host defense, immunomodulation, and fibrosis. Although eosinophils are found among infiltrating cells in a broad spectrum of skin diseases, their pathogenic role remains uncertain. This study aimed to analyze the cytokine expression by eosinophils in differe...

journal_title：Allergy

authors： Roth N,Städler S,Lemann M,Hösli S,Simon HU,Simon D

更新日期：2011-11-01 00:00:00

abstract：:We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation b...

journal_title：Allergy

authors： Apostolovic D,Sánchez-Vidaurre S,Waden K,Curin M,Grundström J,Gafvelin G,Cirkovic Velickovic T,Grönlund H,Thomas WR,Valenta R,Hamsten C,van Hage M

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Information about the influence of housing and occupant characteristics on mite allergen concentrations is crucial to determine which methods could be used to decrease exposure of susceptible subjects. OBJECTIVES:To identify housing and occupant characteristics that are associated with mite allergen concent...

journal_title：Allergy

authors： van Strien RT,Gehring U,Belanger K,Triche E,Gent J,Bracken MB,Leaderer BP

更新日期：2004-06-01 00:00:00

abstract：:The usefulness of the leukocyte migration inhibition factor (LIF) test to detect cow milk (CM) hypersensitivity was studied in 40 children with suspected allergy to CM. Hypersensitivity was carefully investigated by oral milk challenges, which gave a final confirmation of cow milk hypersensitivity in 12 subjects, and ...

journal_title：Allergy

authors： Vanto T,Smogorzewska EM,Viander M,Kalimo K,Koivikko A

更新日期：1987-11-01 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2s) are a recently identified group of cells with the potent capability to produce Th2-type cytokines such as interleukin (IL)-5 and IL-13. Several studies suggest that ILC2s play an important role in the development of allergic diseases and asthma. Activation of pulmonary ILC2s in mu...

journal_title：Allergy

authors： Aron JL,Akbari O

更新日期：2017-08-01 00:00:00

abstract：:Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report, we provide eviden...

journal_title：Allergy

authors： Yousefi S,Morshed M,Amini P,Stojkov D,Simon D,von Gunten S,Kaufmann T,Simon HU

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:In cross-sectional clinical studies, rhinitis has been shown to be strongly associated with co-existing chronic cough. However, to date, this association has been poorly delineated from a prospective and epidemiological standpoint. METHODS:We used data from the 'Pisa Prospective Study', a population-based l...

journal_title：Allergy

authors： Guerra S,Sherrill DL,Baldacci S,Carrozzi L,Pistelli F,Di Pede F,Viegi G

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:New therapies are necessary to address inadequate asthma control in many patients. This study sets out to investigate whether hypoxia-inducible factor (HIF) is essential for development of allergic airway inflammation (AAI) and therefore a potential novel target for asthma treatment. METHODS:Mice conditiona...

journal_title：Allergy

authors： Huerta-Yepez S,Baay-Guzman GJ,Bebenek IG,Hernandez-Pando R,Vega MI,Chi L,Riedl M,Diaz-Sanchez D,Kleerup E,Tashkin DP,Gonzalez FJ,Bonavida B,Zeidler M,Hankinson O

更新日期：2011-07-01 00:00:00

abstract：:Respiratory allergies and subclinical sensitization to aeroallergens were investigated in 129 rural and in 222 urban probands. The incidence of respiratory allergies was not significantly higher in the urban residents. Sensitization to aeroallergens was investigated with Phadezym RAST (house dust mite, Cladosporium, o...

journal_title：Allergy

authors： Popp W,Zwick H,Steyrer K,Rauscher H,Wanke T

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:A favorable outcome of anaphylaxis depends on the rapidity of adequate initial management and epinephrine injection. However, few data on the management of anaphylactic reactions are available. The aim of this study was to investigate the management and awareness of anaphylaxis to foods by mean of an Interne...

journal_title：Allergy

authors： Eigenmann PA,Pastore FD,Zamora SA

更新日期：2001-06-01 00:00:00

abstract：:Although mediators, such as lipids, cytokines, and chemokines, are related to the appearance of an IPR, there has been no reliable indicator to predict conditions for the appearance of an IPR. In this study, we adopted a proteomic approach to investigate the pathogenesis at the level of the plasma proteins and to deve...

journal_title：Allergy

authors： Rhim T,Choi YS,Nam BY,Uh ST,Park JS,Kim YH,Paik YK,Park CS

更新日期：2009-01-01 00:00:00

abstract：:We investigated whether exine-free pollen allergen particles exist together with the intact pollen grains of Japanese cedar (Cryptomeria japonica) in the air during the pollen season in Yamagata City. First, we separated the allergen particles in an Andersen multi-stage air-sampler according to their aerodynamic diame...

journal_title：Allergy

authors： Takahashi Y,Sakaguchi M,Inouye S,Miyazawa H,Imaoka K,Katagiri S

更新日期：1991-11-01 00:00:00

abstract：:IgG-binding to the surface of Langerhans cells (LC) is a feature of primary Sjögren's syndrome and might be associated with qualitative and quantitative defects in LC. Fifteen patients with primary Sjögren's syndrome and 15 healthy controls had a punch biopsy performed from clinically unaffected skin. LC were enumerat...

journal_title：Allergy

authors： Oxholm P,Oxholm A,Manthorpe R

更新日期：1986-08-01 00:00:00

abstract：:Formoterol, a new beta 2-selective long-acting bronchodilator, was compared with terbutaline in terms of ability to inhibit dual phase skin reactions to anti-human IgE in volunteers. Anti-IgE induced an early wheal and flare reaction (WFR) followed by a progressively increasing induration, the late phase reaction (LCR...

journal_title：Allergy

authors： Grönneberg R,Zetterström O

更新日期：1990-07-01 00:00:00

abstract：:Identification and characterization of risk and protective factors for allergy is important for developing strategies for prevention or treatment. The prevalence of allergy is clearly higher in affluent countries than in developing countries like, e.g. Africa. Especially in urban areas of developing countries, allergy...

journal_title：Allergy

authors： van Ree R,Yazdanbakhsh M

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Latex sensitivity is an increasing problem among health-care workers. Allergic responses are associated with changes in nitric oxide (NO) generation and the changes secondary to latex have not been described. METHODS:A total of 22 subjects comprising equal numbers of control volunteers and subjects with sel...

journal_title：Allergy

authors： Tan K,Bruce C,Birkhead A,Thomas PS

更新日期：2001-07-01 00:00:00

abstract：:We investigated the relationship between residence in the neighbourhood of an aluminium smelter and the prevalence of atopy in schoolchildren (7-13 years of age). Atopy was assessed in 556 of the 620 participants by a skin prick test with eight common aeroallergens. The median exposures to sulphur dioxide and fluoride...

journal_title：Allergy

authors： Søyseth V,Kongerud J,Boe J

更新日期：1996-10-01 00:00:00

abstract：:Gastroesophageal reflux disease (GERD) occurs in up to one-third of the adult US population. Most affected individuals are either unaware of their condition or do not seek medical help, relying on nonprescription acid suppressants and antacids for relief. GERD, a common disorder of infancy, old age, and pregnancy, is ...

journal_title：Allergy

authors： Theodoropoulos DS,Lockey RF,Boyce HW Jr,Bukantz SC

更新日期：1999-07-01 00:00:00

abstract：:The IgE-binding components of date palm (Phoenix dactylifera L.) pollen were determined by ELISA and Western blotting in atopic patients in order to identify its major allergens. From a pool of previously identified allergenic fractions and sera from 15 skin-test-positive, atopic subjects, four components of 12, 14.4,...

journal_title：Allergy

authors： Kwaasi AA,Parhar RS,Tipirneni P,Harfi H,al-Sedairy ST

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:The function of skin mast cells has been well documented in IgE-mediated allergic reactions, whereas other mast cell functions are poorly defined. This study aimed at identifying novel mast cell proteins by proteome analysis of primary human skin mast cells. METHODS:The proteome of skin mast cells was compa...

journal_title：Allergy

authors： Gschwandtner M,Paulitschke V,Mildner M,Brunner PM,Hacker S,Eisenwort G,Sperr WR,Valent P,Gerner C,Tschachler E

更新日期：2017-01-01 00:00:00

abstract：:This study was conducted to evaluate how bronchial responsiveness to direct and indirect stimuli relate to nitric oxide producing airway inflammation, and whether the relationship differs between atopic and nonatopic patients with various degrees of bronchial hyperresponsiveness and airway inflammation in a group of o...

journal_title：Allergy

authors： Rouhos A,Ekroos H,Karjalainen J,Sarna S,Sovijärvi AR

更新日期：2005-12-01 00:00:00

abstract：:The parents of 3649 Finnish children and adolescents were interviewed in 1980 to evaluate the prevalence of bronchial asthma, allergic rhinitis and atopic dermatitis. The same group was interviewed 6 years later to determine the incidence of new cases of bronchial asthma in the 1980s. Age- and sex-matched samples were...

journal_title：Allergy

authors： Pöysä L,Korppi M,Pietikäinen M,Remes K,Juntunen-Backman K

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:There are large differences in the prevalence of atopic disease between urban and rural areas of developing countries, without good explanation. Diet has been associated with atopic disease, but studies of specific nutrients are contradictory, cross-sectional studies often being unsupported by trials. We inv...

journal_title：Allergy

authors： Hooper R,Calvert J,Thompson RL,Deetlefs ME,Burney P

更新日期：2008-04-01 00:00:00

abstract：:Pityrosporum orbiculare and Candida albicans extracts were separated by SDS-PAGE, and IgE binding was detected by immunoblotting with 21 patient sera that were RAST positive to both yeasts. Cross-wise inhibition was performed of IgE binding of a serum pool containing IgE antibodies to both yeasts. The pool was mixed w...

journal_title：Allergy

authors： Huang X,Johansson SG,Zargari A,Nordvall SL

更新日期：1995-08-01 00:00:00

abstract：:The hygiene hypothesis states that a reduced exposure to allergens in early life is solely implicated in the growing propensity for allergy sensitization. Important elements of the hypothesis include helminth infection, exposure to endotoxins, exposure to pets and growing up on a farm. However, the hygiene hypothesis ...

journal_title：Allergy

authors： Platts-Mills TA,Erwin E,Heymann P,Woodfolk J

更新日期：2005-01-01 00:00:00

abstract：:Five biologicals have been approved for severe eosinophilic asthma, a well-recognized phenotype. Systematic reviews (SR) evaluated the efficacy and safety of benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab (alphabetical order) compared to standard of care for severe eosinophilic asthma. PubMed, Embase ...

journal_title：Allergy

authors： Agache I,Beltran J,Akdis C,Akdis M,Canelo-Aybar C,Canonica GW,Casale T,Chivato T,Corren J,Del Giacco S,Eiwegger T,Firinu D,Gern JE,Hamelmann E,Hanania N,Mäkelä M,Hernández-Martín I,Nair P,O'Mahony L,Papadopoulos NG

更新日期：2020-05-01 00:00:00