Bioavailability of theophylline from three different tablets in asthmatic patients and their bronchodilating effects in combination with terbutaline inhalation.

Abstract:

:The bioavailability of three different theophylline tablets (microcrystallinic theophylline, Theolair, Nuelin, 3M Riker), choline theophyllinate as a new film-coated tablet (Teovent, Ferrosan, Sweden) and theophyllaminopropanol (Oxyphylline, Draco, Sweden) was investigated in eight adult asthmatics and a randomized, double-blind, cross-over study. Effects on ventilatory capacity (FEV1 and FVC), circulation (heart rate and blood pressure) and skeletal muscle tremor were followed. The theophylline concentration was determined by gas chromatography. Forty-five minutes after theophylline administration the plasma concentrations were almost the same for all four formulations. The bioavailability was also almost identical. The half-life for intravenous theophylline in these asthmatics was 7.4 +/- 0.64. The three tablet formation had equal effect on FEV1 and the effect was sustained throughout the 6-h period. Six hours after theophylline administration five terbutaline inhalations induced the same further increase in FEV1. The results indicate that theophylline alone has only a moderate acute bronchodilating effect at recommended plasma concentrations but gives a good effect when combined with inhaled beta 2-adrenostimulants.

journal_name

Allergy

journal_title

Allergy

authors

Svedmyr K,Mellstrand T,Svedmyr N

doi

10.1111/j.1398-9995.1982.tb01884.x

subject

Has Abstract

pub_date

1982-02-01 00:00:00

pages

111-7

issue

2

eissn

0105-4538

issn

1398-9995

journal_volume

37

pub_type

临床试验,杂志文章,随机对照试验

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